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Gastroenterology
Effectiveness and safety of elbasvir/grazoprevir in Korean patients with hepatitis C virus infection: a nationwide real-world study
Eun Sun Jang, Kyung-Ah Kim, Young Seok Kim, In Hee Kim, Byung Seok Lee, Youn Jae Lee, Woo Jin Chung, Sook-Hyang Jeong
Korean J Intern Med. 2021;36(Suppl 1):S1-S8. Published online June 17, 2020
Background/Aim: This study aimed to establish the real-world effectiveness and safety of grazoprevir/elbasvir (EBR/GZR) therapy in South Korea.
Methods: A total of 242 patients with chronic hepatitis C virus (HCV) genotype 1 or 4 infection who started EBR/GZR were consecutively enrolled from seven..
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Comparison of loss of response between anti-tumor necrosis factor alone and combined use with immunomodulators in patients with inflammatory bowel disease
Seung Wook Hong, Jaewoo Park, Hyuk Yoon, Hye Ran Yang, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Joo Sung Kim
Korean J Intern Med. 2021;36(Suppl 1):S9-S17. Published online June 25, 2020
Background/Aims: Combination therapy with immunomodulators (IMMs) was proposed as a strategy to prevent the development of loss of response (LOR) to anti-tumor necrosis factor (TNF) for patients with inflammatory bowel disease (IBD). However, the effect is unclear in patients already exposed to IMMs..
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Increased risk of gastric cancer in workers with occupational dust exposure
Mo-Yeol Kang, Jiyoun Jung, Jung-Wan Koo, Inah Kim, Hyoung-Ryoul Kim, Jun-Pyo Myong
Korean J Intern Med. 2021;36(Suppl 1):S18-S26. Published online May 7, 2020
Background/Aims: Workers who are exposed to dust in the workplace tend to show a higher incidence of gastric cancer. Nevertheless, scientific evidence to support an association between dust exposure and the risk of gastric cancer is inadequate. This study aimed to investigate whether or not occupati..
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Effect of stent placement on stone recurrence and post-procedural cholangitis after endoscopic removal of common bile duct stones
Jung-Hye Choi, Tae-Yoon Lee, Young-Koog Cheon
Korean J Intern Med. 2021;36(Suppl 1):S27-S34. Published online August 24, 2020
Background/Aims: After endoscopic treatment of common bile duct (CBD) stones, recurrence of choledocholithiasis due to small stone fragments and post-endoscopic retrograde cholangiopancreatography (post-ERCP) cholangitis can occur. We determined the effect of biliary stenting after removal of CBD st..
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Colonoscopy quality in community hospitals and nonhospital facilities in Korea
Jae Gon Lee, Dong Soo Han, Young-Eun Joo, Dae-Seong Myung, Dong Il Park, Seul Ki Kim, Yunho Jung, Won Hyun Lee, Eun Soo Kim, Joon Seok Yoon, Chang Soo Eun
Korean J Intern Med. 2021;36(Suppl 1):S35-S43. Published online May 12, 2020
Background/Aims: High-quality colonoscopy is essential to reduce colorectal cancer-related deaths. Little is known about colonoscopy quality in non-academic practice settings. We aimed to evaluate the quality of colonoscopies performed in community hospitals and nonhospital facilities.
Methods: Col..
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The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in rats
Ali Durmus, Ilgim Durmus, Omer Bender, Oguzhan Karatepe
Korean J Intern Med. 2021;36(Suppl 1):S44-S52. Published online June 19, 2020
Background/Aims: The aim of this study is to investigate the effects of the Hericium erinaceum on an experimental colitis model.
Methods: Twenty-four Wistar albino were included in this study. Rats were divided into three groups. Group 1 (n = 8) was sham group. Group 2 is the group of chemic..
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Cardiology
Feasibility of primary percutaneous coronary intervention via the distal radial approach in patients with ST-elevation myocardial infarction
Yongcheol Kim, Jun-Won Lee, Sang Yeub Lee, Jang-Whan Bae, Sang Jun Lee, Myung Ho Jeong, Seung-Hwan Lee, Youngkeun Ahn
Korean J Intern Med. 2021;36(Suppl 1):S53-S61. Published online March 3, 2020
Background/Aims: Recently, distal radial approach (DRA), called as snuffbox approach, has gained the interest of interventional cardiologists, but there is a lack of data about the feasibility of DRA as an alternative route for primary percutaneous coronary intervention (PCI).
Methods: A total of 1..
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Long-term efficacy of vasodilating β-blocker in patients with acute myocardial infarction: nationwide multicenter prospective registry
Jaehoon Chung, Jung-Kyu Han, Han-Mo Yang, Kyung-Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, Myung Ho Jeong, Hyo-Soo Kim; on behalf of investigators for Korea Acute Myocardial Infarction Registry (KAMIR)
Korean J Intern Med. 2021;36(Suppl 1):S62-S71. Published online July 3, 2020
Background/Aims: Long-term benefit of vasodilating β-blockers is unknown. This study aimed to investigate the long-term benefit of vasodilating β-blockers over conventional β-blockers in patients with acute myocardial infarction (AMI).
Methods: Using nationwide prospective multicenter Korean Acute ..
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Clinical outcomes of endovascular treatment for ruptured thoracic aortic disease
Jong Hyun Choi, Sang-Pil Kim, Han Cheol Lee, Tae Sik Park, Jong Ha Park, Bo Won Kim, Jinhee Ahn, Jin Sup Park, Hye Won Lee, Jun-Hyok Oh, Jung Hyun Choi, Kwang Soo Cha, Taek Jong Hong
Korean J Intern Med. 2021;36(Suppl 1):S72-S79. Published online April 10, 2020
Background/Aims: Untreated rupture of the thoracic aorta is associated with a high mortality rate. We aimed to review the clinical results of endovascular treatment for ruptured thoracic aortic disease.
Methods: We retrospectively reviewed data on 37 patients (mean age, 67.0 ± 15.18 years) treate..
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Clinical significance of high on-treatment platelet reactivity in patients with prolonged clopidogrel therapy
Sehun Kim, Donghoon Han, Jae Hyuk Choi, Eun-Joo Park, Dong Geum Shin, Min-Kyung Kang, Seonghoon Choi, Namho Lee, Jung Rae Cho
Korean J Intern Med. 2021;36(Suppl 1):S80-S89. Published online February 25, 2021
Background/Aims: Prolonged dual antiplatelet therapy (DAPT) with aspirin and clopidogrel beyond 1 year has been shown to reduce ischemic events at the expense of increased bleeding. However, limited data are available on the clinical significance of platelet reactivity (PR) at 1 year.
Methods: We r..
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Effect of body mass index and abdominal obesity on mortality after percutaneous coronary intervention: a nationwide, population-based study
Woo-Hyuk Song, Eun Hui Bae, Jeong Cheon Ahn, Tae Ryom Oh, Yong-Hyun Kim, Jin Seok Kim, Sun-Won Kim, Soo Wan Kim, Kyung-Do Han, Sang-Yup Lim
Korean J Intern Med. 2021;36(Suppl 1):S90-S98. Published online February 25, 2021
Background/Aims: We investigated the impact of obesity on the clinical outcomes following percutaneous coronary intervention (PCI).
Methods: We included South Koreans aged > 20 years who underwent the Korean National Health Screening assessment between 2009 and 2012. Obesity was defined using the b..
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Sex differences in long-term clinical outcomes of acute myocardial infarction according to the presence of diabetes mellitus
Yu Ri Kim, Myung Ho Jeong, Youngkeun Ahn, Ju Han Kim, Young Joon Hong, Min Chul Kim, Kyung Hoon Cho, Xiong Yi Han; other KAMIR-NIH Registry Investigators
Korean J Intern Med. 2021;36(Suppl 1):S99-S113. Published online January 12, 2021
Background/Aims: This study compared long-term clinical outcomes between male and female acute myocardial infarction (AMI) patients with and without diabetes mellitus (DM).
Methods: From November 2011 to December 2015, 13,104 patients with AMI were enrolled in the Korea Acute Myocardial Infarction ..
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Update on association between exposure to renin-angiotensin-aldosterone system inhibitors and coronavirus disease 2019 in South Korea
Jeongkuk Seo, Minkook Son
Korean J Intern Med. 2021;36(Suppl 1):S114-S122. Published online February 25, 2021
Background/Aims: Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there have been concerns about the association between exposure to renin-angiotensin-aldosterone system (RAAS) inhibitors and the risk and severity of COVID-19.
Methods: We performed a case-control study that util..
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Effects of renin-angiotensin system blockers on the risk and outcomes of severe acute respiratory syndrome coronavirus 2 infection in patients with hypertension
Jinwoo Lee, Seong Jin Jo, Youngjin Cho, Ji Hyun Lee, Il-Young Oh, Jin Joo Park, Young-Seok Cho, Dong-Ju Choi
Korean J Intern Med. 2021;36(Suppl 1):S123-S131. Published online February 10, 2021
Background/Aims: There are concerns that the use of renin-angiotensin system (RAS) blockers may increase the risk of being infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or progressing to a severe clinical course after infection. This this study aimed to investigate the i..
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Pulmonology
Pleuroparenchymal fibroelastosis in Korean patients: clinico-radiologic-pathologic features and 2-year follow-up
Jae Ha Lee, Eun Jin Chae, Joon Seon Song, Miae Kim, Jin Woo Song
Korean J Intern Med. 2021;36(Suppl 1):S132-S141. Published online February 24, 2020
Background/Aims: Pleuroparenchymal fibroelastosis (PPFE) is a type of rare idiopathic interstitial pneumonia that is characterized by predominantly upper lobe involvement with pleural fibrosis and subjacent parenchymal fibrosis. This study aimed to determine the clinico-radiologic-pathologic feature..
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A genome wide association study for lung function in the Korean population using an exome array
Kyu-Sun Lee, Kun Hee Kim, Yeon-Mok Oh, Buhm Han, Woo Jin Kim
Korean J Intern Med. 2021;36(Suppl 1):S142-S150. Published online April 29, 2020
Background/Aims: Lung function is an objective indicator of diagnosis and prognosis of respiratory diseases. Many common genetic variants have been associated with lung function in multiple ethnic populations. We looked for coding variants associated with forced expiratory volume in 1 second (FEV
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Characteristics and risk factors associated with missed diagnosis in patients with smear-negative pulmonary tuberculosis
Se Hyun Kwak, Ji Soo Choi, Eun Hye Lee, Su Hwan Lee, Ah Young Leem, Sang Hoon Lee, Song Yee Kim, Kyung Soo Chung, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Joon Chang, Young Ae Kang
Korean J Intern Med. 2021;36(Suppl 1):S151-S159. Published online August 20, 2020
Background/Aims: Delayed diagnosis and treatment of smear-negative pulmonary tuberculosis (TB) are major concerns for TB control. We evaluated characteristics of patients with smear-negative pulmonary TB who received a delayed diagnosis and identified risk factors that may have contributed to this d..
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In vivo therapeutic success of MicroRNA-155 antagomir in a mouse model of pulmonary fibrosis induced by bleomycin
Xiaoyuan Sun, Yu Kang, Shan Xue, Jing Zou, Jiabo Xu, Daoqiang Tang, Hui Qin
Korean J Intern Med. 2021;36(Suppl 1):S160-S169. Published online June 9, 2020
Background/Aims: MicroRNAs (miRNAs) play critical regulatory roles in the pathogenesis of pulmonary fibrosis. The aim of this study was to explore whether miRNA antagomirs could serve as potential therapeutic agents in interstitial lung diseases.
Methods: A mouse model of pulmonary fibrosis was est..
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Endocrinology-metabolism
Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination Survey
Jeonghoon Ha, Jeongmin Lee, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo-Il Kang, Min-Hee Kim
Korean J Intern Med. 2021;36(Suppl 1):S170-S179. Published online June 9, 2020
Background/Aims: Thyroid hormones are involved in wide range of glucose metabolism functions. Overt thyroid dysfunctions are related to altered glucose homeostasis. However, it is not conclusive as to whether subtle changes in thyroid hormones within normal ranges can induce alterations in glucose h..
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Nephrology
L-carnitine treatment attenuates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
Hai Yan Zhao, Hui Ying Li, Jian Jin, Ji Zhe Jin, Long Ye Zhang, Mei Ying Xuan, Xue Mei Jin, Yu Ji Jiang, Hai Lan Zheng, Ying Shun Jin, Yong Jie Jin, Bum Soon Choi, Chul Woo Yang, Shang Guo Piao, Can Li
Korean J Intern Med. 2021;36(Suppl 1):S180-S195. Published online September 18, 2020
Background/Aims: Accumulating evidence indicates that L-carnitine (LC) protects against multiorgan damage through its antioxidant properties and preservation of the mitochondria. Little information is available about the effects of LC on renal fibrosis. This study examined whether LC treatment would..
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Hemato-oncology
Metformin enhances the cytotoxic effect of nilotinib and overcomes nilotinib resistance in chronic myeloid leukemia cells
Yoo Jin Na, Eun Sang Yu, Dae Sik Kim, Dae-Hee Lee, Sang Cheul Oh, Chul Won Choi
Korean J Intern Med. 2021;36(Suppl 1):S196-S206. Published online April 3, 2020
Background/Aims: Nilotinib is used for treating patients with imatinib-sensitive or -resistant chronic myeloid leukemia (CML); however, nilotinib-resistant cases have been observed in recent years. In addition, a considerable number of patients receiving nilotinib developed diabetes. Metformin is a ..
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Determination of the relationship between the fatigue and social support levels of cancer patients: a cross-sectional study
Meltem Akbas, Sule Gokyildiz Surucu, Emine Akca, Cemile Onat Koroglu
Korean J Intern Med. 2021;36(Suppl 1):S207-S216. Published online June 12, 2020
Background/Aims: Cancer is seen as one of the most important health problems of our time. In the world and in our country, the most common death cause after cardiovascular diseases in the order of diseases that result in death is cancer. This descriptive, cross-sectional study is done in order to de..
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Induction chemotherapy followed by concurrent chemoradiotherapy versus CCRT for locally
advanced hypopharynx and base of tongue cancer
Sung Hee Lim, Jong-Mu Sun, Joohyun Hong, Dongryul Oh, Yong Chan Ahn, Man Ki Chung, Han-Sin Jeong, Young-Ik Son, Myung-Ju Ahn, Chung-Hwan Baek, Keunchil Park
Korean J Intern Med. 2021;36(Suppl 1):S217-S224. Published online April 3, 2020
Background/Aims: Clinical trials have not consistently supported the use of induction chemotherapy (IC) for locally advanced head and neck squamous cell cancer. Hypopharynx and base of tongue (BOT) cancer has shown relatively poor survival. We investigated the role of IC in improving outcome over c..
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Physical activity of Korean cancer survivors is associated with age and sex
Jae Hyeon Park, Jung Soo Lee, Yoon Ho Ko, Yeo Hyung Kim
Korean J Intern Med. 2021;36(Suppl 1):S225-S234. Published online May 7, 2020
Background/Aims: This study aimed to assess adherence to physical activity guidelines in cancer survivors and to investigate related factors.
Methods: The cross-sectional data of 39,845 community-dwelling participants aged ≥ 20 years (1,254 cancer survivors) in the Korea National Health and Nutri..
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Surtuin 1 as a potential prognostic biomarker in very elderly patients with colorectal cancer
Guk Jin Lee, Yun Hwa Jung, Tae-Jung Kim, Yosep Chong, Seo-Won Jeong, In Kyu Lee, In Sook Woo
Korean J Intern Med. 2021;36(Suppl 1):S235-S244. Published online July 2, 2020
Background/Aims: Colorectal cancer (CRC) rate increases with aging. Aging-related proteins, such as sirtuins (SIRTs) may be a potential therapeutic target in the elderly patients with CRC. The clinical implications of SIRT1 and SIRT2 have not been reported for elderly patients with cancer. The aim of..
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Different roles of surveillance positron emission tomography according to the histologic subtype of non-Hodgkin’s lymphoma
Yu Ri Kim, Soo-Jeong Kim, June-Won Cheong, Yundeok Kim, Ji Eun Jang, Hyunsoo Cho, Haerim Chung, Yoo Hong Min, Woo Ick Yang, Arthur Cho, Jin Seok Kim
Korean J Intern Med. 2021;36(Suppl 1):S245-S252. Published online June 19, 2020
Background/Aims: Although the use of surveillance 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is discouraged in patients with diffuse large B-cell lymphoma, its usefulness in different subtypes has not been thoroughly investigated.
Methods: We r..
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Infectious diseases
Lopinavir-ritonavir versus hydroxychloroquine for viral clearance and clinical improvement in patients with mild to moderate coronavirus disease 2019
Ji-Won Kim, Eun Jin Kim, Hyun Hee Kwon, Chi Young Jung, Kyung Chan Kim, Jung-Yoon Choe, Hyo-Lim Hong
Korean J Intern Med. 2021;36(Suppl 1):S253-S263. Published online June 16, 2020
Background/Aims: The efficacies of lopinavir-ritonavir or hydroxychloroquine remain to be determined in patients with coronavirus disease 2019 (COVID-19). To compare the virological and clinical responses to lopinavir-ritonavir and hydroxychloroquine treatment in COVID-19 patients.
Methods: This re..
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Rheumatology
Distribution of serum uric acid levels and prevalence of hyper- and hypouricemia in a Korean general population of 172,970
Bon San Koo, Hye-Jin Jeong, Chang-Nam Son, Sang-Hyon Kim, Hyun Jung Kim, Gheun-Ho Kim, Jae-Bum Jun
Korean J Intern Med. 2021;36(Suppl 1):S264-S272. Published online November 24, 2020
Background/Aims: We investigated the distribution of serum uric acid (SUA) levels and estimated the prevalence of hyperuricemia and hypouricemia in the Korean population.
Methods: This cross-sectional study used data from the Korean Genome and Epidemiology Study and included 172,970 participants (5..
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Tocotrienol regulates osteoclastogenesis in rheumatoid arthritis
Kyoung-Woon Kim, Bo-Mi Kim, Ji-Yeon Won, Hong Ki Min, Seoung Joon Lee, Sang-Heon Lee, Hae-Rim Kim
Korean J Intern Med. 2021;36(Suppl 1):S273-S282. Published online June 19, 2020
Background/Aims: The present study aimed to investigate whether tocotrienol regulates interleukin 17 (IL-17)-induced osteoclastogenesis in rheumatoid arthritis (RA).
Methods: We evaluated the effect of tocotrienol on IL-17-induced receptor activator of nuclear factor kappa B ligand (RANKL) producti..
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Allergy
Current practice for diagnosing immediate drug hypersensitivity reactions in Korea
Sung-Yoon Kang, Min-Suk Yang, Woo-Jung Song, Sang-Heon Cho
Korean J Intern Med. 2021;36(Suppl 1):S283-S296. Published online January 5, 2021
Background/Aims: Skin (STs) and drug provocation (DPTs) tests are essential for identifying the culprit drugs causing drug hypersensitivity reactions (DHRs). Several protocols have been developed for the identification of some culprit drugs, but they are neither thoroughly validated nor standardized..
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Original Article
