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Infectious diseases / Original Article
Initial and peak serum levels of Krebs von den Lungen-6 for predicting the prognosis of patients with COVID-19
Geonui Kim, Hyeonwoo Kwon, Sang Hyun Ra, Euijin Chang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim
Korean J Intern Med. 2025;40(2):321-329. Published online February 21, 2025
Background/Aims: Krebs von den Lungen-6 (KL-6) is associated with prognosis in patients with COVID-19. However, there is limited data on the correlation between the prognosis of COVID-19 and varying KL-6 levels at different time points. We investigated the optimal cutoff values of the initial and pe..
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Cardiology / Original Article
Sex-specific impact of the COVID-19 outbreak on the incidence of metabolic syndrome: a comparative study of 2018–2019 and 2020–2021
Kyeong-Hyeon Chun, Hyun-Jin Kim, Dae Ryong Kang, Jang Young Kim, Wonjin Kim, Yong Whi Jeong, Seung Hwan Han, Kwang Kon Koh; on behalf of the Taskforce Team of the Metabolic Syndrome Fact Sheet of the Korean Society of Cardiometabolic Syndrome
Korean J Intern Med. 2025;40(2):262-274. Published online March 1, 2025
Background/Aims: The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted global health, exacerbated metabolic health issues, and altered lifestyle behaviors. This study examined the sex-specific impact of the COVID-19 outbreak on the incidence of metabolic syndrome using data fro..
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Nephrology / Original Article
Kidney replacement therapy trends in end-stage kidney disease patients in South Korea during the COVID-19 pandemic
Ah-Young Kim, Min-Jeong Lee, Heejung Choi, Hankil Lee, Inwhee Park
Korean J Intern Med. 2024;39(6):967-978. Published online October 24, 2024
Background/Aims: The corona virus disease 2019 posed a major risk for end-stage kidney disease (ESKD) cases. Our study aimed to assess changes in kidney replacement therapy (KRT) trends and healthcare access for these patients during the pandemic.
Methods: We retrospectively analyzed nationwide dat..
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Infectious diseases / Original Article
Clinical effects of non-pharmaceutical interventions for COVID-19 on other nationally notifiable infectious diseases in South Korea
Hyun-Jin Lee, Beom Seuk Hwang, Seong Ho Im, Seog-Kyun Mun, Munyoung Chang
Korean J Intern Med. 2024;39(5):823-832. Published online August 13, 2024
Background/Aims: This study aimed to assess the impact of non-pharmaceutical interventions (NPIs) implemented during the COVID-19 pandemic on nationally notifiable infectious diseases (NNIDs) in South Korea.
Methods: Long-term data on seven NNIDs from 2018 to 2021 were analyzed to identify trends a..
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Infectious diseases / Original Article
Impact of the coronavirus disease 2019 pandemic on the incidence of other infectious diseases in the hematology hospital in Korea
Seohee Oh, Yu-Sun Sung, Mihee Jang, Yong-Jin Kim, Hyun-Wook Park, Dukhee Nho, Dong-Gun Lee, Hyeon Woo Yim, Sung-Yeon Cho
Korean J Intern Med. 2024;39(3):513-523. Published online April 23, 2024
Background/Aims: Since the coronavirus disease 2019 (COVID-19) outbreak, hospitals have implemented infection control measures to minimize the spread of the virus within facilities. This study aimed to investigate the impact of COVID-19 on the incidence of healthcare-associated infections (HCAIs) an..
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Pulmonology / Original Article
Risk factors for progressing to critical illness in patients with hospital-acquired COVID-19
Kyung-Eui Lee, Jinwoo Lee, Sang-Min Lee, Hong Yeul Lee
Korean J Intern Med. 2024;39(3):477-487. Published online April 18, 2024
Background/Aims: Risk factors for progression to critical illness in hospital-acquired coronavirus disease 2019 (COVID-19) remain unknown. Here, we assessed the incidence and risk factors for progression to critical illness and determined their effects on clinical outcomes in patients with hospital-..
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Infectious diseases / Original Article
The effects of remdesivir on mortality and the requirement for mechanical ventilation in patients with COVID-19: a systematic review stratified by disease severity
Seungeun Ryoo, Miyoung Choi, Su-Yeon Yu, Young Kyung Yoon, Kyungmin Huh, Eun-Jeong Joo
Korean J Intern Med. 2024;39(1):160-171. Published online December 28, 2023
Background/Aims: The effectiveness of remdesivir treatment in reducing mortality and the requirement for mechanical ventilation (MV) remains uncertain, as randomized controlled trials (RCTs) have produced conflicting results.
Methods: We searched MEDLINE, EMBASE, Cochrane Central Register of Contro..
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Infectious diseases / Original Article
Clinical significance of antinuclear antibody positivity in patients with severe coronavirus disease 2019
Soo Hyun Park, Jin Woong Suh, Kyung-Sook Yang, Jeong Yeon Kim, Sun Bean Kim, Jang Wook Sohn, Young Kyung Yoon
Korean J Intern Med. 2023;38(3):417-426. Published online April 6, 2023
Background/Aims: This study aimed to investigate the clinical characteristics and outcomes of fluorescent antinuclear antibody (FANA)-positive patients admitted for coronavirus disease 2019 (COVID‐19) and identify FANA as a prognostic factor of mortality.
Methods: This retrospective study was con..
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Pulmonology / Original Article
Corticosteroid outcome may be dependent of duration of use in severe COVID-19
[letter]
Jin Hyoung Kim, Yong Sub Na, Song-I Lee, Youn Young Moon, Beom Seuk Hwang, Ae-Rin Baek, Won-Young Kim, Bo Young Lee, Gil Myeong Seong, Moon Seong Baek
Korean J Intern Med. 2023;38(3):382-392. Published online April 11, 2023
Background/Aims: For patients hospitalized with coronavirus disease 2019 (COVID-19) who require supplemental oxygen, the evidence of the optimal duration of corticosteroid is limited. This study aims to identify whether long-term use of corticosteroids is associated with decreased mortality.
Method..
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Rheumatology / Original Article
Incidence of rheumatic diseases during the COVID-19 pandemic in South Korea
Soo Min Ahn, Seongho Eun, Sunghwan Ji, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Ji Seon Oh, Yong-Gil Kim
Korean J Intern Med. 2023;38(2):248-253. Published online January 17, 2023
Background/Aims: The recent coronavirus disease 2019 (COVID-19) pandemic has been associated with changes in the epidemiology of not only infectious diseases but also several non-infectious conditions. This study investigated changes in the recorded incidence of various rheumatic diseases during the..
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Pulmonology / Original Article
Timing of corticosteroids in non-severe non-hospitalized COVID-19 patients: open-label, two-center, randomized controlled study (TICS-COV19 study)
Emad R. Issak, Mariam M. Amin
Korean J Intern Med. 2023;38(2):207-217. Published online January 17, 2023
Background/Aims: Corticosteroids (CSs) are frequently used in coronavirus disease 2019 (COVID-19); however, their utility remains controversial in mild to moderate cases. The timing of CSs initiation during the disease course remains unaddressed. The study aims to evaluate the impact of early CSs in..
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Infectious diseases / Original Article
A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19
Moon Seong Baek, Seong-Ho Choi, Won-Young Kim, Min-Chul Kim, Eun-Jeong Joo, Mi Suk Lee, Hyun Ah Kim, Sook In Jung, Yu Shi Nae, Bongyoung Kim, Yaeji Lim, Jin-Won Chung
Korean J Intern Med. 2023;38(1):101-112. Published online October 25, 2022
Background/Aims: To identify changes in symptoms and pulmonary sequelae in patients with coronavirus disease 2019 (COVID-19).
Methods: Patients with COVID-19 hospitalized at seven university hospitals in Korea between February 2020 and February 2021 were enrolled, provided they had ≥ 1 outpatient..
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Pulmonology / Original Article
Clinical outcomes of and risk factors for secondary infection in patients with severe COVID-19: a multicenter cohort study in South Korea
Yong Sub Na, Ae-Rin Baek, Moon Seong Baek, Won-Young Kim, Jin Hyoung Kim, Bo young Lee, Gil Myeong Seong, Song-I Lee
Korean J Intern Med. 2023;38(1):68-79. Published online November 24, 2022
Background/Aims: Secondary infection with influenza virus occurs in critically ill patients and is associated with substantial morbidity and mortality; however, there is limited information about it in patients with severe coronavirus disease 2019 (COVID-19). Thus, we investigated the clinical outco..
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Infectious diseases / Original Article
Comparison of the rapidity of SARS-CoV-2 immune responses between primary and booster vaccination for COVID-19
Ji Yeun Kim, Ji-Soo Kwon, Hye Hee Cha, So Yun Lim, Seongman Bae, Sung-Han Kim
Korean J Intern Med. 2022;37(6):1234-1240. Published online October 11, 2022
Background/Aims: The rapidity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific memory B or T cell response in vaccinated individuals is important for our understanding of immunopathogenesis of coronavirus disease 2019 (COVID-19). We therefore compared the timing of adequate ..
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Pulmonology / Original Article
Clinical characteristics of patients with COVID-19 vaccine-related pneumonitis: a case series and literature review
Ji Young Park, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Hwan Il Kim, Seung Hun Jang, Ki-Suck Jung, Yong Kyun Kim, Hyun Ah Kim, In Jae Lee
Korean J Intern Med. 2022;37(5):989-1001. Published online August 22, 2022
Background/Aims: Pulmonary toxicities of coronavirus disease 2019 (COVID-19) vaccination are exceedingly rare. However, there are a few reported cases after mRNA vaccination, especially from Asian countries. The purpose of this study was to report the clinical characteristics of patients with COVID-..
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Review
Vaccination strategies for Korean patients with inflammatory bowel disease
Yoo Jin Lee, Eun Soo Kim
Korean J Intern Med. 2022;37(5):920-930. Published online August 8, 2022
Patients with inflammatory bowel disease (IBD) are vulnerable to vaccine-preventable infectious diseases. Immunosuppressive drugs, which are often used to manage IBD, may increase this vulnerability and attenuate vaccine efficacy. Thus, healthcare providers should understand infectious diseases and ..
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Infectious diseases / Original Article
Risk factors and clinical impact of COVID-19-associated pulmonary aspergillosis: Multicenter retrospective cohort study
Raeseok Lee, Sung-Yeon Cho, Dong-Gun Lee, Hyojin Ahn, Hyeah Choi, Su-Mi Choi, Jae-Ki Choi, Jung-Hyun Choi, Shin Young Kim, Youn Jeong Kim, Hyo-Jin Lee
Korean J Intern Med. 2022;37(4):851-863. Published online May 26, 2022
Background/Aims: The risk factors and clinical impacts of coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) remain controversial, and no data have been reported in Korea. This study aimed to investigate the epidemiology and importance of CAPA diagnostic efforts and to ide..
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Cardiology / Original Article
Treatment delay and outcomes of ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention during the COVID-19 era in South Korea
Seok Oh, Myung Ho Jeong, Kyung Hoon Cho, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn
Korean J Intern Med. 2022;37(4):786-799. Published online June 28, 2022
Background/Aims: Little is known about the clinical characteristics and treatment outcomes of ST-segment elevation myocardial infarction (STEMI) in Korea during the coronavirus disease 2019 (COVID-19) era. We aimed to evaluate the clinical characteristics and treatment outcomes of patients with STEM..
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Rheumatology / Original Article
Baseline use of hydroxychloroquine or immunosuppressive drugs and the risk of coronavirus disease 2019
Ji-Won Kim, Sang Gyu Kwak, Hwajeong Lee, Seong-Kyu Kim, Jung-Yoon Choe, Sung-Hoon Park
Korean J Intern Med. 2022;37(3):673-680. Published online March 12, 2021
Background/Aims: The preventive role of hydroxychloroquine (HCQ) on coronavirus disease 2019 (COVID-19) remains unclear. The aim of this study was to examine the effects of HCQ and other immunosuppressive drugs on the incidence of COVID-19.
Methods: The data were collected from the South Korea Nati..
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Infectious diseases / Original Article
Eosinophil-mediated lung inflammation associated with elevated natural killer T cell response in COVID-19 patients
Dong-Min Kim, Jun-Won Seo, Yuri Kim, Uni Park, Na-Young Ha, Hyoree Park, Na Ra Yun, Da Young Kim, Sung Ho Yoon, Yong Sub Na, Do Sik Moon, Sung-Chul Lim, Choon-Mee Kim, Yeon-Sook Kim, Nam-Hyuk Cho
Korean J Intern Med. 2022;37(1):201-209. Published online September 27, 2021
Background/Aims: Coronavirus disease 2019 (COVID-19) is associated with acute respiratory syndrome. The mechanisms underlying the different degrees of pneumonia severity in patients with COVID-19 remain elusive. This study provides evidence that COVID-19 is associated with eosinophil-mediated inflam..
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