Histopathological examination of the resected specimen revealed a well-delineated, sharply circumscribed, oval lymphoid nodule located in the submucosa without involvement of the mucosa (Fig. 2A). The lymphoid cells were mostly small lymphocytes with dense chromatin (Fig. 2B). Immunostaining was positive for CD20 and B-cell lymphoma 2 (bcl-2) but negative for CD3, CD5, CD10, bcl-6, cyclin D1, and SOX11. Based on these findings, the tumor was diagnosed as gastric extranodal marginal zone lymphoma without mucosal involvement. Tests for Helicobacter pylori, including rapid urease test, tissue biopsy, serum antibody, and urea breath test were negative. Abdominopelvic computed tomography (CT) and positron emission tomography-CT (PET-CT) revealed perigastric lymph node enlargement. Bone narrow biopsy showed no involvement of the bone marrow by the lymphoma. The final gastric lymphoma stage was IIE1 based on the Ann Arbor clinical staging, and radiotherapy was administered for perigastric lymph node involvement. No sign of recurrence were seen at the 18-month follow-up visit.

Extranodal marginal zone lymphoma is the most common form of extralymphatic lymphoma, with the highest frequency occurring in the mucosa-associated lymphoid tissue. About 50% to 60% of these lymphomas occur in the gastrointestinal tract; the stomach is the most common site. Gastric extranodal marginal zone lymphomas progress very slowly, rarely metastasize systemically, and in many cases complete remission can be achieved by eradication of H. pylori alone. When extranodal marginal zone lymphomas are multiple and metastasize to lymph nodes, radiotherapy, or systemic chemotherapy are often performed.

All authors declare that informed consent was obtained from the patient to publish these images.