Endocrinology-metabolism / Original Article Persistent influence of past obesity on current adiponectin levels and mortality in patients with type 2 diabetes Min-Ji Kim, Sung-Woo Kim, Bitna Ha, Hyang Sook Kim, So-Hee Kwon, Jonghwa Jin, Yeon-Kyung Choi, Keun-Gyu Park, Jung Guk Kim, In-Kyu Lee, Jae-Han Jeon Korean J Intern Med. 2025;40(2):299-309.   Published online March 1, 2025 DOI: https://doi.org/10.3904/kjim.2024.221                      Background/Aims: Adiponectin, a hormone primarily produced by adipocytes, typically shows an inverse relationship with body mass index (BMI). However, some studies have reported a positive correlation between the two. Thus, this study aimed to examine the relationship between adiponectin level and B..

Endocrinology-metabolism / Original Article Dexamethasone synergizes with high-fat diet to increase lipid deposition in adipocytes Mingli Su, Ying Wang, Zheng Yan, Jia Luo, Jie Yang, Hua Ye, Aiming Liu, Julin Yang Korean J Intern Med. 2025;40(1):92-102.   Published online January 1, 2025 DOI: https://doi.org/10.3904/kjim.2024.022                      Background/Aims: Dexamethasone (DEX) is a widely used exogenous therapeutic glucocorticoid in clinical settings. Its long-term use leads to many side effects. However, its effect on metabolic disorders in individuals on a high-fat diet (HFD) remains poorly understood. Methods: In this study, HFD-fe..

Endocrinology-metabolism / Review Bariatric surgery for treatment of morbid obesity in adults Ki Bum Park, Kyong-Hwa Jun Korean J Intern Med. 2025;40(1):24-39.   Published online January 1, 2025 DOI: https://doi.org/10.3904/kjim.2024.219              Crossref 1                 Morbid obesity requires active intervention, with treatment options including lifestyle modification, pharmacotherapy, and surgery. As the prevalence of obesity continues to rise in Korea, it is crucial for specialists and general practitioners to have a comprehensive understanding of obesity and it..

Endocrinology-metabolism / Original Article Fisher discriminant analysis of multimodal ultrasound in diagnosis of cervical metastatic lymph nodes in papillary thyroid cancer Yixuan Wang, Yue Han, Fei Li, Yuyang Lin, Bei Wang Korean J Intern Med. 2025;40(1):103-114.   Published online October 29, 2024 DOI: https://doi.org/10.3904/kjim.2024.122              Crossref 1                      Background/Aims: The purpose of this study was to develop a diagnostic model utilizing multimodal ultrasound parameters to aid in the detection of cervical lymph node metastasis in papillary thyroid cancer (PTC) patients. Methods: The study included 84 suspicious lymph nodes from 69 PTC patients, a..

Endocrinology-metabolism / Original Article Patterns of hormonal changes in hypophysitis by immune checkpoint inhibitor Hyunji Sang, Yun Kyung Cho, Sang-hyeok Go, Hwa Jung Kim, Eun Hee Koh Korean J Intern Med. 2024;39(5):801-812.   Published online August 30, 2024 DOI: https://doi.org/10.3904/kjim.2023.523              Crossref 1                      Background/Aims: Immune checkpoint inhibitors (ICIs) can induce immune-related adverse events, including endocrine dysfunctions, which can have serious consequences on patient health and quality of life. The clinical course and characteristics of immune-related hypophysitis (irH) are not well establ..

Endocrinology-metabolism / Review Cancer treatment-induced bone loss Yong Jun Choi Korean J Intern Med. 2024;39(5):731-745.   Published online March 5, 2024 DOI: https://doi.org/10.3904/kjim.2023.386              Web of Science 1    Crossref 2                 Cancer treatment-induced bone loss (CTBL) is associated with anti-tumor treatments, including endocrine therapies, chemotherapeutic treatments, radiotherapy, glucocorticoids, and tyrosine kinase inhibitors. Osteoporosis, characterized by the loss of bone mass, can increase the risk of fractures, lea..

Endocrinology-metabolism / Original Article Effects of statin use on serum creatinine phosphokinase levels in normal thyroid function Jeonghoon Ha, Joonyub Lee, Jin Yu, Hakyoung Park, Jiwon Shinn, Seung-Hwan Lee, Jae-Hyoung Cho, Hun-Sung Kim Korean J Intern Med. 2024;39(4):650-658.   Published online June 24, 2024 DOI: https://doi.org/10.3904/kjim.2024.085                 Background/Aims: Statins are common lipid-lowering agents used in dyslipidemia. However, they increase serum creatinine phosphokinase (CPK) levels. Currently, there are no studies on the effect of thyroid-stimulating hormone (TSH) levels on CPK levels after statin administration. Therefore, this stu..

Endocrinology-metabolism / Original Article Efficacy and safety of denosumab treatment for Korean patients with Stage 3b–4 chronic kidney disease and osteoporosis Jin Taek Kim, You Mi Kim, Kyong Yeun Jung, Hoonsung Choi, So Young Lee, Hyo-Jeong Kim Korean J Intern Med. 2024;39(1):148-159.   Published online December 22, 2023 DOI: https://doi.org/10.3904/kjim.2023.292              Web of Science 2    Crossref 2                 Background/Aims: We evaluated the efficacy and safety of denosumab treatment in severe chronic kidney disease (CKD) patients with osteoporosis. We also investigated whether the treatment affects the coronary artery calcifications. Methods: Twenty-seven postmenopausal women with Stage 3b–4 CKD and..

Endocrinology-metabolism / Review Expanding the therapeutic landscape: ezetimibe as non-statin therapy for dyslipidemia Jeongmin Lee, Seung-Hwan Lee Korean J Intern Med. 2023;38(6):797-809.   Published online October 20, 2023 DOI: https://doi.org/10.3904/kjim.2023.243              Web of Science 5    Crossref 6                 Dyslipidemia is a significant risk factor for atherosclerotic cardiovascular disease (ASCVD), and statins are the primary therapeutic options for reducing low-density lipoprotein cholesterol (LDL-C) levels. However, it can be challenging to achieve optimal LDL-C goals with statin monotherapy. Ezetim..

Endocrinology-metabolism / Original Article Cumulative exposure to metabolic syndrome increases thyroid cancer risk in young adults: a population-based cohort study Jinyoung Kim, Kyungdo Han, Mee Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon Korean J Intern Med. 2023;38(4):526-533.   Published online May 18, 2023 DOI: https://doi.org/10.3904/kjim.2022.405              Web of Science 3    Crossref 5                      Background/Aims: A re-increasing trend of thyroid cancer since 2015 has been observed despite a similar examination rate, and the incidence of thyroid cancer among young adults continues to rise. Methods: This study used data from the Korean National Health Insurance Service. Individuals 20–39 year..

Endocrinology-metabolism / Original Article Association between DIO2 Thr92Ala polymorphism and hypertension in patients with hypothyroidism: Korean Genome and Epidemiology Study Young Mi Kang, Bon Seok Koo, Hyon-Seung Yi, Jung Tae Kim, Boyoung Park, Ju Hee Lee, Minho Shong, Yea Eun Kang Korean J Intern Med. 2023;38(2):226-237.   Published online January 17, 2023 DOI: https://doi.org/10.3904/kjim.2022.292              Web of Science 1    Crossref 1                      Background/Aims: Recent evidence has identified the significance of type 2 iodothyronine deiodinase (DIO2) in various diseases. However, the role of DIO2 polymorphism in metabolic parameters in patients with hypothyroidism is not fully understood. Methods: We assessed the polymorphism of the DIO2 g..

Endocrinology-metabolism / Original Article Diabetes screening in South Korea: a new estimate of the number needed to screen to detect diabetes Kyoung Hwa Ha, Kyung Ae Lee, Kyung-Do Han, Min Kyong Moon, Dae Jung Kim Korean J Intern Med. 2023;38(1):93-100.   Published online November 24, 2022 DOI: https://doi.org/10.3904/kjim.2022.283              Web of Science 11    Crossref 12                      Background/Aims: The Korean Diabetes Association (KDA) guidelines recommend adults aged ≥ 40 years and adults aged ≥ 30 years with diabetes risk factors for diabetes screening. This study aimed to determine the age threshold for diabetes screening in Korean adults. Methods: This study was based o..

Endocrinology-metabolism / Original Article Comorbidities associated with high-risk obstructive sleep apnea based on the STOP-BANG questionnaire: a nationwide population-based study Gene Huh, Kyoung do Han, Yong-Moon Park, Chan-Soon Park, Kyu-na Lee, Eun Young Lee, Jung-Hae Cho Korean J Intern Med. 2023;38(1):80-92.   Published online November 10, 2022 DOI: https://doi.org/10.3904/kjim.2022.198              Web of Science 11    Crossref 12                      Background/Aims: We investigated the prevalence, associated factors, and comorbidities of high-risk obstructive sleep apnea (OSA) as determined by the STOP-BANG questionnaire in a Korean adult population. Methods: Data were obtained from 7,650 adults (aged ≥ 40 years) who participated in the Korea ..

Endocrinology-metabolism / Image of interest Polysplenia syndrome with truncal pancreas presenting as diabetic ketoacidosis Hea Min Yu, Jun Choul Lee Korean J Intern Med. 2023;38(1):137-138.   Published online September 22, 2022 DOI: https://doi.org/10.3904/kjim.2022.209

Endocrinology-metabolism / Image of interest A rare adrenocorticotropic hormone-producing nasal neuroendocrine tumor with multiple metastasis So-yun Kim, Yoonchul Ha, Jin Man Kim, Kun ho Kim, Yea Eun Kang Korean J Intern Med. 2023;38(1):134-136.   Published online September 2, 2022 DOI: https://doi.org/10.3904/kjim.2022.227