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Cardiology / Review
Management plans for populations with normal-to-hypertensive blood pressures:
risks and benefits of antihypertensive drug treatment in populations previously defined as
having high-normal blood pressure
Sungha Park
Korean J Intern Med. 2019;34(1):44-49. Published online December 28, 2018
Recent changes in American and European guidelines on the management of arterial hypertension have caused a considerable shift in the landscape of hypertension management. The 2017 American College of Cardiology/American Heart Association/American Society of Hypertension guideline recommends an offi..
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Gastroenterology / Review
Role of the renin-angiotensin system in hepatic fibrosis and portal hypertension
Kwang Yong Shim, Young Woo Eom, Moon Young Kim, Seong Hee Kang, Soon Koo Baik
Korean J Intern Med. 2018;33(3):453-461. Published online February 21, 2018
The renin-angiotensin system (RAS) is an important regulator of cirrhosis and portal hypertension. As hepatic fibrosis progresses, levels of the RAS components angiotensin (Ang) II, Ang-(1–7), angiotensin-converting enzyme (ACE), and Ang II type 1 receptor (AT1R) are increased. The primary effector ..
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Cardiology / Original Article
24-Hour blood pressure response to lower dose (30 mg) fimasartan in Korean patients with mild to moderate essential hypertension
Hae-Young Lee, Cheol-Ho Kim, Jae-Kwan Song, Shung Chull Chae, Myung Ho Jeong, Dong-Soo Kim, Byung-Hee Oh
Korean J Intern Med. 2017;32(6):1025-1036. Published online October 17, 2017
Background/Aims: Fimasartan is an angiotensin type 1 receptor blocker (ARB) which has comparable efficacy and tolerability with other ARBs. The aim of this study was to evaluate 24-hour blood pressure (BP) lowering efficacy and the tolerability of the low dose fimasartan compared with valsartan in p..
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Pulmonology / Original Article
Long-term outcomes of surgery for chronic thromboembolic pulmonary hypertension compared
with medical therapy at a single Korean center
Soo Han Kim, Jae Won Lee, Jung-Min Ahn, Dae-Hee Kim, Jong-Min Song, Sang-Do Lee, Jae Seung Lee
Korean J Intern Med. 2017;32(5):855-864. Published online October 13, 2016
Background/Aims: Pulmonary endarterectomy (PEA) is the gold standard for treating chronic thromboembolic pulmonary hypertension (CTEPH) in Western countries. The aim of this study was to investigate the long-term outcomes of performing PEA on CTEPH patients in comparison with medical therapy at a si..
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Cardiology / Original Article
Maximal pericoronary adipose tissue thickness is associated with hypertension in nonobese
patients with acute or chronic illness
Shinhae Chang, Wangjin Lee, Byounggyu Kwag, Yun Hee Chung, In Sook Kang
Korean J Intern Med. 2017;32(4):668-674. Published online December 6, 2016
Background/Aims: Recent studies have shown an association of epicardial fat thickness with diabetes and hypertension (HTN) in asymptomatic populations. However, there is lack of information as to whether there is similar association between pericoronary adipose tissue (PAT) and HTN in the patients w..
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Nephrology / Original Article
Which dialysis unit blood pressure is the most accurate for predicting home blood pressure in patients undergoing hemodialysis?
In-Cheol Yoon, Hye-Min Choi, Dong-Jin Oh
Korean J Intern Med. 2017;32(1):117-124. Published online April 7, 2016
Background/Aims: We investigated which dialysis unit blood pressure (BP) is the most useful for predicting home BP in patients undergoing hemodialysis (HD). Methods: Patients undergoing HD who had been treated > 3 months were included in this study. Exclusion criteria were hospitalized patients with..
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Cardiology / Original Article
The predictive value of echocardiography for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism in Korea
Jin Sup Park, Jinhee Ahn, Jung Hyun Choi, Hye Won Lee, Jun-Hyok Oh, Han Cheol Lee, Kwang Soo Cha, Taek Jong Hong
Korean J Intern Med. 2017;32(1):85-94. Published online April 5, 2016
Background/Aims: Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening complication after acute pulmonary embolism (APE) and is associated with substantial morbidity and mortality. This study aimed to investigate the incidence of CTEPH after APE in Korea and to determine echoca..
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Pulmonology / Original Article
Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry
So Young Park, Sang Min Lee, Jong Wook Shin, Byoung Whui Choi, Hojoong Kim, Jae Seung Lee, Sang Do Lee, Sung Soo Park, Hwa Sik Moon, Yong Bum Park
Korean J Intern Med. 2016;31(2):305-312. Published online January 29, 2016
Background/Aims: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and o..
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Pulmonology / Original Article
Survival benefits of warfarin in Korean patients with idiopathic pulmonary arterial hypertension
Byung Ju Kang, Yeon-Mok Oh, Sang-Do Lee, Jae Seung Lee
Korean J Intern Med. 2015;30(6):837-845. Published online October 30, 2015
Background/Aims: Idiopathic pulmonary arterial hypertension (IPAH) is an incurable disease with high mortality. Although most studies recommend anticoagulation treatment for IPAH, the benefits are uncertain, particularly in Korea, where it has not been studied. The purpose of this study was to evalu..
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Nephrology / Original Article
Time points for obtaining representative values of 24-hour blood pressure in chronic kidney disease
Jiwon Ryu, Ran-hui Cha, Dong Ki Kim, Ju Hyun Lee, Sun Ae Yoon, Dong Ryeol Ryu, Jieun Oh, Sejoong Kim, Sang-Youb Han, Eun Young Lee, Yon Su Kim
Korean J Intern Med. 2015;30(5):665-674. Published online August 27, 2015
Background/Aims: Ambulatory blood pressure (BP) monitoring has been widely recommended for evaluating the status of BP, but is lacking in practicality. Determination of the specific time points for BP measurement that are representative of 24-hour mean BP could be useful and convenient in hypertensi..
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Cardiology / Original Article
Discordance between ambulatory versus clinic blood pressure according to global cardiovascular risk group
Jinho Shin, Sung Ha Park, Ju Han Kim, Sang Hyun Ihm, Kwang-il Kim, Woo Shik Kim, Wook Bum Pyun, Yu-Mi Kim, Sung-il Choi, Soon Kil Kim
Korean J Intern Med. 2015;30(5):610-619. Published online August 27, 2015
Background/Aims: The detection of white coat hypertension (WCH), treated normalized hypertension, and masked hypertension (MH) is important to improve the effectiveness of hypertension management. However, whether global cardiovascular risk (GCR) profile has any effect on the discordance between amb..
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Rheumatology / Original Article
Pulmonary hypertension in systemic lupus erythematosus: an independent predictor of patient survival
Hong Ki Min, Jae Ho Lee, Seung Min Jung, Jennifer Lee, Kwi Young Kang, Seung-Ki Kwok, Ji Hyeon Ju, Kyung-Su Park, Sung-Hwan Park
Korean J Intern Med. 2015;30(2):232-241. Published online February 27, 2015
Background/Aims: We investigated whether transthoracic echocardiography-suspected pulmonary hypertension (PH) affects survival in systemic lupus erythematosus (SLE) patients and examined factors associated with PH occurrence and survival.
Methods: This retrospective single-center study included 154..
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Cardiology / Original Article
Amlodipine and cardiovascular outcomes in hypertensive patients: meta-analysis comparing amlodipine-based versus other antihypertensive therapy
Seung-Ah Lee, Hong-Mi Choi, Hye-Jin Park, Su-Kyoung Ko, Hae-Young Lee
Korean J Intern Med. 2014;29(3):315-324. Published online April 29, 2014
Background/Aims: This meta-analysis compared the effects of amlodipine besylate, a charged dihydropyridine-type calcium channel blocker (CCB), with other non-CCB antihypertensive therapies regarding the cardiovascular outcome.
Methods: Data from seven long-term outcome trials compa..
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Endocrinology-metabolism / Original Article
Changes in the clinical manifestations of primary aldosteronism
Sun Hwa Kim, Jae Hee Ahn, Ho Cheol Hong, Hae Yoon Choi, Yoon Jung Kim, Nam Hoon Kim, Hye Jin Yoo, Hee Young Kim, Ji A Seo, Nan Hee Kim, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi
Korean J Intern Med. 2014;29(2):217-225. Published online February 27, 2014
Background/Aims: Primary aldosteronism (PA) is now widely recognized to have a higher prevalence than was once thought. In view of its increasing prevalence, we compared chronological changes in clinical manifestations of PA according to different times of diagnosis.
Methods: In total, 85 patients d..
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Rheumatology / Original Article
Meta-analysis of randomized controlled trials of bosentan for treatment of pulmonary arterial hypertension
Young Ho Lee, Gwan Gyu Song
Korean J Intern Med. 2013;28(6):701-707. Published online October 29, 2013
Background/AimsWe assessed the efficacy and safety of bosentan in patients with pulmonary arterial hypertension (PAH). MethodsWe surveyed randomized controlled trials (RCTs) of the efficacy and safety of bosentan in patients with PAH using MEDLI..
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Nephrology / Original Article
Additional antihypertensive effect of magnesium supplementation with an angiotensin II receptor blocker in hypomagnesemic rats
Kyubok Jin, Tae Hee Kim, Yeong Hoon Kim, Yang Wook Kim
Korean J Intern Med. 2013;28(2):197-205. Published online February 27, 2013
Background/AimsMagnesium (Mg) is an essential element for vascular function and blood pressure regulation. Several studies have demonstrated that Mg concentration is inversely associated with blood pressure, and that Mg supplementation attenuates hypertension. The purpose of t..
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Case Report
Aldosterone-Producing Adrenocortical Carcinoma without Hypertension
Min Soo Song, Sung Woo Seo, Sang Byung Bae, Yeo Joo Kim, Sang Jin Kim
Korean J Intern Med. 2012;27(2):221-223. Published online May 31, 2012
Although adrenocortical tumors are common, adrenocortical carcinomas are rare. Moreover, aldosterone-producing adrenocortical carcinomas without hypertension are exceedingly rare, with only two previously reported cases.
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Case Report
A Case of Systemic Lupus Erythematosus Presenting as Malignant Hypertension with Hypertensive Retinopathy
Jung-Yoon Choe, Sung-Hoon Park, Ji-Young Kim, Hyun-Young Jung, Seong-Kyu Kim
Korean J Intern Med. 2010;25(3):341-344. Published online August 31, 2010
The variability of cardiovascular abnormalities is one of the characteristics of systemic lupus erythematosus (SLE). Among the cardiovascular manifestations, hypertension is reported in 14% to 58.1% of patients in diverse ethnic populations, and remains a clinically important issue due to its clo..
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Review
Autosomal Dominant Polycystic Kidney Disease: 2009 Update for Internists
William M. Bennett
Korean J Intern Med. 2009;24(3):165-168. Published online August 26, 2009
Because autosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic abnormalities seen in today's medical practice, many internists will likely treat patients affected by this condition. Genetic abnormalities have been increasingly recognized, and the pathophysiology of..
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Original Article
Prevalence, Predictive Factor, and Clinical Significance of White-Coat Hypertension and Masked Hypertension in Korean Hypertensive patients
Eui-Seock Hwang, Kee-Joon Choi, Duk-Hyun Kang, Gi-Byoung Nam, Jae-Sik Jang, Young-Hoon Jeong, Chang-Hoon Lee, Ji-Young Lee, Hyun-Koo Park, Chong-Hun Park
Korean J Intern Med. 2007;22(4):256-262. Published online December 20, 2007
BackgroundThe prevalence and clinical significance of white-coat hypertension (WCHT) and masked hypertension (MHT) are unknown in Koreans. Here we measure the frequency of WCHT and MHT in hypertensive subjects and identify the epidemiologic and/or clinical factors that predict..
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