| Brief Communications |
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Original Article
Clinical characteristics of coronavirus disease 2019 patients with diarrhea in Daegu
Min Kyu Kang, Kyeong Ok Kim, Min Cheol Kim, Joon Hyun Cho, Sung Bum Kim, Jung Gil Park, Kook Hyun Kim, See Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
Korean J Intern Med. 2020;35(6):1261-1269. Published online September 23, 2020
Background/Aims: Coronavirus disease 2019 (COVID-19) can reportedly cause gastrointestinal symptoms. Therefore, we investigated the clinical characteristics of COVID-19 patients with diarrhea.
Methods: We included 118 COVID-19 patients admitted to a single hospital from February 20 to March 31, 202..
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What should we prepare for the next coronavirus disease 2019 outbreak? A survey on the opinions of infectious diseases specialists in South Korea
Bongyoung Kim, Se Yoon Park, Dong Sik Jung, Sook In Jung, Won Sup Oh, Shin-Woo Kim, Kyong Ran Peck, Hyun-Ha Chang; The Korean Society of Infectious Diseases
Korean J Intern Med. 2020;35(6):1270-1278. Published online September 23, 2020
Background/Aims: This study aimed to collect information on the opinions of Korean infectious disease (ID) experts on coronavirus disease 2019 (COVID-19) and related issues in preparation for a future outbreak.
Methods: A survey was conducted over the course of 5 days (from April 21 to 25, 2020), t..
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| Reviews |
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Nutritional management in patients with chronic kidney disease
Sun Moon Kim, Ji Yong Jung
Korean J Intern Med. 2020;35(6):1279-1290. Published online September 23, 2020
The global prevalence of chronic kidney disease (CKD) is increasing with the aging of populations worldwide. As kidney function declines, the accumulation of metabolic waste products and excessive electrolytes can significantly impair the health of patients with CKD. As nutritional management of pat..
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Renal effects of uric acid: hyperuricemia and hypouricemia
Jung Hwan Park, Yong-Il Jo, Jong-Ho Lee
Korean J Intern Med. 2020;35(6):1291-1304. Published online September 9, 2020
The prevalence of chronic kidney disease (CKD) is increasing worldwide. Although hyperuricemia has been associated with CKD in many studies, it remains controversial whether this is the cause or the result of decreased renal function. Recent observational studies of healthy populations and patients ..
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The clinical impact of gut microbiota in chronic kidney disease
So Mi Kim, Il han Song
Korean J Intern Med. 2020;35(6):1305-1316. Published online September 29, 2020
Gut microorganisms play critical roles in both maintaining host homeostasis and the development of diverse diseases. Gut dysbiosis, an alteration of the composition and function of gut microorganisms, is commonly seen in patients with chronic kidney disease (CKD). CKD itself contributes to a disrupt..
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Recommendations for the management of patients with systemic rheumatic diseases during the coronavirus disease pandemic
Mi Ryoung Seo, Ji-Won Kim, Eun-Jung Park, Seung Min Jung, Yoon-Kyoung Sung, Hyungjin Kim, Gunwoo Kim, Hyun-Sook Kim, Myeung-Su Lee, Jisoo Lee, Ji An Hur, Bum Sik Chin, Joong Sik Eom, Han Joo Baek; The Korean College of Rheumatology working group
Korean J Intern Med. 2020;35(6):1317-1332. Published online September 15, 2020
Patients with systemic rheumatic diseases (SRD) are vulnerable for coronavirus disease (COVID-19). The Korean College of Rheumatology recognized the urgent need to develop recommendations for rheumatologists and other physicians to manage patients with SRD during the COVID-19 pandemic. The working g..
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| Editorials |
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Body mass index at the crossroads of osteoporosis and type 2 diabetes
Jeonghoon Ha, Ki-Hyun Baek
Korean J Intern Med. 2020;35(6):1333-1335. Published online October 28, 2020
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Do all patients with breast cancer benefit from neoadjuvant chemotherapy?
Kyoung Eun Lee
Korean J Intern Med. 2020;35(6):1336-1337. Published online October 28, 2020
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| Original Articles |
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Gastroenterology
Continuous infusion versus intermittent bolus injection of propofol during endoscopic retrograde cholangiopancreatography
Jae Gon Lee, Kyo-Sang Yoo, Young Jae Byun
Korean J Intern Med. 2020;35(6):1338-1345. Published online March 5, 2020
Background/Aims: It is unclear whether continuous infusion or intermittent bolus injection of propofol is better for achieving adequate sedation in endoscopic retrograde cholangiopancreatography (ERCP). We aimed to compare the efficacy and safety of continuous infusion and intermittent bolus injecti..
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Correlation of the grade of hepatic steatosis between controlled attenuation parameter and ultrasound in patients with fatty liver: a multi-center retrospective cohort study
Jeong-Ju Yoo, Yang Jae Yoo, Woo Ram Moon, Seung Up Kim, Soung Won Jeong, Ha Na Park, Min Gyu Park, Jae Young Jang, Su Yeon Park, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Sang Gyune Kim, Young Seok Kim, Ji Hoon Kim, Jong Eun Yeon, Kwan Soo Byun
Korean J Intern Med. 2020;35(6):1346-1353. Published online November 8, 2019
Background/Aims: The controlled attenuation parameter (CAP), based on transient elastography, is widely used for noninvasive assessment of the degree of hepatic steatosis (HS). We investigated the correlation of the degree HS between CAP and ultrasound (US) in patients with HS.
Methods: In total, 9..
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Association between high fatty liver index and development of colorectal cancer: a nationwide cohort study with 21,592,374 Korean
Yoon Jin Choi, Dong Ho Lee, Kyung-Do Han
Korean J Intern Med. 2020;35(6):1354-1363. Published online April 10, 2020
Background/Aims: In Korea, the incidence of colorectal cancer (CRC) and nonalcoholic fatty liver disease (NAFLD) has increased due to a westernized lifestyle. This study investigated whether a high fatty liver index that reflects NAFLD correlates with CRC.
Methods: Data from the National Health Ins..
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Effect of calcineurin inhibitor on post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with liver transplantation: a propensity-matched cohort study
Hyoung-Chul Oh, Jeffrey J. Easler, Ihab I. El Hajj, James Watkins, Evan L. Fogel, Lee McHenry, Stuart Sherman, Hyun Kang, Glen A. Lehman
Korean J Intern Med. 2020;35(6):1364-1370. Published online February 19, 2020
Background/Aims: A calcineurin inhibitor may alter pancreatic function and inflammatory reaction. This study aimed to determine the possible pharmacologic effect of the calcineurin inhibitor, tacrolimus, on pancreatic function, and to determine its preventive effect on post-endoscopic retrograde cho..
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Cardiology
J-curve relationship between corrected QT interval and mortality in acute heart failure patients
Chan Soon Park, Hyun-Jai Cho, Eue-Keun Choi, Sang Eun Lee, Min-Seok Kim, Jae-Joong Kim, Jin-Oh Choi, Eun-Seok Jeon, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Byungsu Yoo, Dong-Ju Choi, Youngkeun Ahn, Kye-Hoon Kim, Myeong-Chan Cho, Byung-Hee Oh, Hae-Young Lee
Korean J Intern Med. 2020;35(6):1371-1384. Published online May 8, 2020
Background/Aims: This study investigated the prognostic power of corrected QT (QTc) interval in patients with acute heart failure (AHF) according to sex.
Methods: We analyzed multicenter Korean Acute Heart Failure registry with patients with AHF admitted from 2011 to 2014. Among them, we analyzed 4..
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The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials
Cain C. T. Clark, Mina Salek, Elahe Aghabagheri, Sadegh Jafarnejad
Korean J Intern Med. 2020;35(6):1385-1399. Published online February 19, 2020
Background/Aims: Global incidence of hypertension is estimated to be, in excess of, one billion people, and given the efficacy of soluble dietary fibers, in particular, Psyllium, to positively impact blood pressure in patients with hypertension, it is of clinical importance that consensus on its sup..
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Fimasartan, an angiotensin II receptor antagonist, ameliorates an in vivo zebrafish model of heart failure
Hailian Quan, Gyu Chul Oh, Seung Hyeok Seok, Hae-Young Lee
Korean J Intern Med. 2020;35(6):1400-1410. Published online March 13, 2020
Background/Aims: Angiotensin II in the failing heart initially helps to maintain cardiac output and blood pressure, but ultimately accelerates its deterioration. In this study, we established a model of arrhythmia-induced heart failure (HF) in zebrafish and investigated the role of renin-angiotensi..
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Pulmonology
A population-based observational study of patients with pulmonary disorders in intensive care unit
Hyun Woo Lee, Eunjeong Ji, Soyeon Ahn, Hye-Joo Yang, Seo-Young Yoon, Tae Yeon Park, Yeon Joo Lee, Jinwoo Lee, Sang-Min Lee, Seung-Hye Choi, Young-Jae Cho
Korean J Intern Med. 2020;35(6):1411-1423. Published online November 25, 2019
Background/Aims: Only a few epidemiologic studies on the patients with pulmonary disorders admitted to intensive care unit exist. We investigated the characteristics and clinical outcomes of the patients with severe pulmonary disorders.
Methods: The sample cohort database of National Health Insuran..
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Age- and sex-related characteristics of the increasing trend of nontuberculous mycobacteria pulmonary disease in a tertiary hospital in South Korea from 2006 to 2016
Youngmok Park, Chi Young Kim, Moo Suk Park, Young Sam Kim, Joon Chang, Young Ae Kang
Korean J Intern Med. 2020;35(6):1424-1431. Published online June 19, 2020
Background/Aims: The incidence rate of nontuberculous mycobacterial pulmonary disease (NTM-PD) is increasing worldwide. However, data regarding the age- and sex-specific epidemiology of NTM-PD are limited. This study aimed to investigate the long-term epidemiologic trends of NTM-PD within the recent..
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Endocrinology-metabolism
Optimal body mass index for minimizing the risk for osteoporosis and type 2 diabetes
Ji Hyun Lee, Jung Hee Kim, A Ram Hong, Sang Wan Kim, Chan Soo Shin
Korean J Intern Med. 2020;35(6):1432-1442. Published online October 30, 2019
Background/Aims: Body mass index (BMI) is positively associated with bone mineral density and type 2 diabetes. We investigated an optimal BMI range for osteoporosis and type 2 diabetes.
Methods: This cross-sectional study used data from the Korea National Health and Nutrition Examination Survey (KN..
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Nephrology
The therapeutic efficacy of water-soluble coenzyme Q10 in an experimental model of tacrolimus-induced diabetes mellitus
Yi Quan, Kang Luo, Sheng Cui, Sun Woo Lim, Yoo Jin Shin, Eun Jeong Ko, Ju Hwan Kim, Sang J. Chung, Soo Kyung Bae, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2020;35(6):1443-1456. Published online April 14, 2020
Background/Aims: Coenzyme Q10 (CoQ10) has antioxidant effects and is commercially available and marketed extensively. However, due to its low bioavailability, its effects are still controversial. We developed a water-soluble CoQ10-based micelle formulation (CoQ10-W) ..
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Characteristics of kidney transplantation recipients over time in South Korea
Sehoon Park, Myoungsuk Kim, Ji Eun Kim, Kwangsoo Kim, Minsu Park, Yong Chul Kim, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
Korean J Intern Med. 2020;35(6):1457-1467. Published online March 30, 2020
Background/Aims: Detailed nationwide information regarding the recent status and time trends of kidney transplantation (KT) in South Korea is limited.
Methods: We performed a nationwide, population-based cohort study using the national claims database of Korea. We included KT recipients from 2008 t..
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Hemato-oncology
Impact of subsequent chemotherapy on the survival of elderly patients with extensive stage small cell lung cancer
Eun Joo Kang, Yoon Ji Choi, Se Ryeon Lee, Hwa Jung Sung, Jung Sun Kim
Korean J Intern Med. 2020;35(6):1468-1476. Published online April 29, 2020
Background/Aims: The prognosis of small cell lung cancer (SCLC) is still poor because of rapid recurrence, despite good response to initial chemotherapy. Additionally, patients’ old ages and comorbidities are often obstacles that make it difficult to apply subsequent treatment after initial treatm..
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Derivation and validation of modified early warning score plus SpO2/FiO2 score for predicting acute deterioration of patients with hematological malignancies
Ju-Ry Lee, Youn-Kyoung Jung, Hwa Jung Kim, Younsuck Koh, Chae-Man Lim, Sang-Bum Hong, Jin Won Huh
Korean J Intern Med. 2020;35(6):1477-1488. Published online March 3, 2020
Background/Aims: Scoring systems play an important role in predicting intensive care unit (ICU) admission or estimating the risk of death in critically ill patients with hematological malignancies. We evaluated the modified early warning score (MEWS) for predicting ICU admissions and in-hospital mor..
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Clinical outcome and predictive factors for docetaxel and epirubicin neoadjuvant chemotherapy of locally advanced breast cancer
Hye Sung Won, Yong Seok Kim, Jeong Soo Kim, Eun Deok Chang, Sae Jung Na, In Yong Whang, Dong Soo Lee
Korean J Intern Med. 2020;35(6):1489-1496. Published online February 21, 2020
Background/Aims: We evaluated the efficacy of docetaxel and epirubicin as neoadjuvant chemotherapy in locally advanced breast cancer and assessed the predictive factors for response to neoadjuvant chemotherapy and prognostic factors related to relapse-free survival.
Methods: Forty patients who rece..
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Infectious diseases
The clinical and economic burden of community-onset complicated skin and skin structure infections in Korea
Yong Kyun Cho, Heung Jeong Woo, Shin Woo Kim, In-Gyu Bae, Young Goo Song, Hee Jin Cheong, Hyuck Lee, Sang Hoon Han, Hee Jung Choi, Chisook Moon, Seong Yeol Ryu, Jian Hur, Ja Cob Lee, Yu Mi Jo, Young Joo Kim
Korean J Intern Med. 2020;35(6):1497-1506. Published online February 20, 2020
Background/Aims: To investigate epidemiologic characteristics, clinical and economic burdens, and factors associated with mortality in complicated skin and skin structure infection (cSSSI) patients in Korea.
Methods: A retrospective, observational, nationwide study was conducted between April to Ju..
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Allergy
Anxiety, depression, and stress in Korean patients with chronic urticaria
Gil-Soon Choi, Young-Hee Nam, Chan-Sun Park, Mi-Yeong Kim, Eun-Jung Jo, Hye-Kyung Park, Hee-Kyoo Kim
Korean J Intern Med. 2020;35(6):1507-1516. Published online May 27, 2020
Background/Aims: Emotional distress is thought to cause or maintain chronic urticaria (CU). We aimed to investigate the presence of anxiety, depression, and stress in Korean adult CU patients and to explore their potential impact on treatment.
Methods: We enrolled 79 CU patients and a disease contr..
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Rheumatology
Pilot study: asymptomatic hyperuricemia patients with obesity and nonalcoholic fatty liver disease have increased risk of double contour sign
Hong Ki Min, Hyonjoung Cho, Sung-Hwan Park
Korean J Intern Med. 2020;35(6):1517-1523. Published online June 13, 2019
Background/Aims: Double contour sign (DCS) is a representative ultrasonographic finding in gout. DCS is evidence of monosodium urate deposit in gouty arthritis and has been identified in some patients with asymptomatic hyperuricemia. However, the specific characteristics of asymptomatic hyperuricemi..
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| Images of interest |
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Endoscopic visualization of an intervention-treated pseudoaneurysm at a duodenal ulcer
Myung-Won You, Chi Hyuk Oh, Se Whan Kwon, Seok Ho Dong
Korean J Intern Med. 2020;35(6):1524-1525. Published online December 30, 2019
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A case of a gigantic thoracic aortic aneurysm initially mimicking acute coronary syndrome and treated endovascularly
Seok Oh, Kyung Hoon Cho, Min Chul Kim, Myung Ho Jeong, Ju Han Kim
Korean J Intern Med. 2020;35(6):1526-1527. Published online June 4, 2020
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Wunderlich syndrome and regression of angiomyolipoma
Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
Korean J Intern Med. 2020;35(6):1528-1529. Published online March 31, 2020
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Extranodal marginal zone lymphoma: an unusual cause of gastric subepithelial tumor
Eun Young Park, Gwang Ha Kim
Korean J Intern Med. 2020;35(6):1530-1531. Published online April 22, 2020
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| Retraction |
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