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Endocrinology-metabolism / Original Article
Fisher discriminant analysis of multimodal ultrasound in diagnosis of cervical metastatic lymph nodes in papillary thyroid cancer
Yixuan Wang, Yue Han, Fei Li, Yuyang Lin, Bei Wang
Korean J Intern Med. 2025;40(1):103-114. Published online October 29, 2024
Background/Aims: The purpose of this study was to develop a diagnostic model utilizing multimodal ultrasound parameters to aid in the detection of cervical lymph node metastasis in papillary thyroid cancer (PTC) patients.
Methods: The study included 84 suspicious lymph nodes from 69 PTC patients, a..
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Endocrinology-metabolism / Original Article
Effects of statin use on serum creatinine phosphokinase levels in normal thyroid function
Jeonghoon Ha, Joonyub Lee, Jin Yu, Hakyoung Park, Jiwon Shinn, Seung-Hwan Lee, Jae-Hyoung Cho, Hun-Sung Kim
Korean J Intern Med. 2024;39(4):650-658. Published online June 24, 2024
Background/Aims: Statins are common lipid-lowering agents used in dyslipidemia. However, they increase serum creatinine phosphokinase (CPK) levels. Currently, there are no studies on the effect of thyroid-stimulating hormone (TSH) levels on CPK levels after statin administration. Therefore, this stu..
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Endocrinology-metabolism / Original Article
Cumulative exposure to metabolic syndrome increases thyroid cancer risk in young adults: a population-based cohort study
Jinyoung Kim, Kyungdo Han, Mee Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
Korean J Intern Med. 2023;38(4):526-533. Published online May 18, 2023
Background/Aims: A re-increasing trend of thyroid cancer since 2015 has been observed despite a similar examination rate, and the incidence of thyroid cancer among young adults continues to rise.
Methods: This study used data from the Korean National Health Insurance Service. Individuals 20–39 year..
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Endocrinology-metabolism / Original Article
Association between DIO2 Thr92Ala polymorphism and hypertension in patients with hypothyroidism: Korean Genome and Epidemiology Study
Young Mi Kang, Bon Seok Koo, Hyon-Seung Yi, Jung Tae Kim, Boyoung Park, Ju Hee Lee, Minho Shong, Yea Eun Kang
Korean J Intern Med. 2023;38(2):226-237. Published online January 17, 2023
Background/Aims: Recent evidence has identified the significance of type 2 iodothyronine deiodinase (DIO2) in various diseases. However, the role of DIO2 polymorphism in metabolic parameters in patients with hypothyroidism is not fully understood.
Methods: We assessed the polymorphism of the DIO2 g..
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Endocrinology-metabolism / Original Article
Clinical features and signaling effects of RET D631Y variant multiple endocrine neoplasia type 2 (MEN2)
Ji-young Lee, Su Yeon Kim, Kwan Hoon Jo, Eun Yeong Mo, Eun Sook Kim, Hye Soo Kim, Je Ho Han, Sung-dae Moon
Korean J Intern Med. 2022;37(2):398-410. Published online December 15, 2021
Background/Aims: Germline mutations of the rearranged during transfection (RET) gene cause multiple endocrine neoplasia type 2 (MEN2). About 85% of RET mutations in MEN2 occur in codon Cys634. The RET D631Y mutation has recently been discovered, and we have studied its molecular expres..
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Endocrinology-metabolism / Original Article
Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination Survey
Jeonghoon Ha, Jeongmin Lee, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo-Il Kang, Min-Hee Kim
Korean J Intern Med. 2021;36(Suppl 1):S170-S179. Published online June 9, 2020
Background/Aims: Thyroid hormones are involved in wide range of glucose metabolism functions. Overt thyroid dysfunctions are related to altered glucose homeostasis. However, it is not conclusive as to whether subtle changes in thyroid hormones within normal ranges can induce alterations in glucose h..
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Endocrinology-metabolism / Original Article
The clinical meaning of pre- and post-ablation thyroglobulin levels at first radioiodine therapy in patients with papillary thyroid cancer
Hee Kyung Kim, Jee Hee Yoon, Jin Seong Cho, Seong Young Kwon, Su Woong Yoo, Ho-Cheol Kang
Korean J Intern Med. 2020;35(5):1164-1172. Published online July 29, 2019
Background/Aims: This study was conducted to identify prognostic factors in patients with papillary thyroid cancer (PTC) at the time of first radioactive iodine (RAI) therapy, and to evaluate the clinical value of the thyroglobulin (Tg) increase after RAI.
Methods: Serum Tg was sampled prior to (pr..
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Nephrology / Original Article
Low parathyroid hormone level predicts infection-related mortality in incident dialysis patients: a prospective cohort study
Yu Ah Hong, Jeong Ho Kim, Yong Kyun Kim, Yoon Kyung Chang, Cheol Whee Park, Suk Young Kim, Yon Su Kim, Shin-Wook Kang, Nam-Ho Kim, Yong-Lim Kim, Chul Woo Yang
Korean J Intern Med. 2020;35(1):160-170. Published online October 28, 2019
Background/Aims: Parathyroid hormone (PTH) is an important factor influencing immunologic dysfunction, but the effect of PTH level on infection-related outcomes remains unclear in incident dialysis.
Methods: We evaluated a multicenter prospective cohort study of 1,771 incident dialysis patients (1,..
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Endocrinology-metabolism / Original Article
Risk factors for hypothyroidism in euthyroid thyroid nodule patients with lymphocytic thyroiditis on fine needle aspiration cytology
Jeong-Min Lee, Jeonghoon Ha, Kwanhoon Jo, Yejee Lim, Min-Hee Kim, Chan-Kwan Jung, So-Lyung Jung, Moo-Il Kang, Bong-Yun Cha, Dong-Jun Lim
Korean J Intern Med. 2019;34(6):1287-1296. Published online March 13, 2018
Background/Aims: Lymphocytic thyroiditis as cytology diagnosis from fine needle aspiration (FNA) is frequently detected in patients with thyroid nodules. However, the clinical outcome for upcoming hypothyroid events has been rarely clarified in euthyroid patients.
Methods: We retrospectively review..
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Endocrinology-metabolism / Original Article
Utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules: efficacy of the standard deviation elasticity
Hye Jeong Kim, Mi Kyung Kwak, In Ho Choi, So-Young Jin, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh, Myung Hi Yoo
Korean J Intern Med. 2019;34(4):850-857. Published online February 23, 2018
Background/Aims: The aim of this study was to address the role of the elasticity index as a possible predictive marker for detecting papillary thyroid carcinoma (PTC) and quantitatively assess shear wave elastography (SWE) as a tool for differentiating PTC from benign thyroid nodules.
Methods: One ..
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Endocrinology-metabolism / Review
Clinical implications of anti-thyroglobulin antibody measurement before surgery in thyroid cancer
Kwanhoon Jo, Dong-Jun Lim
Korean J Intern Med. 2018;33(6):1050-1057. Published online October 30, 2018
Thyroglobulin antibody (TgAb) is a class G immunoglobulin and a conventional marker for thyroid autoimmunity. From a clinical perspective, TgAb is less useful than thyroid peroxidase antibodies for predicting thyroid dysfunction. However, TgAb is found more frequently in differentiated thyroid cance..
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Endocrinology-metabolism / Original Article
Prevalence of thyroid nodules and their associated clinical parameters: a large-scale, multicenter-based health checkup study
Jae Hoon Moon, Min Kyung Hyun, Ja Youn Lee, Jung Im Shim, Tae Hyuk Kim, Hoon Sung Choi, Hwa Young Ahn, Kyung Won Kim, Do Joon Park, Young Joo Park, Ka Hee Yi
Korean J Intern Med. 2018;33(4):753-762. Published online July 7, 2017
Background/Aims: We evaluated the prevalence and characteristics of thyroid nodules detected by thyroid ultrasound (US) at health checkups and the associated clinical parameters.
Methods: A total of 72,319 subjects who underwent thyroid US at three health checkup centers in Korea from January 2004 ..
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Letter to the editor
Multiple metastasis of follicular variant of papillary thyroid carcinoma coexistent with malignant melanoma
Yu Ji Kim, Kyung Ae Lee, Tae Sun Park, Hong Sun Baek, Heung Yong Jin
Korean J Intern Med. 2018;33(3):634-637. Published online January 16, 2017
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Endocrinology-metabolism / Original Article
Reference intervals of thyroid hormones during pregnancy in Korea, an iodine-replete area
Hye Jeong Kim, Yoon Young Cho, Sun Wook Kim, Tae Hyuk Kim, Hye Won Jang, Soo-Youn Lee, Suk-Joo Choi, Cheong-Rae Roh, Jong-Hwa Kim, Jae Hoon Chung, Soo-young Oh
Korean J Intern Med. 2018;33(3):552-560. Published online February 8, 2017
Background/Aims: Maternal thyroid dysfunction has been associated with adverse pregnancy outcomes. The purpose of our study was to establish trimester-specific reference intervals for thyroid hormones in pregnant women in Korea, where iodine intake is more than adequate and to examine pregnancy and ..
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Letter to the editor
Synchronous parathyroid carcinoma and papillary thyroid carcinoma in a patient with long-standing schizophrenia
Cho-Ok Baek, Ki Hoi Kim, Sun Kyung Song
Korean J Intern Med. 2017;32(6):1104-1107. Published online October 17, 2017
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Endocrinology-metabolism / Review
Oncogenes, mitochondrial metabolism, and quality control in differentiated thyroid cancer
Hyon-Seung Yi, Joon Young Chang, Koon Soon Kim, Minho Shong
Korean J Intern Med. 2017;32(5):780-789. Published online August 22, 2017
Thyroid cancer is one of the most common malignancies of endocrine organs, and its incidence rate has increased steadily over the past several decades. Most differentiated thyroid tumors derived from thyroid epithelial cells exhibit slow-growing cancers, and patients with these tumors can achieve a ..
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Letter to the editor
Spontaneous ovarian hyperstimulation syndrome in a young female subject with a lingual thyroid and primary hypothyroidism
Soo Jeong Kim, Jee Hee Yoon, Hee Kyung Kim, Ho-Cheol Kang
Korean J Intern Med. 2017;32(3):559-562. Published online August 11, 2016
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Endocrinology-metabolism / Original Article
Association between thyroid autoimmunity and Helicobacter pylori infection
Yun Mi Choi, Tae Yong Kim, Eui Young Kim, Eun Kyung Jang, Min Ji Jeon, Won Gu Kim, Young Kee Shong, Won Bae Kim
Korean J Intern Med. 2017;32(2):309-313. Published online January 16, 2017
Background/Aims: There have been controversial reports linking Helicobacter pylori infection to autoimmune thyroid disease (AITD). However, data regarding the relationship are limited for Asian populations, which have an extremely high prevalence of H. pylori infection. We performed th..
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Endocrinology-metabolism / Original Article
Serum vitamin D3 levels are not associated with thyroid cancer prevalence in euthyroid subjects without autoimmune thyroid disease
Yun Mi Choi, Won Gu Kim, Tae Yong Kim, Sung Jin Bae, Hong-Kyu Kim, Eun Kyung Jang, Min Ji Jeon, Ji Min Han, Young Kee Shong, Won Bae Kim
Korean J Intern Med. 2017;32(1):102-108. Published online September 1, 2016
Background/Aims: Previous studies have suggested that elevated serum vitamin D levels might protect against thyroid cancer. Elevated serum thyroid stimulating hormone levels and autoimmune thyroid disease (AITD) are suggested to be thyroid cancer promoting factors but have not been well controlled i..
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Letter to the editor
Sporadic medullary microcarcinoma in a male patient with concurrent Hashimoto’s hypothyroidism and Kikuchi disease
Mi-Rim Choi, Seol-Bong Yoo, Ji Hye Kim
Korean J Intern Med. 2016;31(6):1184-1186. Published online January 28, 2016
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