Background/Aims: Despite increased demand for cancer patient’s to make their own decisions based on an adequate understanding of what is involved in chemotherapy, the primary signing agent and the reasons for surrogate signing have not been appropriately evaluated.
Methods: The ethics committee of..
Background/Aims: This study was tried to determine the role of β-catenin in invasion in pancreatic cancer.
Methods: We analyzed cancer invasiveness according to β-catenin expression in pancreatic cancer cell line. We also investigated the change in cancer invasiveness when β-catenin expression was ch..
Background/Aims: The Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) or European Organization for Research and Treatment of Cancer (EORTC) criteria are used to assess metabolic tumor responses. However, tumor responses have shown considerable discrepancies between the morpho..
Background/Aims: The outcome of local treatment for advanced non-small cell lung cancer (NSCLC) remains poor, with therapies such as induction chemotherapy (IC) yielding conflicting results. This study aimed to assess the clinicopathologic and prognostic significance of the excision repair cross-com..
Background/Aims: Various alterations of microRNA (miRNA) expression have been reported in myelodysplastic syndrome (MDS). We aimed to investigate the unique patterns and prognostic significance of miRNA expression in Korean patients with MDS.
Methods: Bone marrow mononuclear cells were collected fr..
Background/Aims: Few studies have addressed whether there are differences in clinical efficacy between intravenous methylprednisolone (methyl-Pd) and intravenous immunoglobulin (IVIg) use.
Methods: We retrospectively compared platelet responses and toxicities associated with these two treatments in..
Background/Aims: To evaluate and select microRNAs relevant to acute myeloid leukemia (AML) pathogenesis, we analyzed differential microRNA expression by quantitative small RNA next-generation sequencing using duplicate marrow samples from individual AML patients.
Methods: For this study, we obtaine..
Jae Ho Byun, Joong Bae Ahn, Sun Young Kim, Jung Hun Kang, Dae Young Zang, Seok Yun Kang, Myoung Joo Kang, Byoung Yong Shim, Sun Kyung Baek, Bong-Seog Kim, Kyung Hee Lee, Soon Il Lee, Sang-Hee Cho, Byeong Seok Sohn, Samyong Kim, In Gyu Hwang, Eun Mi Nam, Bong-Gun Seo, Sang Cheul Oh, Myung-Ah Lee, Sang-Cheol Lee, Ji Hyung Hong, Young Suk Park
Korean J Intern Med. 2019;34(1):165-177. Published online November 28, 2017
Background/Aims: Colorectal cancer is associated with different anatomical, biological, and clinical characteristics. We determined the impact of the primary tumor location in patients with metastatic colorectal cancer (mCRC).
Methods: Demographic data and clinical information were collected from 1..
Background/Aims: This study was conducted to identify risk factors that predict vulnerability to cancer therapy on the basis of the clinical, geriatric, and quality of life assessment before starting treatment in elderly patients.
Methods: Seventy-five patients aged 65 years and over with newly dia..
Sang Kyun Sohn, Joon Ho Moon, In Hee Lee, Jae Sook Ahn, Hyeoung Joon Kim, Joo Seop Chung, Ho Jin Shin, Sung Woo Park, Won Sik Lee, Sang Min Lee, Hawk Kim, Ho Sup Lee, Yang Soo Kim, Yoon Young Cho, Sung Hwa Bae, Ji Hyun Lee, Sung Hyun Kim, Ik Chan Song, Ji Hyun Kwon, Yoo Jin Lee
Korean J Intern Med. 2018;33(6):1194-1202. Published online December 15, 2017
Background/Aims: This study evaluated the role of hypomethylating agents (HMA) compared to best supportive care (BSC) for patients with high or very-high (H/VH) risk myelodysplastic syndrome (MDS) according to the Revised International Prognostic Scoring System.
Methods: A total of 279 H/VH risk MD..
Background/Aims: Elderly patients (≥ 80 years) with colorectal cancer (CRC) tend to avoid active treatment at the time of diagnosis despite of recent advances in treatment. The aim of this study was to determine treatment propensity of elderly patients aged ≥ 80 years with CRC in clinical practice ..
Background/Aims: Data on dexamethasone, cytarabine, and cisplatin (DHAP) as a mobilization regimen, compared to high-dose cyclophosphamide (HDC), for up-front autologous stem cell transplantation (ASCT) in non-Hodgkin’s lymphoma (NHL) is limited.
Methods: Consecutive patients with aggressive NHL ..
Background/Aims: Markers of inflammation have been associated with outcomes in various cancers. The purpose of this study was to evaluate whether systemic inf lammatory markers and their f luctuations can predict survival and chemotherapy response in patients with metastatic gastric cancer (mGC).
Background/Aims: Adoptive therapy with regulatory T (Treg) cells to prevent graft-versus-host disease (GVHD) would benefit from a strategy to improve homing to the sites of inflammation following hematopoietic stem cell transplantation (HSCT). Although donor-derived Treg cells have mainly been used ..
Background/Aims: Renal complications related to BCR-ABL1-negative myeloproliferative neoplasms (MPNs) have not been examined fully in Asian populations.
Methods: We analyzed estimated glomerular filtration rate (eGFR) and its changes with time retrospectively in patients with BCR-ABL1..
Background/Aims: We explored Korean physicians’ policies for surveillance of colorectal cancer (CRC) after curative surgery.
Methods: Web-based self-report questionnaires were developed. Invitations to participate were emailed to physicians who diagnosed and treated CRC from October 1 to Novembe..
Background/Aims: The purpose of the present study was to assess the prevalence of and factors associated with anxiety and depression in Korean patients with advanced gastrointestinal cancer.
Methods: One hundred and twenty consecutive patients with newly diagnosed, advanced gastrointestinal cancer ..
Background/Aims: Managing breakthrough pain (BTP) is important for many cancer patients because of the rapid onset and unpredictable nature of the pain episodes. Fentanyl buccal tablets (FBTs) are a rapid-onset opioid indicated for BTP management. However, FBT titration is needed to optimize BTP ma..
Moon Jin Kim, Young Sam Kim, Sung Yong Oh, Suee Lee, Young-Jin Choi, Young Mi Seol, Min Jae Park, Ki Hyang Kim, Lee Chun Park, Jung Hun Kang, In-Gyu Hwang, Soon Il Lee, Seung Taek Lim, Hyo Song Kim, Ho Yeong Lim, Sun Young Rha, Hyo-Jin Kim
Korean J Intern Med. 2018;33(2):383-390. Published online April 6, 2016
Background/Aims: Because of rarity, role of chemotherapy of bladder adenocarcinoma are still unidentified. Therefore, we performed a retrospective analysis of the clinical features and chemotherapy outcomes of bladder adenocarcinoma.
Methods: Eligible patients for this retrospective analysis were i..
Background/Aims: We investigated the time taken for patients with metastatic non-small cell lung cancer (NSCLC) to develop brain metastases (BM), as well as their subsequent overall median survival following diagnosis, considering the epidermal growth factor receptor (EGFR) mutational status...