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Nephrology / Review
Glial cell line-derived neurotrophic factor and its role in attenuating renal fibrosis: a review
Yousuf Abdulkarim Waheed, Wokuheleza Buberwa, Dong Sun
Korean J Intern Med. 2025;40(2):219-229. Published online December 13, 2023
Chronic kidney disease is estimated to affect approximately 10 to 15% of the Chinese population. Renal fibrosis is characterized by progressive extracellular matrix deposition in the kidney parenchyma with eventual tissue scarring and inevitable deterioration of renal function. Vascular rarefaction,..
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Pulmonology / Original Article
Blood eosinophil count and treatment patterns of chronic obstructive pulmonary disease patients in South Korea using real-world data
Chin Kook Rhee, Yu-Fan Ho, Sumitra Shantakumar, Tim Holbrook, Yein Nam, Kwang‑Ha Yoo
Korean J Intern Med. 2025;40(1):78-91. Published online January 1, 2025
Background/Aims: Chronic obstructive pulmonary disease (COPD) management guidelines have increasingly emphasised the importance of exacerbation prevention, and the role of blood eosinophil count (BEC) as a biomarker for inhaled corticosteroids (ICS) response. This study aimed to describe the distrib..
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Endocrinology-metabolism / Review
Bariatric surgery for treatment of morbid obesity in adults
Ki Bum Park, Kyong-Hwa Jun
Korean J Intern Med. 2025;40(1):24-39. Published online January 1, 2025
Morbid obesity requires active intervention, with treatment options including lifestyle modification, pharmacotherapy, and surgery. As the prevalence of obesity continues to rise in Korea, it is crucial for specialists and general practitioners to have a comprehensive understanding of obesity and it..
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Cardiology / Review
Current status of modifiable risk factors for cardiovascular disease in Korean women
In-Jeong Cho, Mi-Seung Shin
Korean J Intern Med. 2025;40(1):15-23. Published online October 22, 2024
Hypertension, diabetes mellitus, dyslipidemia, obesity, and smoking are the primary modifiable risk factors contributing to the increasing morbidity and mortality rates from cardiovascular disease (CVD) among Korean women. Significant sex-related differences exist in the prevalence, awareness, treat..
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Geriatrics / Original Article
A link between systemic low-grade inflammation and frailty in older adults: clinical evidence from a nationwide population-based study
Min-gu Kang, Hee-Won Jung, Beom-Jun Kim
Korean J Intern Med. 2024;39(6):1011-1020. Published online July 23, 2024
Background/Aims: Despite the possible role of systemic low-grade inflammation on frailty, the majority of previous studies have focused solely on the phenotypic frailty with limited participant numbers, thereby weakening the evidence supporting the notion that circulating C-reactive protein (CRP) co..
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Rheumatology / Original Article
Association between oral health and hyperuricemia in Korean adults: Korea National Health and Nutrition Examination Survey 2016–2019
Junyong Park, Minkook Son, Sung Won Lee, Won Tae Chung, Sang Yeob Lee
Korean J Intern Med. 2024;39(6):1001-1010. Published online October 22, 2024
Background/Aims: Hyperuricemia plays an essential role in the gout. Despite the clinical significance of hyperuricemia, a direct relationship between oral health and hyperuricemia has not been established. We aim to investigate the association between oral health and hyperuricemia.
Methods: We sele..
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Infectious diseases / Original Article
Adverse drug reactions following treatment of latent tuberculosis infection: a linked national tuberculosis surveillance with claims database
Yu-Seon Jung, Sun-Young Jung, Jae-Eun Lee, Kyungeun Lee, Jae Chol Choi
Korean J Intern Med. 2024;39(6):979-988. Published online October 22, 2024
Background/Aims: Few real-world studies explored factors associated with latent tuberculosis infection (LTBI) treatment-related adverse drug reactions (ADRs). This study evaluate ADRs that lead to the discontinuation of LTBI treatment and identify the associated factors, including age groups and dru..
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Gastroenterology / Original Article
Tight junction protein changes in irritable bowel syndrome: the relation of age and disease severity
Sang Un Kim, Ji A Choi, Man-Hoon Han, Jin Young Choi, Ji Hye Park, Moon Sik Kim, Yong Hwan Kwon
Korean J Intern Med. 2024;39(6):906-916. Published online November 1, 2024
Background/Aims: The etiology of irritable bowel syndrome (IBS) is associated with intestinal mucosal barrier damage. However, changes in the tight junction (TJ) proteins in IBS have not been fully elucidated. This study aimed to evaluate TJ protein changes in IBS patients and the relationship betwe..
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Infectious diseases / Original Article
Clinical effects of non-pharmaceutical interventions for COVID-19 on other nationally notifiable infectious diseases in South Korea
Hyun-Jin Lee, Beom Seuk Hwang, Seong Ho Im, Seog-Kyun Mun, Munyoung Chang
Korean J Intern Med. 2024;39(5):823-832. Published online August 13, 2024
Background/Aims: This study aimed to assess the impact of non-pharmaceutical interventions (NPIs) implemented during the COVID-19 pandemic on nationally notifiable infectious diseases (NNIDs) in South Korea.
Methods: Long-term data on seven NNIDs from 2018 to 2021 were analyzed to identify trends a..
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Cardiology / Original Article
Efficacy of single-dose evolocumab injection in early-phase acute myocardial infarction: a retrospective single-center study
Yongcheol Kim, Ji Woong Roh, Oh-Hyun Lee, Seok-Jae Heo, Eui Im, Deok-Kyu Cho, Byeong-Keuk Kim
Korean J Intern Med. 2024;39(5):793-800. Published online June 24, 2024
Background/Aims: Achieving rapid reduction of low-density lipoprotein cholesterol (LDL-C) levels below 55 mg/dL in patients with acute myocardial infarction (AMI) can be challenging with statins alone. This single-center, retrospective study aimed to assess the impact of single-dose injection of evo..
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Cardiology / Review
2024 KSoLA consensus on secondary dyslipidemia
Hoyoun Won, Jae Hyun Bae, Hyunjung Lim, Minji Kang, Minjoo Kim, Sang-Hak Lee; on behalf of the Clinical Practice Guidelines Committee, Korean Society of Lipid and Atherosclerosis (KSoLA)
Korean J Intern Med. 2024;39(5):717-730. Published online August 30, 2024
Elevated blood cholesterol and triglyceride levels induced by secondary causes are frequently observed. The identification and appropriate handling of these causes are essential for secondary dyslipidemia treatment. Major secondary causes of hypercholesterolemia and hypertriglyceridemia include an u..
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Endocrinology-metabolism / Original Article
Effects of statin use on serum creatinine phosphokinase levels in normal thyroid function
Jeonghoon Ha, Joonyub Lee, Jin Yu, Hakyoung Park, Jiwon Shinn, Seung-Hwan Lee, Jae-Hyoung Cho, Hun-Sung Kim
Korean J Intern Med. 2024;39(4):650-658. Published online June 24, 2024
Background/Aims: Statins are common lipid-lowering agents used in dyslipidemia. However, they increase serum creatinine phosphokinase (CPK) levels. Currently, there are no studies on the effect of thyroid-stimulating hormone (TSH) levels on CPK levels after statin administration. Therefore, this stu..
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Pulmonology / Original Article
Timing and predictors of death during treatment in patients with multidrug/rifampin-resistant tuberculosis in South Korea
Eunjeong Son, Hongjo Choi, Jeongha Mok, Young Ae Kang, Dawoon Jeong, Doosoo Jeon
Korean J Intern Med. 2024;39(4):640-649. Published online June 24, 2024
Background/Aims: This study aimed to investigate the timing and predictors of death during treatment among patients with multidrug/rifampin-resistant tuberculosis (MDR/RR-TB) in South Korea.
Methods: This was a retrospective cohort study that included MDR/RR-TB cases notified between 2011 and 2017 ..
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Gastroenterology / Review
Approaches and considerations in the endoscopic treatment of T1 colorectal cancer
Yunho Jung
Korean J Intern Med. 2024;39(4):563-576. Published online May 14, 2024
The detection of early colorectal cancer (CRC) is increasing through the implementation of screening programs. This increased detection enhances the likelihood of minimally invasive surgery and significantly lowers the risk of recurrence, thereby improving patient survival and reducing mortality rat..
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Gastroenterology / Review
Artificial intelligence in colonoscopy: from detection to diagnosis
Eun Sun Kim, Kwang-Sig Lee
Korean J Intern Med. 2024;39(4):555-562. Published online May 2, 2024
This study reviews the recent progress of artificial intelligence for colonoscopy from detection to diagnosis. The source of data was 27 original studies in PubMed. The search terms were “colonoscopy” (title) and “deep learning” (abstract). The eligibility criteria were: (1) the dependent varia..
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Gastroenterology / Review
Strategies to improve screening colonoscopy quality for the prevention of colorectal cancer
Joo Hye Song, Eun Ran Kim
Korean J Intern Med. 2024;39(4):547-554. Published online January 22, 2024
The incidence and mortality of colorectal cancer (CRC) have decreased through regular screening colonoscopy, surveillance, and endoscopic treatment. However, CRC can still be diagnosed after negative colonoscopy. Such CRC is called interval CRC and accounts for 1.8–9.0% of all CRC cases. Most case..
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Infectious diseases / Original Article
Impact of the coronavirus disease 2019 pandemic on the incidence of other infectious diseases in the hematology hospital in Korea
Seohee Oh, Yu-Sun Sung, Mihee Jang, Yong-Jin Kim, Hyun-Wook Park, Dukhee Nho, Dong-Gun Lee, Hyeon Woo Yim, Sung-Yeon Cho
Korean J Intern Med. 2024;39(3):513-523. Published online April 23, 2024
Background/Aims: Since the coronavirus disease 2019 (COVID-19) outbreak, hospitals have implemented infection control measures to minimize the spread of the virus within facilities. This study aimed to investigate the impact of COVID-19 on the incidence of healthcare-associated infections (HCAIs) an..
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Pulmonology / Original Article
Risk factors for progressing to critical illness in patients with hospital-acquired COVID-19
Kyung-Eui Lee, Jinwoo Lee, Sang-Min Lee, Hong Yeul Lee
Korean J Intern Med. 2024;39(3):477-487. Published online April 18, 2024
Background/Aims: Risk factors for progression to critical illness in hospital-acquired coronavirus disease 2019 (COVID-19) remain unknown. Here, we assessed the incidence and risk factors for progression to critical illness and determined their effects on clinical outcomes in patients with hospital-..
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Gastroenterology / Original Article
Prevalence and predictors of multidrug-resistant bacteremia in liver cirrhosis
Aryoung Kim, Byeong Geun Song, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Myung Ji Goh
Korean J Intern Med. 2024;39(3):448-457. Published online April 30, 2024
Background/Aims: Improved knowledge of local epidemiology and predicting risk factors of multidrug-resistant (MDR) bacteria are required to optimize the management of infections. This study examined local epidemiology and antibiotic resistance patterns of liver cirrhosis (LC) patients and evaluated ..
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Gastroenterology / Original Article
Predicting Helicobacter pylori infection from endoscopic features
Jun-young Seo, Ji Yong Ahn, Seonok Kim, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Korean J Intern Med. 2024;39(3):439-447. Published online April 30, 2024
Background: Helicobacter pylori infection, prevalent in more than half of the global population, is associated with various gastrointestinal diseases, including peptic ulcers and gastric cancer. The effectiveness of early diagnosis and treatment in preventing gastric cancer highlights the nee..
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