Nephrology Prognostic role of the neutrophil-to-lymphocyte ratio in patients with chronic kidney disease Jin Kim, Su Hyun Song, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae Korean J Intern Med. 2023;38(5):725-733.   Published online August 17, 2023 DOI: https://doi.org/10.3904/kjim.2023.171              Web of Science 3    Crossref 3                 Background/Aims: The neutrophil-to-lymphocyte ratio (NLR) has a prognostic value in cardiovascular disease, infection, inflammatory disease, and several malignancies. Therefore, the NLR has a possible predictive value in patients with chronic kidney disease (CKD), but this predictive value has not b..

CTLA4-Ig protects tacrolimus-induced oxidative stress via inhibiting the AKT/FOXO3 signaling pathway in rats Long Jin, Nan Shen, Xinyu Wen, Weidong Wang, Sun Woo Lim, Chul Woo Yang Korean J Intern Med. 2023;38(3):393-405.   Published online April 28, 2023 DOI: https://doi.org/10.3904/kjim.2022.293                      Background/Aims: Although the conversion from tacrolimus (TAC) to cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin (CTLA4-Ig) is effective in reducing TAC-induced nephrotoxicity, it remains unclear whether CTLA4-Ig has a direct effect on TAC-induced renal injury. In this study, we evaluate..

Therapeutic effect of multiple functional minicircle vector encoding anti-CD25/IL-10/CXCR3 in allograft rejection model Sun Woo Lim, Yoo Jin Shin, Sheng Cui, Eun Jeong Ko, Seok Ho Yoo, Byung Ha Chung, Chul Woo Yang Korean J Intern Med. 2022;37(5):1031-1049.   Published online June 21, 2022 DOI: https://doi.org/10.3904/kjim.2021.299                      Background/Aims: We previously proposed minicircle vector technology as the potential platform for the development and production of new biologics. In this study, we have designed a novel target molecule for the treatment of allograft rejection and evaluated its feasibility as the therapeutic agent ..

Insufficient early renal recovery and progression to subsequent chronic kidney disease in living kidney donors Yaerim Kim, Eunjeong Kang, Dong-Wan Chae, Jung Pyo Lee, Sik Lee, Soo Wan Kim, Jang-Hee Cho, Miyeun Han, Seungyeup Han, Yong Chul Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Hajeong Lee Korean J Intern Med. 2022;37(5):1021-1030.   Published online April 13, 2022 DOI: https://doi.org/10.3904/kjim.2021.308              Web of Science 3    Crossref 5                      Background/Aims: Renal recovery of a kidney donor after undergoing nephrectomy though challenging is essential. We aimed to examine the effect of estimated glomerular filtration rate (eGFR) percent change at 1-month post-donation on insufficient kidney function after kidney donation. Methods: A tot..

Treatment of rituximab in patients with idiopathic membranous nephropathy: a case series and literature review Soo-Jee Jeon, Ji-Hye Kim, Hee-Won Noh, Ga-Young Lee, Jeong-Hoon Lim, Hee-Yeon Jung, Jang-Hee Cho, Ji-Young Choi, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park Korean J Intern Med. 2022;37(4):830-840.   Published online April 15, 2022 DOI: https://doi.org/10.3904/kjim.2021.155                 Background/Aims: Membranous nephropathy (MN) is a major cause of nephrotic syndrome in adults. This study aimed to evaluate the effect of rituximab (RTX) in patients with idiopathic MN (iMN) who have a high risk of progression. Methods: We retrospectively analyzed data of 13 patients with iMN, who ..

Low waist circumference prior to percutaneous coronary intervention predict the risk for end-stage renal disease: a nationwide Korean population based-cohort study Eun Hui Bae, Sang Yup Lim, Eun Mi Yang, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Bongseong Kim, Kyung-Do Han, Soo Wan Kim Korean J Intern Med. 2022;37(3):639-652.   Published online February 11, 2022 DOI: https://doi.org/10.3904/kjim.2021.313                      Background/Aims: The obesity paradox has been known in end-stage renal disease (ESRD). However, the effect of body mass index (BMI) or waist circumference (WC) prior to percutaneous coronary intervention (PCI) on the development of ESRD is not clear. Methods: Using nationally representative data fr..

The presence of simple renal cysts is associated with an increased risk of albuminuria in young adults Hyo Jin Boo, Jung Eun Lee, Son Mi Chung, Hye Ryoun Jang, Wooseong Huh, Dae Joong Kim, Yoon-Goo Kim Korean J Intern Med. 2022;37(2):425-433.   Published online December 7, 2021 DOI: https://doi.org/10.3904/kjim.2020.576              Web of Science 5    Crossref 7                      Background/Aims: The prevalence of simple renal cysts increases with age; however, they are occasionally found in adults aged < 40 years. This cross-sectional study evaluated the clinical significance of simple cysts in young adults, focusing on their associations with hematuria and albuminuria. Me..

Alleviation of renal ischemia/reperfusion injury by exosomes from induced pluripotent stem cell-derived mesenchymal stem cells Sun Woo Lim, Kyung Woon Kim, Bo Mi Kim, Yoo Jin Shin, Kang Luo, Yi Quan, Sheng Cui, Eun Jeong Ko, Byung Ha Chung, Chul Woo Yang Korean J Intern Med. 2022;37(2):411-424.   Published online September 16, 2021 DOI: https://doi.org/10.3904/kjim.2020.438              Web of Science 14    Crossref 15                 Background/Aims: Renal ischemia followed by reperfusion (I/R) is a leading cause of acute kidney injury (AKI), which is closely associated with high morbidity and mortality. Studies have shown that induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) exert powerful therapeutic..

Plasma oxalic acid and cardiovascular risk in end-stage renal disease patients: a prospective, observational cohort pilot study Natalia Stepanova, Victoria Driianska, Lesya Korol, Lyudmyla Snisar, Larysa Lebed Korean J Intern Med. 2022;37(1):167-178.   Published online June 25, 2021 DOI: https://doi.org/10.3904/kjim.2020.561              Web of Science 6    Crossref 8                      Background/Aims: It was hypothesized that oxalate might be strongly involved in atherogenesis and the inflammatory pathway that could result in an increased risk of cardiovascular disease (CVD) in end-stage renal disease (ESRD) patients. Therefore, this study aimed to address two primary research qu..

The optimal anti-phospholipase A2 receptor cutoff for the diagnosis of idiopathic membranous nephropathy: a single-center retrospective study Chaofan Li, Ping Li, Wenkai Guo, Lei Chen, Jiatong Li, Rong Wang, Bing Chen Korean J Intern Med. 2022;37(1):154-166.   Published online July 22, 2021 DOI: https://doi.org/10.3904/kjim.2020.366              Web of Science 9    Crossref 8                      Background/Aims: Anti-phospholipase A2 receptor (PLA2R) autoantibody is the main biomarker of idiopathic membranous nephropathy (IMN). We aimed to find a new cutoff value of anti-PLA2R for patients with IMN and to explore the relevance between this antibody and baseline clinical parameters. Methods..

Association between the progression of immunoglobulin A nephropathy and a controlled status of hypertension in the first year after diagnosis Tae Ryom Oh, Hong Sang Choi, Se Won Oh, Jieun Oh, Dong Won Lee, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae; on behalf of the Korean GlomeruloNEphritis sTudy (KoGNET) Group Korean J Intern Med. 2022;37(1):146-153.   Published online April 8, 2021 DOI: https://doi.org/10.3904/kjim.2020.205              Web of Science 2    Crossref 3                 Background/Aims: Hypertension is considered a risk factor in immunoglobulin A nephropathy (IgAN). However, after IgAN diagnosis, the relationship between early blood pressure control and renal prognosis remains unclear. This study aimed to analyze the association between the prognosis of IgAN patients and ..