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Gastroenterology
Usefulness of nasal cavity evaluation before high-resolution esophageal manometry in high-risk patients
Hyun Jin Min, Jae Yong Park
Korean J Intern Med. 2024;39(1):86-94. Published online November 30, 2023
Background/Aims: A catheter is inserted through the nasal cavity during high-resolution esophageal manometry (HRM), which may cause adverse events such as pain or epistaxis. Despite these possible safety considerations, studies on this subject are very limited. We aimed to investigate the usefulness..
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Risk factors for anticoagulant-associated gastrointestinal hemorrhage: a systematic review and meta-analysis
Fuxin Ma, Shuyi Wu, Shiqi Li, Zhiwei Zeng, Jinhua Zhang
Korean J Intern Med. 2024;39(1):77-85. Published online December 8, 2023
Background/Aims: There may be many predictors of anticoagulation-related gastrointestinal bleeding (GIB), but until now, systematic reviews and assessments of the certainty of the evidence have not been published. We conducted a systematic review to identify all risk factors for anticoagulant-associ..
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Comparative study of the efficacy and safety of Abexol (suspension versus tablets) in patients with gastrointestinal symptoms
Alfredo Hierro González, Julio César Fernández Travieso, Yoandy Hernández Casas, Susana Borges González, María de los Angeles Camacho Morales, Elena Ferrer Batallie, Anaisa Roja Carralera, Yenney Reyes Nuñez, Sarahi Mendoza Castaño, Maytee Robaina García, Diana Margarita Rey Kaba
Korean J Intern Med. 2024;39(1):57-67. Published online November 30, 2023
Background/Aims: Abexol is a mixture of primary aliphatic alcohols purified from beeswax (Apis mellifera), that produces anti-inflammatory, antioxidant and gastroprotective effects, as well as it is safe and well tolerated. To investigate and compare the efficacy and safety of Abexol (suspens..
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Biomarkers of the relationship of particulate matter exposure with the progression of chronic respiratory diseases
Junghyun Kim, Soo Jie Chung, Woo Jin Kim
Korean J Intern Med. 2024;39(1):25-33. Published online January 1, 2024
A high level of particulate matter (PM) in air is correlated with the onset and development of chronic respiratory diseases. We conducted a systematic literature review, searching the MEDLINE, EMBASE, and Cochrane databases for studies of biomarkers of the effect of PM exposure on chronic respirator..
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Long term management of people with post-tuberculosis lung disease
Wan Seo, Hyung Woo Kim, Ju Sang Kim, Jinsoo Min
Korean J Intern Med. 2024;39(1):7-24. Published online January 1, 2024
Post-tuberculosis lung disease (PTLD) is emerging as a significant area of global interest. As the number of patients surviving tuberculosis (TB) increases, the subsequent long-term repercussions have drawn increased attention due to their profound clinical and socioeconomic impacts. A primary obsta..
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Rheumatology
Nailfold capillaroscopy findings of interstitial pneumonia with autoimmune features
Sang-Heon Lee, Hong Ki Min, Se-Hee Kim, Young Whan Kim, Kwang Ha Yoo, Hee Joung Kim, In Ae Kim, Hae-Rim Kim
Korean J Intern Med. 2023;38(6):903-911. Published online July 25, 2023
Background/Aims: We evaluated nailfold capillaroscopy (NFC) of interstitial pneumonia with autoimmune features (IPAF) and compared it with that of patients with connective tissue disease-interstitial lung disease (CTD-ILD) and idiopathic interstitial pneumonia (IIP).
Methods: Patients with newly di..
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Pulmonology
Alterations in lung and gut microbiota reduce diversity in patients with nontuberculous mycobacterial pulmonary disease
Ji Yeon Choi, Bora Shim, Youngmok Park, Young Ae Kang
Korean J Intern Med. 2023;38(6):879-892. Published online October 23, 2023
Background/Aims: Although the incidence of nontuberculous mycobacteria pulmonary disease (NTM-PD), a chronic infectious disease, is increasing, lung and gut microbiota dysbiosis in NTM patients has rarely been studied and was therefore the focus of this study.
Methods: We analyzed the microbiota di..
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Infectious diseases
Antibiotics use patterns in end-of-life cancer patients and medical staff’s perception of antimicrobial stewardship programs
Min Kwan Kwon, Kyung Hwa Jung, Sungim Choi, Hyeonjeong Kim, Chang-Yun Woo, Mingee Lee, Jeong Geun Ji, Hyo-Ju Son
Korean J Intern Med. 2023;38(5):758-768. Published online August 17, 2023
Background/Aims: While most cancer patients with end-of-life (EOL) care receive antibiotic treatments, antibiotic use should be decided appropriately considering the benefits, side effects, resistance, and cost effects. Antimicrobial stewardship programs (ASP) are important for patients with EOL car..
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Pulmonology
The serotype-specific prevalence of pneumococci in hospitalized pneumonia patients with COPD: a prospective, multi-center, cohort study
Jae Yeol Kim, Jae-Woo Jung, Min-Jong Kang, Deog Kyeom Kim, Hayoung Choi, Young-Jae Cho, Seung Hun Jang, Chang-Hoon Lee, Yeon Mok Oh, Ji Sook Park
Korean J Intern Med. 2023;38(5):714-724. Published online August 17, 2023
Background/Aims: The overall incidence of pneumococcal pneumonia is declining. However, the change in the pathogenic distribution of community-acquired pneumonia (CAP) in chronic obstructive pulmonary disease (COPD) patients and the serotype specificity of Streptococcus pneumoniae have not be..
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The impact of antimicrobial de-escalation therapy in culture-negative pneumonia: a systematic review and meta-analysis
Jae-Uk Song, Jonghoo Lee
Korean J Intern Med. 2023;38(5):704-713. Published online August 17, 2023
Background/Aims: Antimicrobial de-escalation (ADE) remains a challenging strategy in the treatment of pneumonia. We investigated the outcomes of ADE as measured by mortality and duration of the use of antibiotics in patients with culture- negative pneumonia.
Methods: We performed a systematic revie..
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Cardiology
Clinical safety and effectiveness of the Genoss drug-eluting stent in real-world clinical practice
Young Jin Youn, Jun-Won Lee, Sung Gyun Ahn, Seung-Hwan Lee, Junghan Yoon, Jae Hyoung Park, Sang-Yong Yoo, Woong Chol Kang, Nam Ho Lee, Ki Hwan Kwon, Joon Hyung Doh, Sang-Wook Lim, Yang Soo Jang, Dong Woon Jeon, Jung Ho Heo, Woong Gil Choi, Sungsoo Cho, Bong-Ki Lee, Hyonju Jeong, Bum-Kee Hong, Hyun-Hee Choi
Korean J Intern Med. 2023;38(5):683-691. Published online July 7, 2023
Background/Aims: The Genoss DES™ is a novel, biodegradable, polymer-coated, sirolimus-eluting stent with a cobalt- chromium stent platform and thin strut. Although the safety and effectiveness of this stent have been previously investigated, real-world clinical outcomes data are lacking. Therefore,..
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Optimization of guideline-directed medical treatment for heart failure patients with reduced ejection fraction
Minjung Bak, Jin-Oh Choi
Korean J Intern Med. 2023;38(5):595-606. Published online September 1, 2023
With the increasing number of medications demonstrating mortality benefits in heart failure with reduced ejection fraction (HFrEF), the pharmacological treatment of HFrEF is entering a new phase. To enhance outcomes in heart failure patients through medical treatment, the choice of appropriate medic..
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Rheumatology
Comparative effectiveness of JAK inhibitors and biologic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis
Soo-Kyung Cho, Hyoungyoung Kim, Yeo-Jin Song, Hye Won Kim, Eunwoo Nam, Shin-Seok Lee, Hye-Soon Lee, Sung-Hoon Park, Yeon-Ah Lee, Min-Chan Park, Sung Hae Chang, Hyoun-Ah Kim, Seung-Ki Kwok, Hae-Rim Kim, Hyun-Sook Kim, Bo Young Yoon, Wan-Sik Uhm, Yong-Gil Kim, Jae Hoon Kim, Jisoo Lee, Jeongim Choi, Yoon-Kyoung Sung
Korean J Intern Med. 2023;38(4):546-556. Published online June 20, 2023
Background/Aims: We aimed to compare the effectiveness and safety of Janus kinase inhibitors (JAKi) vs. biologic disease- modifying antirheumatic drugs (bDMARD) in Korean patients with rheumatoid arthritis (RA) who had an inadequate response to conventional synthetic DMARDs.
Methods: A quasi-exper..
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Gastroenterology
Efficacy and safety of sofosbuvir–velpatasvir and sofosbuvir–velpatasvir–voxilaprevir for hepatitis C in Korea: a Phase 3b study
Jeong Heo, Yoon Jun Kim, Sung Wook Lee, Youn-Jae Lee, Ki Tae Yoon, Kwan Soo Byun, Yong Jin Jung, Won Young Tak, Sook-Hyang Jeong, Kyung Min Kwon, Vithika Suri, Peiwen Wu, Byoung Kuk Jang, Byung Seok Lee, Ju-Yeon Cho, Jeong Won Jang, Soo Hyun Yang, Seung Woon Paik, Hyung Joon Kim, Jung Hyun Kwon, Neung Hwa Park, Ju Hyun Kim, In Hee Kim, Sang Hoon Ahn, Young-Suk Lim
Korean J Intern Med. 2023;38(4):504-513. Published online June 30, 2023
Background/Aims: Despite the availability of direct-acting antivirals (DAAs) for chronic hepatitis C virus (HCV) infection in Korea, need remains for pangenotypic regimens that can be used in the presence of hepatic impairment, comorbidities, or prior treatment failure. We investigated the efficacy an..
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Ten-day tegoprazan-based concomitant therapy as a first-line treatment for Helicobacter pylori eradication
Yong Hwan Kwon, Seong Woo Jeon, Su Youn Nam, Dong Wook Lee, Ji Hey Park, Hui Jin Bae
Korean J Intern Med. 2023;38(4):493-503. Published online June 28, 2023
Background/Aims: Tegoprazan, a novel potassium-competitive acid blocker, has shown rapid action and gastric acid inhibition. In this study, we evaluated the efficacy of a tegoprazan-based, nonbismuth-containing quadruple (concomitant) therapy for the primary eradication of Helicobacter pylori..
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Infectious diseases
Clinical significance of antinuclear antibody positivity in patients with severe coronavirus disease 2019
Soo Hyun Park, Jin Woong Suh, Kyung-Sook Yang, Jeong Yeon Kim, Sun Bean Kim, Jang Wook Sohn, Young Kyung Yoon
Korean J Intern Med. 2023;38(3):417-426. Published online April 6, 2023
Background/Aims: This study aimed to investigate the clinical characteristics and outcomes of fluorescent antinuclear antibody (FANA)-positive patients admitted for coronavirus disease 2019 (COVID‐19) and identify FANA as a prognostic factor of mortality.
Methods: This retrospective study was con..
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Nephrology
CTLA4-Ig protects tacrolimus-induced oxidative stress via inhibiting the AKT/FOXO3 signaling pathway in rats
Long Jin, Nan Shen, Xinyu Wen, Weidong Wang, Sun Woo Lim, Chul Woo Yang
Korean J Intern Med. 2023;38(3):393-405. Published online April 28, 2023
Background/Aims: Although the conversion from tacrolimus (TAC) to cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin (CTLA4-Ig) is effective in reducing TAC-induced nephrotoxicity, it remains unclear whether CTLA4-Ig has a direct effect on TAC-induced renal injury. In this study, we evaluate..
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Gastroenterology
Clinical and endoscopic characteristics of sessile serrated lesions with dysplasia/carcinoma
Peel Jung, Hyung Wook Kim, Su Bum Park, Dae Hwan Kang, Cheol Woong Choi, Su Jin Kim, Hyeong Seok Nam, Dae Gon Ryu, Dong Hoon Shin, Joo Young Na, Mi Sook Yun
Korean J Intern Med. 2023;38(3):349-361. Published online March 27, 2023
Background/Aims: Some sessile serrated lesions (SSLs) progress into dysplasia and colorectal cancer, however, the clinical and endoscopic characteristics of SSLs with dysplasia remain to be determined. In this study, we elucidated these characteristics in SSLs with dysplasia/carcinoma, compared with..
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Comorbidities and the use of comedications among patients with chronic hepatitis C in Korea: A nationwide cross-sectional study
Kyung Min Kwon, Jae-Jun Shim, Gi-Ae Kim, Bo Ok Kim, Helin Han, Hyun Jung Ahn
Korean J Intern Med. 2023;38(3):338-348. Published online April 10, 2023
Background/Aims: Chronic hepatitis C (CHC) is the second leading cause of liver-related mortality and is more prevalent in the elderly population in Korea. Decisions to initiate treatment and selection of proper antiviral agents may be challenging among elderly patients due to relevant comorbidities..
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Evaluation and management of hypernatremia in adults: clinical perspectives
Giae Yun, Seon Ha Baek, Sejoong Kim
Korean J Intern Med. 2023;38(3):290-302. Published online December 29, 2022
Hypernatremia is an occasionally encountered electrolyte disorder, which may lead to fatal consequences under improper management. Hypernatremia is a disorder of the homeostatic status regarding body water and sodium contents. This imbalance is the basis for the diagnostic approach to hypernatremia...
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