|
Nephrology
Kidney replacement therapy trends in end-stage kidney disease patients in South Korea during the COVID-19 pandemic
Ah-Young Kim, Min-Jeong Lee, Heejung Choi, Hankil Lee, Inwhee Park
Korean J Intern Med. 2024;39(6):967-978. Published online October 24, 2024
Background/Aims: The corona virus disease 2019 posed a major risk for end-stage kidney disease (ESKD) cases. Our study aimed to assess changes in kidney replacement therapy (KRT) trends and healthcare access for these patients during the pandemic.
Methods: We retrospectively analyzed nationwide dat..
|
|
|
Kidney transplantation in the elderly
Byung Hwa Park, Song Yi Kil, Ye Na Kim, Ho Sik Shin, Yeonsoon Jung, Hark Rim
Korean J Intern Med. 2024;39(6):875-881. Published online October 24, 2024
Interest in kidney transplant studies in the elderly population is increasing as more research has been conducted on the immune system. With this review, we hope to encourage the need for research on kidney transplantation in the elderly.
|
|
|
Gastroenterology
Perception of fecal microbiota transplantation in patients with ulcerative colitis in Korea: a KASID multicenter study
Jebyung Park, Sung Noh Hong, Hong Sub Lee, Jongbeom Shin, Eun Hye Oh, Kwangwoo Nam, Gyeol Seong, Hyun Gun Kim, Jin-Oh Kim, Seong Ran Jeon; The Small Intestine Research Group and the Microbiome Research Group of the Korean Association for the Study of Intestinal Diseases (KASID)
Korean J Intern Med. 2024;39(5):783-792. Published online August 30, 2024
Background/Aims: Fecal microbiota transplantation (FMT) is a promising therapy for inducing and maintaining remission in patients with ulcerative colitis (UC). However, FMT has not been approved for UC treatment in Korea. Our study aimed to investigate patient perceptions of FMT under the national m..
|
|
|
Diagnostic and therapeutic advances in adults with acute lymphoblastic leukemia in the era of gene analysis and targeted immunotherapy
Jae-Ho Yoon, Seok Lee
Korean J Intern Med. 2024;39(1):34-56. Published online January 1, 2024
Acute lymphoblastic leukemia (ALL) is one of the most rapidly changing hematological malignancies with advanced understanding of the genetic landscape, detection methods of minimal residual disease (MRD), and the development of immunotherapeutic agents with good clinical outcomes. The annual inciden..
|
|
|
Advanced heart failure: a contemporary approach
Kyeong-Hyeon Chun, Seok-Min Kang
Korean J Intern Med. 2023;38(4):471-483. Published online June 28, 2023
Advanced heart failure (HF) is defined as the persistence of severe symptoms despite the use of optimized medical, surgical, and device therapies. These patients require timely advanced treatments, such as heart transplantation or long-term mechanical circulatory support (MCS). Inotropic agents are ..
|
|
|
Gastroenterology
Recognition and attitudes of Korean physicians toward fecal microbiota transplantation: a survey study
Tae-Geun Gweon, Yoo Jin Lee, Sung Kyun Yim, Seung Yong Kim, Chang Hwan Choi, Young-Seok Cho; on behalf of the Microbiome Research Group of the Korean Society for Neurogastroenterology and Motility
Korean J Intern Med. 2023;38(1):48-55. Published online November 10, 2022
Background/Aims: Fecal microbiota transplantation (FMT) represents a treatment option for recurrent Clostridioides difficile infection (CDI). Recently, FMT has been investigated in various clinical settings other than CDI. This study examined Korean physicians’ recognition of FMT and their attitude..
|
|
|
Nephrology
Therapeutic effect of multiple functional minicircle vector encoding anti-CD25/IL-10/CXCR3 in allograft rejection model
Sun Woo Lim, Yoo Jin Shin, Sheng Cui, Eun Jeong Ko, Seok Ho Yoo, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2022;37(5):1031-1049. Published online June 21, 2022
Background/Aims: We previously proposed minicircle vector technology as the potential platform for the development and production of new biologics. In this study, we have designed a novel target molecule for the treatment of allograft rejection and evaluated its feasibility as the therapeutic agent ..
|
|
|
Omics-based biomarkers for diagnosis and prediction of kidney allograft rejection
Jeong-Hoon Lim, Byung Ha Chung, Sang-Ho Lee, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Yong-Lim Kim, Chan-Duck Kim
Korean J Intern Med. 2022;37(3):520-533. Published online April 15, 2022
Kidney transplantation is the preferred treatment for patients with end-stage kidney disease, because it prolongs survival and improves quality of life. Allograft biopsy is the gold standard for diagnosing allograft rejection. However, it is invasive and reactive, and continuous monitoring is unreal..
|
|
|
Hemato-oncology
Influence of creatinine levels on survival in patients with veno-occlusive disease treated with defibrotide
Seom Gim Kong, Je-Hwan Lee, Young Tak Lim, Ji Hyun Lee, Hyeon-Seok Eom, Hyewon Lee, Do Young Kim, Sung-Nam Lim, Sung-Soo Yoon, Sung-Yong Kim, Ho Sup Lee
Korean J Intern Med. 2022;37(1):179-189. Published online December 14, 2021
Background/Aims: Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is one of the most fatal complications of hematopoietic cell transplantation (HCT), and defibrotide is the only curative drug. We conducted this study to confirm the survival rate of VOD/SOS patients diagnosed in Korea..
|
|
|
Pediatric-inspired regimen with late intensification and increased dose of L-asparaginase for adult acute lymphoblastic leukemia: the KALLA 1406/1407 study
Dong Won Baek, Dae Young Kim, Sang Kyun Sohn, Youngil Koh, Sung-Hoon Jung, Ho-Young Yhim, Yunsuk Choi, Joon Ho Moon
Korean J Intern Med. 2021;36(6):1471-1485. Published online September 24, 2021
Background/Aims: The objective of this study was to evaluate the efficacy and feasibility of the pediatric-inspired regimen of the adult acute lymphoblastic leukemia (ALL) Working Party, the Korean Society of Hematology.
Methods: Data of 99 patients with newly diagnosed ALL, who were treated with t..
|
|
|
Hepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic cell transplantation: historical and current considerations in Korea
Jae-Ho Yoon, Chul Won Choi, Jong-Ho Won
Korean J Intern Med. 2021;36(6):1261-1280. Published online September 24, 2021
Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a rare but severe complication of hematopoietic cell transplantation (HCT) showing high mortality. Multiple risk factors for SOS/VOD were identified, but it is often confused with other hepatic complications due to nonspecif..
|
|
|
Nephrology
Usefulness of BK virus-specific interferon-γ enzyme-linked immunospot assay for predicting the outcome of BK virus infection in kidney transplant recipients
Hyunjoo Bae, Do Hyun Na, Ji-Yeun Chang, Ki Hyun Park, Ji Won Min, Eun Jeong Ko, Hyeyoung Lee, Chul Woo Yang, Byung Ha Chung, Eun-Jee Oh
Korean J Intern Med. 2021;36(1):164-174. Published online April 3, 2020
Background/Aims: To investigate if BK virus (BKV)-specific T cell immunity measured by an interferon-γ enzyme-linked immunospot (ELISPOT) assay can predict the outcome of BK virus infection in kidney transplant recipients (KTRs). Methods: We included 68 KTRs with different viremia status (no virem..
|
|
|
Characteristics of kidney transplantation recipients over time in South Korea
Sehoon Park, Myoungsuk Kim, Ji Eun Kim, Kwangsoo Kim, Minsu Park, Yong Chul Kim, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
Korean J Intern Med. 2020;35(6):1457-1467. Published online March 30, 2020
Background/Aims: Detailed nationwide information regarding the recent status and time trends of kidney transplantation (KT) in South Korea is limited.
Methods: We performed a nationwide, population-based cohort study using the national claims database of Korea. We included KT recipients from 2008 t..
|
|
|
Gastroenterology
Effect of calcineurin inhibitor on post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with liver transplantation: a propensity-matched cohort study
Hyoung-Chul Oh, Jeffrey J. Easler, Ihab I. El Hajj, James Watkins, Evan L. Fogel, Lee McHenry, Stuart Sherman, Hyun Kang, Glen A. Lehman
Korean J Intern Med. 2020;35(6):1364-1370. Published online February 19, 2020
Background/Aims: A calcineurin inhibitor may alter pancreatic function and inflammatory reaction. This study aimed to determine the possible pharmacologic effect of the calcineurin inhibitor, tacrolimus, on pancreatic function, and to determine its preventive effect on post-endoscopic retrograde cho..
|
|
|
Hemato-oncology
Strong association between herpes simplex virus-1 and chemotherapy-induced oral mucositis in patients with hematologic malignancies
Junshik Hong, Hee-Kyung Park, Suhyun Park, Ahreum Lee, Yeon-Hee Lee, Dong-Yeop Shin, Youngil Koh, Ji-Yeob Choi, Sung-Soo Yoon, Youngnim Choi, Inho Kim
Korean J Intern Med. 2020;35(5):1188-1198. Published online September 9, 2019
Background/Aims: A link between oral cavity infections and chemotherapy-induced oral mucositis (CIOM) in patients with hematological malignancies (HMs) undergoing intensive chemotherapy (IC) or hematopoietic stem cell transplantation (HSCT) has been suggested. However, conclusive data are lacking, a..
|
|
|
Is immunological recovery clinically relevant at 100 days after allogeneic transplantation?
Jin Park, Sung Hee Lim, Se Hyung Kim, Jina Yun, Chan Kyu Kim, Sang Cheol Lee, Jong Ho Won, Dae Sik Hong, Seong Kyu Park
Korean J Intern Med. 2020;35(4):957-969. Published online April 21, 2020
Background/Aims: Immune reconstitution following allogeneic hematopoietic stem cell transplantation (HSCT) is affected by multiple variables during the transplantation.
Methods: We assessed the clinical factors contributing to immune function reconstitution at 100 days post-allogeneic HSCT in 114 p..
|
|
|
Cardiology
Clinical significance of postoperative atrial arrhythmias in patients who underwent lung transplantation
Byung Gyu Kim, Jae-Sun Uhm, Pil-Sung Yang, Hee Tae Yu, Tae-Hoon Kim, Boyoung Joung, Hui-Nam Pak, Song Yee Kim, Moo Suk Park, Jin Gu Lee, Hyo Chae Paik, Moon-Hyoung Lee
Korean J Intern Med. 2020;35(4):897-905. Published online November 25, 2019
Background/Aims: Atrial arrhythmia (AA) occasionally occurs after lung transplantation (LT); however, risk factors for AA and their impact on clinical outcomes are inconsistent. We aimed to investigate the incidence, predisposing factors, and clinical outcomes of AA after LT.
Methods: We retrospect..
|
|
|
Infectious diseases
Diagnostic usefulness of the cytomegalovirus (CMV)-specific T cell-based assay for predicting CMV infection after kidney transplant
Taeeun Kim, Hyun-Jeong Lee, Sun-Mi Kim, Joo Hee Jung, Sung Shin, Young-Hoon Kim, Heungsup Sung, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim, Duck Jong Han
Korean J Intern Med. 2020;35(2):438-448. Published online June 7, 2018
Background/Aims: We evaluated the usefulness in kidney transplant (KT) candidates of cytomegalovirus (CMV)-specific enzyme-linked immunospot (ELISPOT) assays for predicting the development of post-transplant CMV infections.
Methods: All adult recipients admitted for living-donor KT between March 20..
|
|
|
Hemato-oncology
Clinical impact of anti-thymocyte globulin on survival and graft-versus-host disease in patients undergoing human leukocyte antigen mismatched allogeneic stem cell transplantation
Taeyun Kim, Yunsuk Choi, Je-Hwan Lee, Silvia Park, Jae-Sook Ahn, Joon-Ho Moon, Ho-Jin Shin, Won Sik Lee, Dajung Kim, Ho Sup Lee
Korean J Intern Med. 2020;35(2):429-437. Published online January 10, 2019
Background/Aims: Rabbit anti-thymocyte globulin (ATG) is usually incorporated in hematopoietic stem cell transplantation (HSCT) to reduce the incidence of graft-versus-host disease (GVHD). This study aimed to find optimal ATG doses in patients undergoing human leukocyte antigen (HLA)-mismatched allo..
|
|
|
Gastroenterology
Time-dependent reversal of significant intrapulmonary shunt after liver transplantation
Xin Jin, Byung Joo Sun, Jae-Kwan Song, Jae-Hyung Roh, Jeong Yoon Jang, Dae-Hee Kim, Young-Suk Lim, Jong-Min Song, Duk-Hyun Kang, Sung Gyu Lee
Korean J Intern Med. 2019;34(3):510-518. Published online March 5, 2018
Background/Aims: Although the association between intrapulmonary shunt (IPS) and liver cirrhosis is clear, data of repeated contrast echocardiography (CE) before and after liver transplantation (LT) to evaluate factors associated with IPS are limited.
Methods: Hand-agitated saline was used for CE a..
|
|
|
