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Cardiology / Original Article
A prospective survey of the persistence of warfarin or NOAC in nonvalvular atrial fibrillation: a COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation (CODE-AF)
Hyeongsoo Kim, Young Soo Lee, Tae-Hoon Kim, Myung-Jin Cha, Jung Myung Lee, Junbeom Park, Jin-Kyu Park, Ki-Woon Kang, Jaemin Shim, Jae-Sun Uhm, Hyung Wook Park, Eue-Keun Choi, Jin-Bae Kim, Changsoo Kim, Jun Kim, Boyoung Joung
Korean J Intern Med. 2020;35(1):99-108. Published online April 25, 2019
Background/Aims: Efforts to reduce stroke in patients with atrial fibrillation (AF) have focused on increasing physician adherence to oral anticoagulant (OAC) guidelines; however, the high early discontinuation rate of vitamin K antagonists (VKAs) is a limitation. Although non-VKA OACs (NOACs) are m..
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Gastroenterology / Original Article
Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis
Jae Gon Lee, Joo Hyun Sohn, Jae Yoon Jeong, Tae Yeob Kim, Sun Min Kim, Young Seo Cho, Yongsoo Kim
Korean J Intern Med. 2020;35(1):88-98. Published online February 25, 2019
Background/Aims: Both hepatic venous pressure gradient (HVPG) and liver stiffness (LS) are useful tools for predicting mortality in patients with cirrhosis. We investigated the combined effect of HVPG and LS on long-term mortality in patients with cirrhosis.
Methods: We retrospectively collected da..
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Gastroenterology / Original Article
Association between clinical risk factors and severity of dysphagia after extubation based on a videofluoroscopic swallowing study
Won-Jong Yang, Eunhee Park, Yu-Sun Min, Jae-Won Huh, Ae Ryoung Kim, Hyun-Min Oh, Tae-Woo Nam, Tae-Du Jung
Korean J Intern Med. 2020;35(1):79-87. Published online January 2, 2020
Background/Aims: This study aimed to evaluate the correlation between clinical risk factors of post-extubation dysphagia (PED) and the severity of impaired pharyngeal swallowing function assessed via videofluoroscopic swallowing studies (VFSSs).
Methods: This study was a retrospective review of med..
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Review
Recent insights regarding the molecular basis of myeloproliferative neoplasms
Mi-Ae Jang, Chul Won Choi
Korean J Intern Med. 2020;35(1):1-11. Published online November 29, 2019
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal disorders characterized by the overproduction of mature blood cells that have an increased risk of thrombosis and progression to acute myeloid leukemia. Next-generation sequencing studies have provided key insights regarding the..
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Rheumatology / Original Article
Standardized, musculoskeletal ultrasonographic reference values for healthy Korean adults
Hyun-Sook Kim, Hae-Rim Kim, Bo Young Kim, Yun Sung Kim, Young Ok Jung, Sung Jae Choi, Hyun-Ok Kim, Jiwon Hwang, Sunggun Lee, Hyoun-Ah Kim, So Young Bang, Ji-Young Chai, Sung-Hoon Park, Chong-Hyeon Yoon
Korean J Intern Med. 2019;34(6):1372-1380. Published online May 4, 2018
Background/Aims: To define standard reference values for musculoskeletal ultrasonography (MSUS) in Korea.
Methods: A total of 251 healthy adults were recruited for this study. Ultrasonography was performed by experienced rheumatologists who had undergone four appropriate training programs in Korea..
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Hemato-oncology / Original Article
The prognostic factors influencing overall survival in uterine cervical cancer with brain metastasis
Hyera Kim, Kang Kook Lee, Mi Hwa Heo, Jin Young Kim
Korean J Intern Med. 2019;34(6):1324-1332. Published online October 26, 2018
Background/Aims: The occurrence of brain metastasis (BM) has increased due to improved overall survival (OS) in uterine cervical cancer. However, research about prognostic factors and therapeutic guidelines for BM in uterine cervical cancer remains scarce due to the rarity of BM in this type of canc..
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Hemato-oncology / Original Article
Poor prognostic factors in human papillomavirus-positive head and neck cancer: who might not be candidates for de-escalation treatment?
Shin Hye Yoo, Chan-Young Ock, Bhumsuk Keam, Sung Joon Park, Tae Min Kim, Jin Ho Kim, Yoon Kyung Jeon, Eun-Jae Chung, Seong Keun Kwon, J. Hun Hah, Tack-Kyun Kwon, Kyeong Chun Jung, Dong-Wan Kim, Hong-Gyun Wu, Myung-Whun Sung, Dae Seog Heo
Korean J Intern Med. 2019;34(6):1313-1323. Published online November 16, 2018
Background/Aims: Since patients with human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have favorable outcomes after treatment, treatment de-escalation for these patients is being actively investigated. However, not all HPV-positive HNSCCs are curable, and some pati..
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Pulmonology / Original Article
Effect of lutein on methotrexate-induced oxidative lung damage in rats: a biochemical and histopathological assessment
Renad Mammadov, Bahadir Suleyman, Selcuk Akturan, Ferda Keskin Cimen, Nezahat Kurt, Zeynep Suleyman, İsmail Malkoc
Korean J Intern Med. 2019;34(6):1279-1286. Published online September 10, 2019
Background/Aims: This study aimed to investigate the effect of lutein on methotrexate (MTX)-induced pulmonary toxicity in rats biochemically and histopathologically.
Methods: The rats in the MTX + lutein (MTXL, n = 6) group were given 1 mg/kg of lutein orally. A 0.9% NaCl solution was administered ..
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Gastroenterology / Original Article
Liver volume index predicts the risk of esophageal variceal hemorrhage in cirrhotic patients on propranolol prophylaxis
Beom Hee Kim, Jung Wha Chung, Chung Seop Lee, Eun Sun Jang, Sook-Hyang Jeong, Nayoung Kim, Jin-Wook Kim
Korean J Intern Med. 2019;34(6):1233-1243. Published online February 18, 2019
Background/Aims: Non-selective β-blockers (NSBBs) are used for primary prevention of esophageal variceal hemorrhage (VH) in patients with portal hypertension, but a significant number of patients develop VH while on NSBB therapy. In this study, we sought to determine whether liver volume can predi..
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Gastroenterology / Original Article
Clinical outcomes of patients with a single hepatocellular carcinoma less than 5 cm treated with transarterial chemoembolization
Min Young Baek, Jeong-Ju Yoo, Soung Won Jeong, Jae Young Jang, Yong Kwon Kim, Shin Ok Jeong, Sae Hwan Lee, Sang Gyune Kim, Sang-Woo Cha, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Boo Sung Kim, Yong Jae Kim, Su Yeon Park
Korean J Intern Med. 2019;34(6):1223-1232. Published online October 26, 2018
Background/Aims: Transarterial chemoembolization (TACE) is performed for single hepatocellular carcinoma (HCC) that are not eligible for surgery or ablation therapy. We investigated the clinical outcomes of patients with a single HCC ≤ 5 cm treated with TACE.
Methods: This study analyzed 175 conse..
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Gastroenterology / Original Article
Quality of information on the Internet for Korean patients with inflammatory bowel disease
Jun Sik Yoon, Sang Jik Lee, Eun Soo Kim, Sung Kook Kim, Min Kyu Jung, Hyun Seok Lee, Yong Hwan Kwon, Su Youn Nam, Seong Woo Jeon, Sun Jin, Joon Seop Lee, Seong Jae Yeo
Korean J Intern Med. 2019;34(6):1215-1222. Published online October 1, 2018
Background/Aims: The Internet is the main resource for health-related information. The incidence of inflammatory bowel disease (IBD) is rapidly increasing in Asian countries. However, the quality of websites for IBD available in this region has not been evaluated. We aimed to evaluate the quality of the..
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Review
Rheumatic complications in cancer patients treated with immune checkpoint inhibitors
Kyung-Ann Lee, Hae-Rim Kim, So Young Yoon
Korean J Intern Med. 2019;34(6):1197-1209. Published online April 25, 2019
Immune checkpoint inhibitors (ICIs) have revolutionized anticancer therapy due to their long-term clinical benefits and immune boosting mechanisms. However, despite their consistent therapeutic effects, the use of ICIs is associated with a spectrum of adverse events due to their autoimmune and auto-..
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Review
Achalasia: treatment, current status and future advances
Lee L. Swanström
Korean J Intern Med. 2019;34(6):1173-1180. Published online March 15, 2019
Achalasia was first described in the 17th century and its treatment continues to be challenging. Palliative treatment involves disruption of the lower esophageal sphincter, which can be accomplished mechanically (balloon dilation or surgical myotomy) or chemically (Botox). True surgical treatment or..
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Rheumatology / Original Article
Treatment patterns of knee osteoarthritis patients in Korea
Ha-Rim Park, Soo-Kyung Cho, Seul Gi Im, Sun-Young Jung, Dalho Kim, Eun Jin Jang, Yoon-Kyoung Sung
Korean J Intern Med. 2019;34(5):1145-1153. Published online March 21, 2018
Background/Aims: To evaluate the treatment patterns of knee osteoarthritis (OA) patients in South Korea.
Methods: Using the Korean nationwide claims database, all knee OA patients in Korea during 2014 were identified by the knee OA diagnostic code (M17) or any OA diagnostic code (M15 to M19) in com..
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Hemato-oncology / Original Article
Long-term rivaroxaban for the treatment of acute venous thromboembolism in patients with active cancer in a prospective multicenter trial
Ho-Young Yhim, Won-Il Choi, Sung-Hyun Kim, Seung-Hyun Nam, Kyoung Ha Kim, Yeung-Chul Mun, Doyeun Oh, Hun-Gyu Hwang, Keun-Wook Lee, Eun-Kee Song, Yong Shik Kwon, Soo-Mee Bang
Korean J Intern Med. 2019;34(5):1125-1135. Published online May 23, 2018
Background/Aims: Limited data are available regarding the efficacy of rivaroxaban for the treatment of cancer-associated venous thromboembolism (VTE). The aim of this study was to evaluate the effectiveness and safety of rivaroxaban for the treatment of VTE in active cancer patients.
Methods: In th..
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Hemato-oncology / Original Article
Clinical activity of fulvestrant in metastatic breast cancer previously treated with endocrine therapy and/or chemotherapy
Mi Hwa Heo, Hee Kyung Kim, Hansang Lee, Ji-Yeon Kim, Jin-Seok Ahn, Young-Hyuck Im, Yeon Hee Park
Korean J Intern Med. 2019;34(5):1100-1106. Published online March 16, 2018
Background/Aims: We conducted a retrospective analysis of the clinical activity of fulvestrant in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC) previously treated with endocrine therapy and/or chemotherapy..
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Nephrology / Original Article
Clinical outcomes and effects of treatment in older patients with idiopathic membranous nephropathy
Yaeni Kim, Hye Eun Yoon, Byung Ha Chung, Bum Soon Choi, Cheol Whee Park, Chul Woo Yang, Yong-Soo Kim, Yu Ah Hong, Suk Young Kim, Yoon-Kyung Chang, Hyeon Seok Hwang
Korean J Intern Med. 2019;34(5):1091-1099. Published online August 14, 2019
Background/Aims: Membranous nephropathy (MN) is the most common primary glomerular disease diagnosed in older patients. Few reports describe the clinical outcomes in older patients with idiopathic MN.
Methods: The outcomes of 135 patients with histologically proven MN were analyzed. ‘Older’ was ..
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Nephrology / Original Article
Shen-Kang protects against tacrolimus-induced renal injury
Long Ye Zhang, Jian Jin, Kang Luo, Shang Guo Piao, Hai Lan Zheng, Ji Zhe Jin, Sun Woo Lim, Bum Soon Choi, Chul Woo Yang, Can Li
Korean J Intern Med. 2019;34(5):1078-1090. Published online February 12, 2018
Background/Aims: Evidence suggests that Shen-Kang (SK), a traditional Chinese herbal medicine, protects against various types of renal injury. In this study, we evaluated whether SK treatment confers renoprotection in a rat model of chronic tacrolimus (TAC) nephropathy.
Methods: Rats were treated d..
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Cardiology / Original Article
The mortality benefit of carvedilol versus bisoprolol in patients with heart failure with reduced ejection fraction
Ki Hong Choi, Ga Yeon Lee, Jin-Oh Choi, Eun-Seok Jeon, Hae-Young Lee, Sang Eun Lee, Jae-Joong Kim, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Myeong-Chan Cho, Hyun-Young Park, Byung-Hee Oh
Korean J Intern Med. 2019;34(5):1030-1039. Published online October 16, 2018
Background/Aims: It is unknown whether different β-blockers (BBs) have variable effects on long-term survival of patients with heart failure with reduced ejection fraction (HFrEF). This study compares the effects of two BBs, carvedilol and bisoprolol, on survival in patients with HFrEF.
Methods: ..
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Gastroenterology / Original Article
Clarithromycin resistance and female gender affect Helicobacter pylori eradication failure in chronic gastritis
Young Woon Chang, Weon Jin Ko, Chi Hyuk Oh, Yoo Min Park, Shin Ju Oh, Jung Rock Moon, Jun-Hyung Cho, Jung-Wook Kim, Jae-Young Jang
Korean J Intern Med. 2019;34(5):1022-1029. Published online June 14, 2018
Background/Aims: The eradication rate of the first-line triple therapy (a proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has gradually decreased in Korea. We evaluated whether clinical parameters, clarithromycin resistance, and CYP2C19 genotype can affect t..
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