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Gastroenterology / Original Article
Impact of liver cirrhosis on the clinical outcomes of patients with COVID-19: a nationwide cohort study of Korea
Dongsub Jeon, Minkook Son, Jonggi Choi
Korean J Intern Med. 2021;36(5):1092-1101. Published online August 18, 2021
Background/Aims: The impact of liver cirrhosis (LC) on the clinical outcomes of patients with coronavirus disease 2019 (COVID-19) remains elusive. This study evaluated the association between LC and the development of severe complications from COVID-19.
Methods: We used the National Health Insuranc..
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Rheumatology / Original Article
Clinical features of Korean elderly patients with antineutrophil cytoplasmic antibody-associated vasculitis
Byung-Woo Yoo, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Korean J Intern Med. 2021;36(3):731-741. Published online August 20, 2020
Background/Aims: We compared the clinical and laboratory data between elderly and non-elderly patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) at diagnosis; further, we investigated the predictors at diagnosis for all-cause mortality and end-stage renal disease (E..
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Endocrinology-metabolism / Original Article
Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study
Yi-Suk Kim, Yong-Moon Park, Kyung-Do Han, Jae-Seung Yun, Yu-Bae Ahn, Seung-Hyun Ko
Korean J Intern Med. 2021;36(3):647-658. Published online July 7, 2020
Background/Aims: Although people with diabetes have been shown to have higher mortality than people without diabetes, there is a lack of data on the association between fasting plasma glucose (FPG) levels and cause-specific mortality rates in the general population.
Methods: A total of 326,547 Kore..
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Cardiology / Original Article
Different therapeutic associations of renin-angiotensin system inhibitors with coronavirus disease 2019 compared with usual pneumonia
Hae-Young Lee, Juhee Ahn, Juhong Park, Chang Kyung Kang, Sung-Ho Won, Dong Wook Kim, Jong-Heon Park, Ki-Hyun Chung, Joon-Sung Joh, JI Hwan Bang, Cheong Hee Kang, Myoung-don Oh, Wook Bum Pyun; The Korean Society of Hypertension; The National Committee for Clinical Management of Emerging Infectious Diseases
Korean J Intern Med. 2021;36(3):617-628. Published online April 16, 2021
Background/Aims: Although it is near concluded that renin-angiotensin system inhibitors do not have a harmful effect on coronavirus disease 2019 (COVID-19), there is no report about whether angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) offer any protective..
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Gastroenterology / Original Article
Effect of Helicobacter pylori treatment on the long-term mortality in patients with type 2 diabetes
Young-Il Kim, Young Ae Kim, Hak Jin Kim, Su-Hyun Kim, Yul Hwangbo, Jae Gyu Kim, Jae J. Kim, Il Ju Choi
Korean J Intern Med. 2021;36(3):584-595. Published online November 25, 2020
Background/Aims: Meta-analyses of randomized trials reported a non-significant increase in overall mortality risk after Helicobacter pylori eradication. In this study, we investigated whether H. pylori treatment is associated with increased risk of overall mortality in patients with ty..
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Infectious diseases / Original Article
Comparison of antimicrobial resistances and clinical features in community-onset Escherichia coli and Klebsiella pneumoniae bacteremia
Hwa Seok Sung, Je Won Lee, Sohyun Bae, Ki Tae Kwon
Korean J Intern Med. 2021;36(2):433-440. Published online March 31, 2020
Background/Aims: The aim of this study was to compare antimicrobial resistance, clinical features, and outcomes of community-onset Escherichia coli (COEC) and Klebsiella pneumoniae (COKP) bacteremia.
Methods: The medical records of patients diagnosed with E. coli or K. pneum..
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Nephrology / Original Article
Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapy
Yohan Park, Tae Hyun Ban, Hyung Duk Kim, Eun Jeong Ko, Jongmin Lee, Seok Chan Kim, Cheol Whee Park, Chul Woo Yang, Yong-Soo Kim, Byung Ha Chung
Korean J Intern Med. 2021;36(2):392-400. Published online July 7, 2020
Background/Aims: We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) can predict mortality in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT).
Methods: This study enrolled 169 patients who underwent serum NGAL testing at CRRT..
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Pulmonology / Original Article
Effect of angiotensin converting enzyme inhibitor and angiotensin II receptor blocker on the patients with sepsis
Hyun Woo Lee, Jae Kyung Suh, Eunjin Jang, Sang-Min Lee
Korean J Intern Med. 2021;36(2):371-381. Published online April 9, 2020
Background/Aims: Inhibitors of the renin-angiotensin system, angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs), reportedly have anti-inflammatory effects. This study assessed the association of prior use of ACE inhibitors and ARBs with sepsis-related clinical..
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Pulmonology / Original Article
Effect of corticosteroid therapy in the early phase of acute respiratory distress syndrome: a propensity-matched cohort study
Moon Seong Baek, Yunkyoung Lee, Sang-Bum Hong, Chae-Man Lim, Younsuck Koh, Jin Won Huh
Korean J Intern Med. 2021;36(1):145-153. Published online March 5, 2020
Background/Aims: It is unclear whether corticosteroid use in patients with acute respiratory distress syndrome (ARDS) improves survival. This study aimed to investigate whether the administration of corticosteroids to patients in the early phase of moderate to severe ARDS is associated with improved..
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Original Article / Brief Communication
Clinical implication and risk factor of pneumonia development in mild coronavirus disease 2019 patients
Hyun Woo Lee, Seo-Young Yoon, Jung-Kyu Lee, Tae Yeon Park, Deog Kyeom Kim, Hee Soon Chung, Eun Young Heo
Korean J Intern Med. 2021;36(1):1-10. Published online December 1, 2020
Background/Aims: Although a majority of coronavirus disease 2019 (COVID-19) cases were characterized as mild, data assessing the development of pneumonia in mild COVID-19 patients are limited. We aimed to examine the effect of pneumonia development on the clinical course of mild COVID-19 in hospital..
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Pulmonology / Original Article
A population-based observational study of patients with pulmonary disorders in intensive care unit
Hyun Woo Lee, Eunjeong Ji, Soyeon Ahn, Hye-Joo Yang, Seo-Young Yoon, Tae Yeon Park, Yeon Joo Lee, Jinwoo Lee, Sang-Min Lee, Seung-Hye Choi, Young-Jae Cho
Korean J Intern Med. 2020;35(6):1411-1423. Published online November 25, 2019
Background/Aims: Only a few epidemiologic studies on the patients with pulmonary disorders admitted to intensive care unit exist. We investigated the characteristics and clinical outcomes of the patients with severe pulmonary disorders.
Methods: The sample cohort database of National Health Insuran..
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Cardiology / Original Article
J-curve relationship between corrected QT interval and mortality in acute heart failure patients
Chan Soon Park, Hyun-Jai Cho, Eue-Keun Choi, Sang Eun Lee, Min-Seok Kim, Jae-Joong Kim, Jin-Oh Choi, Eun-Seok Jeon, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Byungsu Yoo, Dong-Ju Choi, Youngkeun Ahn, Kye-Hoon Kim, Myeong-Chan Cho, Byung-Hee Oh, Hae-Young Lee
Korean J Intern Med. 2020;35(6):1371-1384. Published online May 8, 2020
Background/Aims: This study investigated the prognostic power of corrected QT (QTc) interval in patients with acute heart failure (AHF) according to sex.
Methods: We analyzed multicenter Korean Acute Heart Failure registry with patients with AHF admitted from 2011 to 2014. Among them, we analyzed 4..
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Original Article / Brief Communication
Clinical characteristics of coronavirus disease 2019 patients with diarrhea in Daegu
Min Kyu Kang, Kyeong Ok Kim, Min Cheol Kim, Joon Hyun Cho, Sung Bum Kim, Jung Gil Park, Kook Hyun Kim, See Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
Korean J Intern Med. 2020;35(6):1261-1269. Published online September 23, 2020
Background/Aims: Coronavirus disease 2019 (COVID-19) can reportedly cause gastrointestinal symptoms. Therefore, we investigated the clinical characteristics of COVID-19 patients with diarrhea.
Methods: We included 118 COVID-19 patients admitted to a single hospital from February 20 to March 31, 202..
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Pulmonology / Original Article
Performance of pneumococcal urinary antigen test in patients with community-onset pneumonia: a propensity score-matching study
Jonghoo Lee, Jae-Uk Song
Korean J Intern Med. 2020;35(3):630-640. Published online February 24, 2020
Background/Aims: Although pneumococcal urinary antigen tests (PUATs) have universally been used for the diagnosis of pneumococcal pneumonia, data on the efficacy of these exams are limited. The objective of our study was to investigate the clinical impact of the PUAT in patients with community-onset..
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Infectious diseases / Original Article
Clinical impact of healthcare-associated acquisition in cirrhotic patients with community-onset spontaneous bacterial peritonitis
Jungok Kim, Cheol-In Kang, Geum-Youn Gwak, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song
Korean J Intern Med. 2020;35(1):215-221. Published online March 5, 2018
Background/Aims: Healthcare-associated (HCA) infection is a recently suggested new category of community-onset infections. The implications of HCA infections in terms of diagnosis, treatment, and outcomes of spontaneous bacterial peritonitis (SBP) are not well understood. We sought to delineate the ..
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Nephrology / Original Article
Low parathyroid hormone level predicts infection-related mortality in incident dialysis patients: a prospective cohort study
Yu Ah Hong, Jeong Ho Kim, Yong Kyun Kim, Yoon Kyung Chang, Cheol Whee Park, Suk Young Kim, Yon Su Kim, Shin-Wook Kang, Nam-Ho Kim, Yong-Lim Kim, Chul Woo Yang
Korean J Intern Med. 2020;35(1):160-170. Published online October 28, 2019
Background/Aims: Parathyroid hormone (PTH) is an important factor influencing immunologic dysfunction, but the effect of PTH level on infection-related outcomes remains unclear in incident dialysis.
Methods: We evaluated a multicenter prospective cohort study of 1,771 incident dialysis patients (1,..
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Gastroenterology / Original Article
Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis
Jae Gon Lee, Joo Hyun Sohn, Jae Yoon Jeong, Tae Yeob Kim, Sun Min Kim, Young Seo Cho, Yongsoo Kim
Korean J Intern Med. 2020;35(1):88-98. Published online February 25, 2019
Background/Aims: Both hepatic venous pressure gradient (HVPG) and liver stiffness (LS) are useful tools for predicting mortality in patients with cirrhosis. We investigated the combined effect of HVPG and LS on long-term mortality in patients with cirrhosis.
Methods: We retrospectively collected da..
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Infectious diseases / Original Article
Reevaluation of the impact of methicillin-resistance on outcomes in patients with Staphylococcus aureus bacteremia and endocarditis
Eun-Jeong Joo, Dong Ah Park, Cheol-In Kang, Doo Ryeon Chung, Jae-Hoon Song, Sang Moo Lee, Kyong Ran Peck
Korean J Intern Med. 2019;34(6):1347-1362. Published online January 20, 2018
Background/Aims: Methicillin-resistant Staphylococcus aureus (MRSA) is highly prevalent in hospitals, and has recently emerged in the community. The impact of methicillin-resistance on mortality and medical costs for patients with S. aureus bacteremia (SAB) requires reevaluation.
Meth..
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Pulmonology / Original Article
Mortality of patients with chronic obstructive pulmonary disease: a nationwide populationbased cohort study
Seon Cheol Park, Dong Wook Kim, Eun Cheol Park, Cheung Soo Shin, Chin Kook Rhee, Young Ae Kang, Young Sam Kim
Korean J Intern Med. 2019;34(6):1272-1278. Published online October 16, 2019
Background/Aims: Chronic obstructive pulmonary disease (COPD) is a major cause of mortality in the world. There are no population-based studies on longterm mortality in COPD patients in Korea.
Methods: Using the large, population-based, National Health Insurance Service- National Sample Cohort (NHI..
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Nephrology / Original Article
Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease
Seon Ha Baek, Ran-hui Cha, Shin Wook Kang, Cheol Whee Park, Dae Ryong Cha, Sung Gyun Kim, Sun Ae Yoon, Sejoong Kim, Sang-Youb Han, Jung Hwan Park, Jae Hyun Chang, Chun Soo Lim, Yon Su Kim, Ki Young Na
Korean J Intern Med. 2019;34(4):858-866. Published online November 29, 2017
Background/Aims: Patients with chronic kidney disease (CKD) have been found to show markedly increased rates of end-stage renal disease, major adverse cardiovascular and cerebrovascular events (MACCEs), and mortality. Therefore, new biomarkers are required for the early detection of such clinical ou..
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