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Pulmonology / Original Article
Fatty liver index and development of lung cancer: a nationwide cohort study
Jihye Lim, Bongseong Kim, Kyungdo Han, Jeong Uk Lim
Korean J Intern Med. 2025;40(2):275-285. Published online October 22, 2024
Background/Aims: This study aimed to evaluate the impact of steatotic liver disease severity on the cumulative incidence of lung cancer utilizing data from the Korea National Health Insurance Service (NHIS).
Methods: This study examined the risk of lung cancer in the general population in conjuncti..
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Endocrinology-metabolism / Original Article
Fisher discriminant analysis of multimodal ultrasound in diagnosis of cervical metastatic lymph nodes in papillary thyroid cancer
Yixuan Wang, Yue Han, Fei Li, Yuyang Lin, Bei Wang
Korean J Intern Med. 2025;40(1):103-114. Published online October 29, 2024
Background/Aims: The purpose of this study was to develop a diagnostic model utilizing multimodal ultrasound parameters to aid in the detection of cervical lymph node metastasis in papillary thyroid cancer (PTC) patients.
Methods: The study included 84 suspicious lymph nodes from 69 PTC patients, a..
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Pulmonology / Original Article
Short-term and long-term outcomes of critically ill patients with solid malignancy: a retrospective cohort study
Su Yeon Lee, Jin Won Huh, Sang-Bum Hong, Chae-Man Lim, Jee Hwan Ahn
Korean J Intern Med. 2024;39(6):957-966. Published online October 22, 2024
Background/Aims: With the global increase in patients with solid malignancies, it is helpful to understand the outcomes of intensive care unit (ICU) admission for these patients. This study evaluated the risk factors for ICU mortality and the shortand long-term outcomes in patients with solid malign..
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Endocrinology-metabolism / Original Article
Patterns of hormonal changes in hypophysitis by immune checkpoint inhibitor
Hyunji Sang, Yun Kyung Cho, Sang-hyeok Go, Hwa Jung Kim, Eun Hee Koh
Korean J Intern Med. 2024;39(5):801-812. Published online August 30, 2024
Background/Aims: Immune checkpoint inhibitors (ICIs) can induce immune-related adverse events, including endocrine dysfunctions, which can have serious consequences on patient health and quality of life. The clinical course and characteristics of immune-related hypophysitis (irH) are not well establ..
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Gastroenterology / Review
Approaches and considerations in the endoscopic treatment of T1 colorectal cancer
Yunho Jung
Korean J Intern Med. 2024;39(4):563-576. Published online May 14, 2024
The detection of early colorectal cancer (CRC) is increasing through the implementation of screening programs. This increased detection enhances the likelihood of minimally invasive surgery and significantly lowers the risk of recurrence, thereby improving patient survival and reducing mortality rat..
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Gastroenterology / Review
Strategies to improve screening colonoscopy quality for the prevention of colorectal cancer
Joo Hye Song, Eun Ran Kim
Korean J Intern Med. 2024;39(4):547-554. Published online January 22, 2024
The incidence and mortality of colorectal cancer (CRC) have decreased through regular screening colonoscopy, surveillance, and endoscopic treatment. However, CRC can still be diagnosed after negative colonoscopy. Such CRC is called interval CRC and accounts for 1.8–9.0% of all CRC cases. Most case..
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Gastroenterology / Original Article
Impact of hepatitis B virus infection on the risk of gallbladder polyps: a cohort study
Nam Hee Kim, Hong Joo Kim, Ji Hun Kang
Korean J Intern Med. 2023;38(6):844-853. Published online October 18, 2023
Background/Aims: We aimed to determine whether hepatitis B virus (HBV) or hepatitis C virus (HCV) infection remains an important risk factor for gallbladder polyps (GBPs) in the current context of reduced prevalence of these infections.
Methods: The cohort included 392,913 asymptomatic adults who unde..
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Gastroenterology / Original Article
Factors influencing occurrence of metachronous gastric cancer after endoscopic resection: a systematic review and meta-analysis
Younghee Choe, Jae Myung Park, Joon Sung Kim, Yu Kyung Cho, Byung-Wook Kim, Myung-Gyu Choi
Korean J Intern Med. 2023;38(6):831-843. Published online November 1, 2023
Background/Aims: Metachronous gastric cancer (MGC) can occur after endoscopic resection for gastric cancer. Further studies on factors other than Helicobacter pylori infection are needed. This systematic review and meta-analysis aimed to evaluate risk factors for metachronous recurrence of en..
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Gastroenterology / Original Article
Cancer risk in patients with Peutz-Jeghers syndrome in Korea: a retrospective multi-center study
Su Hwan Kim, Eun Ran Kim, Jae Jun Park, Eun Sun Kim, Hyeon Jeong Goong, Kyeong Ok Kim, Ji Hyung Nam, Yehyun Park, Sang Pyo Lee, Hyun Joo Jang; KSGE; Research Group of Capsule Endoscopy and Artificial Intelligence in Imaging
Korean J Intern Med. 2023;38(2):176-185. Published online December 15, 2022
Background/Aims: There have been little research on the cancer risks of patients with Peutz-Jeghers syndrome (PJS) in Korea. We aimed to investigate the clinical features of PJS patients and their cancer incidence rate.
Methods: Patients with PJS from nine medical centers were enrolled. In those pa..
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Rheumatology / Original Article
Prevalence, incidence, and risk factors of malignancy in patients with rheumatoid arthritis: a nationwide cohort study from Korea
Kyung Min Ko, Su-Jin Moon
Korean J Intern Med. 2023;38(1):113-124. Published online August 20, 2021
Background/Aims: This study aims to evaluate the incidence of malignancy in patients with rheumatoid arthritis (RA) and to investigate risk factors for such in a nationwide, population-based cohort.
Methods: In a large, prospective, observational cohort study, 5,077 patients with RA were enrolled f..
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Gastroenterology / Original Article
Analysis of the gut microbiome using extracellular vesicles in the urine of patients with colorectal cancer
Hyuk Yoon, Nam-Eun Kim, Jihye Park, Cheol Min Shin, Nayoung Kim, Dong Ho Lee, Jae Yong Park, Chang Hwan Choi, Jae Gyu Kim, Young Soo Park
Korean J Intern Med. 2023;38(1):27-38. Published online November 10, 2022
Background/Aims: We evaluated the gut microbiome using extracellular vesicles (EVs) in the urine of patients with colorectal cancer (CRC) to determine whether gut-microbe-derived EVs could be a potential biomarker for the diagnosis of CRC.
Methods: EVs were isolated from the urine of patients with ..
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Hemato-oncology / Original Article
Capecitabine and temozolomide for metastatic intermediate to high-grade pancreatic neuroendocrine neoplasm: a single center experience
Sathathone Douangprachanh, Hyun Jin Joo, Hyeong Min Park, Nayoung Han, Hye Young Jang, Young Hwan Koh, Tae Hyun Kim, Sung-Sik Han, Sang-Jae Park, Woo Jin Lee, Sang Myung Woo, Jung Won Chun
Korean J Intern Med. 2022;37(6):1216-1222. Published online November 1, 2022
Background/Aims: The combination of capecitabine and temozolomide (CAPTEM) is one of the treatment options for metastatic pancreatic neuroendocrine neoplasms (pNENs). This study aims to evaluate the efficacy of CAPTEM in patients with metastatic intermediate to high-grade pancreatic neuroendocrine t..
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Hemato-oncology / Original Article
Association between serum ferritin levels and colorectal cancer risk in Korea
Hyunho Kim, Kyungdo Han, Seung-Hyun Ko, Ho Jung An
Korean J Intern Med. 2022;37(6):1205-1215. Published online October 25, 2022
Background/Aims: The concentration of serum ferritin, a storage form of iron, may be associated with carcinogenesis in various cancers. There are only limited studies on the relationship between serum ferritin levels and colorectal cancer (CRC) risk, especially in the Asian population. This study ai..
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Gastroenterology / Original Article
Factors associated with the risk of colorectal neoplasia in young adults under age 40
Ilsoo Kim, Han Hee Lee, Young Jae Ko, Ho Eun Chang, Dae Young Cheung, Bo-In Lee, Young-Seok Cho, Jin Il Kim, Myung-Gyu Choi
Korean J Intern Med. 2022;37(5):969-978. Published online July 25, 2022
Background/Aims: Recent epidemiologic studies have shown a continued increase in colorectal cancer incidence among younger adults. Little is known about the factors that contribute to the development of young-onset colorectal neoplasia (CRN).
Methods: A cross-sectional analysis was performed for ind..
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Pulmonology / Original Article
Prognostic outcome of treatment modalities for epidermal growth factor receptor-mutated advanced lung cancer
Seung Hun Jang, Dong Yoon Lee, Jihyeon Jeong, Won-Il Choi
Korean J Intern Med. 2022;37(4):811-820. Published online June 3, 2022
Background/Aims: The treatment of epidermal growth factor receptor (EGFR)-mutated lung cancer cases has shown remarkable development in the past two decades. However, there have been limited studies comparing the prognostic effects of EGFR-tyrosine kinase inhibitor (TKI) and other treatment modaliti..
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Hemato-oncology / Original Article
Geriatric functional assessment for decision-making on adjuvant chemotherapy in older colon cancer patients
Hyun Jin Bang, Hyun Jeong Shim, Ga Ram Kim, Jun Eul Hwang, Woo Kyun Bae, Ik Joo Chung, Sang Hee Cho
Korean J Intern Med. 2022;37(3):660-672. Published online April 15, 2022
Background/Aims: Despite the increasing need for geriatric assessment prior to chemotherapy, the method for this assessment remains inadequate for older cancer patients. We aimed to propose a simple assessment method to predict the performance of adjuvant chemotherapy in older patients after colon c..
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Hemato-oncology / Original Article
Analysis of thromboembolic events in head and neck cancer patients who underwent concurrent chemoradiotherapy with cisplatin
[corrected-article]
Hundo Cho, Jin-Hyuk Choi, Seok Yun Kang, Hyun Woo Lee, Yong Won Choi, Tae-Hwan Kim, Mi Sun Ahn, Chul-Ho Kim, Yoo Seob Shin, Jeon Yeob Jang, Young-Taek Oh, Jaesung Heo, Seung Soo Sheen
Korean J Intern Med. 2022;37(3):653-659. Published online April 20, 2022
Background/Aims: The study investigated the incidence of thromboembolic events (TEE) in head and neck (H&N) cancer patients who received concurrent chemoradiotherapy (CCRT) with cisplatin, and analyzed the factors affecting TEE occurrence
Methods: Two hundred and fifty-seven patients who started CC..
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Rheumatology / Original Article
Cancer risk in Korean patients with gout
Yoon-Jeong Oh, Yun Jong Lee, Eunyoung Lee, Bumhee Park, Jae-Woo Kwon, Jeongwon Heo, Ki Won Moon
Korean J Intern Med. 2022;37(2):460-467. Published online March 23, 2021
Background/Aims: Using a nationwide cohort, we investigated the cancer risk in Korean patients with gout.
Methods: Data were obtained from the Korean National Health Insurance Service Database. Patients with gout were defined as those aged ≥ 20 years who were diagnosed with gout and received anti..
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Endocrinology-metabolism / Original Article
Clinical features and signaling effects of RET D631Y variant multiple endocrine neoplasia type 2 (MEN2)
Ji-young Lee, Su Yeon Kim, Kwan Hoon Jo, Eun Yeong Mo, Eun Sook Kim, Hye Soo Kim, Je Ho Han, Sung-dae Moon
Korean J Intern Med. 2022;37(2):398-410. Published online December 15, 2021
Background/Aims: Germline mutations of the rearranged during transfection (RET) gene cause multiple endocrine neoplasia type 2 (MEN2). About 85% of RET mutations in MEN2 occur in codon Cys634. The RET D631Y mutation has recently been discovered, and we have studied its molecular expres..
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Gastroenterology / Original Article
Positive fecal immunochemical test results are associated with non-colorectal cancer mortality
Yoon Suk Jung, Jinhee Lee, Chang Mo Moon
Korean J Intern Med. 2022;37(2):313-321. Published online September 29, 2021
Background/Aims: Studies have reported an association between fecal occult blood and increased all-cause, non-colorectal cancer (CRC) as well as CRC mortality. This study aimed to determine whether positive fecal immunochemistry test (FIT) results are associated with death from various causes in the..
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