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| Korean J Intern Med > Volume 40(6); 2025 > Article |
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| Study | Country | Target sample | Study participants | Follow-up duration | Residual kidney function eligibility/Actual residual kidney function | Outcome | Results |
|---|---|---|---|---|---|---|---|
| PRIDE [42] | Republic of Korea | 428 |
Twice-weekly HD vs. Thrive-weekly HD Age ≥ 60 yr |
24 mo | UO ≥ 500 mL/day |
Primary outcome: all-cause hospitalization Secondary outcome: dialysis-related hospitalization rate, length of hospital day, mortality rate, and quality of life |
In progress |
| TWOPLUS [40] | United States | 50 |
Twice-weekly HD for 6 wk followed by thrice-weekly at week 7 (n = 23) vs. Thrice-weekly HD (n = 25) Mean age: 61.3 ± 14.0 |
12 mo |
KrU ≥ 5 mL/min/1.73 m2 Urine output ≥ 500 mL/day /24-h urine volume (mL/day): Twice-weekly HD group: 914 ± 522 Thrice-weekly HD: 1,424 ± 955 |
Primary outcome: feasibility Secondary outcome: RKF (24-h urine volume, urea clearance, creatinine clearance), total urea clearance, and volume status |
Incremental HD group vs. conventional HD group Percentage change in urine volume from baseline to week 24: +22.8 vs. −28.2 (estimated difference of 51.0 (−0.7 to 102.8) Percentage change in average renal urea and creatinine clearance from baseline to week 24: +12.4 vs. −45.5 |
| Impact of incremental versus conventional initiation of hemodialysis on residual kidney function [41] | United Kindom | 54 |
Twice-weekly HD for 3.5–4 h (n = 29) vs. Thrive-weekly HD for 3.5–4 h (n = 26) Mean age: Incremental HD: 61.4 ± 15.2 vs. Standard HD: 63.1 ± 12.3 |
12 mo |
KrU ≥ 3 mL/min/1.73 m2/Twice-weekly HD group: 4.41 (4.00–5.69) Thrice-weekly HD group: 4.21 (3.65–5.17) |
Primary outcome: feasibility, change in RKF (BSA-corrected GFR slope), and hospitalization rate related to dialysis complications Secondary outcome: frailty, quality of life, cognitive function, and biochemistry |
Incremental HD group vs. conventional HD group Hospitalization events: IRR 0.31 (0.17–0.59, p < 0.001) Change in RKF (mL/min/1.73 m2): −0.32 ± 0.38 vs. −0.08 ± 0.51 (p = 0.07) |
| IHDIP [43] | Spain | 152 | Once a week HD vs. Thrive-weekly HD | 24 mo | KrU ≥ 4 mL/min/1.73 m2 |
Primary outcome: survival Secondary outcome: hospitalization rate, RKF preservation, HD adequacy, biochemistry, and quality of life |
In progress |
| REAL LIFE [44] | Italy and Poland | 116 | Once-weekly HD vs. Thrive-weekly HD | 24 mo |
KrU between 5 and 10 mL/min/1.73 m2 UO ≥ 600 mL/day |
Primary outcome: loss of RKF, defined as UO ≤ 200 mL/day Secondary outcome: survival, biochemistry, and composite cardiovascular events |
In progress |
| Initiating renal replacement therapy through incremental hemodialysis [45] | Spain | 88 | Twice-weekly HD vs. Thrive-weekly HD | 12 mo | KrU ≥ 2.5 mL/min/1.73 m2 |
Primary outcome: loss of RKF, defined as UO < 100 mL/day Secondary outcome: mortality, hospitalization rate, biochemistry, HD adequacy, and quality of life |
In progress |
| INCH-HD [46] | Australia and Canada | 372 | Twice-weekly HD vs. Thrive-weekly HD | 18 mo | UO ≥ 500 mL/day |
Primary outcome: health-related quality of life (KDQOL-SF) Secondary outcome: RKF, mortality, MACE, and hospitalization rate |
In progress |
| INCHVETS [47] | United States | 252 | Twice-weekly HD vs. Thrive-weekly HD | 12 mo | UO ≥ 500 mL/day and KrU >3 mL/min |
Primary outcome: health-related quality of life (SF-36) Secondary outcome: RKF, HD adequacy, and dialysis symptoms |
In progress |
| Initial PD prescription | Incrementation | Increased PD prescription |
|---|---|---|
| CAPD | ||
| 1.5 L × 4 exchanges | Increase dwell volumes 2 | L × 4 exchangesa) |
| 2 L × 2–3 exchanges only during daytime | Increase the number of exchanges and add night dwell | 2 L × 4 exchangesa) |
| 1 × 2 L icodextrin long dwell during night | Add daytime dwell | 2 L × 2–3 exchanges during daytime + 2 L icodextrin long dwell during night |
| 4 × 2 L exchanges only on weekdays | Increase frequency | Every day for a weeka) |
| APD | ||
| 3 × 1.5 L cycled over 6 h during night | Increase dwell volumes | 2 L × 3 cycled over 6 h during night |
| 3 × 2 L cycled over 6 h during night | Increase number of exchanges | 2 L × 4 cycled over 8 h during night |
| 4 × 2 L cycled over 8 h during night | Add daytime dwell | 2 L × 4 cycled over 8 h during night + 2 L icodextrin long dwell during daytimea) |
| 4 × 2 L cycled every other day | Increase frequency | Every day for a weeka) |
| Tool | Domain | Classification | Strength | Limitation | Association with clinical outcomes in older patients with ESKD |
|---|---|---|---|---|---|
| Fried frailty phenotype | Weight loss, exhaustion, physical activity, weakness, and slowness |
Robust: 0 Pre-frail: 1–2 Frail: 3–5 |
Comprehensive assessment of observed performance and self-reported physical function | Measurements, such as grip strength and walking test, are not easy to execute in routine practice, Lack of co-morbidities and psychosocial components |
Mortality [90,92–94] Hospitalization [93,94], Emergency visits [93] |
| Frailty index | 38 frailty components (comorbidities, disabilities, physical function, and self-reported health, etc.) |
Total score of deficits /Total available items: Robust: ≤ 0.08 Pre-frail: 0.09–0.24 Frail: ≥ 0.25 |
Multidimensional assessment of frailty, including psychosocial aspects, cognitive function, and co-morbidities | Timing-consuming and complex to implement in routine clinical care | Mortality and Hospitalization [95] |
| Short physical performance battery | Usual gait speed, repeated standing up from the chair, and standing balance |
Worst performance = 0 Best performance = 12 Frailty: ≤ 9 |
Rapid and objective assessment, Test-retest reliability, clinical applicability | Lack of evaluation of aerobic capacity and psychosocial factor, such as self-efficacy | Mortality and Hospitalization [96] |
| FRAIL scale | Five items of self-report questionnaire: Fatigue, Resistance, Ambulation, Illness, and Loss of weight |
Robust: 0 Pre-frail: 1–2 Frail: ≥ 3 |
Simple and rapid assessment | Lack of objective assessment | N/A |
| Clinical frailty scale | Nine descriptors of composite levels of mobility, energy, physical activity, and function |
Very fit = 1 Terminally ill = 9 Frail: ≥ 5 |
Reflection of overall competency in daily life activities, Easy applicability in routine clinical practice | Subjective clinical judgement by the healthcare provider could lead to misclassification | Mortality [97] |
| Groningen frailty indicator | 15 items of self-reported disabilities in four domains (physical, cognitive, social, and psychological) | Frail: ≥ 4 | Short questionnaire and good feasibility, Usefulness as a frailty screening tool | Lack of objective assessment | Mortality and Hospitalization [91] |
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