Cardiology / Original Article Long-term clinical outcome and risk stratification across stages of cardiovascular-kidney-metabolic syndrome in a nationwide cohort Hyun-Jin Kim, Byung Sik Kim, Hasung Kim, Jungkuk Lee, Ha Hye Jo, Dong Wook Kim, Jeong-Hun Shin, Ki-Chul Sung Korean J Intern Med. 2025;40(6):975-989.   Published online October 28, 2025 DOI: https://doi.org/10.3904/kjim.2025.194                      Background/Aims: Cardiovascular-kidney-metabolic (CKM) syndrome is a continuum of metabolic, cardiovascular, and kidney dysfunctions. This study aimed to evaluate the association between CKM stages and the risk of adverse composite clinical outcomes. Methods: This retrospective cohort study used da..

Cardiology / Original Article Association of the triglyceride-glucose index with cardiovascular outcomes across cardiovascular-kidney-metabolic syndrome stages Byung Sik Kim, Hyun-Jin Kim, Shinje Moon, Hasung Kim, Jungkuk Lee, Jeong-Hun Shin Korean J Intern Med. 2025;40(6):961-974.   Published online October 31, 2025 DOI: https://doi.org/10.3904/kjim.2025.082                      Background/Aims: Cardiovascular-kidney-metabolic (CKM) syndrome reflects the interplay between metabolic dysfunction, chronic kidney disease, and cardiovascular disease. Insulin resistance (IR) is a key driver of CKM and is associated with adverse cardiovascular outcomes. The triglyceride-glucose (T..

Cardiology / Review Coagulopathy and platelet abnormalities in patients with inflammatory bowel disease Dae Sung Kim, Won Moon Korean J Intern Med. 2025;40(6):866-875.   Published online October 31, 2025 DOI: https://doi.org/10.3904/kjim.2025.118                 Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is associated with a hypercoagulable state that increases thromboembolic complication risk. The interaction between inflammation and coagulation increases risk by upregulating coagulation factors, downregulating natu..

Cardiology / Image of interest Left main coronary artery compression associated with unfavorable thoracic anatomy Daeung Ohn, Yeon-Jik Choi, Jin-Young Yoo, Suk-Min Seo, Junghoon Lee Korean J Intern Med. 2025;40(6):1065-1067.   Published online October 31, 2025 DOI: https://doi.org/10.3904/kjim.2025.172

Cardiology / Original Article Impact of guideline-directed medical therapy on the cardiac or non-cardiac death in acute myocardial infarction Jin-Ho Choi, Dahee Hyun, Seung Ho Hur, Seung Woon Rha, Seung Jae Joo, Hyo-Soo Kim, Myung Ho Jeong; on behalf of KAMIR-NIH investigators Korean J Intern Med. 2025;40(5):780-789.   Published online August 29, 2025 DOI: https://doi.org/10.3904/kjim.2025.068              Web of Science 1    Crossref 1                      Background/Aims: While the clinical effectiveness of guideline-directed medical therapy (GDMT) is well established in patients with acute myocardial infarction (AMI), its specific impact on cause-specific mortality remains unclear. This study aimed to investigate the impact of GDMT on both cardiac a..

Cardiology / Original Article Automatic quantitative analysis of atherosclerotic aortic plaques in patients with embolic cerebral infarction using deep learning Hye Jin Bang, Jae-Hyeong Park, Sun Geu Chae, Suk Joo Bae, Ji-Hoon Jung, You Hee Cho, Jong Won Park, Dae-Won Kim, Jung Sun Cho Korean J Intern Med. 2025;40(5):767-779.   Published online August 26, 2025 DOI: https://doi.org/10.3904/kjim.2024.360                      Background/Aims: Transesophageal echocardiography (TEE) is a commonly used imaging modality for assessing embolic stroke of undetermined source (ESUS) in clinical practice. We aimed to develop an automatic plaque segmentation model based on U-net and evaluate its clinical usefulness in patients with..

Cardiology / Original Article Effect of tegoprazan on temporal variability of platelet reactivity in patients treated with clopidogrel after coronary stenting Oh-Hyun Lee, Ji Woong Roh, Yongcheol Kim, Eui Im, Deok-Kyu Cho Korean J Intern Med. 2025;40(5):759-766.   Published online March 25, 2025 DOI: https://doi.org/10.3904/kjim.2024.399                      Background/Aims: Data on the interactions between clopidogrel and tegoprazan are limited. We compared the effects of tegoprazan and proton-pump inhibitors (PPIs) on platelet reactivity. Methods: Using database data from March 2020 to January 2023, we retrospectively evaluated 262 patients who were ..

Cardiology / Review Physical activity for prevention of cardiovascular disease: consensus statement of Korean Society of Cardio-cerebrovascular Disease Prevention Ye Seul Yang, Eu Jeong Ku, Seung-Hyun Ko, Eun-Jung Rhee, Sang-Hyun Ihm, Sung Hee Choi, Won-Young Lee; on Behalf of Committee of Clinical Practice Guideline; Korean Society of Cardio-cerebrovascular Disease Prevention Korean J Intern Med. 2025;40(5):696-709.   Published online August 29, 2025 DOI: https://doi.org/10.3904/kjim.2025.206                 Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, highlighting the need for effective preventive strategies. This consensus statement emphasizes the critical role of regular physical activity, including aerobic and muscle-strengthening exercises, in reducing key CVD risk..

Cardiology / Editorial Turning evidence into action: the real challenge of guideline-directed medical therapy in acute myocardial infarction Jong Shin Woo Korean J Intern Med. 2025;40(5):693-695.   Published online August 29, 2025 DOI: https://doi.org/10.3904/kjim.2025.251

Cardiology / Editorial Hidden benefits beyond herpes zoster: a potential preventive strategy against hepatobiliary diseases Dong Wook Kim, Tae Jun Song Korean J Intern Med. 2025;40(5):691-692.   Published online August 29, 2025 DOI: https://doi.org/10.3904/kjim.2025.262

Cardiology / Image of interest Beat-to-beat alternans Chan-Hee Lee, Melvin M. Scheinman Korean J Intern Med. 2025;40(4):687-688.   Published online May 21, 2025 DOI: https://doi.org/10.3904/kjim.2024.372              Crossref 1

Cardiology / Original Article Detection rate by time period and predictors of serious arrhythmias in unexplained syncope: a multicenter implantable loop recorder registry study Juwon Kim, Il-Young Oh, Myung-Jin Cha, Jinhee Ahn, So-Ryoung Lee, Sung Ho Lee, Jae-Sun Uhm, Pil-Sung Yang, Jaemin Shim, Hyoung-Seob Park, Junbeom Park, Jun Hyung Kim, Ki-Hun Kim, Jumsuk Ko, Hong Euy Lim, Ju Youn Kim Korean J Intern Med. 2025;40(4):616-625.   Published online July 1, 2025 DOI: https://doi.org/10.3904/kjim.2024.364              Crossref 1                      Background/Aims: Although an implantable loop recorder (ILR) is a valuable tool for investigation of unexplained syncope, there are limited data regarding time course to diagnosis and predictors of serious arrhythmias as a cause of unexplained syncope. We sought to investigate diagnosis rate by time..

Cardiology / Review Role of catheter ablation in patients with heart failure and atrial fibrillation Min-Su Jung, Hyoung-Seob Park Korean J Intern Med. 2025;40(4):533-545.   Published online July 1, 2025 DOI: https://doi.org/10.3904/kjim.2024.284                 Atrial fibrillation (AF) and heart failure (HF) frequently coexist with other cardiovascular conditions and adversely affect each other. Over the past few decades, there have been therapeutic advances in AF and HF; however, whether rate-control or rhythm-control is the superior approach for these pa..

Cardiology / Editorial Unexplained syncope: what time-to-diagnosis and risk profiles tell us Yoon Jung Park Korean J Intern Med. 2025;40(4):529-530.   Published online July 1, 2025 DOI: https://doi.org/10.3904/kjim.2025.180

Cardiology / Original Article Short-term effects of PCSK-9 inhibitors on percutaneous coronary intervention in patients with acute coronary syndrome Dong Hyun Gim, In Young Choi, Young-Jae Ki, Hyun Kuk Kim, Sung Soo Kim, Keun-Ho Park, Heesang Song, Dong-Hyun Choi Korean J Intern Med. 2025;40(3):438-448.   Published online April 30, 2025 DOI: https://doi.org/10.3904/kjim.2024.363                      Background/Aims: Proprotein-converting enzyme subtilisin-kexin type 9 (PCSK9) inhibitors act more promptly and efficiently than statins and reduce the risk of cardiovascular events in patients with acute coronary syndrome (ACS). This study aimed to assess the short-term effects of perioperative admi..

Cardiology / Original Article Fact sheet: nationwide trends in dietary intakes among Korean adults, 2013-2022 Hannah Oh, Garam Jo, Oh Yoen Kim, Hyunjung Lim, SuJin Song, Jeong-Hwa Choi, Jae Hyun Bae, Eun-Sun Jin, Rockli Kim, Yujin Lee, In-Kyung Jeong, Min-Jeong Shin; on Behalf of the Committee of Nutrition and Public Relation of the Korean Society of Lipid and Atherosclerosis Korean J Intern Med. 2025;40(3):427-437.   Published online March 25, 2025 DOI: https://doi.org/10.3904/kjim.2024.337              Web of Science 4    Crossref 6                      Background/Aims: Cardiovascular disease is the leading cause of death worldwide. This study aimed to investigate the recent nationwide trends in major dietary risk factors for dyslipidemia and atherosclerosis. Methods: We estimated age-standardized mean intakes of fresh fruits, fresh vegetables, wh..

Cardiology / Review Obesity and heart failure with preserved ejection fraction: focus on new drugs and future direction in medical treatment Se-Eun Kim, Byung-Su Yoo Korean J Intern Med. 2025;40(3):357-370.   Published online April 30, 2025 DOI: https://doi.org/10.3904/kjim.2024.387                 Obesity is a major risk factor for heart failure with preserved ejection fraction (HFpEF) and contributes through multiple pathophysiological pathways, including systemic inflammation, neurohormonal activation, and mechanical inhibition. The treatment of obesity has shown significant potential for i..

Cardiology / Original Article Sex-specific impact of the COVID-19 outbreak on the incidence of metabolic syndrome: a comparative study of 2018–2019 and 2020–2021 Kyeong-Hyeon Chun, Hyun-Jin Kim, Dae Ryong Kang, Jang Young Kim, Wonjin Kim, Yong Whi Jeong, Seung Hwan Han, Kwang Kon Koh; on behalf of the Taskforce Team of the Metabolic Syndrome Fact Sheet of the Korean Society of Cardiometabolic Syndrome Korean J Intern Med. 2025;40(2):262-274.   Published online March 1, 2025 DOI: https://doi.org/10.3904/kjim.2024.288              Crossref 1                      Background/Aims: The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted global health, exacerbated metabolic health issues, and altered lifestyle behaviors. This study examined the sex-specific impact of the COVID-19 outbreak on the incidence of metabolic syndrome using data fro..

Cardiology / Original Article Explainable paroxysmal atrial fibrillation diagnosis using an artificial intelligence-enabled electrocardiogram Yeongbong Jin, Bonggyun Ko, Woojin Chang, Kang-Ho Choi, Ki Hong Lee Korean J Intern Med. 2025;40(2):251-261.   Published online February 21, 2025 DOI: https://doi.org/10.3904/kjim.2024.130              Web of Science 1                   Background/Aims: Atrial fibrillation (AF) significantly contributes to global morbidity and mortality. Paroxysmal atrial fibrillation (PAF) is particularly common among patients with cryptogenic strokes or transient ischemic attacks and has a silent nature. This study aims to develop reliable artifi..

Cardiology / Review Sex differences in diagnosis and treatment of heart failure: toward precision medicine Soo Yong Lee, Seong-Mi Park Korean J Intern Med. 2025;40(2):196-207.   Published online March 1, 2025 DOI: https://doi.org/10.3904/kjim.2024.338              Web of Science 3    Crossref 3                 There are sex-related differences in the pathophysiology and phenotype of heart failure (HF) as well as the pharmacokinetics and pharmacodynamics of drugs between women and men due to biological differences, such as heart and vessel size, response to blood volume and pressure, body water and muscle ..