| Reviews |
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Hepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic cell transplantation: historical and current considerations in Korea
Jae-Ho Yoon, Chul Won Choi, Jong-Ho Won
Korean J Intern Med. 2021;36(6):1261-1280. Published online September 24, 2021
Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a rare but severe complication of hematopoietic cell transplantation (HCT) showing high mortality. Multiple risk factors for SOS/VOD were identified, but it is often confused with other hepatic complications due to nonspecif..
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Role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease
Yousuf Waheed, Fan Yang, Dong Sun
Korean J Intern Med. 2021;36(6):1281-1293. Published online July 8, 2021
Previous research has investigated whether hyperuricemia serves as an independent risk factor for cardiovascular and renal diseases. Hyperuricemia is defined as an abnormally high level of uric acid (UA; i.e., serum urate level > 6.8 mg/dL). Hyperuricemia has been considered a complication of chroni..
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Recent advances in airway imaging using micro-computed tomography and computed tomography for chronic obstructive pulmonary disease
Naoya Tanabe, Toyohiro Hirai
Korean J Intern Med. 2021;36(6):1294-1304. Published online October 6, 2021
Chronic obstructive pulmonary disease (COPD) is a complex lung disease characterized by a combination of airway disease and emphysema. Emphysema is classified as centrilobular emphysema (CLE), paraseptal emphysema (PSE), or panlobular emphysema (PLE), and airway disease extends from the respiratory,..
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Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma
Andrew Li, Hiang Ping Chan, Phyllis X.L. Gan, Mei Fong Liew, W.S. Fred Wong, Hui-Fang Lim
Korean J Intern Med. 2021;36(6):1305-1319. Published online October 12, 2021
Approximately 25% to 40% of patients with chronic obstructive pulmonary disease (COPD) have the eosinophilic endotype. It is important to identify this group accurately because they are more symptomatic and are at increased risk for exacerbations and accelerated decline in forced expiratory volume i..
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| Editorials |
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Optimizing glucose control for diabetic patients undergoing percutaneous coronary intervention
Haseong Chang, Sung-Hea Kim
Korean J Intern Med. 2021;36(6):1320-1322. Published online November 1, 2021
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| Original Articles |
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Gastroenterology
HER-2 positivity is a high risk of recurrence of stage I gastric cancer
Seonhoo Kim, Yeon-Ji Kim, Woo Chul Chung
Korean J Intern Med. 2021;36(6):1327-1337. Published online August 26, 2021
Background/Aims: The treatment of gastric cancer remains unsatisfactory. We aimed to investigate the prognostic value of immunohistochemical staining in gastric cancer.
Methods: We analyzed 505 (279 early staged, 226 advanced-staged) gastric cancer tissues from patients who underwent radical gastri..
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Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
Young Jung Kim, Young Koog Cheon, Tae Yoon Lee, Seong-Hwan Chang, Mi-Hye Yu
Korean J Intern Med. 2021;36(6):1338-1346. Published online June 21, 2021
Background/Aims: Postoperative abdominal fluid collection (PAFC) is a frequent complication of pancreatobiliary cancer surgery. The effects of the existence and duration of PAFC are not well known. This study aimed to assess the effects of PAFC on patient prognosis after surgery for pancreatobiliary..
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Impact of non-hepatic hyperammonemia on mortality in intensive care unit patients: a retrospective cohort study
Jae Heon Kim, Hankyu Jeon, Sang Soo Lee, I Re Heo, Jung Woo Choi, Hee Jin Kim, Ra Ri Cha, Jae Min Lee, Hyun Jin Kim
Korean J Intern Med. 2021;36(6):1347-1355. Published online July 15, 2021
Background/Aims: The effect of hyperammonemia on the mortality in patients with liver cirrhosis is well documented. However, little is known about the impact of hyperammonemia on mortality among intensive care unit patients without hepatic disease. We aimed to investigate factors associated with non..
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Clinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell carcinomas
Zhiqin Chen, Sihan Li, Zheng He, Guang Li
Korean J Intern Med. 2021;36(6):1356-1364. Published online April 29, 2020
Background/Aims: We aimed to study the clinical characteristics, treatment modality, and the prognosis of synchronous multiple primary esophageal squamous cell carcinomas (SMPESCC).
Methods: A total of 117 SMPESCC cases were evaluated retrospectively from 2010 to 2015.
Results: The most common loc..
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Cardiology
Long-term effects of the mean hemoglobin A1c levels after percutaneous coronary intervention in patients with diabetes
Jaekyung Bae, Ji-Hyung Yoon, Jung-Hee Lee, Jong-Ho Nam, Chan-Hee Lee, Jang-Won Son, Ung Kim, Jong-Seon Park, Dong-Gu Shin
Korean J Intern Med. 2021;36(6):1365-1376. Published online October 14, 2021
Background/Aims: The clinical benefit of strict blood glucose-lowering therapy for patients with coronary artery disease (CAD) is still debated. We aimed to evaluate the long-term outcomes of patients with diabetes who underwent percutaneous coronary intervention (PCI), according to the mean hemoglo..
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Association between secondhand smoke exposure and new-onset hypertension in self-reported never smokers verified by cotinine
Byung Jin Kim, Jeong-Gyu Kang, Bum Soo Kim
Korean J Intern Med. 2021;36(6):1377-1388. Published online June 9, 2021
Background/Aims: There is no study assessing the effect of changes of secondhand smoke (SHS) exposure and new-onset hypertension. We investigated the effect of a change of SHS exposure status on new-onset hypertension in self-reported and cotinine-verified never smokers.
Methods: Out of individuals..
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Pulmonology
Atrial fibrillation in critically ill patients who received prolonged mechanical ventilation: a nationwide inpatient report
Zhen Lin, Hedong Han, Wei Guo, Xin Wei, Zhijian Guo, Shujie Zhai, Shuai Li, Yiming Ruan, Fangyuan Hu, Dongdong Li, Jia He
Korean J Intern Med. 2021;36(6):1389-1401. Published online July 12, 2021
Background/Aims: To evaluate temporal trends of atrial fibrillation (AF) prevalence in critically ill patients who received prolonged mechanical ventilation (MV) in the United States.
Methods: We used the 2008 to 2014 National Inpatient Sample to compute the weighted prevalence of AF among hospital..
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Survey of the management of patients with bronchiectasis: a pilot investigation in Asian populations
Ho Cheol Kim, Masaru Suzuki, Hui Fang Lim, Le Thi Tuyet Lan, Ho Lam Nguyen, Jeng-Shing Wang, Kang-Yun Lee, Jae Seung Lee, Yeon-Mok Oh, Sang Do Lee, Hayoung Choi, Hyun Lee, Sei Won Lee
Korean J Intern Med. 2021;36(6):1402-1409. Published online June 16, 2021
Background/Aims: Although international guidelines for bronchiectasis management have been published in Western countries, there is a lack of data about their application in Asian populations including patients with different phenotypes. We aimed to investigate the current status of bronchiectasis m..
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Chest computed tomography scan as an initial diagnostic method for tuberculosis infection detected by mass screening
Dong-Hyun Joo, Hyun Woo Lee, Seo-Young Yoon, Tae Yun Park, Eun Young Heo, Deog Kyeom Kim, Hee Soon Chung, Jung-Kyu Lee
Korean J Intern Med. 2021;36(6):1410-1419. Published online July 15, 2021
Background/Aims: We assessed the diagnostic yield of chest computed tomography (CT) as an initial diagnostic method for patients with a tuberculosis (TB) infection detected by mass screening in a country with an intermediate TB burden.
Methods: A retrospective study was conducted on patients with T..
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Nephrology
Human kidney organoids model the tacrolimus nephrotoxicity and elucidate the role of autophagy
Jin Won Kim, Sun Ah Nam, Eunjeong Seo, Jong Young Lee, Dohui Kim, Ji Hyeon Ju, Sun Woo Lim, Hong Lim Kim, Hyung Wook Kim, Chul Woo Yang, Jin Kim, Dong Sung Kim, Yong Kyun kim
Korean J Intern Med. 2021;36(6):1420-1436. Published online July 27, 2021
Background/Aims: Tacrolimus has been used as an immunosuppressive agent in organ transplantation. Despite the therapeutic benefits, tacrolimus’s use is limited due to its nephrotoxicity. To reduce tacrolimus nephrotoxicity, effective humanized experimental models may be helpful. Here, we modeled t..
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Nicotine exacerbates tacrolimus-induced renal injury by programmed cell death
Yu Ji Jiang, Sheng Cui, Kang Luo, Jun Ding, Qi Yan Nan, Shang Guo Piao, Mei Ying Xuan, Hai Lan Zheng, Yong Jie Jin, Ji Zhe Jin, Jung Pyo Lee, Byung Ha Chung, Bum Soon Choi, Chul Woo Yang, Can Li
Korean J Intern Med. 2021;36(6):1437-1449. Published online October 21, 2021
Background/Aims: Cigarette smoking is an important modifiable risk factor in kidney disease progression. However, the underlying mechanisms for this are lacking. This study aimed to assess whether nicotine (NIC), a major toxic component of cigarette smoking, would exacerbates tacrolimus (TAC)-induce..
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Hemato-oncology
Survival impact of adherence to tyrosine kinase inhibitor in chronic myeloid leukemia
Yundeok Kim, Tae-Hwa Go, Jaeyeon Jang, Jii Bum Lee, Seung Taek Lim, Kwang Yong Shim, Jong In Lee, Jee Hyun Kong
Korean J Intern Med. 2021;36(6):1450-1458. Published online November 1, 2021
Background/Aims: Adherence to tyrosine kinase inhibitors (TKIs) has become a critical aspect of care in chronic myeloid leukemia (CML). We aimed to examine the association of TKI adherence with overall survival (OS) outcomes in Korean patients diagnosed with CML and treated with TKIs using data from..
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The effect of the response to the coronavirus disease pandemic on treatment outcomes in patients with lymphoma and multiple myeloma
Ka-Won Kang, Byung-Hyun Lee, Min Ji Jeon, Eun Sang Yu, Dae Sik Kim, Se Ryeon Lee, Hwa Jung Sung, Chul Won Choi, Yong Park, Byung Soo Kim
Korean J Intern Med. 2021;36(6):1459-1470. Published online October 21, 2021
Background/Aims: Relatively little data are available on how the response to the coronavirus disease 2019 (COVID-19) pandemic has affected treatment outcomes in patients receiving chemotherapy for lymphoma or multiple myeloma. We aimed to determine the effect of COVID-19 countermeasures on treatment..
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Pediatric-inspired regimen with late intensification and increased dose of L-asparaginase for adult acute lymphoblastic leukemia: the KALLA 1406/1407 study
Dong Won Baek, Dae Young Kim, Sang Kyun Sohn, Youngil Koh, Sung-Hoon Jung, Ho-Young Yhim, Yunsuk Choi, Joon Ho Moon
Korean J Intern Med. 2021;36(6):1471-1485. Published online September 24, 2021
Background/Aims: The objective of this study was to evaluate the efficacy and feasibility of the pediatric-inspired regimen of the adult acute lymphoblastic leukemia (ALL) Working Party, the Korean Society of Hematology.
Methods: Data of 99 patients with newly diagnosed ALL, who were treated with t..
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Infectious diseases
Can reactogenicity predict immunogenicity after COVID-19 vaccination?
Young Hoon Hwang, Kyoung-Ho Song, Yunsang Choi, Suryeong Go, Su-Jin Choi, Jongtak Jung, Chang Kyung Kang, Pyoeng Gyun Choe, Nam-Joong Kim, Wan Beom Park, Myoung-don Oh
Korean J Intern Med. 2021;36(6):1486-1491. Published online May 28, 2021
Background/Aims: This study aimed to assess the association between local and systemic reactogenicity and humoral immunogenicity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination.
Methods: Adverse events were prospectively evaluated using an electronic diary in 135 heal..
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Rheumatology
Clinical influences of anticentromere antibody on primary Sjögren’s syndrome in a prospective Korean cohort
Youngjae Park, Jennifer Lee, Jung Hee Koh, Jung Yoon Choe, Yoon-Kyoung Sung, Shin-Seok Lee, Ji-Min Kim, Sung-Hwan Park, Seung-Ki Kwok
Korean J Intern Med. 2021;36(6):1492-1503. Published online August 24, 2020
Background/Aims: This study was performed to clarify inf luences of anticentromere antibody (ACA) on clinical phenotypes of primary Sjögren’s syndrome (pSS) patients in Korea. Methods: We assessed 318 patients who met the 2016 American College of Rheumatology/ European League Against Rheumatism cla..
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Reliability and validity of the Korean version of the University of California–Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract instrument in patients with systemic sclerosis
Tae Hee Lee, Joon Seong Lee, Suyeon Park, Kyung-Ann Lee, Hyun-Sook Kim
Korean J Intern Med. 2021;36(6):1504-1514. Published online February 10, 2021
Background/Aims: Systemic sclerosis (SSc) is associated with a wide range of gastrointestinal (GI) changes. The University of California–Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract (UCLA SCTC GIT 2.0) instrument is a self-administered GI assessment instrument for patie..
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Predictors of joint damage in patients with rheumatoid arthritis: focus on short- and long-term effects of intra-articular glucocorticoid injections
Jung Hee Koh, Hanna Lee, Seung-Geun Lee
Korean J Intern Med. 2021;36(6):1515-1526. Published online February 15, 2021
Background/Aims: To investigate the short- and long-term efficacy of intra-articular glucocorticoid injections (IAGI) in patients with rheumatoid arthritis (RA).
Methods: This was a retrospective study of RA patients who had active arthritis in the hand or wrist joints and who received IAGI (or not..
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| Correspondence |
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Male hypogonadism caused by a homozygous missense mutation of the LHB gene
Jie Chen, Wen-ting Yi, Yuan-Qing Cui, Wen-ting Wang, Xiong Wang
Korean J Intern Med. 2021;36(6):1527-1529. Published online October 12, 2021
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| Images of interest |
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Isolated gastric Kaposi’s sarcoma in a non-AIDS/HIV patient with coexisting collagenous gastritis and microscopic colitis
Andrey P. Kiryukhin, Alexander S. Tertychnyy, Petr L. Shcherbakov, Alexandr S. Inozemtsev, Olga A. Kolokolnikova
Korean J Intern Med. 2021;36(6):1530-1531. Published online February 5, 2021
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Complete regression of metastatic malignant melanoma endoscopically after nivolumab administration
Dae Gon Ryu, Cheol Woong Choi, Su Jin Kim, Dae Hwan Kang, Su Bum Park
Korean J Intern Med. 2021;36(6):1532-1533. Published online February 5, 2021
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Single device transcatheter closure for double atrial septal defect under real time three-dimensional image guidance
Young Kyoung Sa, Chul Soo Park, Eun Joo Cho, Yoon Seok Choi, Heung Seok Kim
Korean J Intern Med. 2021;36(6):1534-1536. Published online July 15, 2021
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COVID-19 vaccine-induced acute generalized exanthematous pustulosis
Sung-Yoon Kang, So-Young Park, Jung-Hyun Kim, Sang Min Lee, Sang Pyo Lee
Korean J Intern Med. 2021;36(6):1537-1538. Published online June 16, 2021
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