| Reviews |
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Cardiology / Review
Transcatheter aortic valve implantation for symptomatic severe aortic stenosis and its expanding clinical indications
Hyungdon Kook, Young-Hyo Lim
Korean J Intern Med. 2026;41(3):373-383. Published online February 24, 2026
Transcatheter aortic valve implantation (TAVI) is a minimally invasive treatment for symptomatic severe aortic stenosis (AS) that was initially developed for patients with prohibitive surgical risk. Since the first-in-human procedure in 2002, TAVI has gained global acceptance owing to its favorable ..
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Endocrinology-metabolism / Review
Delayed gastric emptying induced by glucagon-like peptide-1 receptor agonists and its implications for perioperative risk during anesthesia
Donghee Kang, Dughyun Choi
Korean J Intern Med. 2026;41(3):384-395. Published online May 1, 2026
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed for managing type 2 diabetes mellitus and obesity because of their glucose-lowering, weight-reducing, and cardiovascular benefits. However, their potential to delay gastric emptying has raised growing concern in periop..
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Hemato-oncology / Review
Germline DDX41 mutations in myeloid neoplasms: a comprehensive review
Je-Hwan Lee, Eun-Hye Hur, Young-Uk Cho
Korean J Intern Med. 2026;41(3):396-410. Published online May 1, 2026
DEAD-box helicase 41 (DDX41)-associated myeloid neoplasms represent a distinct hereditary cancer syndrome and have emerged as the most common form of genetic predisposition to adult-onset hematologic malignancies, accounting for 3–5% of adults with myelodysplastic syndrome and acute myeloid..
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Allergy / Review
Eperisone-induced immediate hypersensitivity reactions
Gyu-Young Hur, Jung-Won Park
Korean J Intern Med. 2026;41(3):411-417. Published online May 1, 2026
Eperisone hydrochloride is a centrally acting muscle relaxant commonly prescribed for musculoskeletal pain, particularly in Korea and Japan. It induces relaxation of skeletal and vascular smooth muscle through central nervous system modulation and peripheral mechanisms, although its precise biochemi..
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Allergy / Review
Targeting immune dysregulation in chronic spontaneous urticaria: beyond antihistamines
Young-Min Ye
Korean J Intern Med. 2026;41(3):418-431. Published online May 1, 2026
Chronic urticaria (CU) is characterized by recurrent wheals and angioedema lasting longer than six weeks. It affects approximately 0.5–1.4% of the population and profoundly impairs the quality of life. The disease exhibits a variable course, with many patients experiencing symptoms for several yea..
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| Original Article |
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Gastroenterology / Original Article
Comparison between ligation-assisted and precutting endoscopic mucosal resection for small rectal neuroendocrine tumors: a CHASID study
Sunghyeok Ryou, Yunho Jung, Dae Sung Kim, Hee Seok Moon, Hoon Sup Koo, Hyun Deok Shin, Ki Bae Bang, Kyu Chan Huh; Chungcheong-Daejeon Association for the Study of Intestinal Diseases (CHASID)
Korean J Intern Med. 2026;41(3):432-440. Published online May 1, 2026
Background/Aims: Few studies have compared modified endoscopic mucosal resection (EMR) techniques for small rectal neuroendocrine tumors (NETs). This study evaluated the clinical outcomes of ligation-assisted EMR (EMR-L) and precutting EMR (EMR-P) for the treatment of small rectal NETs.
Methods: We..
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| Editorial |
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Editorial
Beyond technique: toward strategy-based endoscopic resection for rectal neuroendocrine tumors
Seong-Jung Kim
Korean J Intern Med. 2026;41(3):441-442. Published online May 1, 2026
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| Original Articles |
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Original Article
Association between remnant cholesterol and colorectal cancer risk in Korea: a nationwide population-based study
Minkook Son, Jong Yoon Lee, Chi Hyeon Choi, Yeo Wool Kang, Sang Yi Moon, Myeonseok Koh
Korean J Intern Med. 2026;41(3):443-453. Published online May 1, 2026
Background/Aims: Remnant cholesterol (RC) has emerged as a novel lipid marker with potential implications in cardiovascular and metabolic diseases. However, its association with colorectal cancer (CRC) remains unclear.
Methods: We conducted a retrospective cohort study using data from 364,626 Korea..
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Original Article
Incidence and risk factors of rebleeding in Crohn’s disease patients with acute lower gastrointestinal bleeding
Gabin Moon, Kyeong Ok Kim, Sung Noh Hong, Seong Joon Koh, Sung Hoon Jung, Chang Hwan Choi, Eun Mi Song, Hong Sub Lee, Yoo Jin Lee, Ki Bae Bang; On behalf of the IBD Research Group of the Korean Association for the Study of Intestinal Diseases
Korean J Intern Med. 2026;41(3):454-461. Published online January 1, 2026
Background/Aims: Acute lower gastrointestinal bleeding (LGIB) in Crohn’s disease (CD) is a rare but potentially life-threatening complication. This study aimed to investigate the incidence and risk factors of rebleeding in CD patients with LGIB.
Methods: We retrospectively analyzed 137 CD patient..
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Original Article
Comparison of the efficacy and safety of endoscopic and fluoroscopic balloon dilatation in benign esophageal strictures
Kwangbeom Park, Chang Hoon Oh, Do Hoon Kim, Ji Hoon Shin, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Korean J Intern Med. 2026;41(3):462-473. Published online May 1, 2026
Background/Aims: Balloon dilatation under endoscopic or fluoroscopic guidance is regarded as the gold standard for treating benign esophageal strictures. However, no prior studies have compared endoscopic balloon dilatation (EBD) with fluoroscopic balloon dilatation (FBD). We aimed to compare the ef..
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Cardiology / Original Article
Clinical outcomes of heart failure with improved ejection fraction in patients treated with angiotensin receptor–neprilysin inhibitor
Dong-Eon Kim, Min Gyu Kong, Saerom Kim, Inki Moon, Hyun Woo Park, Hyung-Oh Choi, Hye Sun Seo, Yoon Haeng Cho, Nae-Hee Lee, Kwan Yong Lee, Ho-Jun Jang, Je Sang Kim, Ik Jun Choi, Jon Suh
Korean J Intern Med. 2026;41(3):474-484. Published online May 1, 2026
Background/Aims: Improvement of left ventricular ejection fraction (LVEF) in heart failure with reduced ejection fraction (HFrEF) has been associated with favorable outcomes; however, corresponding data in patients treated with angiotensin receptor– neprilysin inhibitors (ARNIs) remain limited. Thi..
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Endocrinology-metabolism / Original Article
Does physical activity reduce cardiovascular risk associated with knee osteoarthritis in type 2 diabetes? A nationwide cohort study
Dojoon Park, Kyuho Kim, Hae-Seok Koh, Kyungdo Han, Youn-Ho Choi
Korean J Intern Med. 2026;41(3):485-500. Published online May 1, 2026
Background/Aims: Knee osteoarthritis (OA), type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD) share overlapping mechanisms but are often managed independently. We evaluated whether knee OA increases CVD risk in Korean T2DM patients and whether physical activity (PA) modifies this risk..
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Endocrinology-metabolism / Original Article
Trabecular bone score differs among prediabetes phenotypes: the potential mediating role of visceral adiposity
Yong Jun Choi, Ja Young Jeon, Kyoung Hwa Ha, Dae Jung Kim
Korean J Intern Med. 2026;41(3):501-513. Published online May 1, 2026
Background/Aims: Prediabetes comprises heterogeneous metabolic phenotypes that may differentially affect bone quality. While type 2 diabetes increases fracture risk despite preserved bone mineral density, phenotype-specific effects on bone quality during prediabetes remain unclear. We compared trabe..
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| Editorial |
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Editorial
Not all prediabetes is the same in its effect for bone health
Jeonghoon Ha
Korean J Intern Med. 2026;41(3):514-515. Published online May 1, 2026
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| Original Articles |
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Infectious diseases / Original Article
Cross-neutralizing antibody responses among individuals with or without bivalent vaccine: a six-month prospective cohort study
Hye Hee Cha, Ji Yeun Kim, Seung Beom Kim, Junho Cha, Ji-Soo Kwon, Woori Kim, Ju Yeon Son, Choi Young Jang, Min-Chul Kim, So Yun Lim, Sung-Han Kim
Korean J Intern Med. 2026;41(3):516-523. Published online May 1, 2026
Background/Aims: Although the COVID-19 pandemic has officially ended, SARS-CoV-2 continues to circulate with periodic surges and may exhibit seasonal patterns. Understanding the importance of prompt immunization, particularly in individuals with prior infection, is crucial for developing future vacc..
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Rheumatology / Original Article
LncRNA as a diagnostic marker for rheumatoid arthritis: a systematic review and meta-analysis
Lin-ling Luo, Yu-tong Chen, Yi-ning Xu, Miao Lu, Xi-de Liu
Korean J Intern Med. 2026;41(3):524-536. Published online May 1, 2026
Background/Aims: Rheumatoid arthritis (RA) is categorized as an autoimmune disorder characterized by the absence of a definitive cure. In this investigation, we executed a systematic review and diagnostic meta-analysis to ascertain the diagnostic efficacy of long non-coding RNAs (lncRNAs) in the ide..
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Rheumatology / Original Article
Opposing associations of muscle and fat mass changes on serum uric acid levels: a 2-year longitudinal cohort study
Jiwon Hwang, Mi Yeon Lee, Joong Kyong Ahn
Korean J Intern Med. 2026;41(3):537-554. Published online May 1, 2026
Background/Aims: Obesity elevates serum uric acid (SUA) levels, but the influence of muscle mass remains unclear. As a major endogenous purine pool, skeletal muscle may affect SUA dynamics. We evaluated the impact of changes in body components, including skeletal muscle mass index (SMI), fat mass in..
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| Correspondence |
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| Images of interest |
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Gastroenterology / Image of interest
Subacute respiratory symptoms in a patient with Crohn’s disease and ankylosing spondylitis
Doohyuck Lee, Kwangwoo Nam, Ho Jin Yong, Juntae Kim, Miil Kang
Korean J Intern Med. 2026;41(3):557-559. Published online February 27, 2026
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Gastroenterology / Image of interest
Fecal microbiota transplantation for marked colonic dilatation
Eunseo Cho, Jung-Hwan Lee, Ji-Taek Hong, Kye Sook Kwon, Yong Woon Shin
Korean J Intern Med. 2026;41(3):560-562. Published online May 1, 2026
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