| Editorials |
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Gastroenterology / Editorial
Treatment strategies for octogenarians with esophageal cancer: changing age-based treatment paradigms
Jaewon Hyung
Korean J Intern Med. 2025;40(2):165-167. Published online March 1, 2025
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Cardiology / Editorial
Pandemics extend beyond infectious diseases: the emerging threat of non-communicable diseases
Moojun Kim, Chan Joo Lee
Korean J Intern Med. 2025;40(2):168-169. Published online March 1, 2025
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| Reviews |
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Gastroenterology / Review
Role of endoscopic ultrasound in the diagnosis and local ablative therapy of pancreatic neuroendocrine tumors
Yun Je Song, Jun Kyeong Lim, Jun-Ho Choi
Korean J Intern Med. 2025;40(2):170-180. Published online February 25, 2025
Advancements in diagnostic technology have led to the improved detection of pancreatic neuroendocrine tumors (PNETs) and thus to an increase in the number of reported cases. Endoscopic ultrasound (EUS) technology, including in combination with contrast-enhanced harmonic imaging, aids in distinguishi..
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Gastroenterology / Review
Metabolic musculoskeletal disorders in patients with inflammatory bowel disease
Young Joo Yang, Seong Ran Jeon
Korean J Intern Med. 2025;40(2):181-195. Published online March 1, 2025
Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is a chronic inflammatory disorder that affects not only the gastrointestinal tract but also extraintestinal organs, leading to various extraintestinal manifestations and complications. Among these, musculoske..
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Cardiology / Review
Sex differences in diagnosis and treatment of heart failure: toward precision medicine
Soo Yong Lee, Seong-Mi Park
Korean J Intern Med. 2025;40(2):196-207. Published online March 1, 2025
There are sex-related differences in the pathophysiology and phenotype of heart failure (HF) as well as the pharmacokinetics and pharmacodynamics of drugs between women and men due to biological differences, such as heart and vessel size, response to blood volume and pressure, body water and muscle ..
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Pulmonology / Review
Current perspectives on interstitial lung abnormalities
Ju Hyun Oh, Jin Woo Song
Korean J Intern Med. 2025;40(2):208-218. Published online March 1, 2025
Interstitial lung abnormalities (ILAs) are early indicators of interstitial lung disease, often identified incidentally via computed tomography of the chest. This review explores the diagnostic criteria for ILAs as outlined by the Fleischner Society, highlights associated risk factors, examines thei..
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Nephrology / Review
Glial cell line-derived neurotrophic factor and its role in attenuating renal fibrosis: a review
Yousuf Abdulkarim Waheed, Wokuheleza Buberwa, Dong Sun
Korean J Intern Med. 2025;40(2):219-229. Published online December 13, 2023
Chronic kidney disease is estimated to affect approximately 10 to 15% of the Chinese population. Renal fibrosis is characterized by progressive extracellular matrix deposition in the kidney parenchyma with eventual tissue scarring and inevitable deterioration of renal function. Vascular rarefaction,..
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| Original Articles |
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Gastroenterology / Original Article
Clinical outcomes of esophageal squamous cell carcinoma in patients aged over 80 years
Dae Gon Ryu, Cheol Woong Choi, Su Jin Kim, Su Bum Park, Jin Ook Jang, Bong Soo Son
Korean J Intern Med. 2025;40(2):230-242. Published online February 21, 2025
Background/Aims: The clinical outcomes and optimal treatment of esophageal squamous cell carcinoma (ESCC) in elderly patients are unclear. This study aimed to assess the clinical outcomes of ESCC in patients aged ≥ 80 years.
Methods: Medical records of patients diagnosed with ESCC between Decembe..
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Gastroenterology / Original Article
Characteristics and outcomes of portal vein thrombosis in patients with inflammatory bowel disease in Korea
Ki Jin Kim, Su-Bin Song, Jung-Bin Park, June Hwa Bae, Ji Eun Baek, Ga Hee Kim, Min-Jun Kim, Seung Wook Hong, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Chang Sik Yu, Yong-Sik Yoon, Jong-Lyul Lee, Min Hyun Kim, Ho-Su Lee, Sang Hyoung Park
Korean J Intern Med. 2025;40(2):243-250. Published online December 23, 2024
Background/Aims: Portal vein thrombosis (PVT) frequently occurs in patients with inflammatory bowel disease (IBD), particularly when influenced by factors such as abdominal infections, IBD flare-ups, or surgical procedures. The implications of PVT range from immediate issues such as intestinal ische..
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Cardiology / Original Article
Explainable paroxysmal atrial fibrillation diagnosis using an artificial intelligence-enabled electrocardiogram
Yeongbong Jin, Bonggyun Ko, Woojin Chang, Kang-Ho Choi, Ki Hong Lee
Korean J Intern Med. 2025;40(2):251-261. Published online February 21, 2025
Background/Aims: Atrial fibrillation (AF) significantly contributes to global morbidity and mortality. Paroxysmal atrial fibrillation (PAF) is particularly common among patients with cryptogenic strokes or transient ischemic attacks and has a silent nature. This study aims to develop reliable artifi..
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Cardiology / Original Article
Sex-specific impact of the COVID-19 outbreak on the incidence of metabolic syndrome: a comparative study of 2018–2019 and 2020–2021
Kyeong-Hyeon Chun, Hyun-Jin Kim, Dae Ryong Kang, Jang Young Kim, Wonjin Kim, Yong Whi Jeong, Seung Hwan Han, Kwang Kon Koh; on behalf of the Taskforce Team of the Metabolic Syndrome Fact Sheet of the Korean Society of Cardiometabolic Syndrome
Korean J Intern Med. 2025;40(2):262-274. Published online March 1, 2025
Background/Aims: The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted global health, exacerbated metabolic health issues, and altered lifestyle behaviors. This study examined the sex-specific impact of the COVID-19 outbreak on the incidence of metabolic syndrome using data fro..
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Pulmonology / Original Article
Fatty liver index and development of lung cancer: a nationwide cohort study
Jihye Lim, Bongseong Kim, Kyungdo Han, Jeong Uk Lim
Korean J Intern Med. 2025;40(2):275-285. Published online October 22, 2024
Background/Aims: This study aimed to evaluate the impact of steatotic liver disease severity on the cumulative incidence of lung cancer utilizing data from the Korea National Health Insurance Service (NHIS).
Methods: This study examined the risk of lung cancer in the general population in conjuncti..
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Pulmonology / Original Article
Impact of tracheostomy on clinical outcomes in ventilated patients with severe pneumonia: a propensity-matched cohort study
Hayoung Seong, Hyojin Jang, Wanho Yoo, Saerom Kim, Soo Han Kim, Kwangha Lee
Korean J Intern Med. 2025;40(2):286-298. Published online March 1, 2025
Background/Aims: Tracheostomy is a crucial intervention for severe pneumonia patients requiring prolonged mechanical ventilation (MV). However, debate persists regarding the influence of tracheostomy timing and performance on long-term survival outcomes. This study utilized propensity score matching..
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Endocrinology-metabolism / Original Article
Persistent influence of past obesity on current adiponectin levels and mortality in patients with type 2 diabetes
Min-Ji Kim, Sung-Woo Kim, Bitna Ha, Hyang Sook Kim, So-Hee Kwon, Jonghwa Jin, Yeon-Kyung Choi, Keun-Gyu Park, Jung Guk Kim, In-Kyu Lee, Jae-Han Jeon
Korean J Intern Med. 2025;40(2):299-309. Published online March 1, 2025
Background/Aims: Adiponectin, a hormone primarily produced by adipocytes, typically shows an inverse relationship with body mass index (BMI). However, some studies have reported a positive correlation between the two. Thus, this study aimed to examine the relationship between adiponectin level and B..
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Nephrology / Original Article
Predicting renal function using fundus photography: role of confounders
Hyun-Woong Park, Hae Ri Kim, Ki Yup Nam, Bum Jun Kim, Taeseen Kang
Korean J Intern Med. 2025;40(2):310-320. Published online March 1, 2025
Background/Aims: The kidneys and retina are highly vascularized organs that frequently exhibit shared pathologies, with nephropathy often associated with retinopathy. Previous studies have successfully predicted estimated glomerular filtration rates (eGFRs) using fundus photographs. We evaluated the..
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Infectious diseases / Original Article
Initial and peak serum levels of Krebs von den Lungen-6 for predicting the prognosis of patients with COVID-19
Geonui Kim, Hyeonwoo Kwon, Sang Hyun Ra, Euijin Chang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim
Korean J Intern Med. 2025;40(2):321-329. Published online February 21, 2025
Background/Aims: Krebs von den Lungen-6 (KL-6) is associated with prognosis in patients with COVID-19. However, there is limited data on the correlation between the prognosis of COVID-19 and varying KL-6 levels at different time points. We investigated the optimal cutoff values of the initial and pe..
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Rheumatology / Original Article
Increased risk of dementia in patients with primary Sjogren’s syndrome: a nationwide population-based cohort study
Kyung-Ann Lee, Hyeji Jeon, Hyun-Sook Kim, Kyomin Choi, Gi Hyeon Seo
Korean J Intern Med. 2025;40(2):330-338. Published online February 21, 2025
Background/Aims: This nationwide cohort study aimed to evaluate (1) whether primary Sjogren’s syndrome (pSS) can contribute to the development of dementia and (2) whether the use of hydroxychloroquine (HCQ) can decrease the incidence of dementia in patients with pSS using the Health Insurance Revi..
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| Images of interest |
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Nephrology / Image of interest
Renal recovery from membranous lupus nephritis with antineutrophil cytoplasmic antibody-associated glomerulonephritis with belimumab
Wenfeng Wang, Zishan Lin, Bingjing Jiang, Yanfang Xu
Korean J Intern Med. 2025;40(2):339-340. Published online February 25, 2025
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Rheumatology / Image of interest
Acute gouty arthritis of the atlantoaxial joint
Su Jin Choi, Min Wook So, Sunggun Lee, Seung Won Choi, Doo-Ho Lim
Korean J Intern Med. 2025;40(2):341-342. Published online February 21, 2025
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