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Pulmonology / Original Article
Efficacy of lower dose pirfenidone for idiopathic pulmonary fibrosis in real practice: a retrospective cohort study
Hyeontaek Hwang, Jung-Kyu Lee, Sun Mi Choi, Yeon Joo Lee, Young-Jae Cho, Ho Il Yoon, Jae Ho Lee, Choon-Taek Lee, Young Whan Kim, Jong Sun Park
Korean J Intern Med. 2022;37(2):366-376. Published online July 27, 2021
Background/Aims: Pirfenidone slows the progression of idiopathic pulmonary fibrosis (IPF). We investigated its efficacy and safety in terms of dose and disease severity in real-world patients with IPF.
Methods: This multicenter retrospective cohort study investigated 338 patients treated with pirfe..
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Gastroenterology / Original Article
Rectal NSAIDs-based combination modalities are superior to single modalities for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a network meta-analysis
Tae Young Park, Hyun Kang, Geun Joo Choi, Hyoung-Chul Oh
Korean J Intern Med. 2022;37(2):322-339. Published online February 16, 2022
Background/Aims: Different modalities have been employed to reduce the risk and severity of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). However, there has been a paucity of studies comparing the efficacy of various prophylactic modalities for preventing PEP. This n..
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Rheumatology / Original Article
Efficacy and safety of hydroxychloroquine in osteoarthritis: a systematic review and meta-analysis of randomized controlled trials
Ambrish Singh, Anirudh Kotlo, Zhiqiang Wang, Thusharika Dissanayaka, Siddharth Das, Benny Antony
Korean J Intern Med. 2022;37(1):210-221. Published online April 22, 2021
Background/Aims: Conventional disease-modifying anti-rheumatic drugs have been trialed in osteoarthritis (OA). Hydroxychloroquine (HCQ), which has shown its effectiveness in rheumatoid arthritis, has been trialed for the treatment of OA; however, its efficacy and safety remain unclear. This systemat..
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Infectious diseases / Original Article
Eosinophil-mediated lung inflammation associated with elevated natural killer T cell response in COVID-19 patients
Dong-Min Kim, Jun-Won Seo, Yuri Kim, Uni Park, Na-Young Ha, Hyoree Park, Na Ra Yun, Da Young Kim, Sung Ho Yoon, Yong Sub Na, Do Sik Moon, Sung-Chul Lim, Choon-Mee Kim, Yeon-Sook Kim, Nam-Hyuk Cho
Korean J Intern Med. 2022;37(1):201-209. Published online September 27, 2021
Background/Aims: Coronavirus disease 2019 (COVID-19) is associated with acute respiratory syndrome. The mechanisms underlying the different degrees of pneumonia severity in patients with COVID-19 remain elusive. This study provides evidence that COVID-19 is associated with eosinophil-mediated inflam..
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Hemato-oncology / Original Article
Characteristics and treatment patterns in older patients with locally advanced head and neck cancer (KCSG HN13-01)
Eun Joo Kang, Yun-Gyoo Lee, Bhumsuk Keam, Jin-Hyuk Choi, Jin-Soo Kim, Keon Uk Park, Kyoung Eun Lee, Hyo Jung Kim, Keun-Wook Lee, Min Kyoung Kim, Hee Kyung Ahn, Seong Hoon Shin, Jii Bum Lee, Jung Hye Kwon, Hye Ryun Kim, Sung-Bae Kim, Hwan Jung Yun
Korean J Intern Med. 2022;37(1):190-200. Published online December 21, 2021
Background/Aims: Treatment decisions for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) are complicated, and multi-modal treatments are usually indicated. However, it is challenging for older patients to complete treatments. Thus, we investigated disease characteristics, real-world..
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Hemato-oncology / Original Article
Influence of creatinine levels on survival in patients with veno-occlusive disease treated with defibrotide
Seom Gim Kong, Je-Hwan Lee, Young Tak Lim, Ji Hyun Lee, Hyeon-Seok Eom, Hyewon Lee, Do Young Kim, Sung-Nam Lim, Sung-Soo Yoon, Sung-Yong Kim, Ho Sup Lee
Korean J Intern Med. 2022;37(1):179-189. Published online December 14, 2021
Background/Aims: Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is one of the most fatal complications of hematopoietic cell transplantation (HCT), and defibrotide is the only curative drug. We conducted this study to confirm the survival rate of VOD/SOS patients diagnosed in Korea..
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Nephrology / Original Article
The optimal anti-phospholipase A2 receptor cutoff for the diagnosis of idiopathic membranous nephropathy: a single-center retrospective study
Chaofan Li, Ping Li, Wenkai Guo, Lei Chen, Jiatong Li, Rong Wang, Bing Chen
Korean J Intern Med. 2022;37(1):154-166. Published online July 22, 2021
Background/Aims: Anti-phospholipase A2 receptor (PLA2R) autoantibody is the main biomarker of idiopathic membranous nephropathy (IMN). We aimed to find a new cutoff value of anti-PLA2R for patients with IMN and to explore the relevance between this antibody and baseline clinical parameters.
Methods..
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Pulmonology / Original Article
Laboratory and radiological discrimination between tuberculous and malignant pleural effusions with high adenosine deaminase levels
Jaehee Lee, Ji Eun Park, Sun Ha Choi, Hyewon Seo, Sang Yub Lee, Jae Kwang Lim, Seung Soo Yoo, Shin Yup Lee, Seung Ick Cha, Jae Yong Park, Chang Ho Kim
Korean J Intern Med. 2022;37(1):137-145. Published online July 15, 2021
Background/Aims: Pleural fluid adenosine deaminase (ADA) levels are useful in discriminating tuberculous pleural effusions (TPEs) from malignant pleural effusions (MPEs). However, some patients with MPE exhibit high-ADA levels, which may mimic TPEs. There is limited data regarding the differential d..
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Pulmonology / Original Article
Clinical efficacy of adjuvant chemotherapy in stage IB (< 4 cm) non-small cell lung cancer patients with high-risk factors
Juwhan Choi, Jee Youn Oh, Young Seok Lee, Kyung Hoon Min, Jae Jeong Shim, Sue In Choi, Dong Won Park, Chan Kwon Park, Eun Joo Kang, Hwan Seok Yong, Bong Kyung Shin, Hyun Koo Kim, Sung Yong Lee
Korean J Intern Med. 2022;37(1):127-136. Published online July 29, 2021
Background/Aims: Adjuvant chemotherapy is the standard of care for resected stage II-IIIA non-small cell lung cancer (NCSLC). The efficacy of adjuvant chemotherapy in stage IB (< 4 cm) NSCLC with high-risk factors is controversial.
Methods: This retrospective multicenter study included 285 stage IB..
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Cardiology / Original Article
Reference diameter and characteristics of the distal radial artery based on ultrasonographic assessment
Jun-Won Lee, Jung-Woo Son, Tae-Hwa Go, Dae Ryong Kang, Sang Jun Lee, Se Eun Kim, Dong-Hyuk Cho, Young Jun Park, Young Jin Youn, Min-Soo Ahn, Sung Gyun Ahn, Jang-Young Kim, Byung-Su Yoo, Junghan Yoon, Seung-Hwan Lee
Korean J Intern Med. 2022;37(1):109-118. Published online December 29, 2021
Background/Aims: While distal radial artery (DRA) access is increasingly being used for diagnostic coronary angiography, limited information is available regarding DRA size. We aimed to determine the DRA reference diameters of Korean patients and identify the predictors of DRA diameter < 2.3 mm.
Me..
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Gastroenterology / Original Article
Extracellular vesicles derived from small intestinal lamina propria reduce antigen-specific immune response
Tae-Seop Shin, Jae Yong Park, Yoon-Keun Kim, Jae Gyu Kim
Korean J Intern Med. 2022;37(1):85-95. Published online August 25, 2021
Background/Aims: Extracellular vesicles (EVs) are secreted from various types of cells and have specific functions related to their origin. EVs are observed in the small intestinal lamina propria (lpEVs), but their function remains unclear. This study aimed to investigate the role of lpEVs.
Method..
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Gastroenterology / Original Article
Anti-fibrotic effects of branched-chain amino acids on hepatic stellate cells
Hae Lim Lee, Jungmin Lee, Jung Hoon Cha, Sungwoo Cho, Pil Soo Sung, Wonhee Hur, Seung Kew Yoon, Si Hyun Bae
Korean J Intern Med. 2022;37(1):53-62. Published online July 29, 2021
Background/Aims: Patients with liver cirrhosis (LC) have low levels of branchedchain amino acids (BCAAs). There is accumulating evidence that BCAAs have anti- fibrotic effects in cirrhosis. This study is aimed to evaluate the effect of BCAAs on the function and phenotype of activated hepatic stellate..
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Review
Is there sufficient evidence to justify changes in dietary habits in heart failure patients? A systematic review
Alejandra García-García, Luis A. Alvarez-Sala-Walther, Hae-Young Lee, Cristina Sierra, Domingo Pascual-Figal, Miguel Camafort
Korean J Intern Med. 2022;37(1):37-47. Published online September 6, 2021
The incidence and prevalence of heart failure (HF) is increasing worldwide, leading to high morbidity and mortality. The global management of HF involves lifestyle changes in addition to pharmacological treatments. Changes include exercise and dietary recommendations, mainly salt and fluid restricti..
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Review
Current status of the diagnosis of chronic pancreatitis by ultrasonographic elastography
Kazunori Nakaoka, Senju Hashimoto, Ryoji Miyahara, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Takamichi Kuwahara, Hiroyuki Tanaka, Yoshiki Hirooka
Korean J Intern Med. 2022;37(1):27-36. Published online December 15, 2021
Chronic pancreatitis (CP) is pathologically characterized by the loss of exocrine pancreatic parenchyma, irregular fibrosis, cellular infiltration, and ductal abnormalities. Diagnosing CP objectively is difficult because standard diagnostic criteria are insufficient. The change of parenchymal hardne..
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Rheumatology / Original Article
Tocotrienol regulates osteoclastogenesis in rheumatoid arthritis
Kyoung-Woon Kim, Bo-Mi Kim, Ji-Yeon Won, Hong Ki Min, Seoung Joon Lee, Sang-Heon Lee, Hae-Rim Kim
Korean J Intern Med. 2021;36(Suppl 1):S273-S282. Published online June 19, 2020
Background/Aims: The present study aimed to investigate whether tocotrienol regulates interleukin 17 (IL-17)-induced osteoclastogenesis in rheumatoid arthritis (RA).
Methods: We evaluated the effect of tocotrienol on IL-17-induced receptor activator of nuclear factor kappa B ligand (RANKL) producti..
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Infectious diseases / Original Article
Lopinavir-ritonavir versus hydroxychloroquine for viral clearance and clinical improvement in patients with mild to moderate coronavirus disease 2019
Ji-Won Kim, Eun Jin Kim, Hyun Hee Kwon, Chi Young Jung, Kyung Chan Kim, Jung-Yoon Choe, Hyo-Lim Hong
Korean J Intern Med. 2021;36(Suppl 1):S253-S263. Published online June 16, 2020
Background/Aims: The efficacies of lopinavir-ritonavir or hydroxychloroquine remain to be determined in patients with coronavirus disease 2019 (COVID-19). To compare the virological and clinical responses to lopinavir-ritonavir and hydroxychloroquine treatment in COVID-19 patients.
Methods: This re..
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Hemato-oncology / Original Article
Different roles of surveillance positron emission tomography according to the histologic subtype of non-Hodgkin’s lymphoma
Yu Ri Kim, Soo-Jeong Kim, June-Won Cheong, Yundeok Kim, Ji Eun Jang, Hyunsoo Cho, Haerim Chung, Yoo Hong Min, Woo Ick Yang, Arthur Cho, Jin Seok Kim
Korean J Intern Med. 2021;36(Suppl 1):S245-S252. Published online June 19, 2020
Background/Aims: Although the use of surveillance 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is discouraged in patients with diffuse large B-cell lymphoma, its usefulness in different subtypes has not been thoroughly investigated.
Methods: We r..
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Hemato-oncology / Original Article
Induction chemotherapy followed by concurrent chemoradiotherapy versus CCRT for locally
advanced hypopharynx and base of tongue cancer
Sung Hee Lim, Jong-Mu Sun, Joohyun Hong, Dongryul Oh, Yong Chan Ahn, Man Ki Chung, Han-Sin Jeong, Young-Ik Son, Myung-Ju Ahn, Chung-Hwan Baek, Keunchil Park
Korean J Intern Med. 2021;36(Suppl 1):S217-S224. Published online April 3, 2020
Background/Aims: Clinical trials have not consistently supported the use of induction chemotherapy (IC) for locally advanced head and neck squamous cell cancer. Hypopharynx and base of tongue (BOT) cancer has shown relatively poor survival. We investigated the role of IC in improving outcome over c..
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Nephrology / Original Article
L-carnitine treatment attenuates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
Hai Yan Zhao, Hui Ying Li, Jian Jin, Ji Zhe Jin, Long Ye Zhang, Mei Ying Xuan, Xue Mei Jin, Yu Ji Jiang, Hai Lan Zheng, Ying Shun Jin, Yong Jie Jin, Bum Soon Choi, Chul Woo Yang, Shang Guo Piao, Can Li
Korean J Intern Med. 2021;36(Suppl 1):S180-S195. Published online September 18, 2020
Background/Aims: Accumulating evidence indicates that L-carnitine (LC) protects against multiorgan damage through its antioxidant properties and preservation of the mitochondria. Little information is available about the effects of LC on renal fibrosis. This study examined whether LC treatment would..
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Pulmonology / Original Article
A genome wide association study for lung function in the Korean population using an exome array
Kyu-Sun Lee, Kun Hee Kim, Yeon-Mok Oh, Buhm Han, Woo Jin Kim
Korean J Intern Med. 2021;36(Suppl 1):S142-S150. Published online April 29, 2020
Background/Aims: Lung function is an objective indicator of diagnosis and prognosis of respiratory diseases. Many common genetic variants have been associated with lung function in multiple ethnic populations. We looked for coding variants associated with forced expiratory volume in 1 second (FEV
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