Nephrology / Image of interest Renal recovery from membranous lupus nephritis with antineutrophil cytoplasmic antibody-associated glomerulonephritis with belimumab Wenfeng Wang, Zishan Lin, Bingjing Jiang, Yanfang Xu Korean J Intern Med. 2025;40(2):339-340.   Published online February 25, 2025 DOI: https://doi.org/10.3904/kjim.2024.278

Nephrology / Original Article Predicting renal function using fundus photography: role of confounders Hyun-Woong Park, Hae Ri Kim, Ki Yup Nam, Bum Jun Kim, Taeseen Kang Korean J Intern Med. 2025;40(2):310-320.   Published online March 1, 2025 DOI: https://doi.org/10.3904/kjim.2024.076                 Background/Aims: The kidneys and retina are highly vascularized organs that frequently exhibit shared pathologies, with nephropathy often associated with retinopathy. Previous studies have successfully predicted estimated glomerular filtration rates (eGFRs) using fundus photographs. We evaluated the..

Nephrology / Review Glial cell line-derived neurotrophic factor and its role in attenuating renal fibrosis: a review Yousuf Abdulkarim Waheed, Wokuheleza Buberwa, Dong Sun Korean J Intern Med. 2025;40(2):219-229.   Published online December 13, 2023 DOI: https://doi.org/10.3904/kjim.2023.246                 Chronic kidney disease is estimated to affect approximately 10 to 15% of the Chinese population. Renal fibrosis is characterized by progressive extracellular matrix deposition in the kidney parenchyma with eventual tissue scarring and inevitable deterioration of renal function. Vascular rarefaction,..

Nephrology / Original Article Kidney replacement therapy trends in end-stage kidney disease patients in South Korea during the COVID-19 pandemic Ah-Young Kim, Min-Jeong Lee, Heejung Choi, Hankil Lee, Inwhee Park Korean J Intern Med. 2024;39(6):967-978.   Published online October 24, 2024 DOI: https://doi.org/10.3904/kjim.2024.052              Crossref 2                 Background/Aims: The corona virus disease 2019 posed a major risk for end-stage kidney disease (ESKD) cases. Our study aimed to assess changes in kidney replacement therapy (KRT) trends and healthcare access for these patients during the pandemic. Methods: We retrospectively analyzed nationwide dat..

Nephrology / Review Steps to understanding diabetes kidney disease: a focus on metabolomics Hyo Jin Kim, Sang Heon Song Korean J Intern Med. 2024;39(6):898-905.   Published online October 22, 2024 DOI: https://doi.org/10.3904/kjim.2024.111              Web of Science 1    Crossref 1                 Diabetic nephropathy (DN), a leading cause of chronic kidney disease and end-stage kidney disease (ESKD), poses global health challenges given its increasing prevalence. DN increases the risk of mortality and cardiovascular events. Early identification and appropriate DN management are crucial. Howe..

Nephrology / Review Machine learning approaches toward an understanding of acute kidney injury: current trends and future directions Inyong Jeong, Nam-Jun Cho, Se-Jin Ahn, Hwamin Lee, Hyo-Wook Gil Korean J Intern Med. 2024;39(6):882-897.   Published online October 29, 2024 DOI: https://doi.org/10.3904/kjim.2024.098              Crossref 1                      Acute kidney injury (AKI) is a significant health challenge associated with adverse patient outcomes and substantial economic burdens. Many authors have sought to prevent and predict AKI. Here, we comprehensively review recent advances in the use of artificial intelligence (AI) to predict AKI, and t..

Nephrology / Review Kidney transplantation in the elderly Byung Hwa Park, Song Yi Kil, Ye Na Kim, Ho Sik Shin, Yeonsoon Jung, Hark Rim Korean J Intern Med. 2024;39(6):875-881.   Published online October 24, 2024 DOI: https://doi.org/10.3904/kjim.2024.089                 Interest in kidney transplant studies in the elderly population is increasing as more research has been conducted on the immune system. With this review, we hope to encourage the need for research on kidney transplantation in the elderly.

Nephrology / Editorial Impact of COVID-19 on end-stage kidney disease incidence and clinical practice Hayne Cho Park, Young-Ki Lee Korean J Intern Med. 2024;39(6):872-874.   Published online November 1, 2024 DOI: https://doi.org/10.3904/kjim.2024.350

Nephrology / Original Article Obesity is associated with incident chronic kidney disease in individuals with normal renal function Su Hyun Song, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae Korean J Intern Med. 2024;39(5):813-822.   Published online August 13, 2024 DOI: https://doi.org/10.3904/kjim.2023.491              Web of Science 1    Crossref 2                      Background/Aims: Obesity has known to be a modifiable risk factor associated with worse outcomes in chronic kidney disease (CKD), but few studies have examined the impact of obesity on CKD incidence in the general population. The purpose of this study was to investigate the role of body mass index (..

Nephrology / Editorial Obesity and chronic kidney disease, an important piece in the puzzle of Cardiovascular–Kidney– Metabolic syndrome Young Youl Hyun Korean J Intern Med. 2024;39(5):700-701.   Published online August 30, 2024 DOI: https://doi.org/10.3904/kjim.2024.273

Nephrology / Image of interest Primary peritoneal carcinoma presented with abdominal pain in patient with kidney transplantation Eunmi Jo, Sang Heon Song Korean J Intern Med. 2024;39(4):693-694.   Published online April 29, 2024 DOI: https://doi.org/10.3904/kjim.2023.254              Crossref 1

Nephrology / Original Article A retrospective study on the efficacy of Roxadustat in peritoneal dialysis patients with erythropoietin hyporesponsiveness Jie Liu, Shuang Li, Fan Yang, Tianyu Li, Rui Li, Yousuf Waheed, Chen Meng, Shulin Li, Kun Liu, Yanshan Tong, Haisheng Xu, Chuankuo Tian, Xinglei Zhou Korean J Intern Med. 2024;39(3):488-500.   Published online April 23, 2024 DOI: https://doi.org/10.3904/kjim.2023.520              Crossref 1                 Background/Aims: Roxadustat, an oral medication for treating renal anemia, is a hypoxia-inducible factor prolyl hydroxylase inhibitor used for regulating iron metabolism and promoting erythropoiesis. To investigate the efficacy and safety of roxadustat in patients undergoing peritoneal dialysis (PD)..

Nephrology / Original Article Prognostic role of the neutrophil-to-lymphocyte ratio in patients with chronic kidney disease Jin Kim, Su Hyun Song, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae Korean J Intern Med. 2023;38(5):725-733.   Published online August 17, 2023 DOI: https://doi.org/10.3904/kjim.2023.171              Web of Science 9    Crossref 10                 Background/Aims: The neutrophil-to-lymphocyte ratio (NLR) has a prognostic value in cardiovascular disease, infection, inflammatory disease, and several malignancies. Therefore, the NLR has a possible predictive value in patients with chronic kidney disease (CKD), but this predictive value has not b..

Nephrology / Editorial Reassessing the role of the neutrophil-to-lymphocyte ratio in chronic kidney disease patients Yu Ho Lee Korean J Intern Med. 2023;38(5):579-580.   Published online September 1, 2023 DOI: https://doi.org/10.3904/kjim.2023.328

Nephrology / Original Article CTLA4-Ig protects tacrolimus-induced oxidative stress via inhibiting the AKT/FOXO3 signaling pathway in rats Long Jin, Nan Shen, Xinyu Wen, Weidong Wang, Sun Woo Lim, Chul Woo Yang Korean J Intern Med. 2023;38(3):393-405.   Published online April 28, 2023 DOI: https://doi.org/10.3904/kjim.2022.293              Web of Science 2    Crossref 2                      Background/Aims: Although the conversion from tacrolimus (TAC) to cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin (CTLA4-Ig) is effective in reducing TAC-induced nephrotoxicity, it remains unclear whether CTLA4-Ig has a direct effect on TAC-induced renal injury. In this study, we evaluate..

Nephrology / Review Recent updates in therapeutic approach using tolvaptan for autosomal dominant polycystic kidney disease Yaerim Kim, Seungyeup Han Korean J Intern Med. 2023;38(3):322-331.   Published online April 25, 2023 DOI: https://doi.org/10.3904/kjim.2022.376              Web of Science 1    Crossref 2                 As a genetic disease, there has been a long-standing effort to identify therapeutic options for autosomal dominant polycystic kidney disease (ADPKD). Following the development of tolvaptan, a vasopressin 2 receptor antagonist, the treatment strategy for ADPKD patients with rapid disease progression ..

Nephrology / Review Sarcopenia in chronic kidney disease: from bench to bedside Da Woon Kim, Sang Heon Song Korean J Intern Med. 2023;38(3):303-321.   Published online April 20, 2023 DOI: https://doi.org/10.3904/kjim.2022.338              Web of Science 8    Crossref 12                 Sarcopenia is a condition characterized by a loss of muscle mass and function. In chronic kidney disease (CKD), where a chronic catabolic state exists, sarcopenia commonly occurs through various mechanisms, resulting in muscle wasting and decreased muscle endurance. Sarcopenic patients with CKD have..

Nephrology / Review Evaluation and management of hypernatremia in adults: clinical perspectives Giae Yun, Seon Ha Baek, Sejoong Kim Korean J Intern Med. 2023;38(3):290-302.   Published online December 29, 2022 DOI: https://doi.org/10.3904/kjim.2022.346              Web of Science 7    Crossref 14                 Hypernatremia is an occasionally encountered electrolyte disorder, which may lead to fatal consequences under improper management. Hypernatremia is a disorder of the homeostatic status regarding body water and sodium contents. This imbalance is the basis for the diagnostic approach to hypernatremia...

Nephrology / Review The role of roxadustat in chronic kidney disease patients complicated with anemia Jie Liu, Fan Yang, Yousuf Waheed, Shulin Li, Kun Liu, Xinglei Zhou Korean J Intern Med. 2023;38(2):147-156.   Published online January 2, 2023 DOI: https://doi.org/10.3904/kjim.2022.318              Web of Science 5    Crossref 7                 The incidence of chronic kidney disease (CKD) is increasing worldwide and the current prevalence rate is 13.4%. There are > 120 million CKD patients in China and this number is expected to increase. One of the main abnormalities in patients with CKD and kidney impairment is decreased synthesis of er..