| Reviews |
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Gastroenterology / Review
Role of the renin-angiotensin system in hepatic fibrosis and portal hypertension
Kwang Yong Shim, Young Woo Eom, Moon Young Kim, Seong Hee Kang, Soon Koo Baik
Korean J Intern Med. 2018;33(3):453-461. Published online February 21, 2018
The renin-angiotensin system (RAS) is an important regulator of cirrhosis and portal hypertension. As hepatic fibrosis progresses, levels of the RAS components angiotensin (Ang) II, Ang-(1–7), angiotensin-converting enzyme (ACE), and Ang II type 1 receptor (AT1R) are increased. The primary effector ..
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Cardiology / Review
How to tackle congestion in acute heart failure
Pieter Martens, Wilfried Mullens
Korean J Intern Med. 2018;33(3):462-473. Published online April 11, 2018
Acute heart failure is a common complication of chronic heart failure and is associated with a high risk for subsequent mortality and morbidity. In 90% of case acute heart failure is the resultant of congestion, a manifestation of fluid build-up due to increased filling pressures. As residual conges..
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Cardiology / Review
Expanding transcatheter aortic valve replacement into uncharted indications
Guson Kang, Juyong Brian Kim
Korean J Intern Med. 2018;33(3):474-482. Published online March 20, 2018
Since the first-in-man transcatheter delivery of an aortic valve prosthesis in 2002, the landscape of aortic stenosis therapeutics has shifted dramatically. While initially restricted to non-surgical cases, progressive advances in transcatheter aortic valve replacement and our understanding of its s..
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ETC / Review
Fundamental role of dendritic cells in inducing Th2 responses
Byoungjae Kim, Tae Hoon Kim
Korean J Intern Med. 2018;33(3):483-489. Published online March 5, 2018
A mysterious puzzle in immunology is how the immune system decides what types of immune response to initiate against various stimuli. Although much is known about control of T helper 1 (Th1) and Th17 responses, the mechanisms that initiate Th2 responses remain obscure. Antigen-presenting cells, part..
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| Editorials |
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| Original Articles |
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Gastroenterology / Original Article
Efficacy of preoperative percutaneous cholecystostomy in the management of acute cholecystitis according to severity grades
Seong Yeol Kim, Kyo-Sang Yoo
Korean J Intern Med. 2018;33(3):497-505. Published online January 6, 2017
Background/Aims: The aim of this retrospective study was to assess the efficacy of percutaneous cholecystostomy (PC) for patients with acute cholecystitis (AC) according to severity.
Methods: A total of 325 patients who underwent cholecystectomy between January 2008 and October 2010 were enrolled. ..
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Gastroenterology / Original Article
Effect of Helicobacter pylori eradication on the regression of gastric polyps in National Cancer Screening Program
Su Youn Nam, Bum Joon Park, Kum Hei Ryu, Ji Hyung Nam
Korean J Intern Med. 2018;33(3):506-511. Published online December 14, 2017
Background/Aims: Western guidelines recommend Helicobacter pylori eradication in H. pylori-associated gastric polyps; however, there is no standard guideline in Korea. The aim of this study is to assess the effect of H. pylori eradication on the regression of gastric hyperplasti..
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Cardiology / Original Article
Prognostic value of total triiodothyronine and free thyroxine levels for the heart failure in patients with acute myocardial infarction
Min Gyu Kang, Jong Ryeal Hahm, Kye-Hwan Kim, Hyun-Woong Park, Jin-Sin Koh, Seok-Jae Hwang, Jin-Yong Hwang, Jong Hwa Ahn, Yongwhi Park, Young-Hoon Jeong, Jeong Rang Park, Choong Hwan Kwak
Korean J Intern Med. 2018;33(3):512-521. Published online January 11, 2017
Background/Aims: Although a low triiodothyronine (T3) state is closely associated with heart failure (HF), it is uncertain whether total T3 levels on admission is correlated with the clinical outcomes of acute myocardial infarction (AMI). The aim of this study is to investigate the prognostic value..
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Cardiology / Original Article
Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatment
Hyung Joon Joo, Ji-Young Park, Soon Jun Hong, Kyoung-Ah Kim, Seung Hoon Lee, Jae-Young Cho, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim
Korean J Intern Med. 2018;33(3):522-531. Published online October 19, 2017
Background/Aims: Although epigallocatechin-3-gallate (EGCG), which is found in high contents in the dried leaves of green tea, has been reported to have an anti-platelet effect, synergistic effects of EGCG in addition to current anti-platelet medications remains to be elucidated.
Methods: Blood sam..
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Pulmonology / Original Article
Histopathologic heterogeneity of acute respiratory distress syndrome revealed by surgical lung biopsy and its clinical implications
Jimyung Park, Yeon Joo Lee, Jinwoo Lee, Sung Soo Park, Young-Jae Cho, Sang-Min Lee, Young Whan Kim, Sung Koo Han, Chul-Gyu Yoo
Korean J Intern Med. 2018;33(3):532-540. Published online November 1, 2017
Background/Aims: Diffuse alveolar damage (DAD) is the histopathologic hallmark of acute respiratory distress syndrome (ARDS). However, there are several non-DAD conditions mimicking ARDS. The purpose of this study was to investigate the histopathologic heterogeneity of ARDS revealed by surgical lung..
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Pulmonology / Original Article
Combination of carboplatin and intermittent normobaric hyperoxia synergistically suppresses benzo[a]pyrene-induced lung cancer
Hea Yon Lee, In Kyoung Kim, Hye In Lee, Hwa Young Lee, Hye Seon Kang, Chang Dong Yeo, Hyun Hui Kang, Hwa Sik Moon, Sang Haak Lee
Korean J Intern Med. 2018;33(3):541-551. Published online December 15, 2017
Background/Aims: We explored the effects of intermittent normobaric hyperoxia alone or combined with chemotherapy on the growth, general morphology, oxidative stress, and apoptosis of benzo[a]pyrene (B[a]P)-induced lung tumors in mice.
Methods: Female A/J mice were given a single dose of B[a]P and ..
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Endocrinology-metabolism / Original Article
Reference intervals of thyroid hormones during pregnancy in Korea, an iodine-replete area
Hye Jeong Kim, Yoon Young Cho, Sun Wook Kim, Tae Hyuk Kim, Hye Won Jang, Soo-Youn Lee, Suk-Joo Choi, Cheong-Rae Roh, Jong-Hwa Kim, Jae Hoon Chung, Soo-young Oh
Korean J Intern Med. 2018;33(3):552-560. Published online February 8, 2017
Background/Aims: Maternal thyroid dysfunction has been associated with adverse pregnancy outcomes. The purpose of our study was to establish trimester-specific reference intervals for thyroid hormones in pregnant women in Korea, where iodine intake is more than adequate and to examine pregnancy and ..
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Nephrology / Original Article
Comparison of tolvaptan treatment between patients with the SIADH and congestive heart failure: a single-center experience
Gun Ha Park, Chang Min Lee, Jae Won Song, Moon Chan Jung, Jwa Kyung Kim, Young Rim Song, Hyung Jik Kim, Sung Gyun Kim
Korean J Intern Med. 2018;33(3):561-567. Published online March 13, 2017
Background/Aims: Tolvaptan is a very effective treatment for hypervolemic or euvolemic hyponatremia. We compared the clinical efficacy of and response to tolvaptan in patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and congestive heart failure (CHF).
Methods: We r..
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Nephrology / Original Article
Effects of colchicine on renal fibrosis and apoptosis in obstructed kidneys
Sejoong Kim, Eun Sook Jung, Jeonghwan Lee, Nam Ju Heo, Ki Young Na, Jin Suk Han
Korean J Intern Med. 2018;33(3):568-576. Published online March 18, 2017
Background/Aims: Colchicine is an established drug for microtubule stabilization that may reduce tissue injury. No data were available that its effects may depend on the dosage of colchicine. We investigated the anti-fibrotic and apoptotic effects of various dose of colchicine in a unilateral urete..
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Hemato-oncology / Original Article
Initial titration with 200 μg fentanyl buccal tablets: a retrospective safety analysis in Korean cancer patients
Mi-Young Kwon, Ha-Na Cho, Dong-Hoe Koo, Yun-Gyoo Lee, Sukjoong Oh, Seung-Sei Lee
Korean J Intern Med. 2018;33(3):577-584. Published online January 24, 2017
Background/Aims: Managing breakthrough pain (BTP) is important for many cancer patients because of the rapid onset and unpredictable nature of the pain episodes. Fentanyl buccal tablets (FBTs) are a rapid-onset opioid indicated for BTP management. However, FBT titration is needed to optimize BTP ma..
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Hemato-oncology / Original Article
Prevalence of and factors associated with anxiety and depression in Korean patients with newly diagnosed advanced gastrointestinal cancer
Junghwa Chung, Gawon Ju, Jiyoul Yang, Jiwon Jeong, Yusook Jeong, Moon Ki Choi, Jihyun Kwon, Ki Hyeong Lee, Seung Taik Kim, Hye Sook Han
Korean J Intern Med. 2018;33(3):585-594. Published online February 14, 2017
Background/Aims: The purpose of the present study was to assess the prevalence of and factors associated with anxiety and depression in Korean patients with advanced gastrointestinal cancer.
Methods: One hundred and twenty consecutive patients with newly diagnosed, advanced gastrointestinal cancer ..
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Infectious diseases / Original Article
Changing trends in clinical characteristics and antibiotic susceptibility of Klebsiella pneumoniae bacteremia
Miri Hyun, Chang In Noh, Seong Yeol Ryu, Hyun Ah Kim
Korean J Intern Med. 2018;33(3):595-603. Published online November 10, 2017
Background/Aims: Klebsiella pneumoniae is second most common organism of gram-negative bacteremia in Korea and one of the most common cause of urinary tract infection, and intra-abdominal infection.
Methods: We compared clinical and microbiological characteristics about K. pneumoniae ..
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Allergy / Original Article
The virtual asthma guideline e-learning program: learning effectiveness and user satisfaction
Sung-Yoon Kang, Sae-Hoon Kim, Yong-Eun Kwon, Tae-Bum Kim, Hye-Kyung Park, Heung-Woo Park, Yoon-Seok Chang, Young-Koo Jee, Hee-Bom Moon, Kyung-Up Min, Sang-Heon Cho
Korean J Intern Med. 2018;33(3):604-611. Published online July 21, 2017
Background/Aims: Effective educational tools are important for increasing adherence to asthma guidelines and clinical improvement of asthma patients. We developed a computer-based interactive education program for asthma guideline named the Virtual Learning Center for Asthma Management (VLCAM). We e..
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Rheumatology / Original Article
Grape seed proanthocyanidin extract ameliorates murine autoimmune arthritis through regulation of TLR4/MyD88/NF-κB signaling pathway
Sang-Hyon Kim, Jihye Bang, Chang-Nam Son, Won-Ki Baek, Ji-Min Kim
Korean J Intern Med. 2018;33(3):612-621. Published online June 3, 2016
Background/Aims: Grape seed proanthocyanidin extract (GSPE) has been reported to have a beneficial effect on regulating inf lammation. However, the anti-inflammatory mechanism of GSPE remains unclear. The aim of this study was to verify the influence of GSPE on the Toll-like receptor 4 (TLR4)-mediat..
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Rheumatology / Original Article
Baseline extent of damage predicts spinal radiographic progression in Korean patients with ankylosing spondylitis treated with golimumab
Jeong Seok Lee, Yeong Wook Song, Tae Hwan Kim, Won Tae Chung, Seung Geun Lee, Sung Hwan Park, Gwan Gyu Song, Dae Young Yu, Stephen Xu, Eun Young Lee
Korean J Intern Med. 2018;33(3):622-628. Published online January 20, 2017
Background/Aims: For patients with ankylosing spondylitis (AS), golimumab has consistent efficacy in controlling disease activity over 5 years but its benefit in preventing radiographic progression was less clear at 4 years. To predict radiographic progression, we analyzed the baseline characteristi..
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| Letters to the editor |
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Letter to the editor
Multivessel spontaneous coronary artery dissection presenting as acute myocardial infarction
Seung Ki Moon, Seung Uk Lee, Dong Hoon Yang, Cheol Min Bak, Shin Hyoung Jo, Sung Soo Kim, Dong Goo Kang, Sang Ki Cho
Korean J Intern Med. 2018;33(3):629-631. Published online April 20, 2016
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Letter to the editor
Histologically confirmed nonbacterial thrombotic endocarditis in a febrile leukemic patient
Eun Gyo Jeong, Mi-Hyang Jung, Ho-Joong Youn
Korean J Intern Med. 2018;33(3):632-633. Published online June 26, 2017
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Letter to the editor
Multiple metastasis of follicular variant of papillary thyroid carcinoma coexistent with malignant melanoma
Yu Ji Kim, Kyung Ae Lee, Tae Sun Park, Hong Sun Baek, Heung Yong Jin
Korean J Intern Med. 2018;33(3):634-637. Published online January 16, 2017
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Letter to the editor
Hypogonadotrophic hypogonadism due to a mutation in the luteinizing hormone β-subunit gene
Jae Won Song, Hyo-Jeong Hwang, Chang Min Lee, Gun Ha Park, Chul Sik Kim, Seong Jin Lee, Sung-Hee Ihm
Korean J Intern Med. 2018;33(3):638-641. Published online January 16, 2017
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Letter to the editor
Loeffler endocarditis in chronic eosinophilic leukemia with FIP1L1/PDGFRA rearrangement: full recovery with low dose imatinib
Dae Sik Kim, Sunki Lee, Chul Won Choi
Korean J Intern Med. 2018;33(3):642-644. Published online June 28, 2017
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| Images of interest |
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Image of interest
A growing hepatic mass in a cryptogenic cirrhosis patient
Ji Soo Song, Hee Chul Yu, Woo Sung Moon
Korean J Intern Med. 2018;33(3):645-646. Published online October 19, 2017
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Image of interest
Paget disease in a radius
Ruiguo Zhang, Guizhi Zhang, Renfei Wang, Qiang Jia, Jian Tan
Korean J Intern Med. 2018;33(3):647-648. Published online March 19, 2018
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