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Pulmonology
Mechanical ventilation in patients with idiopathic pulmonary fibrosis in Korea: a nationwide cohort study
Jae Kyeom Sim, Seok Joo Moon, Juwhan Choi, Jee Youn Oh, Young Seok Lee, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Jae Jeong Shim
Korean J Intern Med. 2024;39(2):295-305. Published online February 8, 2024
Background/Aims: The prognosis of patients with idiopathic pulmonary fibrosis (IPF) and respiratory failure requiring mechanical ventilation is poor. Therefore, mechanical ventilation is not recommended. Recently, outcomes of mechanical ventilation, including those for patients with IPF, have improv..
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Granulocyte colony-stimulating factor in bronchoalveolar lavage fluid is a potential biomarker for prognostic prediction of idiopathic pulmonary fibrosis
Jong-Uk Lee, Jae Sung Choi, Min Kyung Kim, Sun A Min, Jong-Sook Park, Choon-Sik Park
Korean J Intern Med. 2022;37(5):979-988. Published online June 22, 2022
Background/Aims: Neutrophilia is frequently observed in bronchoalveolar lavage fluid (BALF) of idiopathic pulmonary fibrosis (IPF) patients. Granulocyte colony-stimulating factor (G-CSF) is a potent neutrophil-activating glycoprotein. However, the clinical implications of G-CSF remain poorly underst..
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Prevalence and impact of airway diseases on clinical outcomes in idiopathic pulmonary fibrosis
Heemoon Park, Jaeyoung Cho, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Sang-Min Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Sun Mi Choi
Korean J Intern Med. 2022;37(2):387-397. Published online December 7, 2021
Background/Aims: The prevalence and effects of airway diseases, including asthma, eosinophilic bronchitis (EB), chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap (ACO) have not been thoroughly studied in patients with idiopathic pulmonary fibrosis (IPF). This study aimed to evalu..
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Efficacy of lower dose pirfenidone for idiopathic pulmonary fibrosis in real practice: a retrospective cohort study
Hyeontaek Hwang, Jung-Kyu Lee, Sun Mi Choi, Yeon Joo Lee, Young-Jae Cho, Ho Il Yoon, Jae Ho Lee, Choon-Taek Lee, Young Whan Kim, Jong Sun Park
Korean J Intern Med. 2022;37(2):366-376. Published online July 27, 2021
Background/Aims: Pirfenidone slows the progression of idiopathic pulmonary fibrosis (IPF). We investigated its efficacy and safety in terms of dose and disease severity in real-world patients with IPF.
Methods: This multicenter retrospective cohort study investigated 338 patients treated with pirfe..
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In vivo therapeutic success of MicroRNA-155 antagomir in a mouse model of pulmonary fibrosis induced by bleomycin
Xiaoyuan Sun, Yu Kang, Shan Xue, Jing Zou, Jiabo Xu, Daoqiang Tang, Hui Qin
Korean J Intern Med. 2021;36(Suppl 1):S160-S169. Published online June 9, 2020
Background/Aims: MicroRNAs (miRNAs) play critical regulatory roles in the pathogenesis of pulmonary fibrosis. The aim of this study was to explore whether miRNA antagomirs could serve as potential therapeutic agents in interstitial lung diseases.
Methods: A mouse model of pulmonary fibrosis was est..
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Pleuroparenchymal fibroelastosis in Korean patients: clinico-radiologic-pathologic features and 2-year follow-up
Jae Ha Lee, Eun Jin Chae, Joon Seon Song, Miae Kim, Jin Woo Song
Korean J Intern Med. 2021;36(Suppl 1):S132-S141. Published online February 24, 2020
Background/Aims: Pleuroparenchymal fibroelastosis (PPFE) is a type of rare idiopathic interstitial pneumonia that is characterized by predominantly upper lobe involvement with pleural fibrosis and subjacent parenchymal fibrosis. This study aimed to determine the clinico-radiologic-pathologic feature..
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Upregulation of receptor tyrosine kinase-like orphan receptor 2 in idiopathic pulmonary fibrosis
Ji-Hye Son, Jong-Uk Lee, Susie Chin, Eun-Suk Go, Jai-Seong Park, Hwa-Kyun Shin, Hun Soo Chang, Jong-Sook Park, Choon-Sik Park
Korean J Intern Med. 2021;36(4):914-923. Published online September 21, 2020
Background/Aims: Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a major regulator of Wnt signaling, which is involved in fibroblast dysfunction. Because its role has not been evaluated in idiopathic pulmonary fibrosis (IPF), we examined the clinical implications of ROR2 expression.
Metho..
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Modifiers of TGF-b1 effector function as novel therapeutic targets of pulmonary fibrosis
Chang-Min Lee, Jin Wook Park, Won-Kyung Cho, Yang Zhou, Boram Han, Pyoung Oh Yoon, Jeiwook Chae, Jack A Elias, Chun Geun Lee
Korean J Intern Med. 2014;29(3):281-290. Published online April 29, 2014
Pulmonary fibrosis is a fatal progressive disease with no effective therapy. Transforming growth factor (TGF)-b1 has long been regarded as a central mediator of tissue fibrosis that involves multiple organs including skin, liver, kidney, and lung. Thus, TGF-b1 and its signaling pathways have been at..
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