|
Infectious diseases / Original Article
Initial and peak serum levels of Krebs von den Lungen-6 for predicting the prognosis of patients with COVID-19
Geonui Kim, Hyeonwoo Kwon, Sang Hyun Ra, Euijin Chang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim
Korean J Intern Med. 2025;40(2):321-329. Published online February 21, 2025
Background/Aims: Krebs von den Lungen-6 (KL-6) is associated with prognosis in patients with COVID-19. However, there is limited data on the correlation between the prognosis of COVID-19 and varying KL-6 levels at different time points. We investigated the optimal cutoff values of the initial and pe..
|
|
|
Gastroenterology / Original Article
Characteristics and outcomes of portal vein thrombosis in patients with inflammatory bowel disease in Korea
Ki Jin Kim, Su-Bin Song, Jung-Bin Park, June Hwa Bae, Ji Eun Baek, Ga Hee Kim, Min-Jun Kim, Seung Wook Hong, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Chang Sik Yu, Yong-Sik Yoon, Jong-Lyul Lee, Min Hyun Kim, Ho-Su Lee, Sang Hyoung Park
Korean J Intern Med. 2025;40(2):243-250. Published online December 23, 2024
Background/Aims: Portal vein thrombosis (PVT) frequently occurs in patients with inflammatory bowel disease (IBD), particularly when influenced by factors such as abdominal infections, IBD flare-ups, or surgical procedures. The implications of PVT range from immediate issues such as intestinal ische..
|
|
|
Gastroenterology / Original Article
Clinical outcomes of esophageal squamous cell carcinoma in patients aged over 80 years
Dae Gon Ryu, Cheol Woong Choi, Su Jin Kim, Su Bum Park, Jin Ook Jang, Bong Soo Son
Korean J Intern Med. 2025;40(2):230-242. Published online February 21, 2025
Background/Aims: The clinical outcomes and optimal treatment of esophageal squamous cell carcinoma (ESCC) in elderly patients are unclear. This study aimed to assess the clinical outcomes of ESCC in patients aged ≥ 80 years.
Methods: Medical records of patients diagnosed with ESCC between Decembe..
|
|
|
Gastroenterology / Review
Role of endoscopic ultrasound in the diagnosis and local ablative therapy of pancreatic neuroendocrine tumors
Yun Je Song, Jun Kyeong Lim, Jun-Ho Choi
Korean J Intern Med. 2025;40(2):170-180. Published online February 25, 2025
Advancements in diagnostic technology have led to the improved detection of pancreatic neuroendocrine tumors (PNETs) and thus to an increase in the number of reported cases. Endoscopic ultrasound (EUS) technology, including in combination with contrast-enhanced harmonic imaging, aids in distinguishi..
|
|
|
Endocrinology-metabolism / Original Article
Fisher discriminant analysis of multimodal ultrasound in diagnosis of cervical metastatic lymph nodes in papillary thyroid cancer
Yixuan Wang, Yue Han, Fei Li, Yuyang Lin, Bei Wang
Korean J Intern Med. 2025;40(1):103-114. Published online October 29, 2024
Background/Aims: The purpose of this study was to develop a diagnostic model utilizing multimodal ultrasound parameters to aid in the detection of cervical lymph node metastasis in papillary thyroid cancer (PTC) patients.
Methods: The study included 84 suspicious lymph nodes from 69 PTC patients, a..
|
|
|
Endocrinology-metabolism / Original Article
Dexamethasone synergizes with high-fat diet to increase lipid deposition in adipocytes
Mingli Su, Ying Wang, Zheng Yan, Jia Luo, Jie Yang, Hua Ye, Aiming Liu, Julin Yang
Korean J Intern Med. 2025;40(1):92-102. Published online January 1, 2025
Background/Aims: Dexamethasone (DEX) is a widely used exogenous therapeutic glucocorticoid in clinical settings. Its long-term use leads to many side effects. However, its effect on metabolic disorders in individuals on a high-fat diet (HFD) remains poorly understood.
Methods: In this study, HFD-fe..
|
|
|
Pulmonology / Original Article
Blood eosinophil count and treatment patterns of chronic obstructive pulmonary disease patients in South Korea using real-world data
Chin Kook Rhee, Yu-Fan Ho, Sumitra Shantakumar, Tim Holbrook, Yein Nam, Kwang‑Ha Yoo
Korean J Intern Med. 2025;40(1):78-91. Published online January 1, 2025
Background/Aims: Chronic obstructive pulmonary disease (COPD) management guidelines have increasingly emphasised the importance of exacerbation prevention, and the role of blood eosinophil count (BEC) as a biomarker for inhaled corticosteroids (ICS) response. This study aimed to describe the distrib..
|
|
|
Rheumatology / Review
Literature review of non-pharmacological treatment for patients with axial spondyloarthritis
Jina Yeo, Mi Ryoung Seo, Jun Won Park, Yeon-Ah Lee, Ju Ho Lee, Eun Ha Kang, Seon Mi Ji, Han Joo Baek
Korean J Intern Med. 2025;40(1):40-48. Published online May 27, 2024
Axial spondyloarthritis (axSpA) is a chronic inflammatory disorder affecting the sacroiliac joints and axial spine. Along with pharmacotherapy, non-pharmacological interventions for axSpA are crucial and constitute the cornerstone of treatment. Here, we review the evidence for non-pharmacological tr..
|
|
|
Endocrinology-metabolism / Review
Cancer treatment-induced bone loss
Yong Jun Choi
Korean J Intern Med. 2024;39(5):731-745. Published online March 5, 2024
Cancer treatment-induced bone loss (CTBL) is associated with anti-tumor treatments, including endocrine therapies, chemotherapeutic treatments, radiotherapy, glucocorticoids, and tyrosine kinase inhibitors. Osteoporosis, characterized by the loss of bone mass, can increase the risk of fractures, lea..
|
|
|
Cardiology / Review
2024 KSoLA consensus on secondary dyslipidemia
Hoyoun Won, Jae Hyun Bae, Hyunjung Lim, Minji Kang, Minjoo Kim, Sang-Hak Lee; on behalf of the Clinical Practice Guidelines Committee, Korean Society of Lipid and Atherosclerosis (KSoLA)
Korean J Intern Med. 2024;39(5):717-730. Published online August 30, 2024
Elevated blood cholesterol and triglyceride levels induced by secondary causes are frequently observed. The identification and appropriate handling of these causes are essential for secondary dyslipidemia treatment. Major secondary causes of hypercholesterolemia and hypertriglyceridemia include an u..
|
|
|
Rheumatology / Original Article
Impact of socioeconomic status on biologics utilization in rheumatoid arthritis: revealing inequalities and healthcare efficiency
Hye Won Kim, Yeon Ju Lee, You-Jung Ha, Eun Bong Lee, Yun Jong Lee, Eun Ha Kang
Korean J Intern Med. 2024;39(4):668-679. Published online February 29, 2024
Background/Aims: This cross-sectional study aimed to investigate biologics treatment disparities in rheumatoid arthritis (RA) patients based on socioeconomic status (SES).
Methods: Data from the KOrean Observational Study Network for Arthritis (KORONA) database were analyzed to assess various facto..
|
|
|
Allergy / Original Article
Association between specific IgE to staphylococcal enterotoxin B and the eosinophilic phenotype of asthma
Soyoon Sim, Youngwoo Choi, Eun-Mi Yang, Hae-Sim Park
Korean J Intern Med. 2024;39(4):659-667. Published online July 1, 2024
Background/Aims: Sensitization to staphylococcal superantigens (SAgs) could contribute to asthma severity. However, its relevance with eosinophilic phenotype has not yet been clarified. This study aimed to investigate associations between serum specific IgE levels to SAg and eosinophilic airway infl..
|
|
|
Gastroenterology / Original Article
Clinical course of asymptomatic duodenal subepithelial lesions
Seokin Kang, Kwangbeom Park, Do Hoon Kim, Yuri Kim, Hee Kyong Na, Jeong Hoon Lee, Ji Yong Ahn, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Korean J Intern Med. 2024;39(4):603-611. Published online June 13, 2024
Background/Aims: There is limited knowledge regarding the management of duodenal subepithelial lesions (SELs) owing to a lack of understanding of their natural course. This study aimed to assess the natural course of asymptomatic duodenal SELs and provide management recommendations.
Methods: Patien..
|
|
|
Gastroenterology / Original Article
Increasing correlation between oral and gastric microbiota during gastric carcinogenesis
Hee Sang You, Jae Yong Park, Hochan Seo, Beom Jin Kim, Jae Gyu Kim
Korean J Intern Med. 2024;39(4):590-602. Published online June 24, 2024
Background/Aims: Recent research has increasingly focused on the role of the gastric microbiome in the development of gastric cancer. We aimed to investigate the changes in the microbiome during gastric carcinogenesis in structural and functional aspects, with a specific focus on the association bet..
|
|
|
Gastroenterology / Review
Artificial intelligence in colonoscopy: from detection to diagnosis
Eun Sun Kim, Kwang-Sig Lee
Korean J Intern Med. 2024;39(4):555-562. Published online May 2, 2024
This study reviews the recent progress of artificial intelligence for colonoscopy from detection to diagnosis. The source of data was 27 original studies in PubMed. The search terms were “colonoscopy” (title) and “deep learning” (abstract). The eligibility criteria were: (1) the dependent varia..
|
|
|
Gastroenterology / Review
Strategies to improve screening colonoscopy quality for the prevention of colorectal cancer
Joo Hye Song, Eun Ran Kim
Korean J Intern Med. 2024;39(4):547-554. Published online January 22, 2024
The incidence and mortality of colorectal cancer (CRC) have decreased through regular screening colonoscopy, surveillance, and endoscopic treatment. However, CRC can still be diagnosed after negative colonoscopy. Such CRC is called interval CRC and accounts for 1.8–9.0% of all CRC cases. Most case..
|
|
|
Hemato-oncology / Original Article
Geriatric risk model for older patients with diffuse large B-cell lymphoma (GERIAD): a prospective multicenter cohort study
Ho-Young Yhim, Yong Park, Jeong-A Kim, Ho-Jin Shin, Young Rok Do, Joon Ho Moon, Min Kyoung Kim, Won Sik Lee, Dae Sik Kim, Myung-Won Lee, Yoon Seok Choi, Seong Hyun Jeong, Kyoung Ha Kim, Jinhang Kim, Chang-Hoon Lee, Ga-Young Song, Deok-Hwan Yang, Jae-Yong Kwak
Korean J Intern Med. 2024;39(3):501-512. Published online January 30, 2024
Background/Aims: Optimal risk stratification based on simplified geriatric assessment to predict treatment-related toxicity and survival needs to be clarified in older patients with diffuse large B-cell lymphoma (DLBCL).
Methods: This multicenter prospective cohort study enrolled newly diagnosed pat..
|
|
|
Hemato-oncology / Original Article
Prognostic Significance Of Sequential 18f-fdg Pet/Ct During Frontline Treatment Of Peripheral T Cell Lymphomas
Ga-Young Song, Sung-Hoon Jung, Seo-Yeon Ahn, Mihee Kim, Jae-Sook Ahn, Je-Jung Lee, Hyeoung-Joon Kim, Jang Bae Moon, Su Woong Yoo, Seong Young Kwon, Jung-Joon Min, Hee-Seung Bom, Sae-Ryung Kang, Deok-Hwan Yang
Korean J Intern Med. 2024;39(2):327-337. Published online January 25, 2024
Background/Aims: The prognostic significance of 18F-fluorodeoxyglucose (FDG)-positron emission tomography-computed tomography (PET/CT) in peripheral T-cell lymphomas (PTCLs) are controversial. We explored the prognostic impact of sequential 18F-FDG PET/CT during frontline chemo..
|
|
|
Pulmonology / Original Article
Clinical impact of pleural fluid carcinoembryonic antigen on therapeutic strategy and efficacy in lung adenocarcinoma patients with malignant pleural effusion
Jaehee Lee, Deok Heon Lee, Ji Eun Park, Yong Hoon Lee, Sun Ha Choi, Hyewon Seo, Seung Soo Yoo, Shin Yup Lee, Seung-Ick Cha, Jae Yong Park, Chang Ho Kim
Korean J Intern Med. 2024;39(2):318-326. Published online February 14, 2024
Background/Aims: Epidermal growth factor receptor (EGFR) mutation is important in determining the treatment strategy for advanced lung cancer patients with malignant pleural effusion (MPE). Contrary to serum carcinoembryonic antigen (S-CEA) levels, the associations between pleural fluid CEA (PF-CEA)..
|
|
|
Pulmonology / Original Article
Relationship between metformin use and mortality in tuberculosis patients with diabetes: a nationwide cohort study
Eunki Chung, Dawoon Jeong, Jeongha Mok, Doosoo Jeon, Hee-Yeon Kang, Heejin Kim, Heesun Kim, Hongjo Choi, Young Ae Kang
Korean J Intern Med. 2024;39(2):306-317. Published online February 6, 2024
Background/Aims: To determine whether metformin, which is considered a host-directed therapy for tuberculosis (TB), is effective in improving the prognosis of patients with TB and diabetes mellitus (DM), who have higher mortality than those without DM.
Methods: This cohort study included patients w..
|
|
|
