| Reviews |
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Gastroenterology
Endoscopy training in Korea
Joon Sung Kim, Byung-Wook Kim
Korean J Intern Med. 2019;34(2):237-241. Published online February 25, 2019
It is essential to maintain high-quality endoscopy given the increasing number of endoscopic screens performed in Korea. The training of fellows to perform endoscopies is challenging. The rapid development of endoscopic techniques and rising patient complexity increase the training pressures. At the..
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Recent advances in the diagnosis and management of chronic pancreatitis
Chang-Il Kwon, Jae Hee Cho, Sung Hoon Choi, Kwang Hyun Ko, Temel Tirkes, Mark A. Gromski, Glen A. Lehman
Korean J Intern Med. 2019;34(2):242-260. Published online February 25, 2019
Chronic pancreatitis is a chronic condition characterized by pancreatic inflammation that causes fibrosis and the destruction of exocrine and endocrine tissues. Chronic pancreatitis is a progressive disease, and no physiological treatment is available to reverse its course. However, with advances in..
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Endoscopic management of anastomotic stricture after living-donor liver transplantation
Dong Wook Lee, Jimin Han
Korean J Intern Med. 2019;34(2):261-268. Published online February 25, 2019
The most effective and fundamental treatment for end-stage liver disease is liver transplantation. Deceased-donor liver transplantation has been performed for many of these cases. However, living-donor liver transplantation (LDLT) has emerged as an alternative because it enables timely procurement o..
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Cardiology
Chronic venous insufficiency and varicose veins of the lower extremities
Young Jin Youn, Juyong Lee
Korean J Intern Med. 2019;34(2):269-283. Published online October 26, 2018
Chronic venous insufficiency (CVI) of the lower extremities manifests itself in various clinical spectrums, ranging from asymptomatic but cosmetic problems to severe symptoms, such as venous ulcer. CVI is a relatively common medical problem but is often overlooked by healthcare providers because of ..
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| Editorials |
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The utility of ezetimibe therapy in nonalcoholic fatty liver disease
Baek Gyu Jun, Gab Jin Cheon
Korean J Intern Med. 2019;34(2):284-285. Published online February 25, 2019
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Fluoroquinolone resistance in multidrug-resistant tuberculosis patients
Hyun-Woo Lee, Jae-Joon Yim
Korean J Intern Med. 2019;34(2):286-287. Published online February 25, 2019
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| Original Articles |
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Gastroenterology
Predictors for the need for endoscopic therapy in patients with presumed acute upper gastrointestinal bleeding
Su Sun Kim, Kyung Up Kim, Sung Jun Kim, Seung In Seo, Hyoung Su Kim, Myoung Kuk Jang, Hak Yang Kim, Woon Geon Shin
Korean J Intern Med. 2019;34(2):288-295. Published online December 15, 2017
Background/Aims: Selecting patients with an urgent need for endoscopic hemostasis is difficult based only on simple parameters of presumed acute upper gastrointestinal bleeding. This study assessed easily applicable factors to predict cases in need of urgent endoscopic hemostasis due to acute upper ..
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Ezetimibe decreased nonalcoholic fatty liver disease activity score but not hepatic steatosis
Hyo Young Lee, Dae Won Jun, Hyun Jung Kim, Hyunwoo Oh, Waqar Khalid Saeed, Hyeongsik Ahn, Ramsey C. Cheung, Mindie H. Nguyen
Korean J Intern Med. 2019;34(2):296-304. Published online March 20, 2018
Background/Aims: A number of clinical trials reported varying effects of cholesterol lowering agents in nonalcoholic fatty liver disease (NAFLD) patients. We, therefore, assessed the changes in hepatic steatosis and NAFLD activity score (NAS) after treatment with cholesterol lowering agents in NAFLD..
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Clinical features of snoring patients during sedative endoscopy
Jung Wha Chung, Nayoung Kim, Jee Hye Wee, Jaebong Lee, Jongchan Lee, Soohoon Kwon, Young-Jae Hwang, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Jin-Wook Kim
Korean J Intern Med. 2019;34(2):305-314. Published online November 15, 2017
Background/Aims: Snoring is the sound of turbulence and vibration of the upper respiratory tissues and has been identified as a risk factor of obstructive sleep apnea (OSA) and cardiovascular disease. The aim of this study was to identify associated clinical factors in snoring patients undergoing se..
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Cardiology
Heart rate recovery and diastolic blood pressure ratio on the treadmill test predict an induction and recurrence of vasovagal syncope
Yu Jeong Choi, Ki-Woon Kang, Sang Hyun Jang, Jae Guk Kim, Soo Joo Lee, Kyung Tea Jung
Korean J Intern Med. 2019;34(2):315-323. Published online December 18, 2017
Background/Aims: The induction and recurrence of syncope is a concerning situation that could be unpredicted in the vasovagal syncope (VVS). We investigated a simple predictor for the induced and recurrent VVS during Head-Up table-tilt Test (HUT) and clinically follow-up.
Methods: The 143 consecut..
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A score for decision making during percutaneous coronary intervention in acute myocardial infarction patients with multivessel disease
Hae Chang Jeong, Joon Ho Ahn, Min Chul Kim, Doo Sun Sim, Keun Ho Park, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Ki-Bae Seung, Kiyuk Chang, Youngkeun Ahn
Korean J Intern Med. 2019;34(2):324-334. Published online March 20, 2018
Background/Aims: The optimal percutaneous coronary intervention (PCI) strategy in patients with acute myocardial infarction (AMI) with multivessel disease (MVD) is uncertain. This study was designed to develop a novel and simple tool for assessing an individualized and optimized PCI strategy in AMI ..
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Pulmonology
Evaluation of high resolution computed tomography findings of cystic fibrosis
Ayse Senay Sasihuseyinoglu, Derya Ufuk Altıntaş, Sureyya Soyupak, Dilek Dogruel, Mustafa Yılmaz, Mahir Serbes, Gulsah Duyuler
Korean J Intern Med. 2019;34(2):335-343. Published online July 6, 2018
Background/Aims: Morphological changes due to lung disease in patients with cystic fibrosis (CF) were evaluated using high resolution computed tomography (HRCT), and the HRCT scores obtained using the Bhalla scoring system were correlated with those obtained using clinical and laboratory indicators...
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Trend of multidrug and fluoroquinolone resistance in Mycobacterium tuberculosis isolates from 2010 to 2014 in Korea: a multicenter study
Hyeonseok Kim, Jeong Ha Mok, Bohyoung Kang, Taehoon Lee, Hyun-Kyung Lee, Hang Jea Jang, Yu Ji Cho, Doosoo Jeon
Korean J Intern Med. 2019;34(2):344-352. Published online July 27, 2018
Background/Aims: This study was conducted to evaluate the recent prevalence and trend of anti-tuberculosis (TB) drug resistance with a focus on multidrug-resistance (MDR) and fluoroquinolone resistance in South Korea.
Methods: We retrospectively reviewed the drug susceptibility testing results of c..
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Endocrinology-metabolism
Non-fasting triglyceride levels in the Korean population with and without ischemic heart disease and cerebrovascular disease
Seo Young Lee, Bo Kyung Koo, Min Kyong Moon
Korean J Intern Med. 2019;34(2):353-364. Published online November 15, 2017
Background/Aims: Associations between non-fasting triglyceride (TG) levels and a risk of ischemic heart disease (IHD) and cerebrovascular accident (CVA) have been suggested in Caucasians. We aimed to investigate whether non-fasting TG levels reflect the risk of IHD/CVA in Koreans.
Methods: We conduc..
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Nephrology
The effects of addition of coenzyme Q10 to metformin on sirolimus-induced diabetes mellitus
In O Sun, Long Jin, Jian Jin, Sun Woo Lim, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2019;34(2):365-374. Published online December 13, 2017
Background/Aims: This study was performed to determine whether adding coenzyme Q10 (CoQ10) to metformin (MET) has a beneficial effect as a treatment for sirolimus (SRL)-induced diabetes mellitus (DM).
Methods: DM was induced in rats by daily treatment with SRL (0.3 mg/kg, subc..
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Usefulness of valacyclovir prophylaxis for cytomegalovirus infection after anti-thymocyte globulin as rejection therapy
Eun Jeong Ko, Ji Hyun Yu, Chul Woo Yang, Byung Ha Chung
Korean J Intern Med. 2019;34(2):375-382. Published online December 15, 2017
Background/Aims: Anti-thymocyte globulin (ATG) treatment for acute T-cell mediated rejection (TCMR) can increase the risk of cytomegalovirus (CMV) infection. We aimed to evaluate the effect of valacyclovir prophylaxis against CMV infection after ATG administration as anti-rejection therapy.
Methods..
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Hemato-oncology
Methylprednisolone versus intravenous immune globulin as an initial therapy in adult primary immune thrombocytopenia
Chul Hee Kim, Yoon Seok Choi, Ji Young Moon, Duck Yong Kim, So Yeon Lee, Hyo Jin Lee, Hwan Jung Yun, Samyong Kim, Deog Yeon Jo, Ik Chan Song
Korean J Intern Med. 2019;34(2):383-389. Published online November 27, 2017
Background/Aims: Few studies have addressed whether there are differences in clinical efficacy between intravenous methylprednisolone (methyl-Pd) and intravenous immunoglobulin (IVIg) use.
Methods: We retrospectively compared platelet responses and toxicities associated with these two treatments in..
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Expression and prognostic significance of microRNAs in Korean patients with myelodysplastic syndrome
Yunsuk Choi, Eun-Hye Hur, Ju Hyun Moon, Bon-Kwan Goo, Dae Ro Choi, Je-Hwan Lee
Korean J Intern Med. 2019;34(2):390-400. Published online November 15, 2017
Background/Aims: Various alterations of microRNA (miRNA) expression have been reported in myelodysplastic syndrome (MDS). We aimed to investigate the unique patterns and prognostic significance of miRNA expression in Korean patients with MDS.
Methods: Bone marrow mononuclear cells were collected fr..
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Prognostic role of beclin-1 in locally advanced non-small cell lung cancer in patients receiving docetaxel-platinum induction chemotherapy
Hee Yeon Lee, Jung Ha Shin, Kyo-Young Lee, Jae Kil Park, Sook Whan Sung, Yeon Sil Kim, Jin-Hyoung Kang, Jeong-Oh Kim
Korean J Intern Med. 2019;34(2):401-408. Published online September 6, 2018
Background/Aims: The outcome of local treatment for advanced non-small cell lung cancer (NSCLC) remains poor, with therapies such as induction chemotherapy (IC) yielding conflicting results. This study aimed to assess the clinicopathologic and prognostic significance of the excision repair cross-com..
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Infectious diseases
Incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in Korea
Jeong Eun Lee, Shinwon Lee, Sang Heon Song, Ihm Soo Kwak, Sun Hee Lee
Korean J Intern Med. 2019;34(2):409-417. Published online October 12, 2017
Background/Aims: Little is known about tenofovir disoproxil fumarate (TDF)-induced nephrotoxicity in human immunodeficiency virus (HIV)-infected patients in Korea. The objective of this study was to evaluate the incidence and risk factors of TDF-associated nephrotoxicity among HIV-infected patients ..
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Allergy
Epidemiology of urticaria including physical urticaria and angioedema in Korea
Jeong-Hun Seo, Jae-Woo Kwon
Korean J Intern Med. 2019;34(2):418-425. Published online May 11, 2018
Background/Aims: Despite the high burden and frequency of urticaria, its epidemiology is not well known. We investigated the epidemiology of various type of urticaria in Korea and changes in its annual prevalence over 5 years.
Methods: We used data from the 2010 to 2014 Health Insurance Review and ..
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Rheumatology
Clinical significance of anti-dense fine speckled 70 antibody in patients with fibromyalgia
Jisoo Jeong, Dong Hyun Kim, Gun Park, Suyeon Park, Hyun-Sook Kim
Korean J Intern Med. 2019;34(2):426-433. Published online November 24, 2017
Background/Aims: Fibromyalgia (FM) is a common rheumatologic disease characterized by chronic widespread pain, along with various clinical manifestations including atypical autoimmune characteristics. Despite its high prevalence, there remain no approved laboratory tests to identify specific manifes..
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Clinical characteristics associated with occurrence and poor prognosis of interstitial lung disease in rheumatoid arthritis
Ji Ae Yang, Jeong Seok Lee, Jin Kyun Park, Eun Bong Lee, Yeong Wook Song, Eun Young Lee
Korean J Intern Med. 2019;34(2):434-441. Published online March 28, 2017
Background/Aims: To analyze clinical characteristics of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA), especially in patients with poor prognosis.
Methods: Seventy-seven RA patients with ILD and 231 age, sex, and disease duration-matched RA patients without ILD were enr..
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Clinical features and prognoses of acute transverse myelitis in patients with systemic lupus erythematosus
Soo Min Ahn, Seokchan Hong, Doo-Ho Lim, Byeongzu Ghang, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo
Korean J Intern Med. 2019;34(2):442-451. Published online January 5, 2018
Background/Aims: Acute transverse myelitis (ATM) is a severe complication of systemic lupus erythematosus (SLE). This study evaluated the clinical factors related to outcome in patients with SLE-associated ATM.
Methods: The medical records of patients diagnosed with SLE-associated ATM between Janu..
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| Images of interest |
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Primary large cell neuroendocrine carcinoma of the common hepatic duct mimicking a Klatskin tumor
Ji Yeon Koo, Kook Hyun Kim, Tae Nyeun Kim
Korean J Intern Med. 2019;34(2):452-453. Published online February 23, 2018
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Sclerosing mesenteritis mimicking mesenteric malignancy
Jung Yeop Lee, Ki Jung Yun, Dong Baek Kang, Tae Hyeon Kim, Hyung Ku Chon
Korean J Intern Med. 2019;34(2):454-455. Published online January 5, 2018
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Iatrogenic huge intracardiac air embolism during chest computed tomography
Seunghoon Cho, Hancheol Lee, Sanghoon Shin, Jong-Kwan Park, Se-Jung Yoon
Korean J Intern Med. 2019;34(2):456-457. Published online January 5, 2018
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| Corrigendum |
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N-acetyl-l-cysteine controls osteoclastogenesis through regulating Th17 differentiation and RANKL production in rheumatoid arthritis
Hae-Rim Kim, Kyoung-Woon Kim, Bo-Mi Kim, Kyung-Ann Lee, Sang-Heon Lee
Korean J Intern Med. 2019;34(2):458-458. Published online February 25, 2019
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