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Cardiology / Original Article
HFA-PEFF scores: prognostic value in heart failure with preserved left ventricular ejection fraction
Koichi Egashira, Daisuke Sueta, Takashi Komorita, Eiichiro Yamamoto, Hiroki Usuku, Takanori Tokitsu, Koichiro Fujisue, Taiki Nishihara, Fumi Oike, Masafumi Takae, Shinsuke Hanatani, Seiji Takashio, Miwa Ito, Kenshi Yamanaga, Satoshi Araki, Hirofumi Soejima, Koichi Kaikita, Kenichi Matsushita, Kenichi Tsujita
Korean J Intern Med. 2022;37(1):96-108. Published online December 21, 2021
Background/Aims: The Heart Failure Association (HFA)-PEFF score is recognized as a simple method to diagnose heart failure (HF) with preserved ejection fraction (HFpEF). This study aimed to evaluate the relationship between HFA-PEFF scores and cardiovascular outcomes in HFpEF patients.
Methods: A to..
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Gastroenterology / Original Article
Extracellular vesicles derived from small intestinal lamina propria reduce antigen-specific immune response
Tae-Seop Shin, Jae Yong Park, Yoon-Keun Kim, Jae Gyu Kim
Korean J Intern Med. 2022;37(1):85-95. Published online August 25, 2021
Background/Aims: Extracellular vesicles (EVs) are secreted from various types of cells and have specific functions related to their origin. EVs are observed in the small intestinal lamina propria (lpEVs), but their function remains unclear. This study aimed to investigate the role of lpEVs.
Method..
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Gastroenterology / Original Article
Seroprevalence of viral infectious diseases and associated factors in Korean patients with inflammatory bowel diseases
Hee Seung Hong, Jiwon Jung, Sang Hyoung Park, Hwa Jung Kim, Sung Wook Hwang, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
Korean J Intern Med. 2022;37(1):73-84. Published online September 6, 2021
Background/Aims: Data on the immunoprotective status against measles, mumps, rubella, varicella zoster virus (VZV), hepatitis A virus (HAV), and Epstein-Barr virus (EBV) infection in patients with inflammatory bowel disease (IBD) are still lacking. Therefore, we investigated the seropositivity rates..
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Gastroenterology / Original Article
Current trends in the management of pancreatic cystic neoplasms in Korea: a national survey
Hyung Ku Chon, Sung Hoon Moon, Sang Wook Park, Woo Hyun Paik, Chang Nyol Paik, Byoung Kwan Son, Tae Jun Song, Dong Won Ahn, Eaum Seok Lee, Yun Nah Lee, Yoon Suk Lee, Jae Min Lee, Tae Joo Jeon, Chang-Hwan Park, Kwang Bum Cho, Dong Wook Lee
Korean J Intern Med. 2022;37(1):63-72. Published online July 29, 2021
Background/Aims: The study aimed to investigate the current practice patterns in the management of pancreatic cystic neoplasms in Korea.
Methods: An electronic survey was systematically distributed by email to members of the Korean Pancreatobiliary Association from December 2019 to February 2020.
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Gastroenterology / Original Article
Anti-fibrotic effects of branched-chain amino acids on hepatic stellate cells
Hae Lim Lee, Jungmin Lee, Jung Hoon Cha, Sungwoo Cho, Pil Soo Sung, Wonhee Hur, Seung Kew Yoon, Si Hyun Bae
Korean J Intern Med. 2022;37(1):53-62. Published online July 29, 2021
Background/Aims: Patients with liver cirrhosis (LC) have low levels of branchedchain amino acids (BCAAs). There is accumulating evidence that BCAAs have anti- fibrotic effects in cirrhosis. This study is aimed to evaluate the effect of BCAAs on the function and phenotype of activated hepatic stellate..
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Editorial
Efficacy of hydroxychloroquine for knee osteoarthritis
Young Ho Lee
Korean J Intern Med. 2022;37(1):51-52. Published online December 29, 2021
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Review
Is there sufficient evidence to justify changes in dietary habits in heart failure patients? A systematic review
Alejandra García-García, Luis A. Alvarez-Sala-Walther, Hae-Young Lee, Cristina Sierra, Domingo Pascual-Figal, Miguel Camafort
Korean J Intern Med. 2022;37(1):37-47. Published online September 6, 2021
The incidence and prevalence of heart failure (HF) is increasing worldwide, leading to high morbidity and mortality. The global management of HF involves lifestyle changes in addition to pharmacological treatments. Changes include exercise and dietary recommendations, mainly salt and fluid restricti..
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Review
Current status of the diagnosis of chronic pancreatitis by ultrasonographic elastography
Kazunori Nakaoka, Senju Hashimoto, Ryoji Miyahara, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Takamichi Kuwahara, Hiroyuki Tanaka, Yoshiki Hirooka
Korean J Intern Med. 2022;37(1):27-36. Published online December 15, 2021
Chronic pancreatitis (CP) is pathologically characterized by the loss of exocrine pancreatic parenchyma, irregular fibrosis, cellular infiltration, and ductal abnormalities. Diagnosing CP objectively is difficult because standard diagnostic criteria are insufficient. The change of parenchymal hardne..
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Review
Metformin and its therapeutic applications in autoimmune inflammatory rheumatic disease
Ji-Won Kim, Jung-Yoon Choe, Sung-Hwan Park
Korean J Intern Med. 2022;37(1):13-26. Published online December 10, 2021
Metformin is a first-line therapeutic agent for type 2 diabetes. Apart from its glucose- lowering effect, metformin is attracting interest regarding possible therapeutic benefits in various other conditions. As metformin regulates cell metabolism, proliferation, growth, and autophagy, it may also mo..
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Review
Aerosolized antibiotics in the treatment of hospital-acquired pneumonia/ventilator-associated pneumonia
Yun Jung Jung, Eun Jin Kim, Young Hwa Choi
Korean J Intern Med. 2022;37(1):1-12. Published online October 21, 2021
Aerosolized antibiotics are being increasingly used to treat respiratory infections, especially those caused by drug-resistant pathogens. Their use in the treatment of hospital-acquired pneumonia and ventilator-associated pneumonia in critically ill patients is especially significant. They are also ..
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Allergy / Original Article
Current practice for diagnosing immediate drug hypersensitivity reactions in Korea
Sung-Yoon Kang, Min-Suk Yang, Woo-Jung Song, Sang-Heon Cho
Korean J Intern Med. 2021;36(Suppl 1):S283-S296. Published online January 5, 2021
Background/Aims: Skin (STs) and drug provocation (DPTs) tests are essential for identifying the culprit drugs causing drug hypersensitivity reactions (DHRs). Several protocols have been developed for the identification of some culprit drugs, but they are neither thoroughly validated nor standardized..
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Rheumatology / Original Article
Tocotrienol regulates osteoclastogenesis in rheumatoid arthritis
Kyoung-Woon Kim, Bo-Mi Kim, Ji-Yeon Won, Hong Ki Min, Seoung Joon Lee, Sang-Heon Lee, Hae-Rim Kim
Korean J Intern Med. 2021;36(Suppl 1):S273-S282. Published online June 19, 2020
Background/Aims: The present study aimed to investigate whether tocotrienol regulates interleukin 17 (IL-17)-induced osteoclastogenesis in rheumatoid arthritis (RA).
Methods: We evaluated the effect of tocotrienol on IL-17-induced receptor activator of nuclear factor kappa B ligand (RANKL) producti..
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Rheumatology / Original Article
Distribution of serum uric acid levels and prevalence of hyper- and hypouricemia in a Korean general population of 172,970
Bon San Koo, Hye-Jin Jeong, Chang-Nam Son, Sang-Hyon Kim, Hyun Jung Kim, Gheun-Ho Kim, Jae-Bum Jun
Korean J Intern Med. 2021;36(Suppl 1):S264-S272. Published online November 24, 2020
Background/Aims: We investigated the distribution of serum uric acid (SUA) levels and estimated the prevalence of hyperuricemia and hypouricemia in the Korean population.
Methods: This cross-sectional study used data from the Korean Genome and Epidemiology Study and included 172,970 participants (5..
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Infectious diseases / Original Article
Lopinavir-ritonavir versus hydroxychloroquine for viral clearance and clinical improvement in patients with mild to moderate coronavirus disease 2019
Ji-Won Kim, Eun Jin Kim, Hyun Hee Kwon, Chi Young Jung, Kyung Chan Kim, Jung-Yoon Choe, Hyo-Lim Hong
Korean J Intern Med. 2021;36(Suppl 1):S253-S263. Published online June 16, 2020
Background/Aims: The efficacies of lopinavir-ritonavir or hydroxychloroquine remain to be determined in patients with coronavirus disease 2019 (COVID-19). To compare the virological and clinical responses to lopinavir-ritonavir and hydroxychloroquine treatment in COVID-19 patients.
Methods: This re..
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Hemato-oncology / Original Article
Different roles of surveillance positron emission tomography according to the histologic subtype of non-Hodgkin’s lymphoma
Yu Ri Kim, Soo-Jeong Kim, June-Won Cheong, Yundeok Kim, Ji Eun Jang, Hyunsoo Cho, Haerim Chung, Yoo Hong Min, Woo Ick Yang, Arthur Cho, Jin Seok Kim
Korean J Intern Med. 2021;36(Suppl 1):S245-S252. Published online June 19, 2020
Background/Aims: Although the use of surveillance 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is discouraged in patients with diffuse large B-cell lymphoma, its usefulness in different subtypes has not been thoroughly investigated.
Methods: We r..
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Hemato-oncology / Original Article
Surtuin 1 as a potential prognostic biomarker in very elderly patients with colorectal cancer
Guk Jin Lee, Yun Hwa Jung, Tae-Jung Kim, Yosep Chong, Seo-Won Jeong, In Kyu Lee, In Sook Woo
Korean J Intern Med. 2021;36(Suppl 1):S235-S244. Published online July 2, 2020
Background/Aims: Colorectal cancer (CRC) rate increases with aging. Aging-related proteins, such as sirtuins (SIRTs) may be a potential therapeutic target in the elderly patients with CRC. The clinical implications of SIRT1 and SIRT2 have not been reported for elderly patients with cancer. The aim of..
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Hemato-oncology / Original Article
Physical activity of Korean cancer survivors is associated with age and sex
Jae Hyeon Park, Jung Soo Lee, Yoon Ho Ko, Yeo Hyung Kim
Korean J Intern Med. 2021;36(Suppl 1):S225-S234. Published online May 7, 2020
Background/Aims: This study aimed to assess adherence to physical activity guidelines in cancer survivors and to investigate related factors.
Methods: The cross-sectional data of 39,845 community-dwelling participants aged ≥ 20 years (1,254 cancer survivors) in the Korea National Health and Nutri..
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Hemato-oncology / Original Article
Induction chemotherapy followed by concurrent chemoradiotherapy versus CCRT for locally
advanced hypopharynx and base of tongue cancer
Sung Hee Lim, Jong-Mu Sun, Joohyun Hong, Dongryul Oh, Yong Chan Ahn, Man Ki Chung, Han-Sin Jeong, Young-Ik Son, Myung-Ju Ahn, Chung-Hwan Baek, Keunchil Park
Korean J Intern Med. 2021;36(Suppl 1):S217-S224. Published online April 3, 2020
Background/Aims: Clinical trials have not consistently supported the use of induction chemotherapy (IC) for locally advanced head and neck squamous cell cancer. Hypopharynx and base of tongue (BOT) cancer has shown relatively poor survival. We investigated the role of IC in improving outcome over c..
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Hemato-oncology / Original Article
Determination of the relationship between the fatigue and social support levels of cancer patients: a cross-sectional study
Meltem Akbas, Sule Gokyildiz Surucu, Emine Akca, Cemile Onat Koroglu
Korean J Intern Med. 2021;36(Suppl 1):S207-S216. Published online June 12, 2020
Background/Aims: Cancer is seen as one of the most important health problems of our time. In the world and in our country, the most common death cause after cardiovascular diseases in the order of diseases that result in death is cancer. This descriptive, cross-sectional study is done in order to de..
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