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Rheumatology / Original Article
Tumor necrosis factor inhibitor prescribing and persistence by specialty in radiographic axial spondyloarthritis: a Korean claims study
Bon San Koo, Ye-Jee Kim, Yeo-Jin Lee, Yong-Gil Kim, Tae-Hwan Kim
Korean J Intern Med. 2026;41(4):766-778. Published online July 1, 2026
Background/Aims: Although several studies have shown that specialist care may be associated with better outcomes, methodological limitations have made it difficult to draw definitive conclusions. Therefore, we examined real-world patterns of tumor necrosis factor inhibitor (TNFi) use for radiographi..
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Cardiology / Original Article
Prognostic significance of 1-year versus baseline high-sensitivity C-reactive protein after acute myocardial infarction: nationwide landmark results
Seok-Woo Seong, Hyun Woong Park, Jae-Hwan Lee, Jin-Ok Jeong, Mi Joo Kim, Pil Sang Song, Seon-Ah Jin, Kye Taek Ahn, Myung Ho Jeong, Sang Hyun Park, Jin-Yong Hwang; KAMIR Investigators
Korean J Intern Med. 2026;41(4):690-705. Published online July 1, 2026
Background/Aims: Residual inflammatory risk after acute myocardial infarction (AMI) remains an important determinant of long-term outcomes despite optimal lipid-lowering therapy. The prognostic significance of serial high-sensitivity C-reactive protein (hs-CRP) measurements beyond the acute phase re..
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Cardiology / Review
Transcatheter aortic valve implantation for symptomatic severe aortic stenosis and its expanding clinical indications
Hyungdon Kook, Young-Hyo Lim
Korean J Intern Med. 2026;41(3):373-383. Published online February 24, 2026
Transcatheter aortic valve implantation (TAVI) is a minimally invasive treatment for symptomatic severe aortic stenosis (AS) that was initially developed for patients with prohibitive surgical risk. Since the first-in-human procedure in 2002, TAVI has gained global acceptance owing to its favorable ..
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Endocrinology-metabolism / Original Article
Development of Simple Assessment tool for predict imminent risk of Fracture in Elderly women
So Young Park, Sujin Kwon, Kyoung Jin Kim, Seong Hee Ahn, Ha Young Kim, Kyoung Min Kim; the Epidemiology Committee of the Korean Society of Bone Metabolism
Korean J Intern Med. 2026;41(2):277-285. Published online March 1, 2026
Background/Aims: Previously developed fracture risk prediction models primarily estimate long-term risk and are limited in their ability to predict imminent fractures. We developed a simplified and practical model to predict the short-term fracture risk (1- to 3-year risk) in elderly Korean women.
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Gastroenterology / Review
The epidemiology of inflammatory bowel disease: exploring the impacts of environmental factors
Jihye Park, Jae Hee Cheon
Korean J Intern Med. 2026;41(2):186-196. Published online December 4, 2025
Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are distinct chronic immune-mediated intestinal inflammatory disorders. The pathogenesis of IBD is complex and involves a combination of genetic and environmental factors, the gut microbiome, and the host immune syste..
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Rheumatology / Original Article
Treatment satisfaction and its determinants in Korean patients with rheumatoid arthritis and systemic lupus erythematosus
Hyo Jin Choi, Mi Ryoung Seo, Eunji Kim, Han Joo Baek
Korean J Intern Med. 2025;40(6):1042-1051. Published online October 28, 2025
Background/Aims: This study aimed to evaluate the treatment satisfaction and its determinants in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
Methods: This cross-sectional study was conducted between September 2021 and December 2021. Data on demographics, clinical..
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Nephrology / Review
Clinical challenges and individualized approaches to dialysis therapy in older adults
Sungmi Kim, Yu Ah Hong
Korean J Intern Med. 2025;40(6):909-926. Published online October 31, 2025
Global population aging has substantially increased in the number of older adults who undergo kidney replacement therapy (KRT). Age-related physiological changes and functional dependence in this population lead to the multifaceted clinical and ethical challenges associated with KRT. Geriatric syndr..
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Rheumatology / Original Article
Factors influencing delayed attainment of low disease activity in rheumatoid arthritis patients continuing targeted therapy
Yeo-Jin Song, Soo-Kyung Cho, Se Rim Choi, Shin-Seok Lee, Hye-Soon Lee, Sung-Hoon Park, Yeon-Ah Lee, Min-Chan Park, Hyoun-Ah Kim, Soo-Bin Lee, Ha-Rim Park, Eunwoo Nam, Yoon-Kyoung Sung
Korean J Intern Med. 2025;40(5):835-844. Published online August 29, 2025
Background/Aims: To identify factors associated with achieving low disease activity (LDA) after 48 weeks of targeted therapy in patients with rheumatoid arthritis (RA) despite not meeting treat-to-target (T2T) criteria at week 24.
Methods: Data were collected from a multicenter, prospective observa..
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Nephrology / Original Article
Association of kidney function and proteinuria with lower-extremity dysfunction in older Korean adults: a cross-sectional study
Bongjo Kim, Eun-Bin Lim, Young Sang Lyu, Minkook Son, Youngmin Yoon
Korean J Intern Med. 2025;40(5):823-834. Published online July 25, 2025
Background/Aims: Chronic kidney disease (CKD) is associated with complications that affect physical function and mobility. This study investigated the associations between kidney function, proteinuria, and lower-extremity dysfunction.
Methods: Data were obtained from the Korean National Health Insu..
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Infectious diseases / Review
Appropriate timing of antibiotic initiation in patients with sepsis or septic shock: a systematic review and meta-analysis
Nam Su Ku, Yongseop Lee, Dae Won Park
Korean J Intern Med. 2025;40(5):725-733. Published online August 26, 2025
Evidence supporting antibiotic administration within 3 hours in sepsis without shock is limited. Therefore, we conducted a systematic review and meta-analysis to determine whether the timing of antibiotic initiation influences mortality in patients with sepsis or septic shock. We comprehensively searched Pub..
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Pulmonology / Original Article
Efficacy and safety of first-line afatinib in older patients with advanced EGFR-mutated non-small cell lung cancer
Mi-Hyun Kim, Hayoung Seong, Soo Han Kim, Min Ki Lee, Insu Kim, Kyung Soo Hong, June Hong Ahn, Jung Seop Eom
Korean J Intern Med. 2025;40(4):626-633. Published online July 1, 2025
Background/Aims: This study investigated the efficacy and safety of first-line afatinib treatment in older patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC).
Methods: This retrospective, multicenter, observational cohort study included 103 patients aged..
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Allergy / Original Article
Comparison of extrafine and non-extrafine inhaled corticosteroids/long-acting β2-agonists as maintenance and reliever therapy in asthma: a randomized open-label crossover trial
Sang Pyo Lee, Sang Min Lee, Sung-Yoon Kang
Korean J Intern Med. 2025;40(3):491-501. Published online April 30, 2025
Background/Aims: Asthma is characterized by chronic inflammation. Inhaled corticosteroids (ICS) remain the cornerstone of anti-inflammatory therapy, targeting both the large and small airways.
Methods: This randomized open-label crossover trial included 30 patients receiving step 3 inhaled medicati..
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Rheumatology / Original Article
Increased risk of dementia in patients with primary Sjogren’s syndrome: a nationwide population-based cohort study
Kyung-Ann Lee, Hyeji Jeon, Hyun-Sook Kim, Kyomin Choi, Gi Hyeon Seo
Korean J Intern Med. 2025;40(2):330-338. Published online February 21, 2025
Background/Aims: This nationwide cohort study aimed to evaluate (1) whether primary Sjogren’s syndrome (pSS) can contribute to the development of dementia and (2) whether the use of hydroxychloroquine (HCQ) can decrease the incidence of dementia in patients with pSS using the Health Insurance Revi..
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Cardiology / Review
Sex differences in diagnosis and treatment of heart failure: toward precision medicine
Soo Yong Lee, Seong-Mi Park
Korean J Intern Med. 2025;40(2):196-207. Published online March 1, 2025
There are sex-related differences in the pathophysiology and phenotype of heart failure (HF) as well as the pharmacokinetics and pharmacodynamics of drugs between women and men due to biological differences, such as heart and vessel size, response to blood volume and pressure, body water and muscle ..
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Gastroenterology / Review
Role of endoscopic ultrasound in the diagnosis and local ablative therapy of pancreatic neuroendocrine tumors
Yun Je Song, Jun Kyeong Lim, Jun-Ho Choi
Korean J Intern Med. 2025;40(2):170-180. Published online February 25, 2025
Advancements in diagnostic technology have led to the improved detection of pancreatic neuroendocrine tumors (PNETs) and thus to an increase in the number of reported cases. Endoscopic ultrasound (EUS) technology, including in combination with contrast-enhanced harmonic imaging, aids in distinguishi..
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Cardiology / Original Article
Predictive value and optimal cut-off level of high-sensitivity troponin T in patients with acute pulmonary embolism
Moojun Kim, Chang-Ok Seo, Yong-Lee Kim, Hangyul Kim, Hye Ree Kim, Yun Ho Cho, Jeong Yoon Jang, Jong-Hwa Ahn, Min Gyu Kang, Kyehwan Kim, Jin-Sin Koh, Seok-Jae Hwang, Jin Yong Hwang, Jeong Rang Park
Korean J Intern Med. 2025;40(1):65-77. Published online January 1, 2025
Background/Aims: Elevated troponin levels predict in-hospital mortality and influence decisions regarding thrombolytic therapy in patients with acute pulmonary embolism (PE). However, the usefulness of high-sensitivity troponin T (hsTnT) regarding PE remains uncertain. We aimed to establish the opti..
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Rheumatology / Review
Literature review of non-pharmacological treatment for patients with axial spondyloarthritis
Jina Yeo, Mi Ryoung Seo, Jun Won Park, Yeon-Ah Lee, Ju Ho Lee, Eun Ha Kang, Seon Mi Ji, Han Joo Baek
Korean J Intern Med. 2025;40(1):40-48. Published online May 27, 2024
Axial spondyloarthritis (axSpA) is a chronic inflammatory disorder affecting the sacroiliac joints and axial spine. Along with pharmacotherapy, non-pharmacological interventions for axSpA are crucial and constitute the cornerstone of treatment. Here, we review the evidence for non-pharmacological tr..
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Cardiology / Review
Current status of modifiable risk factors for cardiovascular disease in Korean women
In-Jeong Cho, Mi-Seung Shin
Korean J Intern Med. 2025;40(1):15-23. Published online October 22, 2024
Hypertension, diabetes mellitus, dyslipidemia, obesity, and smoking are the primary modifiable risk factors contributing to the increasing morbidity and mortality rates from cardiovascular disease (CVD) among Korean women. Significant sex-related differences exist in the prevalence, awareness, treat..
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Cardiology / Review
Screening and diagnosis of atrial fibrillation using wearable devices
Yoon Jung Park, Myung Hwan Bae
Korean J Intern Med. 2025;40(1):7-14. Published online May 3, 2024
In recent years, the development and use of various devices for the screening of atrial fibrillation (AF) have significantly increased. Such devices include 12-lead electrocardiogram (ECG), photoplethysmography systems, and single-lead ECG and ECG patches. This review outlines several studies that h..
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Pulmonology / Original Article
Development and validation of novel simple prognostic model for predicting mortality in Korean intensive care units using national insurance claims data
Ah Young Leem, Soyul Han, Kyung Soo Chung, Su Hwan Lee, Moo Suk Park, Bora Lee, Young Sam Kim
Korean J Intern Med. 2024;39(4):625-639. Published online April 19, 2024
Background/Aims: Intensive care unit (ICU) quality is largely determined by the mortality rate. Therefore, we aimed to develop and validate a novel prognostic model for predicting mortality in Korean ICUs, using national insurance claims data.
Methods: Data were obtained from the health insurance c..
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