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Hemato-oncology
The impact of primary tumor location in patients with metastatic colorectal cancer: a Korean Cancer Study Group CO12-04 study
Jae Ho Byun, Joong Bae Ahn, Sun Young Kim, Jung Hun Kang, Dae Young Zang, Seok Yun Kang, Myoung Joo Kang, Byoung Yong Shim, Sun Kyung Baek, Bong-Seog Kim, Kyung Hee Lee, Soon Il Lee, Sang-Hee Cho, Byeong Seok Sohn, Samyong Kim, In Gyu Hwang, Eun Mi Nam, Bong-Gun Seo, Sang Cheul Oh, Myung-Ah Lee, Sang-Cheol Lee, Ji Hyung Hong, Young Suk Park
Korean J Intern Med. 2019;34(1):165-177. Published online November 28, 2017
Background/Aims: Colorectal cancer is associated with different anatomical, biological, and clinical characteristics. We determined the impact of the primary tumor location in patients with metastatic colorectal cancer (mCRC).
Methods: Demographic data and clinical information were collected from 1..
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Pulmonology
Prolonged low-dose cyclophosphamide treatment after pulse therapy attenuates lung injury in rats with paraquat intoxication
Jie Gao, Shunyi Feng, Yong Li
Korean J Intern Med. 2018;33(6):1137-1142. Published online May 31, 2018
Background/Aims: This study tested the hypothesis that prolonged low-dose cyclophosphamide (CTX) treatment after pulse therapy attenuate paraquat (PQ)-induced lung injury in rats.
Methods: PQ (25 mg/kg) was administered intraperitoneally to induce PQ-intoxicated rat model. The rats were randomly di..
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Hemato-oncology
The neutrophil-to-lymphocyte ratio prechemotherapy and postchemotherapy as a prognostic marker in metastatic gastric cancer
Hyunho Kim, Sang Mi Ro, Ji Hyun Yang, Joon Won Jeong, Ji Eun Lee, Sang Young Roh, In-Ho Kim
Korean J Intern Med. 2018;33(5):990-999. Published online May 4, 2018
Background/Aims: Markers of inflammation have been associated with outcomes in various cancers. The purpose of this study was to evaluate whether systemic inf lammatory markers and their f luctuations can predict survival and chemotherapy response in patients with metastatic gastric cancer (mGC).
M..
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Rheumatology
Drug survival of tumor necrosis factor α inhibitors in patients with ankylosing spondylitis in Korea
Hyemin Jeong, Yeong Hee Eun, In Young Kim, Hyungjin Kim, Joong Kyong Ahn, Jaejoon Lee, Eun-Mi Koh, Hoon-Suk Cha
Korean J Intern Med. 2018;33(2):407-416. Published online October 12, 2016
Background/Aims: To evaluate drug survival of the tumor necrosis factor α inhibitors (TNFi) and risk factors for the drug discontinuation in patients with ankylosing spondylitis (AS).
Methods: We retrospectively evaluated 487 AS patients at a single tertiary hospital. Among the TNFi users, drug s..
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Drug survival and the associated predictors in South Korean patients with rheumatoid arthritis
receiving tacrolimus
Eun-Young Park, Seung-Geun Lee, Eun-Kyoung Park, Dong-Wan Koo, Ji-Heh Park, Geun-Tae Kim, Hee-Sang Tag, Hyun-Ok Kim, Young-Sun Suh
Korean J Intern Med. 2018;33(1):193-202. Published online April 6, 2016
Background/Aims: To investigate the drug survival rate of tacrolimus (TAC) and analyze the potential predictors of this rate in patients with rheumatoid arthritis (RA) in routine care.
Methods: In this retrospective longitudinal study, we enrolled 102 RA patients treated with TAC from April 2009 to..
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Hemato-oncology
Clinical features and treatment outcomes of blastic plasmacytoid dendritic cell neoplasm: a single-center experience in Korea
Hae Su Kim, Hee-Jin Kim, Sun-Hee Kim, Joon Young Choi, Young Hyeh Ko, Won Seog Kim, Chul Won Jung, Seok Jin Kim
Korean J Intern Med. 2017;32(5):890-899. Published online August 18, 2017
Background/Aims: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy that typically presents in the form of skin manifestations with or without lymph node and bone marrow involvement. Given its rarity and recent recognition as a distinct pathological entity, no stan..
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Pulmonology
Long-term outcomes of surgery for chronic thromboembolic pulmonary hypertension compared
with medical therapy at a single Korean center
Soo Han Kim, Jae Won Lee, Jung-Min Ahn, Dae-Hee Kim, Jong-Min Song, Sang-Do Lee, Jae Seung Lee
Korean J Intern Med. 2017;32(5):855-864. Published online October 13, 2016
Background/Aims: Pulmonary endarterectomy (PEA) is the gold standard for treating chronic thromboembolic pulmonary hypertension (CTEPH) in Western countries. The aim of this study was to investigate the long-term outcomes of performing PEA on CTEPH patients in comparison with medical therapy at a si..
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Gastroenterology
Incidence and clinical characteristics of gastroenteropancreatic neuroendocrine tumor in Korea:
a single-center experience
Chul-Hyun Lim, In Seok Lee, Byoung Yeon Jun, Jin Su Kim, Yu Kyung Cho, Jae Myung Park, Sang Young Roh, Myung Ah Lee, Sang Woo Kim, Myung-Gyu Choi
Korean J Intern Med. 2017;32(3):452-458. Published online March 29, 2016
Background/Aims: Neuroendocrine tumors (NETs) may originate from heterogeneous neuroendocrine cells. The incidence is increasing worldwide, and World Health Organization (WHO) updated its classification in 2010. We investigated clinical characteristics of gastroenteropancreatic NETs in a single cent..
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Combination transarterial chemoembolization and radiofrequency ablation therapy for early hepatocellular carcinoma
Myeong Jun Song, Si Hyun Bae, June Sung Lee, Sung Won Lee, Do Seon Song, Chan Ran You, Jong Young Choi, Seung Kew Yoon
Korean J Intern Med. 2016;31(2):242-252. Published online February 15, 2016
Background/Aims: We compared the recurrence of hepatocellular carcinoma (HCC) and the survival of patients who received radiofrequency ablation (RFA) after transarterial chemoembolization (TACE) with patients treated with TACE or RFA alone.
Methods: This study included 201 patients with HCC, who were..
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Nephrology
Impact of dialysis modality on technique survival in end-stage renal disease patients
Jong-Hak Lee, Sun-Hee Park, Jeong-Hoon Lim, Young-Jae Park, Sang Un Kim, Kyung-Hee Lee, Kyung-Hoon Kim, Seung Chan Park, Hee-Yeon Jung, Owen Kwon, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim
Korean J Intern Med. 2016;31(1):106-115. Published online December 28, 2015
Background/Aims: This study analyzed the risk factors for technique survival in dialysis patients and compared technique survival rates between hemodialysis (HD) and peritoneal dialysis (PD) in a prospective cohort of Korean patients.
Methods: A total of 1,042 patients undergoing dialysis from Sept..
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Long-term survival after concurrent chemoradiation therapy for esophageal cancer with tracheal
invasion
Joon Hyun Cho, Tae Nyeun Kim
Korean J Intern Med. 2015;30(6):931-933. Published online October 30, 2015
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Hemato-oncology
Clinical efficacy of erlotinib, a salvage treatment for non-small cell lung cancer patients following gefitinib failure
Kyoung Min Cho, Bhumsuk Keam, Tae Min Kim, Se-Hoon Lee, Dong-Wan Kim, Dae Seog Heo
Korean J Intern Med. 2015;30(6):891-898. Published online October 30, 2015
Background/Aims: The purpose of this study was to identify predictive factors for erlotinib treatment in non-small cell lung cancer (NSCLC) patients following gefitinib failure.
Methods: Forty-five patients with NSCLC who were treated with erlotinib following gefitinib failure at Seoul National Uni..
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Pulmonology
Survival benefits of warfarin in Korean patients with idiopathic pulmonary arterial hypertension
Byung Ju Kang, Yeon-Mok Oh, Sang-Do Lee, Jae Seung Lee
Korean J Intern Med. 2015;30(6):837-845. Published online October 30, 2015
Background/Aims: Idiopathic pulmonary arterial hypertension (IPAH) is an incurable disease with high mortality. Although most studies recommend anticoagulation treatment for IPAH, the benefits are uncertain, particularly in Korea, where it has not been studied. The purpose of this study was to evalu..
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Nephrology
Immunologic and non-immunologic complications of a third kidney transplantation
Hyun Seon Kim, Jae Young Kim, Eun Jin Kang, Yoon Seok Choi, Ji-Il Kim, In Sung Moon, Bum Soon Choi, Cheol Whee Park, Chul Woo Yang, Yong-Soo Kim, Byung Ha Chung
Korean J Intern Med. 2015;30(5):657-664. Published online August 27, 2015
Background/Aims: Patients who undergo repeat kidney transplantations (KTs) are considered at high risk for experiencing immunologic and non-immunologic complications. In this study, we investigated the clinical outcomes, including medical and surgical complications, of patients who underwent a third..
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Rheumatology
Pulmonary hypertension in systemic lupus erythematosus: an independent predictor of patient survival
Hong Ki Min, Jae Ho Lee, Seung Min Jung, Jennifer Lee, Kwi Young Kang, Seung-Ki Kwok, Ji Hyeon Ju, Kyung-Su Park, Sung-Hwan Park
Korean J Intern Med. 2015;30(2):232-241. Published online February 27, 2015
Background/Aims: We investigated whether transthoracic echocardiography-suspected pulmonary hypertension (PH) affects survival in systemic lupus erythematosus (SLE) patients and examined factors associated with PH occurrence and survival.
Methods: This retrospective single-center study included 154..
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Nephrology
Relationship between duration of hospital-acquired acute kidney injury and mortality: a prospective observational study
Jinyoung Yoo, Ji Sung Lee, Jiyeon Lee, Jin Seok Jeon, Hyunjin Noh, Dong Cheol Han, Soon Hyo Kwon
Korean J Intern Med. 2015;30(2):205-211. Published online February 27, 2015
Background/Aims: New definitions of acute kidney injury (AKI) have recently emerged. Some studies have suggested that duration of AKI is an additional predictive parameter for mortality. Here, we evaluated whether AKI duration was predictive of long-term mortality in patients with hospital-acquired ..
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Comparison of Patients Starting Hemodialysis with Those Underwent Hemodialysis 15 Years Ago at the Same Dialysis Center in Korea
Su Jin Seok, Jung Hoon Kim, Hyo Wook Gil, Jong Oh Yang, Eun Young Lee, Sae Yong Hong
Korean J Intern Med. 2010;25(2):188-194. Published online June 1, 2010
Background/AimsMaintenance dialysis is made decreased the death rate of patients with end-stage renal disease; however, mortality is still high. The aim of this study was to identify the association between clinical parameters at the start of hemodialysis with survival and com..
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Elevation of Serum Ferritin is Associated with the Outcome of Patients with Newly Diagnosed Multiple Myeloma
Moo-Kon Song, Joo-Seop Chung, Young-Mi Seol, Ho-Jin Shin, Young-Jin Choi, Goon-Jae Cho
Korean J Intern Med. 2009;24(4):368-373. Published online November 27, 2009
Background/AimsSerum ferritin is a marker of acute phase reactions and iron storage. In addition, hematologic malignancies are associated with elevated serum ferritin levels. Other studies have suggested that ferritin is a surrogate for advanced disease and has an impact on re..
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Factors for Determining Survival in Acute Organophosphate Poisoning
Eun-Jung Kang, Su-Jin Seok, Kwon-Hyun Lee, Hyo-Wook Gil, Jong-Oh Yang, Eun-Young Lee, Sae-Yong Hong
Korean J Intern Med. 2009;24(4):362-367. Published online November 27, 2009
Background/AimsOrganophosphate poisoning has a high mortality rate. Recently, differences among organophosphorus insecticides in human self-poisoning were reported. This study investigated the prognostic risk factors and the mortality of different organophosphates following ac..
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Epstein-Barr Virus-Positivity in Tumor has no Correlation with the Clinical Outcomes of Patients with Angioimmunoblastic T-cell Lymphoma
Yuna Lee, Keun-Wook Lee, Jee-Hyun Kim, Soo-Mee Bang, Jong Seok Lee, Byeong-Bae Park, Won Seok Kim, Cheolwon Suh, Jung Hun Kang, Baek Yeol Ryoo, Jae Hoon Lee, Dong Bok Shin
Korean J Intern Med. 2008;23(1):30-36. Published online March 20, 2008
Background/AimsEpstein-Barr virus (EBV) is involved in the pathogenesis of angioimmunoblastic T-cell lymphoma (AILT), but its precise role and prognostic impact are not clear. This study aimed to evaluate the incidence of EBV-postitivity in the tumor and bone ..
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