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Review

July 1, 2026


Recent advances in the management of small bowel Crohn’s disease
Kwangwoo Nam, Hee Seok Moon
Korean J Intern Med. 2026;41(4):563-571.

Crohn’s disease (CD) is a chronic inflammatory disorder of the bowel characterized by alternating periods of remission and relapse. Although CD can affect any part of the gastrointestinal tract, small...

Review

July 1, 2026


Korean expert consensus on the management of thrombotic thrombocytopenic purpura
Seo-Yeon Ahn, Junshik Hong, Jin Seok Kim, et al.
Korean J Intern Med. 2026;41(4):572-584.

Thrombotic thrombocytopenic purpura (TTP) is a rare but life-threatening thrombotic microangiopathy resulting from severe ADAMTS13 deficiency. Although effective treatments, such as therapeutic plasma exchange, immunosuppressive therapy with rituximab, and caplacizumab,...

Review

July 1, 2026


Use of corticosteroids in sepsis and infectious diseases: a narrative review
Jong Hun Kim
Korean J Intern Med. 2026;41(4):585-596.

Critically ill patients with septic shock exhibit dysregulated host inflammatory responses. Critical illness-related corticosteroid insufficiency (CIRCI) has been recognized as a potential contributor to poor outcomes in critically ill patients....

Review

July 1, 2026


Autoimmune diseases in the era of COVID-19: emerging mechanisms, clinical implications, vaccine considerations, and future directions
Jaehyun Kong, Seohyun Hong, Jiyeon Oh, et al.
Korean J Intern Med. 2026;41(4):597-619.

The coronavirus disease 2019 (COVID-19) pandemic has highlighted a complex, bidirectional relationship between SARSCoV-2 infection and autoimmune diseases. This review examines how SARS-CoV-2 infection influences the incidence, progression, and outcomes...

Review

July 1, 2026


From Sjögren syndrome to Sjögren disease: rethinking classification and diagnostic complexity
Jennifer Jooha Lee, Howook Jeon, Hyun-Sook Kim, et al.
Korean J Intern Med. 2026;41(4):620-635.

Sjögren syndrome (SS), traditionally regarded as a sicca-predominant condition, is now recognized as a systemic autoimmune disease characterized by type I interferon activation, B-cell hyperactivity, and periepithelial lymphocytic infiltration. This...

Original Article

July 1, 2026


Hepatitis B core-related antigen as a multifaceted biomarker in chronic hepatitis B: implications for immune activity and hepatocellular carcinoma prediction
Kwon Yong Tak, Seok Hwan Kim, Myeong Jun Song
Korean J Intern Med. 2026;41(4):636-648.

Background/Aims: Hepatitis B core-related antigen (HBcrAg) reflects both serum hepatitis B virus (HBV) DNA and intrahepatic covalently closed circular DNA activity, offering potential advantages over conventional biomarkers in monitoring chronic...

Original Article

July 1, 2026


The 2020 disease burden and economic implications of digestive diseases in Korea: a nation-wide comprehensive study
Eui Sun Jeong, Hye-Kyung Jung, Younhee Kim, et al.
Korean J Intern Med. 2026;41(4):649-662.

Background/Aims: Digestive diseases are highly prevalent and contribute substantially to healthcare utilization and costs. However, national-level data on digestive diseases burden in Korea are limited. This study aimed to estimate...

Original Article

July 1, 2026


Distal radial access in acute coronary syndrome patients with good arterial pulsation: a subgroup analysis from the KODRA registry
Jun-Won Lee, Su Yong Kim, Jung Ho Heo, et al.
Korean J Intern Med. 2026;41(4):663-675.

Background/Aims: Distal radial access (DRA) has been associated with fewer access-site complications, but evidence in acute coronary syndrome (ACS) remains limited. This study evaluated the feasibility and safety of DRA...

Original Article

July 1, 2026


The medical impact of emergent banning of N-nitrosodimethylamine: contaminated antihypertensive drug
Juhee Ahn, Sungho Won, Jong-Heon Park, et al.
Korean J Intern Med. 2026;41(4):676-689.

Background/Aims: Concerns exist regarding the potential carcinogenic effect of N-nitrosodimethylamine (NDMA) as a contaminant of the antihypertensive medication, valsartan. This study evaluated the association of NDMA-contaminated valsartan with cancer incidence. Methods:...

Original Article

July 1, 2026


Prognostic significance of 1-year versus baseline high-sensitivity C-reactive protein after acute myocardial infarction: nationwide landmark results
Seok-Woo Seong, Hyun Woong Park, Jae-Hwan Lee, et al.
Korean J Intern Med. 2026;41(4):690-705.

Background/Aims: Residual inflammatory risk after acute myocardial infarction (AMI) remains an important determinant of long-term outcomes despite optimal lipid-lowering therapy. The prognostic significance of serial high-sensitivity C-reactive protein (hs-CRP) measurements...

Original Article

July 1, 2026


Financial burden of glycemic control: a single-center retrospective study of diabetes costs in South Korean patients
Han-Sang Baek, Sungju Kim, Dong-Jun Lim, et al.
Korean J Intern Med. 2026;41(4):706-720.

Background/Aims: The impact of glycemic control on healthcare costs is a critical research area. In this study, we aimed to evaluate the relationship between hemoglobin A1c (HbA1c) levels and healthcare...

Original Article

July 1, 2026


Restrictive lung function and smoking increase lung cancer risk in tuberculosis survivors: a cohort study
Yun-Gyoo Lee, Hyun-Il Gil, Dayeon Seo, et al.
Korean J Intern Med. 2026;41(4):721-730.

Background/Aims: Individuals with prior tuberculosis (TB) infection represent a high-risk group for lung cancer due to chronic pulmonary damage. Although associations between TB and lung cancer have been established, this...

Original Article

July 1, 2026


Prognostic analysis according to adjuvant chemotherapy and anti-HER2 therapy following surgery in T1a/b HER2-positive breast cancer
Woochan Park, Koung Jin Suh, Jeongmin Seo, et al.
Korean J Intern Med. 2026;41(4):734-747.

Background/Aims: The optimal adjuvant chemotherapy and anti-human epidermal growth factor receptor 2 (HER2) therapy regimen following surgery for T1a/b HER2-positive breast cancer remains debatable. Methods: In this single-center retrospective analysis, we...

Original Article

July 1, 2026


Association of hyperuricemia with valvular heart disease and the modifying effect of obesity
Seung Min Jung, Sang-Hyuk Jung, Su-Nam Lee, et al.
Korean J Intern Med. 2026;41(4):748-762.

Background/Aims: Hyperuricemia has been widely associated with cardiovascular health, but its relationship with incident valvular heart disease (VHD) remains uncertain. This study investigated the association between hyperuricemia and VHD, and...

Original Article

July 1, 2026


Tumor necrosis factor inhibitor prescribing and persistence by specialty in radiographic axial spondyloarthritis: a Korean claims study
Bon San Koo, Ye-Jee Kim, Yeo-Jin Lee, et al.
Korean J Intern Med. 2026;41(4):766-778.

Background/Aims: Although several studies have shown that specialist care may be associated with better outcomes, methodological limitations have made it difficult to draw definitive conclusions. Therefore, we examined real-world patterns...
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    • Current Issue
    Volume 41(4); Jul 2026
    Response to comment on “Incidence and risk factors for osteoporotic fractures in patients with systemic lupus erythematosus versus matched controls”
    Chang Seong Kim, Kyung-Do Han, Hong Sang Choi, et al.
    [Epub ahead of print]

    Correspondence

    April 21, 2020
    Comparison of antiplatelet treatment in patients with clopidogrel nonresponders with or without carriage of CYP2C19 polymorphism
    Yun Myoung Ko, Jeong Kyung Kim, Jeong Hee Kim, et al.
    [Epub ahead of print]

    Original Article

    May 31, 2018
    Treadmill exercise-induced E/e’ elevation as a predictor of cardiovascular event in end-stage renal disease on peritoneal dialysis
    Jong Ho Shin, Ki-Woon Kang, Jung Ho Kim, et al.
    [Epub ahead of print]

    Original Article

    November 11, 2016

    Korean Journal of
    Internal Medicine

    Print ISSN: 1226-3303
    Online ISSN: 2005-6648

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