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Ahead of Print
> Browse Articles > Ahead of Print
A paradigm shift in studies based on rheumatoid arthritis clinical registries
Soo-Kyung Cho, Yoon-Kyoung Sung
Received December 11, 2018 Accepted January 2, 2018 Published online February 18, 2019
DOI:
https://doi.org/10.3904/kjim.2018.440
[Epub ahead of print]
Clinical research is the study of aspects of patient health or illness that are closely related to clinical practice. In the late 20th and early 21th century, outcomes for patients with rheumatoid arthritis (RA) improved dramatically due to breakthroughs in new drugs. Patient-reported outcome measur..
Liver volume index predicts the risk of esophageal variceal hemorrhage in cirrhotic patients on propranolol prophylaxis
Beom Hee Kim, Jung Wha Chung, Chung Seop Lee, Eun Sun Jang, Sook-Hyang Jeong, Nayoung Kim, Jin-Wook Kim
Received April 1, 2018 Accepted May 21, 2018 Published online February 18, 2019
DOI:
https://doi.org/10.3904/kjim.2018.120
[Epub ahead of print]
Background/Aims: Non-selective β-blockers (NSBBs) are used for primary prevention of esophageal variceal hemorrhage (VH) in patients with portal hypertension, but a significant number of patients develop VH while on NSBB therapy. In this study, we sought to determine whether liver volume can predi..
Attitudes toward advance directives and prognosis in patients with heart failure: a pilot study
JinShil Kim, Minjeong An, Seongkum Heo, Mi-Seung Shin
Received April 12, 2018 Accepted July 5, 2018 Published online February 15, 2019
DOI:
https://doi.org/10.3904/kjim.2018.158
[Epub ahead of print]
Background/Aims: Advance directives (ADs) in Korean patients with heart failure (HF) and the associations of attitude towards ADs and HF prognosis with ADs were initially assessed using the model of the Korean-Advance Directive (K-AD). Methods: Twenty-four patients with HF (age, 67.1 years; men, 58..
Cellular immunotherapy in multiple myeloma
Manh-Cuong Vo, Thangaraj Jaya Lakshmi, Sung-Hoon Jung, Duck Cho, Hye-Seong Park, Tan-Huy Chu, Hyun-Ju Lee, Hyeoung-Joon Kim, Sang-Ki Kim, Je-Jung Lee
Received September 6, 2018 Accepted December 4, 2018 Published online February 15, 2019
DOI:
https://doi.org/10.3904/kjim.2018.325
[Epub ahead of print]
In multiple myeloma (MM), the impaired function of several types of immune cells favors the tumor’s escape from immune surveillance and, therefore, its growth and survival. Tremendous improvements have been made in the treatment of MM over the past decade but cellular immunotherapy using dendritic..
A prospective randomized clinical study evaluating the efficacy and compliance of oral sulfate solution and 2-L ascorbic acid plus polyethylene glycol
Ki Hwan Kwon, Ji Ae Lee, Yun Jeong Lim, Beom Jae Lee, Moon Kyung Joo, Yu Ra Sim, Wonjae Choi, Taehyun Kim, Ji Yoon Kim, Ei Rie Cho, Yoon Tae Jeen, Jong-Jae Park
Received August 7, 2017 Accepted October 31, 2018 Published online January 30, 2019
DOI:
https://doi.org/10.3904/kjim.2017.275
[Epub ahead of print]
Background/Aims: Oral sulfate solution (OSS) is an emerging cleansing agent for bowel preparation. However, data comparing OSS to other conventional bowel preparations in Asian patients are limited. Therefore, the objective of this study was to compare the efficacy and tolerability of OSS to ascorbi..
Prognostic significance of malnutrition for long-term mortality in community-acquired pneumonia: a propensity score matched analysis
Hye Ju Yeo, Ki Sup Byun, Junhee Han, June Hyun Kim, Seung Eun Lee, Seong Hoon Yoon, Doosoo Jeon, Yun Seong Kim, Woo Hyun Cho
Received January 25, 2018 Accepted June 13, 2018 Published online January 29, 2019
DOI:
https://doi.org/10.3904/kjim.2018.037
[Epub ahead of print]
Background/Aims: The impact of malnutrition on the outcome of hospitalized adults with community-acquired pneumonia (CAP) has not been fully investigated. This study evaluated the prevalence and prognostic significance of malnutrition in a Korean population with CAP. Methods: In total, 198 patients ..
Outcomes and clinical relevance of stool multiplex bacterial polymerase chain reaction in patients with acute diarrhea: single center experience
Won Gun Kwack, Yun Jeong Lim, Ki Hwan Kwon, Jae Woo Chung, Jin Young Oh
Received May 24, 2017 Accepted August 19, 2018 Published online January 29, 2019
DOI:
https://doi.org/10.3904/kjim.2017.189
[Epub ahead of print]
Background/Aims: Diagnostic stool multiplex polymerase chain reaction (PCR) testing has attracted considerable interest, because of its high sensitivity, short turnaround time, and ability to detect multiple organisms simultaneously. This study investigates the clinical usefulness of a stool multipl..
Clinical features and recurrent attack in gout patients according to serum urate levels during an acute attack
Jung Sun Lee, Oh Chan Kwon, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Seokchan Hong
Received June 13, 2018 Accepted July 18, 2018 Published online January 28, 2019
DOI:
https://doi.org/10.3904/kjim.2018.205
[Epub ahead of print]
Background/Aims: A substantial portion of gout patients have normal serum urate levels during an acute attack but data on the clinical characteristics and risk of recurrence compared with hyperuricemic patients are limited. Methods: In this retrospective cohort study, clinical features of normourice..
D-dimer/troponin ratio in the differential diagnosis of acute pulmonary embolism from non-ST elevation myocardial infarction
Jong Yoon Kim, Kye Hun Kim, Jae Yeong Cho, Doo Sun Sim, Hyun Ju Yoon, Nam Sik Yoon, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park
Received April 25, 2018 Accepted August 14, 2018 Published online January 28, 2019
DOI:
https://doi.org/10.3904/kjim.2018.153
[Epub ahead of print]
Background/Aims: The aim of this study was to investigate useful cardiac biomarkers in the differential diagnosis of acute pulmonary embolism (APE) with troponin elevation from acute non-ST elevation myocardial infarction (NSTEMI). Methods: A total of 771 consecutive NSTEMI patients with D-dimer mea..
Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity
Kichul Shin, Sung Soo Kim, Sang-Heon Lee, Seung-Jae Hong, Sung Jae Choi, Jung-Yoon Choe, Seung-Geun Lee, Hoon-Suk Cha, Eun Young Lee, Sung-Hwan Park, Jin-Wuk Hur, Sung Soo Na, Chang-Hee Suh, Min Wook So, Seung Won Choi, Dong-Hyuk Sheen, Won Park, Shin-Seok Lee, Wan Hee Ryu, Jin Seok Kim, Jung Soo Song, Hye Soon Lee, Seong Ho Kim, Dae-Hyun Yoo
Received April 12, 2018 Accepted July 5, 2018 Published online January 28, 2019
DOI:
https://doi.org/10.3904/kjim.2018.137
[Epub ahead of print]
Background/Aims: The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive rheumatoid arthritis (RA) in daily clinical practice. Methods: This was ..
Immunological measurement of aspartate/alanine aminotransferase in predicting liver fibrosis and inflammation
Hyun Jeong Kim, Sang Yeol Kim, Suk Pyo Shin, Young Joo Yang, Chang Seok Bang, Gwang Ho Baik, Dong Joon Kim, Young Lim Ham, Eui Yul Choi, Ki Tae Suk
Received June 19, 2018 Accepted October 1, 2018 Published online January 23, 2019
DOI:
https://doi.org/10.3904/kjim.2018.214
[Epub ahead of print]
Background/Aims: Enzymatic analysis of aspartate/alanine aminotransferase (AST/ALT) does not exactly represent the progression of liver fibrosis or inflammation. Immunoassay for AST (cytoplasmic [c] AST/mitochondrial [m] AST) and ALT (ALT1/ALT2) has been suggested as one alternatives for enzymatic a..
A rare case of an enlarged celiac lymph node diagnosed as an epidermal inclusion cyst
Sung Bum Kim, Kook Hyun Kim, Tae Nyeun Kim, Chan Woo Cho, Joon Hyuk Choi
Received October 7, 2018 Accepted November 10, 2018 Published online January 18, 2019
DOI:
https://doi.org/10.3904/kjim.2018.358
[Epub ahead of print]
Clinical impact of anti-thymocyte globulin on survival and graft-versus-host disease in patients undergoing human leukocyte antigen mismatched allogeneic stem cell transplantation
Taeyun Kim, Yunsuk Choi, Je-Hwan Lee, Silvia Park, Jae-Sook Ahn, Joon-Ho Moon, Ho-Jin Shin, Won Sik Lee, Dajung Kim, Ho Sup Lee
Received December 27, 2017 Accepted May 4, 2018 Published online January 10, 2019
DOI:
https://doi.org/10.3904/kjim.2018.317
[Epub ahead of print]
Background/Aims: Rabbit anti-thymocyte globulin (ATG) is usually incorporated in hematopoietic stem cell transplantation (HSCT) to reduce the incidence of graft-versus-host disease (GVHD). This study aimed to find optimal ATG doses in patients undergoing human leukocyte antigen (HLA)-mismatched allo..
Molecular targeted therapies for microscopic polyangiitis and granulomatosis with polyangiitis
Masayoshi Harigai, Michi Tsutsumino, Hideto Takada, Kenji Nagasaka
Received October 13, 2018 Accepted November 17, 2018 Published online January 9, 2019
DOI:
https://doi.org/10.3904/kjim.2018.366
[Epub ahead of print]
Clinical trials and observational studies have established cyclophosphamide (CY) or rituximab plus glucocorticoid (GC) as standard remission induction therapies in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). However, because these regimens are associated ..
Giant intra-abdominal cystic lymphangioma
Fatih Altintoprak, Mustafa Yener Uzunoglu, Kayhan Ozdemir, Enis Dikicier, Zeynep Kahyaoglu
Received January 21, 2017 Accepted July 15, 2017 Published online January 7, 2019
DOI:
https://doi.org/10.3904/kjim.2017.029
[Epub ahead of print]
Application of machine learning in rheumatic disease research
Ki-Jo Kim, Ilias Tagkopoulos
Received September 23, 2018 Accepted November 18, 2018 Published online December 31, 2018
DOI:
https://doi.org/10.3904/kjim.2018.349
[Epub ahead of print]
Over the past decade, there has been a paradigm shift in how clinical data are collected, processed and utilized. Machine learning and artificial intelligence, fueled by breakthroughs in high-performance computing, data availability and algorithmic innovations, are paving the way to effective analys..
Serum levels of carbohydrate antigen 125 in combination with N-terminal pro-brain natriuretic peptide in patients with acute decompensated heart failure
Jae Yong Yoon, Dong Heon Yang, Hyun Jun Cho, Nam Kyun Kim, Chang-Yeon Kim, Jihyun Son, Jae-Hyung Roh, Se Yong Jang, Myung Hwan Bae, Jang Hoon Lee, Hun Sik Park, Yongkeun Cho, Shung Chull Chae
Received September 7, 2017 Accepted January 26, 2018 Published online December 31, 2018
DOI:
https://doi.org/10.3904/kjim.2017.313
[Epub ahead of print]
Background/Aims: Carbohydrate antigen 125 (CA-125) is an emerging prognostic biomarker for heart failure. We aimed to test the long-term prognostic value of CA-125 in combination with N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with acute decompensated heart failure (ADHF). Met..
Unusual milia-type intradermal tophi in a patient with gout
Mingyo Kim, Sang-Il Lee, Yun-Hong Cheon
Received September 28, 2018 Accepted October 4, 2018 Published online December 31, 2018
DOI:
https://doi.org/10.3904/kjim.2018.352
[Epub ahead of print]
Retinal artery occlusion after herpes zoster mandibularis in a patient with systemic lupus erythematosus
Gae-Eil Jang, Hyun-Sook Kim
Received October 14, 2018 Accepted November 8, 2018 Published online December 28, 2018
DOI:
https://doi.org/10.3904/kjim.2018.368
[Epub ahead of print]
Efficacy and predictors of response to inhaled corticosteroid treatment for chronic cough
Ji Young Hong, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Ki-Suck Jung, Seung Hun Jang
Received August 24, 2017 Accepted May 4, 2018 Published online December 13, 2018
DOI:
https://doi.org/10.3904/kjim.2017.291
[Epub ahead of print]
Background/Aims: Inhaled corticosteroids (ICS) are a treatment of choice for eosinophilic airway diseases, but their efficacy for other causes of chronic cough is controversial. Methods: We conducted a prospective observational study to determine the ICS efficacy and clinical predictors of response t..
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