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The causal association between sarcopenia and colorectal cancer: a Mendelian Randomization analysis
Shu Ran, Min-Fei Zhao, Bao-Lin Liu
Korean J Intern Med. 2023;38(2):266-268. Published online February 20, 2023
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Geriatrics
The prognostic value of comprehensive geriatric assessment on the management of older patients with small cell lung cancer
You Jin Chun, Kwang Joon Kim, Ji Yeon Lee, Ji Won Choi, Tae Hee Kim, Hye Ryun Kim, Byoung Chul Cho, Min Hee Hong, Chang Oh Kim
Korean J Intern Med. 2023;38(2):254-263. Published online January 19, 2023
Background/Aims: The prognostic value of a comprehensive geriatric assessment (CGA) for the management of older small cell lung cancer (SCLC) patients remains to be established.
Methods: A retrospective cohort enrolled 21 SCLC patients over 65 years from March 2018 to 2019 at the Yonsei Cancer Cent..
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Rheumatology
Incidence of rheumatic diseases during the COVID-19 pandemic in South Korea
Soo Min Ahn, Seongho Eun, Sunghwan Ji, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Ji Seon Oh, Yong-Gil Kim
Korean J Intern Med. 2023;38(2):248-253. Published online January 17, 2023
Background/Aims: The recent coronavirus disease 2019 (COVID-19) pandemic has been associated with changes in the epidemiology of not only infectious diseases but also several non-infectious conditions. This study investigated changes in the recorded incidence of various rheumatic diseases during the..
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Hemato-oncology
Predictive role of absolute lymphocyte count in daratumumab-treated patients with relapsed/ refractory multiple myeloma
[corrected-article]
Hee Jeong Cho, Jae-Cheol Jo, Yoo Jin Lee, Myung Won Lee, Do Young Kim, Ho Jin Shin, Sung Nam Im, Ji Hyun Lee, Sung Hwa Bae, Young Rok Do, Won Sik Lee, Min Kyung Kim, Jina Jung, Jung Min Lee, Ju-Hyung Kim, Dong Won Baek, Sang-Kyun Sohn, Joon Ho Moon
Korean J Intern Med. 2023;38(2):238-247. Published online January 26, 2023
Background/Aims: Daratumumab has shown an encouraging antitumor effect in patients with multiple myeloma (MM), and was known to alter the immune properties by off-targeting immunosuppressive cells. Here, we aimed to evaluate the change in absolute lymphocyte count (ALC) as a surrogate marker for pre..
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Endocrinology-metabolism
Association between DIO2 Thr92Ala polymorphism and hypertension in patients with hypothyroidism: Korean Genome and Epidemiology Study
Young Mi Kang, Bon Seok Koo, Hyon-Seung Yi, Jung Tae Kim, Boyoung Park, Ju Hee Lee, Minho Shong, Yea Eun Kang
Korean J Intern Med. 2023;38(2):226-237. Published online January 17, 2023
Background/Aims: Recent evidence has identified the significance of type 2 iodothyronine deiodinase (DIO2) in various diseases. However, the role of DIO2 polymorphism in metabolic parameters in patients with hypothyroidism is not fully understood.
Methods: We assessed the polymorphism of the DIO2 g..
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Pulmonology
Real-world evaluation of atezolizumab and etoposide-carboplatin as a first-line treatment for extensive-stage small cell lung cancer
Soo Han Kim, Eun Jung Jo, Jeongha Mok, Kwangha Lee, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee, Jung Seop Eom, Mi-Hyun Kim
Korean J Intern Med. 2023;38(2):218-225. Published online February 21, 2023
Background/Aims: Despite the obvious benefits of adding immune checkpoint inhibitors to platinum-etoposide chemotherapy in patients with extensive-stage small-cell lung cancer (ES-SCLC), real-world data remain scarce.
Methods: This retrospective study included 89 patients with ES-SCLC treated with ..
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Timing of corticosteroids in non-severe non-hospitalized COVID-19 patients: open-label, two-center, randomized controlled study (TICS-COV19 study)
Emad R. Issak, Mariam M. Amin
Korean J Intern Med. 2023;38(2):207-217. Published online January 17, 2023
Background/Aims: Corticosteroids (CSs) are frequently used in coronavirus disease 2019 (COVID-19); however, their utility remains controversial in mild to moderate cases. The timing of CSs initiation during the disease course remains unaddressed. The study aims to evaluate the impact of early CSs in..
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Cardiology
The role of discharge checklist in guideline-directed medical therapy for heart failure patients
Helsi Rismiati, Kyu-Sun Lee, Jeehoon Kang, Hyun-Jai Cho, Hae-Young Lee
Korean J Intern Med. 2023;38(2):195-206. Published online February 21, 2023
Background/Aims: Initiation of guideline-directed medical therapy (GDMT) during hospitalization is recommended for patients with heart failure (HF). However, GDMT is underutilized in real-world practice. This study evaluated the role of a discharge checklist on GDMT.
Methods: This was a single-cent..
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Gastroenterology
Outcomes according to treatment modalities as a bridge to curative surgery for malignant obstruction of the proximal colon: stent versus stoma
Yong Eun Park, Seung Min Hong, Seung Bum Lee, Hong Sub Lee, Dong Hoon Baek, Rari Cha, Jong Yoon Lee, Tae Oh Kim, Jong Hoon Lee; Busan Ulsan Gyeongnam Intestinal Study Group Society (BIGS)
Korean J Intern Med. 2023;38(2):186-194. Published online January 2, 2023
Background/Aims: The optimal treatment for acute malignant obstruction of the proximal colon (MOPC, proximal to the splenic flexure) remains challenging. Emergency resection, the traditional modality for MOPC, has shown significantly high mortality and morbidity rates, according to recent studies. T..
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Cancer risk in patients with Peutz-Jeghers syndrome in Korea: a retrospective multi-center study
Su Hwan Kim, Eun Ran Kim, Jae Jun Park, Eun Sun Kim, Hyeon Jeong Goong, Kyeong Ok Kim, Ji Hyung Nam, Yehyun Park, Sang Pyo Lee, Hyun Joo Jang; KSGE; Research Group of Capsule Endoscopy and Artificial Intelligence in Imaging
Korean J Intern Med. 2023;38(2):176-185. Published online December 15, 2022
Background/Aims: There have been little research on the cancer risks of patients with Peutz-Jeghers syndrome (PJS) in Korea. We aimed to investigate the clinical features of PJS patients and their cancer incidence rate.
Methods: Patients with PJS from nine medical centers were enrolled. In those pa..
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Helicobacter pylori eradication reduces risk for recurrence of gastric hyperplastic polyp after endoscopic resection
Young Sin Cho, Su Youn Nam, Hee Seok Moon, Tae Ho Kim, Sung Eun Kim, Jin Tae Jung
Korean J Intern Med. 2023;38(2):167-175. Published online November 28, 2022
Background/Aims: Little is known about the effect of Helicobacter pylori eradication on the recurrence of gastric hyperplastic polyps after endoscopic resection. Thus, we evaluated the recurrence rate of gastric hyperplastic polyps based on H. pylori eradication following endoscopic re..
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Obesity-related heart failure with preserved ejection fraction: diagnostic and therapeutic challenges
Mi-Hyang Jung, Mi-Seung Shin
Korean J Intern Med. 2023;38(2):157-166. Published online February 6, 2023
The prevalence of heart failure with preserved ejection fraction (HFpEF) has increased in recent decades. In particular, obesity-related HFpEF is a distinct and frequently encountered phenotype; however, its diagnosis is complex. Furthermore, the management of obesity-related HFpEF has not been esta..
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The role of roxadustat in chronic kidney disease patients complicated with anemia
Jie Liu, Fan Yang, Yousuf Waheed, Shulin Li, Kun Liu, Xinglei Zhou
Korean J Intern Med. 2023;38(2):147-156. Published online January 2, 2023
The incidence of chronic kidney disease (CKD) is increasing worldwide and the current prevalence rate is 13.4%. There are > 120 million CKD patients in China and this number is expected to increase. One of the main abnormalities in patients with CKD and kidney impairment is decreased synthesis of er..
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Corticosteroids for non-severe COVID-19 infections? Too early to conclude
Sunghoon Park
Korean J Intern Med. 2023;38(2):144-146. Published online February 27, 2023
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Esophageal wall thickening due to salivary gland heterotopia
Dae Gon Ryu, Cheol Woong Choi, Su Jin Kim
Korean J Intern Med. 2023;38(1):139-140. Published online September 1, 2022
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Polysplenia syndrome with truncal pancreas presenting as diabetic ketoacidosis
Hea Min Yu, Jun Choul Lee
Korean J Intern Med. 2023;38(1):137-138. Published online September 22, 2022
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A rare adrenocorticotropic hormone-producing nasal neuroendocrine tumor with multiple metastasis
So-yun Kim, Yoonchul Ha, Jin Man Kim, Kun ho Kim, Yea Eun Kang
Korean J Intern Med. 2023;38(1):134-136. Published online September 2, 2022
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Rheumatology
Incidence and prevalence of seropositive rheumatoid arthritis among Korean women of childbearing age: a nationwide population-based study
Min Kyung Chung, Chan Hee Lee, Jin Su Park, Hyun Sun Lim, Jisoo Lee
Korean J Intern Med. 2023;38(1):125-133. Published online May 19, 2022
Background/Aims: Women with rheumatoid arthritis (RA) are often diagnosed with the disease during their reproductive years; however, its incidence and prevalence among women of childbearing age have not been studied. The objective of this study was to estimate the incidence and prevalence of seropos..
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