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Rheumatology / Original Article
Mortality in patients with rheumatoid arthritis-associated interstitial lung disease treated with an anti-tumor necrosis factor agent
Bon San Koo, Seokchan Hong, You Jae Kim, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo
Korean J Intern Med. 2015;30(1):104-109. Published online December 30, 2014
Background/Aims: To evaluate the impact on mortality of anti-tumor necrosis factor (anti-TNF) treatment of rheumatoid arthritis-associated interstitial lung disease (RA-ILD).
Methods: We retrospectively reviewed the medical records of 100 RA-ILD patients who visited our tertiary care medical center..
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Rheumatology / Original Article
Early effects of tumor necrosis factor inhibition on bone homeostasis after soluble tumor necrosis factor receptor use
Mie Jin Lim, Seong Ryul Kwon, Kowoon Joo, Min Jung Son, Shin-Goo Park, Won Park
Korean J Intern Med. 2014;29(6):807-813. Published online October 31, 2014
Background/Aims: Our aim was to assess whether short-term treatment with soluble tumor necrosis factor (TNF) receptor affects circulating markers of bone metabolism in rheumatoid arthritis (RA) patients.
Methods: Thirty-three active RA patients, treated with oral disease-modifying antirheumatic dru..
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Rheumatology / Original Article
Efficacy and safety of tofacitinib for active rheumatoid arthritis with an inadequate response to methotrexate or disease-modifying antirheumatic drugs: a meta-analysis of randomized controlled trials
Gwan Gyu Song, Sang-Cheol Bae, Young Ho Lee
Korean J Intern Med. 2014;29(5):656-663. Published online August 28, 2014
Background/Aims: The aim of this study was to assess the efficacy and safety of tofacitinib (5 and 10 mg twice daily) in patients with active rheumatoid arthritis (RA).
Methods: A systematic review of randomized controlled trials (RCTs) that examined the efficacy and safety of tofacitinib in patien..
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Rheumatology / Original Article
SKI306X inhibition of glycosaminoglycan degradation in human cartilage involves down-regulation of cytokine-induced catabolic genes
Choong Hyeok Choi, Tae-Hwan Kim, Yoon-Kyoung Sung, Chan-Bum Choi, Young-In Na, Hunseung Yoo, Jae-Bum Jun
Korean J Intern Med. 2014;29(5):647-655. Published online August 28, 2014
Background/Aims: SKI306X, a mixed extract of three herbs, Clematis mandshurica (CM), Prunella vulgaris (PV), and Trichosanthes kirilowii (TK), is chondroprotective in animal models of osteoarthritis (OA). The objectives of this study were to invest..
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Rheumatology / Original Article
Resting energy expenditure is not associated with disease activity in women with rheumatoid arthritis: cross-sectional study
Jung-Yoon Choe, Sung-Hoon Park, Hwajeong Lee, Hyun Hee Kwon, Seong-Kyu Kim
Korean J Intern Med. 2014;29(4):516-524. Published online June 27, 2014
Background/Aims: Increased resting energy expenditure (REE) in rheumatoid arthritis (RA) patients is thought to be caused by hypermetabolism associated with production of proinflammatory cytokines. Our aim in the present study was to explore the possible association between REE and disease activity ..
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Letter to the editor
Unusual metatarsophalangeal joint deformity in an advanced rheumatoid foot
Seung-Min Jung, Jae Hoon Ahn, Sung-Hwan Park, Kyung-Su Park
Korean J Intern Med. 2014;29(3):402-403. Published online April 29, 2014
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Etc. - Orthopedic / Original Article
Evaluation of the effect of D-002, a mixture of beeswax alcohols, on osteoarthritis symptoms
Roberto Puente, José Illnait, Rosa Mas, Daisy Carbajal, Sarahí Mendoza, Julio César Fernández, Meilis Mesa, Rafael Gámez, Pablo Reyes
Korean J Intern Med. 2014;29(2):191-202. Published online February 27, 2014
Background/Aims: Nonsteroidal anti-inflammatory drugs relieve osteoarthritis (OA) symptoms but cause adverse effects. D-002, a mixture of beeswax alcohols, is effective against experimental OA. A pilot study found that D-002 (50 mg/day) for 8 weeks improves OA symptoms. The aim of this study was to ..
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Rheumatology / Original Article
Poor agreement between QuantiFERON-TB
Gold test and tuberculin skin test results for the
diagnosis of latent tuberculosis infection in
rheumatoid arthritis patients and healthy controls
Joo-Hyun Lee, Hae Sook Sohn, Jin Ho Chun, Hyoun-Ah Kim, Chang Hee Suh, Yun Woo Lee, Bo Young Yoon
Korean J Intern Med. 2014;29(1):76-84. Published online January 2, 2014
Background/Aims: We investigated the agreement between the QuantiFERON-
TB Gold (QFT‑Gold) test and the tuberculin skin test (TST) in the diagnosis
of latent tuberculosis infection in patients with rheumatoid arthritis (RA), compared
with healthy controls, in Korea.
Methods: We recruited 64 pa..
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Rheumatology / Review
S100A8/A9 as a biomarker for synovial inflammation
and joint damage in patients with rheumatoid
arthritis
Kwi Young Kang, Jung-Won Woo, Sung-Hwan Park
Korean J Intern Med. 2014;29(1):12-19. Published online January 2, 2014
S100A8 and S100A9 are major leukocyte proteins, known as damage-associated
molecular patterns, found at high concentrations in the synovial fluid of patients
with rheumatoid arthritis (RA). A heterodimeric complex of S100A8/A9 is secreted
by activated leukocytes and binds to Toll-like receptor 4,..
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Rheumatology / Original Article
The presence of MEFV gene mutations in patients with primary osteoarthritis who require surgery
Sedat Yilmaz, Hakan Erdem, Servet Tunay, Deniz Torun, Halil Genc, Yusuf Tunca, Omer Karadag, Ismail Simsek, Muhterem Bahce, Salih Pay, Ayhan Dinc
Korean J Intern Med. 2013;28(5):594-598. Published online August 14, 2013
Background/AimsChronic arthritis of familial Mediterranean fever (FMF) involves weight-bearing joints and can occur in patients without a history of acute attack. Our aim was to investigate a possible causal relationship between FMF and osteoarthritis in a population in which ..
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Rheumatology / Original Article
Is the frequency of metabolic syndrome higher in South Korean women with rheumatoid arthritis than in healthy subjects?
Seung-Geun Lee, Ji-Min Kim, Sun-Hee Lee, Kye-Hyung Kim, Ji-Hye Kim, Ji-Won Yi, Woo-Jin Jung, Young-Eun Park, Seong-Hu Park, Joung-Wook Lee, Seung-Hoon Baek, Jun-Hee Lee, Geun-Tae Kim
Korean J Intern Med. 2013;28(2):206-215. Published online February 27, 2013
Background/AimsTo compare the frequency of metabolic syndrome (MetS) and magnitude of insulin resistance, measured by the homeostatic model assessment of insulin resistance (HOMA-IR), between South Korean women with rheumatoid arthritis (RA) and healthy subjects, and to evalua..
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Rheumatology / Original Article
Greater prevalence of seropositivity for anti-cyclic citrullinated peptide antibody in unaffected first-degree relatives in multicase rheumatoid arthritis-affected families
Seong-Kyu Kim, Jisuk Bae, Hwajeong Lee, Ji Hun Kim, Sung-Hoon Park, Jung-Yoon Choe
Korean J Intern Med. 2013;28(1):45-53. Published online December 28, 2012
Background/AimsThis study determined the prevalence and determinants of seropositivity for rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) antibody, and anti-mutated citrullinated vimentin (anti-MCV) antibody in unaffected first-degree relatives (FDRs) of ..
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Review
Recent Paradigm Shifts in the Diagnosis and Treatment of Rheumatoid Arthritis
Young Ok Jung, Hyun Ah Kim
Korean J Intern Med. 2012;27(4):378-387. Published online November 27, 2012
Rheumatoid arthritis (RA) is a progressive inflammatory disease with severe symptoms of pain and stiffness. Chronic persistent inflammation of RA often leads to joint destruction, deformity and limitation of function, which ultimately results in significant deterioration of quality of life (QoL)...
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Original Article
Cultural Adaptation of a Compliance Questionnaire for Patients with Rheumatoid Arthritis to a Korean Version
Ju Yeun Lee, So Young Lee, Hyeon Joo Hahn, In Ja Son, Suh Gyung Hahn, Eun Bong Lee
Korean J Intern Med. 2011;26(1):28-33. Published online March 2, 2011
Background/AimsThe Compliance Questionnaire-Rheumatology (CQR) is a validated scale to evaluate patient compliance for anti-rheumatic medications. We developed a Korean version of the CQR (KCQR) and confirmed its reliability and validity. Methods
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Original Article
A Comparison of Three Different Guidelines for Osteoporosis Treatment in Patients with Rheumatoid Arthritis in Korea
Jiyeol Yoon, Seong-Ryul Kwon, Mie-Jin Lim, Kowoon Joo, Chang-Gi Moon, Jihun Jang, Won Park
Korean J Intern Med. 2010;25(4):436-446. Published online November 27, 2010
Background/AimsOsteoporotic fractures are an important comorbidity with rheumatoid arthritis (RA). We determined the overall fracture risk as assessed by the World Health Organization (WHO)'s FRAX® tool in Korean patients with seropositive RA. Additionally, we compared treatm..
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Original Article
Engagement of Toll-Like Receptor 3 Induces Vascular Endothelial Growth Factor and Interleukin-8 in Human Rheumatoid Synovial Fibroblasts
Su-Jin Moon, Mi-Kyung Park, Hye-Jwa Oh, Seon-Yeong Lee, Seung-Ki Kwok, Mi-La Cho, Ji Hyeon Ju, Kyung-Su Park, Ho-Youn Kim, Sung-Hwan Park
Korean J Intern Med. 2010;25(4):429-435. Published online November 27, 2010
Background/AimsAngiogenesis, which is a critical step in the initiation and progression of rheumatoid arthritis (RA), involves pro-angiogenic factors, including interleukin (IL)-8 and vascular endothelial growth factor (VEGF). We investigated the role of Toll-like receptor 3 (..
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Original Article
Induction of Macrophage Migration Inhibitory Factor in ConA-Stimulated Rheumatoid Arthritis Synovial Fibroblasts through the P38 MAP Kinase-Dependent Signaling Pathway
Hae-Rim Kim, Mi-Kyung Park, Mi-La Cho, Kyoung-Woon Kim, Hye-Joa Oh, Jin-Sil Park, Yang-Mi Heo, Sang-Heon Lee, Ho-Youn Kim, Sung-Hwan Park
Korean J Intern Med. 2010;25(3):317-326. Published online August 31, 2010
Background/AimsThis study was undertaken to identify the intracellular signaling pathway involved in induction of macrophage migration inhibitory factor (MIF) in human rheumatoid arthritis (RA) synovial fibroblasts. MethodsHuman RA synovial fibr..
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Case Report
Inflammatory Polyarthritis in a Patient with Psoriasis: Is It Psoriatic Arthritis or Rheumatoid Arthrirtis?
Kwang-Hoon Lee, Myoung-Kyun Son, You-Jung Ha, Sang-Tae Choi, Sang-Won Lee, Yong-Beom Park, Soo-Kon Lee
Korean J Intern Med. 2010;25(2):224-226. Published online June 1, 2010
Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. There are no generally accepted diagnostic criteria for PsA. Indeed, the diagnosis of this inflammatory arthritis is made by exclusion of other possible diseases and based upon immunologic, radiologic, and clinical ..
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Original Article
Correlation of Anti-Cyclic Citrullinated Antibody with Hand Joint Erosion Score in Rheumatoid Arthritis Patients
Hyun Hee Kim, JiHun Kim, Sung-Hoon Park, Seong-Kyu Kim, Ok-Dong Kim, Jung-Yoon Choe
Korean J Intern Med. 2010;25(2):201-206. Published online June 1, 2010
Background/AimsTo examine the correlation between radiological joint damage and serological parameters in early rheumatoid arthritis (RA). MethodsThis retrospective study reviewed the records of 216 patients diagnosed with RA and classified them..
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Review
Description of the Efficacy and Safety of Three New Biologics in the Treatment of Rheumatoid Arthritis
Steven S. Storage, Harsh Agrawal, Daniel E. Furst
Korean J Intern Med. 2010;25(1):1-17. Published online February 26, 2010
English articles on abatacept, golimumab, and tocilizumab in rheumatoid arthritis published between 2002 and 2009 were reviewed systematically. All randomized clinical trials, open-label extensions, meta-analyses, and reviews were examined. There were thirteen articles on abatacept, four on goli..
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