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Gastroenterology
The role of PD-1/PD-L1 pathway in ulcerative colitis and changes following tonsil-derived mesenchymal stem cells treatment
Eun Mi Song, Yang Hee Joo, Sung-Ae Jung, Ju-Ran Byeon, A-Reum Choe, Yehyun Park, Chung Hyun Tae, Chang Mo Moon, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim
Korean J Intern Med. 2024;39(6):917-930. Published online November 1, 2024
Background/Aims: The programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway has not been fully evaluated in inflammatory bowel disease. We evaluated PD-1/PD-L1 levels in patients with ulcerative colitis (UC) and their significance in tonsil-derived mesenchymal stem cells (TMSCs) treatme..
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Vaccination strategies for Korean patients with inflammatory bowel disease
Yoo Jin Lee, Eun Soo Kim
Korean J Intern Med. 2022;37(5):920-930. Published online August 8, 2022
Patients with inflammatory bowel disease (IBD) are vulnerable to vaccine-preventable infectious diseases. Immunosuppressive drugs, which are often used to manage IBD, may increase this vulnerability and attenuate vaccine efficacy. Thus, healthcare providers should understand infectious diseases and ..
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Management of inflammatory bowel disease beyond tumor necrosis factor inhibitors: novel biologics and small-molecule drugs
Soo-Young Na, You Sun Kim
Korean J Intern Med. 2022;37(5):906-919. Published online August 10, 2022
The incidence and prevalence of inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, have increased in Asia and developing countries. In the past two decades, anti-tumor necrosis factor (TNF) agents have revolutionized the treatment of IBD, in part by decreasing the..
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Updates on conventional therapies for inflammatory bowel diseases: 5-aminosalicylates, corticosteroids, immunomodulators, and anti-TNF-α
Jihye Park, Jae Hee Cheon
Korean J Intern Med. 2022;37(5):895-905. Published online July 27, 2022
The incidence and prevalence of inflammatory bowel diseases (IBDs) are rapidly increasing worldwide. IBDs are considered an emerging problem not only in Western countries but also in developing counties. The relapses and complications of active IBD mandate various medications. Nevertheless, hospital..
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Inflammatory bowel disease in Korea: epidemiology and pathophysiology
Jung Won Lee, Chang Soo Eun
Korean J Intern Med. 2022;37(5):885-894. Published online July 29, 2022
Inflammatory bowel disease (IBD) refers to a group of disorders, including Crohn’s disease and ulcerative colitis, that exhibit similar but distinct manifestations. These diseases are characterized by refractory and chronic inflammation of the bowel. IBD is usually accompanied by severe symptoms. ..
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Gastroenterology
Seroprevalence of viral infectious diseases and associated factors in Korean patients with inflammatory bowel diseases
Hee Seung Hong, Jiwon Jung, Sang Hyoung Park, Hwa Jung Kim, Sung Wook Hwang, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
Korean J Intern Med. 2022;37(1):73-84. Published online September 6, 2021
Background/Aims: Data on the immunoprotective status against measles, mumps, rubella, varicella zoster virus (VZV), hepatitis A virus (HAV), and Epstein-Barr virus (EBV) infection in patients with inflammatory bowel disease (IBD) are still lacking. Therefore, we investigated the seropositivity rates..
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Comparison of loss of response between anti-tumor necrosis factor alone and combined use with immunomodulators in patients with inflammatory bowel disease
Seung Wook Hong, Jaewoo Park, Hyuk Yoon, Hye Ran Yang, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Joo Sung Kim
Korean J Intern Med. 2021;36(Suppl 1):S9-S17. Published online June 25, 2020
Background/Aims: Combination therapy with immunomodulators (IMMs) was proposed as a strategy to prevent the development of loss of response (LOR) to anti-tumor necrosis factor (TNF) for patients with inflammatory bowel disease (IBD). However, the effect is unclear in patients already exposed to IMMs..
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Improving the care of inflammatory bowel disease (IBD) patients: perspectives and strategies for IBD center management
Jihye Park, Sinyoung Park, Shin Ae Lee, Soo Jung Park, Jae Hee Cheon
Korean J Intern Med. 2021;36(5):1040-1048. Published online August 5, 2021
The incidence and prevalence rates of inf lammatory bowel disease (IBD) have been increasing in East Asian countries over the past few decades. Accordingly, the general understanding and awareness of IBD among healthcare professionals has increased considerably in this region. This increase is ultim..
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Gastroenterology
Quality of information on the Internet for Korean patients with inflammatory bowel disease
Jun Sik Yoon, Sang Jik Lee, Eun Soo Kim, Sung Kook Kim, Min Kyu Jung, Hyun Seok Lee, Yong Hwan Kwon, Su Youn Nam, Seong Woo Jeon, Sun Jin, Joon Seop Lee, Seong Jae Yeo
Korean J Intern Med. 2019;34(6):1215-1222. Published online October 1, 2018
Background/Aims: The Internet is the main resource for health-related information. The incidence of inflammatory bowel disease (IBD) is rapidly increasing in Asian countries. However, the quality of websites for IBD available in this region has not been evaluated. We aimed to evaluate the quality of the..
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Development, validation, and application of a novel tool to measure disease-related knowledge in patients with inflammatory bowel disease
Hyuk Yoon, Suk-Kyun Yang, Hoonsub So, Ko Eun Lee, Sang Hyoung Park, Sung-Ae Jung, Joong Haeng Choh, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee
Korean J Intern Med. 2019;34(1):81-89. Published online November 29, 2017
Background/Aims: The Crohn’s and Colitis Knowledge (CCKNOW) score does not reflect updated knowledge relating to inflammatory bowel disease (IBD). The aim of this study was to develop, validate, and apply a novel tool to measure disease-related knowledge in IBD patients.
Methods: A questionnaire ..
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The usefulness of fecal calprotectin in assessing inflammatory bowel disease activity
Yang Woon Lee, Kang-Moon Lee, Ji Min Lee, Yoon Yung Chung, Dae Bum Kim, Yeon Ji Kim, Woo Chul Chung, Chang-Nyol Paik
Korean J Intern Med. 2019;34(1):72-80. Published online January 20, 2018
Background/Aims: Fecal calprotectin (FC) is known to correlate with disease activity and can be used as a predictor for relapse or treatment response in inflammatory bowel disease (IBD). We evaluated the usefulness of FC as a biomarker for disease activity in patients with IBD using both enzyme-link..
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Changing treatment paradigms for the management of inflammatory bowel disease
Jong Pil Im, Byong Duk Ye, You Sun Kim, Joo Sung Kim
Korean J Intern Med. 2018;33(1):28-35. Published online December 28, 2017
Inf lammatory bowel disease (IBD) is a chronic and progressive inf lammatory condition of the gastrointestinal tract causing bowel damage, hospitalizations, surgeries, and disability. Although there has been much progress in the management of IBD with established and evolving therapies, most current..
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Novel treatments for inflammatory bowel disease
Hyo Sun Lee, Soo-Kyung Park, Dong Il Park
Korean J Intern Med. 2018;33(1):20-27. Published online December 11, 2017
Increased understanding of the immunopathology of inflammatory bowel disease (IBD) has led to the development of targeted therapies and has unlocked a new era in IBD treatment. The development of treatment options aimed at a variety of pathological mechanisms offers new hope for customized therapies..
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Rheumatology
Ileocolonoscopic findings in patients with ankylosing spondylitis: a single center retrospective
study
Soo Min Ahn, Yong-Gil Kim, Seung-Hyeon Bae, Doo-Ho Lim, Seokchan Hong, Sang Hyoung Park, Chang-Keun Lee, Bin Yoo
Korean J Intern Med. 2017;32(5):916-922. Published online August 11, 2017
Background/Aims: In some Western countries, up to 50% of patients with ankylosing spondylitis (AS) have subclinical gut inflammation. This study was conducted to evaluate the prevalence and severity of gut inflammation and to determine clinical factors associated with colonic inflammation in Korean ..
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Gastroenterology
Identification of distinctive clinical significance in hospitalized patients with endoscopic duodenal mucosal lesions
Yeji Han, Hye-Kyung Jung, Ji Young Chang, Chang Mo Moon, Seong-Eun Kim, Ki-Nam Shim, Sung-Ae Jung, Joo-Young Kim, Ji-Yun Bae, Sae-In Kim, Ji-Hyun Lee, Sanghui Park
Korean J Intern Med. 2017;32(5):827-835. Published online August 21, 2017
Background/Aims: Duodenitis is not infrequent finding in patient undergoing endoscopy. However, hospitalized patients have a higher incidence of secondary duodenal mucosal lesions that might be related with inflammatory bowel disease (IBD), cytomegalovirus (CMV) infection, tuberculosis, immunologic ..
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Investigation of pulmonary involvement in inflammatory bowel disease in an experimental
model of colitis
Bunyamin Aydin, Yıldıran Songur, Necla Songur, Oğuzhan Aksu, Altug Senol, I. Metin Ciris, Recep Sutcu
Korean J Intern Med. 2016;31(5):853-859. Published online August 19, 2016
Background/Aims: Inflammatory bowel disease (IBD) may also involve various extra-intestinal organs. Clinical studies have found asymptomatic/symptomatic pulmonary involvement in 1% to 6% of patients with IBD. The present study histopathologically investigated pulmonary involvement in an experimental..
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Diet, microbiota, and inflammatory bowel disease: lessons from Japanese foods
Takanori Kanai, Katsuyoshi Matsuoka, Makoto Naganuma, Atsushi Hayashi, Tadakazu Hisamatsu
Korean J Intern Med. 2014;29(4):409-415. Published online June 27, 2014
The incidence and prevalence of inflammatory bowel diseases (IBDs) including ulcerative colitis and Crohn disease are rapidly increasing in Western countries and in developed Asian countries. Although biologic agents targeting the immune system have been effective in patients with IBD, cessation of ..
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A case of hemophagocytic syndrome in a patient with fulminant ulcerative colitis superinfected by cytomegalovirus
Jun Il Mun, Sung Jae Shin, Byung Hyun Yu, Jee Hoon Koo, Dong Hoon Kim, Ki Myoung Lee, Kwang Jae Lee
Korean J Intern Med. 2013;28(3):352-355. Published online May 1, 2013
Hemophagocytic syndrome (HPS) is an uncommon hematological disorder that manifests as fever, splenomegaly, and jaundice, with hemophagocytosis in the bone marrow and other tissues pathologically. Secondary HPS is associated with malignancy and infection, especially viral infection. The prevalence..
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