| Characteristics and outcomes of portal vein thrombosis in patients with inflammatory bowel disease in Korea |
Ki Jin Kim1, Su-Bin Song1, Jung-Bin Park1, June Hwa Bae1, Ji Eun Baek1, Ga Hee Kim1, Min-Jun Kim1, Seung Wook Hong1, Sung Wook Hwang1, Dong-Hoon Yang1, Byong Duk Ye1, Jeong-Sik Byeon1, Seung-Jae Myung1, Suk-Kyun Yang1, Chang Sik Yu2, Yong-Sik Yoon2, Jong-Lyul Lee2, Min Hyun Kim2, Ho-Su Lee3, and Sang Hyoung Park1
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1Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
2Department of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
3Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea |
Corresponding Author:
Sang Hyoung Park , Tel: +82-2-3010-5768, Fax: +82-2-476-0824, Email: shpark78@amc.seoul.kr
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Received: May 16, 2024; Revised: August 20, 2024; Accepted: September 3, 2024. |
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| Abstract |
Background/Aims: Portal vein thrombosis (PVT) frequently occurs in patients with inflammatory bowel disease (IBD), particularly when influenced by factors such as abdominal infections, IBD flare-ups, or surgical procedures. The implications of PVT range from immediate issues such as intestinal ischemia to long-term concerns including portal hypertension and its complications. However, there is a notable gap in comprehensive studies on PVT in IBD, especially with the increasing incidence of IBD in Asia. This research aimed to evaluate the clinical features and outcomes of PVT in patients with IBD at a leading hospital in South Korea.
Methods: This retrospective analysis reviewed adult patients diagnosed with both IBD and PVT from 1989 to 2021 at a renowned South Korean medical center. The study focused on patient characteristics, specifics of PVT, administered treatments, and outcomes, all confirmed through enhanced CT scans.
Results: A total of 78 patients met the study’s criteria. Notably, only 20.5% (16/78) were treated with oral anticoagulants; however, a vast majority (96.2%; 75/78) achieved complete radiographic resolution (CRR). When comparing patients receiving anticoagulants to those who did not, a significant preference for anticoagulant use was observed in cases where the main portal vein was affected, as opposed to just the left or right veins (p = 0.006). However, multivariable analysis indicated that neither anticoagulant use nor previous surgeries significantly impacted CRR.
Conclusions: Patients with IBD and PVT generally had favorable outcomes, regardless of anticoagulant use. |
| Keywords:
Inflammatory bowel disease ; Venous thrombosis ; Diagnostic imaging ; Anticoagulation |
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