| Reviews |
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Gastroenterology / Review
Optimizing multiple diagnostic modalities for small bowel evaluation: a strategic approach
Dong Jun Oh, Yun Jeong Lim
Korean J Intern Med. 2026;41(5):785-798. Published online September 1, 2026
Over the past two decades, the small bowel, once considered a diagnostic “blind spot,” has become fully and comprehensively accessible. This review summarizes recent advances in the main diagnostic modalities: capsule endoscopy (CE), device-assisted enteroscopy (DAE), computed tomography enterogr..
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Gastroenterology / Review
Epidemiological and clinical trends of malignant small-bowel tumors in Asia
Jung Rock Moon, Seong Ran Jeon
Korean J Intern Med. 2026;41(5):799-807. Published online August 26, 2026
Malignant small-bowel tumors are uncommon, accounting for < 5% of all gastrointestinal cancers, yet their incidence has exhibited a steady rise in both Western and Asian populations. This increase is attributed to expanded use of advanced diagnostic modalities and improved registry completeness. Mali..
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Gastroenterology / Review
Current insights into the diagnosis and management of small bowel bleeding
Sang Hyun Kim, Ja Seol Koo
Korean J Intern Med. 2026;41(5):808-818. Published online September 1, 2026
Small bowel bleeding accounts for 5–10% of gastrointestinal (GI) hemorrhage and remains a diagnostic challenge because of its diverse etiologies and subtle clinical presentation. Advances in small bowel imaging have refined the diagnostic approach and have led to the replacement of the term obscur..
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Cardiology / Review
Heart failure with preserved ejection fraction in women: a sex-specific clinical review
Soo-Jin Kim, Mi-Seung Shin
Korean J Intern Med. 2026;41(5):819-830. Published online September 1, 2026
Heart failure with preserved ejection fraction (HFpEF) affects approximately half of the current heart failure population and demonstrates marked sex-related differences in pathophysiology, clinical presentation, and therapeutic response. These distinctions reflect the divergent biological pathways ..
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Pulmonology / Review
Health effects of air pollution on chronic respiratory diseases
Yong Suk Jo, Jin Woo Song
Korean J Intern Med. 2026;41(5):831-846. Published online September 1, 2026
Exposure to both outdoor and indoor air pollution poses significant global public health challenges at all life stages. As the respiratory system serves as the primary entry route for inhaled pollutants, extensive evidence has demonstrated the detrimental effects of various air pollutants on respira..
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| Original Article |
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Gastroenterology / Original Article
Population-specific rare variants influence age at diagnosis in Korean inflammatory bowel disease
Mina Cho, DongHwan Shin, Jongwook Yu, Jae Hee Cheon, Ju Han Kim
Korean J Intern Med. 2026;41(5):847-857. Published online September 1, 2026
Background/Aims: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is increasing in East Asia. Most known susceptibility loci, identified primarily in Europeans, remain insufficient to explain clinical heterogeneity in Asians. We performed whole-exome..
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| Editorial |
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Gastroenterology / Editorial
Beyond susceptibility: do population-specific rare variants shape age at diagnosis in Korean inflammatory bowel disease?
Soo-kyung Park
Korean J Intern Med. 2026;41(5):858-861. Published online September 1, 2026
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Gastroenterology / Original Article
Clinical feasibility of deep learning-assisted classification of Helicobacter pylori infection in endoscopic imagery: a reader study
Jun-young Seo, Jiseon Kang, Do Hoon Kim, Namkug Kim
Korean J Intern Med. 2026;41(5):862-872. Published online September 1, 2026
Background/Aims: Detecting Helicobacter pylori infection through endoscopic imaging is a preferred method to address the limitations of invasive diagnostics. We have developed a deep learning (DL) model to classify these images based on their H. pylori infection status and to evaluate its pot..
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Cardiology / Original Article
Prognostic implications of functional significance, high-risk plaque and vessel characteristics in patients with diabetes mellitus
Jin-Eun Song, Seokhun Yang, Masahiro Hoshino, Taishi Yonetsu, Jinlong Zhang, Eun-Seok Shin, Joon-Hyung Doh, Chang-Wook Nam, Jianan Wang, Shaoliang Chen, Nobuhiro Tanaka, Hitoshi Matsuo, Takashi Kubo, Hyuk-Jae Chang, Tsunekazu Kakuta, Bon-Kwon Koo
Korean J Intern Med. 2026;41(5):873-883. Published online September 1, 2026
Background/Aims: We investigated the prognostic value of high-risk plaque (HRP) and high-risk vessel (HRV) characteristics on coronary computed tomography angiography (CCTA) alongside fractional flow reserve (FFR) in patients with diabetes mellitus (DM).
Methods: We analyzed 307 vessels from 184 dia..
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Cardiology / Original Article
Prognostic significance of artificial intelligence-quantified late gadolinium enhancement on cardiac magnetic resonance in hypertrophic cardiomyopathy
Young-Sang Jeong, Jong-Il Park, Kang-Un Choi, Jong-Ho Nam, Chan-Hee Lee, Jang-Won Son, Ung Kim, Jong-Seon Park, Eunjung Kong
Korean J Intern Med. 2026;41(5):884-893. Published online September 1, 2026
Background/Aims: This study aimed to evaluate the prognostic value of artificial intelligence (AI)-based late gadolinium enhancement (LGE) quantification using cardiovascular magnetic resonance (CMR) in patients with hypertrophic cardiomyopathy (HCM).
Methods: We retrospectively analyzed 142 patien..
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Pulmonology / Original Article
Probable obesity hypoventilation syndrome in a Korean medical intensive care unit: clinical characteristics and outcomes
Kyu Jin Lee, Hong Yeul Lee, Jinwoo Lee, Sang-Min Lee, Jaeyoung Cho
Korean J Intern Med. 2026;41(5):894-904. Published online September 1, 2026
Background/Aims: Obesity hypoventilation syndrome (OHS) is associated with morbidity and intensive care unit (ICU) utilization. However, data from Asian ICUs are limited. We evaluated the proportion, characteristics, and outcomes of probable OHS among obese patients admitted to a medical ICU (MICU) in ..
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| Editorial |
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Pulmonology / Editorial
Obesity hypoventilation syndrome in the Korean intensive care unit: rare disease or simply overlooked?
Bora Lee, Sang Haak Lee
Korean J Intern Med. 2026;41(5):905-906. Published online September 1, 2026
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Endocrinology-metabolism / Original Article
Parathyroid hormone–related protein–mediated hypercalcemia of malignancy: insights from a multicenter clinical data warehouse
Jinyoung Kim, Yuri Shin, Jeonghoon Ha, Chaiho Jeong, Jeongmin Lee, Kwanhoon Jo, Jang Won Son, Jae-Seung Yun, Ihnsuk Lee, Dong-Jun Lim, Hyuk-Sang Kwon, Ki-Ho Song, Ki-Hyun Baek
Korean J Intern Med. 2026;41(5):907-915. Published online September 1, 2026
Background/Aims: Parathyroid hormone–related protein (PTHrP) is a major mediator of hypercalcemia in patients with malignancy; however, understanding of PTHrP-mediated hypercalcemia remains limited because available evidence has largely been derived from small case series.
Methods: We retrospectiv..
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Endocrinology-metabolism / Original Article
Diabetes progression and severe hypoglycemia: a nationwide cohort study of 2,475,605 adults with type 2 diabetes mellitus
Kyu-Na Lee, Bongseong Kim, Mee Kyoung Kim, Sukil Kim
Korean J Intern Med. 2026;41(5):916-926. Published online September 1, 2026
Background/Aims: Severe hypoglycemia (SH) is a major concern in type 2 diabetes mellitus (T2DM). We evaluated whether a composite diabetes progression score could predict incident SH.
Methods: Using the Korean National Health Insurance Service database, we identified 2,475,605 adults with T2DM who und..
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Nephrology / Original Article
Mortality risk associated with permanent central venous catheter use in the oldest-old population: a nationwide cohort study
Joo Un Park, Chang Min Park, Do Hyoung Kim, Hyangkyoung Kim, Byung Ha Chung, Hyung Seok Lee, Sang Jun Park, Min-ho Kim, Hoon Suk Park
Korean J Intern Med. 2026;41(5):927-939. Published online September 1, 2026
Background/Aims: Owing to aging-related factors, arteriovenous access (AV) is difficult to establish in older patients; central venous catheter (CVC) access is used instead. However, evidence on long-term outcomes of permanent vascular access types in the oldest-old adults (≥ 80 yr) is lacking. We..
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Allergy / Original Article
Clinical and immunologic features of adult primary antibody deficiency according to IVIGRT exposure
Jung-Eun Han, Hyun young Lee, Haeng Jun Kim, Yoo Seob Shin, Yeong-Min Ye, Hae-Sim Park
Korean J Intern Med. 2026;41(5):940-951. Published online September 1, 2026
Background/Aims: Primary antibody deficiency (PAD) in adults is increasingly recognized, but remains underdiagnosed and undertreated. We described the clinical and immunologic features of adult patients with PAD according to real-world exposure to intravenous immunoglobulin replacement therapy (IVIGR..
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Rheumatology / Original Article
Concomitant cryoglobulinaemic vasculitis alongside ANCA-associated vasculitis: concurrence or coincidental individual occurrence
Jeong Yeop Whang, Jang Woo Ha, Jihye Chung, Yong-Beom Park, Jaewoo Song, Younhee Park, Sang-Won Lee
Korean J Intern Med. 2026;41(5):952-960. Published online September 1, 2026
Background/Aims: Cryoglobulinaemic vasculitis (CryoVas) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) share the common characteristic of being small vessel vasculitides but exhibit significant differences in pathologic findings. This study investigated the incidence rate of cry..
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| Images of interest |
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Cardiology / Image of interest
Blocked premature atrial contractions mimicking severe sinus bradycardia
Chang Hee Kwon
Korean J Intern Med. 2026;41(5):961-962. Published online September 1, 2026
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Rheumatology / Image of interest
Castleman disease-like mesenteric lymphadenopathy in a Korean adult ultimately diagnosed with familial Mediterranean fever
Hee Won Park, Seo Yeon Youn, Gyeongsin Park, Youngjae Park
Korean J Intern Med. 2026;41(5):963-964. Published online August 26, 2026
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| Corrigendum |
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Corrigendum
Comparative efficacy and safety of warfarin and direct oral anticoagulants in patients with end-stage kidney disease and atrial fibrillation
Yujin Yang, Sun Hwa Lee, Wonmook Hwang, Ji Hoon Jung, Jae-Hyeong Park
Korean J Intern Med. 2026;41(5):965-965. Published online September 1, 2026
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| Retractions |
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Retraction
Treadmill exercise-induced E/e’ elevation as a predictor of cardiovascular event in end-stage renal disease on peritoneal dialysis
Jong Ho Shin, Ki-Woon Kang, Jung Ho Kim, Jung Yeon Chin, Nae Yu Kim, Sang Hyun Park, Won Ho Kim, Yu Jeong Choi, Kyung Tae Jung
Korean J Intern Med. 2026;41(5):966-966. Published online September 1, 2026
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Retraction
Comparison of antiplatelet treatment in patients with clopidogrel nonresponders with or without carriage of CYP2C19 polymorphism
Yun Myoung Ko, Jeong Kyung Kim, Jeong Hee Kim, Sang-Ho Park, Rak Kyeong Choi
Korean J Intern Med. 2026;41(5):967-967. Published online September 1, 2026
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