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Rheumatology
A retrospective observational study of the appropriate starting dose of febuxostat in patients with gout
Joondon Lee, Jinseok Kim, Byeongzu Ghang, Wooseong Jeong
Korean J Intern Med. 2023;38(3):427-433. Published online November 3, 2022
Background/Aims: The occurrence of gout attacks at the start of uric acid lowering treatment worsens compliance. We aimed to determine the appropriate dose of febuxostat to reduce the occurrence of gout attacks during the initial treatment period.
Methods: We retrospectively analyzed the data of ..
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Infectious diseases
Clinical significance of antinuclear antibody positivity in patients with severe coronavirus disease 2019
Soo Hyun Park, Jin Woong Suh, Kyung-Sook Yang, Jeong Yeon Kim, Sun Bean Kim, Jang Wook Sohn, Young Kyung Yoon
Korean J Intern Med. 2023;38(3):417-426. Published online April 6, 2023
Background/Aims: This study aimed to investigate the clinical characteristics and outcomes of fluorescent antinuclear antibody (FANA)-positive patients admitted for coronavirus disease 2019 (COVID‐19) and identify FANA as a prognostic factor of mortality.
Methods: This retrospective study was con..
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Hemato-oncology
Efficacy of the granisetron transdermal system for the control of nausea and vomiting induced by highly emetogenic chemotherapy: a multicenter, randomized, controlled trial
Der Sheng Sun, Yoon Ho Ko, Jong Youl Jin, In Sook Woo, Suk Young Park, Yun Ae Eom, Jin Hyoung Kang, Hoon Kyo Kim
Korean J Intern Med. 2023;38(3):406-416. Published online March 11, 2022
Background/Aims: We compared the efficacy of the granisetron transdermal system (GTS) with that of ondansetron for controlling chemotherapy-induced nausea and vomiting (CINV) in patients treated with highly emetogenic chemotherapy (HEC).
Methods: We randomized a total of 389 patients to groups trea..
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Nephrology
CTLA4-Ig protects tacrolimus-induced oxidative stress via inhibiting the AKT/FOXO3 signaling pathway in rats
Long Jin, Nan Shen, Xinyu Wen, Weidong Wang, Sun Woo Lim, Chul Woo Yang
Korean J Intern Med. 2023;38(3):393-405. Published online April 28, 2023
Background/Aims: Although the conversion from tacrolimus (TAC) to cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin (CTLA4-Ig) is effective in reducing TAC-induced nephrotoxicity, it remains unclear whether CTLA4-Ig has a direct effect on TAC-induced renal injury. In this study, we evaluate..
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Pulmonology
Corticosteroid outcome may be dependent of duration of use in severe COVID-19
[letter]
Jin Hyoung Kim, Yong Sub Na, Song-I Lee, Youn Young Moon, Beom Seuk Hwang, Ae-Rin Baek, Won-Young Kim, Bo Young Lee, Gil Myeong Seong, Moon Seong Baek
Korean J Intern Med. 2023;38(3):382-392. Published online April 11, 2023
Background/Aims: For patients hospitalized with coronavirus disease 2019 (COVID-19) who require supplemental oxygen, the evidence of the optimal duration of corticosteroid is limited. This study aims to identify whether long-term use of corticosteroids is associated with decreased mortality.
Method..
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Cardiology
Influence of an abnormal ankle-brachial index on ischemic and bleeding events in patients undergoing percutaneous coronary intervention
Hangyul Kim, Seung Do Lee, Hyo Jin Lee, Hye Ree Kim, Kyehwan Kim, Jin-Sin Koh, Seok-Jae Hwang, Jin-Yong Hwang, Jong-Hwa Ahn, Yongwhi Park, Young-Hoon Jeong, Jeong Rang Park, Min Gyu Kang
Korean J Intern Med. 2023;38(3):372-381. Published online April 20, 2023
Background/Aims: Bleeding events after percutaneous coronary intervention (PCI) have important prognostic implications. Data on the influence of an abnormal ankle-brachial index (ABI) on both ischemic and bleeding events in patients undergoing PCI are limited.
Methods: We included patients who unde..
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Gastroenterology
The diagnostic significance of hepatitis C virus antibody levels for chronic hepatitis C virus infection
Jin Gu Kang, Myoung Kuk Jang, Jung Hee Kim, Jang Han Jung, Ji Won Park, Sung Eun Kim, Sang Hoon Park, Myung Seok Lee, Ki Tae Suk, Dong Joon Kim, Hyoung Su Kim
Korean J Intern Med. 2023;38(3):362-371. Published online April 11, 2023
Background/Aims: Although anti-hepatitis C virus (HCV) assay is widely used to screen for HCV infection, it has a high false-positive (FP) rate in low-risk populations. We investigated the accuracy of anti-HCV signal-to-cutoff (S/CO) ratio to distinguish true-positive (TP) from FP HCV infection.
Me..
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Clinical and endoscopic characteristics of sessile serrated lesions with dysplasia/carcinoma
Peel Jung, Hyung Wook Kim, Su Bum Park, Dae Hwan Kang, Cheol Woong Choi, Su Jin Kim, Hyeong Seok Nam, Dae Gon Ryu, Dong Hoon Shin, Joo Young Na, Mi Sook Yun
Korean J Intern Med. 2023;38(3):349-361. Published online March 27, 2023
Background/Aims: Some sessile serrated lesions (SSLs) progress into dysplasia and colorectal cancer, however, the clinical and endoscopic characteristics of SSLs with dysplasia remain to be determined. In this study, we elucidated these characteristics in SSLs with dysplasia/carcinoma, compared with..
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Comorbidities and the use of comedications among patients with chronic hepatitis C in Korea: A nationwide cross-sectional study
Kyung Min Kwon, Jae-Jun Shim, Gi-Ae Kim, Bo Ok Kim, Helin Han, Hyun Jung Ahn
Korean J Intern Med. 2023;38(3):338-348. Published online April 10, 2023
Background/Aims: Chronic hepatitis C (CHC) is the second leading cause of liver-related mortality and is more prevalent in the elderly population in Korea. Decisions to initiate treatment and selection of proper antiviral agents may be challenging among elderly patients due to relevant comorbidities..
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Current concerns on journal article with preprint: Korean Journal of Internal Medicine perspectives
Hyoung-Chul Oh, Hyun Kang
Korean J Intern Med. 2023;38(3):332-337. Published online April 13, 2023
Preprints are preliminary research reports that have not yet been peer-reviewed. They have been widely adopted to promote the timely dissemination of research across many scientific fields. In August 1991, Paul Ginsparg launched an electronic bulletin board intended to serve a few hundred colleagues..
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Recent updates in therapeutic approach using tolvaptan for autosomal dominant polycystic kidney disease
Yaerim Kim, Seungyeup Han
Korean J Intern Med. 2023;38(3):322-331. Published online April 25, 2023
As a genetic disease, there has been a long-standing effort to identify therapeutic options for autosomal dominant polycystic kidney disease (ADPKD). Following the development of tolvaptan, a vasopressin 2 receptor antagonist, the treatment strategy for ADPKD patients with rapid disease progression ..
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Sarcopenia in chronic kidney disease: from bench to bedside
Da Woon Kim, Sang Heon Song
Korean J Intern Med. 2023;38(3):303-321. Published online April 20, 2023
Sarcopenia is a condition characterized by a loss of muscle mass and function. In chronic kidney disease (CKD), where a chronic catabolic state exists, sarcopenia commonly occurs through various mechanisms, resulting in muscle wasting and decreased muscle endurance. Sarcopenic patients with CKD have..
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Evaluation and management of hypernatremia in adults: clinical perspectives
Giae Yun, Seon Ha Baek, Sejoong Kim
Korean J Intern Med. 2023;38(3):290-302. Published online December 29, 2022
Hypernatremia is an occasionally encountered electrolyte disorder, which may lead to fatal consequences under improper management. Hypernatremia is a disorder of the homeostatic status regarding body water and sodium contents. This imbalance is the basis for the diagnostic approach to hypernatremia...
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Omega-3 fatty acids and atrial fibrillation
Ji Hye Huh, Sang-Ho Jo
Korean J Intern Med. 2023;38(3):282-289. Published online December 14, 2022
Although some clinical trials have demonstrated reduced incidence of cardiovascular disease with the use of omega-3 fatty acids, others have found an increased risk of atrial fibrillation (AF). AF is the most common sustained cardiac arrhythmia worldwide. It is associated with high morbidity and mor..
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Significance of antinuclear antibodies in patients with COVID-19
Oh-Hyun Cho
Korean J Intern Med. 2023;38(3):280-281. Published online April 28, 2023
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Ankle brachial index: a simple path to the future
Jong Shin Woo
Korean J Intern Med. 2023;38(3):277-279. Published online April 28, 2023
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Endoscopic unusual appearance of stomach in a patient with Crohn’s disease
Xu Wang, Juan Yu, Wei-Lin Yang, Wei-Feng Huang
Korean J Intern Med. 2023;38(2):275-276. Published online December 14, 2022
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Stumbling across transthyretin amyloid cardiomyopathy during diagnostic work-up for stomach cancer
Hyun-Ki Lee, Yun-Seok Choi, Eun Ji Han, Yeoun Eun Sung, Jong-Chan Youn
Korean J Intern Med. 2023;38(2):273-274. Published online November 2, 2022
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Boerhaave syndrome initially presenting as acute coronary syndrome with systolic total obstruction of myocardial bridge
Seok Oh, Yong-Kyu Lee, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong
Korean J Intern Med. 2023;38(2):271-272. Published online October 25, 2022
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