| Reviews |
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Current status and therapeutic considerations of hypertension in the elderly
Ju-Hee Lee, Kwang-Il Kim, Myeong-Chan Cho
Korean J Intern Med. 2019;34(4):687-695. Published online July 1, 2019
As the prevalence of hypertension in the elderly population is increasing, information regarding the characteristics, optimal blood pressure targets, and special considerations for elderly hypertensive patients is needed to improve clinical outcomes. Various factors should be considered when managin..
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Current status of pulmonary arterial hypertension in Korea
Albert Youngwoo Jang, Wook-Jin Chung
Korean J Intern Med. 2019;34(4):696-707. Published online July 1, 2019
Pulmonary arterial hypertension (PAH) is characterized by remodeling of the distal pulmonary arteries resulting in high pulmonary vascular resistance and, eventually, right ventricular heart failure. Although current advances in PAH therapy have improved outcomes, poor survival remains a reality wor..
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Application of machine learning in rheumatic disease research
Ki-Jo Kim, Ilias Tagkopoulos
Korean J Intern Med. 2019;34(4):708-722. Published online December 31, 2018
Over the past decade, there has been a paradigm shift in how clinical data are collected, processed and utilized. Machine learning and artificial intelligence, fueled by breakthroughs in high-performance computing, data availability and algorithmic innovations, are paving the way to effective analys..
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| Guideline |
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2018 Guidelines for the management of dyslipidemia
[corrected-article]
Eun-Jung Rhee, Hyeon Chang Kim, Jae Hyeon Kim, Eun Young Lee, Byung Jin Kim, Eun Mi Kim, YoonJu Song, Jeong Hyun Lim, Hae Jin Kim, Seonghoon Choi, Min Kyong Moon, Jin Oh Na, Kwang-Yeol Park, Mi Sun Oh, Sang Youb Han, Junghyun Noh, Kyung Hee Yi, Sang-Hak Lee, Soon-Cheol Hong, In-Kyung Jeong
Korean J Intern Med. 2019;34(4):723-771. Published online July 1, 2019
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| Editorials |
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| Original Articles |
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Gastroenterology
Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease
Sang Bong Ahn, Dae Won Jun, Kiseok Jang, Byung Hoon Lee, Kye Jung Shin
Korean J Intern Med. 2019;34(4):777-784. Published online February 23, 2018
Background/Aims: Intestinal cholesterol absorption includes intestinal Niemann-Pick C1-like 1 (NPC1L1) and is an important target pathway in nonalcoholic fatty liver disease (NAFLD). We investigated the expression of NPC1L1 and its correlation with liver X receptor (LXR) expression in peripheral mon..
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Current status of endoscopic submucosal dissection for early gastric cancer in Korea: role and benefits
Sang Gyun Kim, Da Hyun Lyu, Chan Mi Park, Na Rae Lee, Jiyoung Kim, Youngju Cha, Hwoon-Yong Jung
Korean J Intern Med. 2019;34(4):785-793. Published online June 21, 2018
Background/Aims: This study was aimed to investigate the current clinical status of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in Korea based on a National Health Insurance (NHI) database between 2011 and 2014.
Methods: The claims data of ESD for EGC in Korean NHI were re..
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Daclatasvir and asunaprevir combination therapy for patients with chronic hepatitis C virus genotype 1b infection in real world
Jae Young Oh, Byung Seok Kim, Chang Hyeong Lee, Jeong Eun Song, Heon Ju Lee, Jung Gil Park, Jae Seok Hwang, Woo Jin Chung, Byoung Kuk Jang, Young Oh Kweon, Won Young Tak, Soo Young Park, Se Young Jang, Jeong Ill Suh, Sang Gyu Kwak
Korean J Intern Med. 2019;34(4):794-801. Published online May 25, 2018
Background/Aims: Previous studies have reported a high rate of sustained virologic response (SVR) and a low rate of serious adverse events with the use of daclatasvir (DCV) and asunaprevir (ASV) combination therapy. We evaluated the efficacy and safety of DCV and ASV combination therapy for patient..
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Efficacy of long-term tenofovir disoproxil fumarate therapy in chronic hepatitis B patients with partial virologic response in real practice
Jeong Eun Song, Chang Hyeong Lee, Byung Seok Kim
Korean J Intern Med. 2019;34(4):802-810. Published online April 8, 2019
Background/Aims: The optimal management of chronic hepatitis B (CHB) patients with partial virologic response (PVR) to tenofovir disoproxil fumarate (TDF) remains unclear. We aimed to evaluate the long-term efficacy of prolonged TDF therapy in treatment-naïve CHB patients with PVR to TDF therapy in..
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Cardiology
Serum levels of carbohydrate antigen 125 in combination with N-terminal pro-brain natriuretic peptide in patients with acute decompensated heart failure
Jae Yong Yoon, Dong Heon Yang, Hyun Jun Cho, Nam Kyun Kim, Chang-Yeon Kim, Jihyun Son, Jae-Hyung Roh, Se Yong Jang, Myung Hwan Bae, Jang Hoon Lee, Hun Sik Park, Yongkeun Cho, Shung Chull Chae
Korean J Intern Med. 2019;34(4):811-818. Published online December 31, 2018
Background/Aims: Carbohydrate antigen 125 (CA-125) is an emerging prognostic biomarker for heart failure. We aimed to test the long-term prognostic value of CA-125 in combination with N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with acute decompensated heart failure (ADHF).
Met..
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Intravascular imaging analysis of a drug-eluting balloon followed by a bare metal stent compared to a drug-eluting stent for treatment of de novo lesions
Wonsuk Choi, In-Ho Chae, Jin Joo Park, Sun-Hwa Kim, Si-Hyuck Kang, Il-Young Oh, Chang-Hwan Yoon, Young-Seok Cho, Tae-Jin Youn, Dong-Ju Choi
Korean J Intern Med. 2019;34(4):819-829. Published online July 4, 2018
Background/Aims: After a study comparing drug-eluting stents (DESs) to sequential treatment with drug-eluting balloons (DEBs) and bare metal stents (BMSs), we retrospectively analysed strut malapposition and neointimal hyperplasia in de novo coronary lesions using optical coherence tomography (OCT) ..
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Pulmonology
Birt-Hogg-Dubé syndrome in Korean: clinicoradiologic features and long term follow-up
Joo Hee Lee, Min Joo Jeon, Joon Seon Song, Eun Jin Chae, Jin-Ho Choi, Gu-Hwan Kim, Jin Woo Song
Korean J Intern Med. 2019;34(4):830-840. Published online October 26, 2018
Background/Aims: Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant disorder that is characterized by skin fibrofolliculomas, pulmonary cysts, and renal tumors. The objective of this study was to describe the features of Korean patients with BHD syndrome.
Methods: Clinical data were retro..
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Prognostic significance of malnutrition for long-term mortality in community-acquired
pneumonia: a propensity score matched analysis
Hye Ju Yeo, Ki Sup Byun, Junhee Han, June Hyun Kim, Seung Eun Lee, Seong Hoon Yoon, Doosoo Jeon, Yun Seong Kim, Woo Hyun Cho
Korean J Intern Med. 2019;34(4):841-849. Published online January 29, 2019
Background/Aims: The impact of malnutrition on the outcome of hospitalized adults with community-acquired pneumonia (CAP) has not been fully investigated. This study evaluated the prevalence and prognostic significance of malnutrition in a Korean population with CAP. Methods: In total, 198 patients ..
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Endocrinology-metabolism
Utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules: efficacy of the standard deviation elasticity
Hye Jeong Kim, Mi Kyung Kwak, In Ho Choi, So-Young Jin, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh, Myung Hi Yoo
Korean J Intern Med. 2019;34(4):850-857. Published online February 23, 2018
Background/Aims: The aim of this study was to address the role of the elasticity index as a possible predictive marker for detecting papillary thyroid carcinoma (PTC) and quantitatively assess shear wave elastography (SWE) as a tool for differentiating PTC from benign thyroid nodules.
Methods: One ..
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Nephrology
Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease
Seon Ha Baek, Ran-hui Cha, Shin Wook Kang, Cheol Whee Park, Dae Ryong Cha, Sung Gyun Kim, Sun Ae Yoon, Sejoong Kim, Sang-Youb Han, Jung Hwan Park, Jae Hyun Chang, Chun Soo Lim, Yon Su Kim, Ki Young Na
Korean J Intern Med. 2019;34(4):858-866. Published online November 29, 2017
Background/Aims: Patients with chronic kidney disease (CKD) have been found to show markedly increased rates of end-stage renal disease, major adverse cardiovascular and cerebrovascular events (MACCEs), and mortality. Therefore, new biomarkers are required for the early detection of such clinical ou..
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Association between initial vascular access and survival in hemodialysis according to age
Ha Yeon Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Korean J Intern Med. 2019;34(4):867-876. Published online November 20, 2017
Background/Aims: This study aims to demonstrate whether the association between initial vascular access and mortality among hemodialysis patients varies by age.
Methods: We conducted a retrospective study that included 2,552 patients who started hemodialysis. Vascular access was divided into three ..
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Hemato-oncology
The impact of sarcopenia on health-related quality of life in elderly people: Korean National
Health and Nutrition Examination Survey
Der Sheng Sun, Hyunyong Lee, Hyeon Woo Yim, Hye Sung Won, Yoon Ho Ko
Korean J Intern Med. 2019;34(4):877-884. Published online November 27, 2017
Background/Aims: The purpose of the study is to investigate the associations between sarcopenia and health-related quality of life in elderly men and women in Korea.
Methods: In a cross-sectional study using data from 2008 to 2011 Korean National Health and Nutrition Examination Survey, 4,937 adult..
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Clinical significance of rituximab infusion-related reaction in diffuse large B-cell lymphoma patients receiving R-CHOP
Kyoung Min Cho, Bhumsuk Keam, Hyerim Ha, Miso Kim, Jae-Woo Jung, Woo-Jung Song, Tae Min Kim, Yoon Kyung Jeon, Hye-Ryun Kang, Dong-Wan Kim, Chul Woo Kim, Dae Seog Heo
Korean J Intern Med. 2019;34(4):885-893. Published online November 20, 2017
Background/Aims: This study was to evaluate the clinical significance of infusion-related reaction (IRR) of rituximab in diffuse large B-cell lymphoma (DLBCL) patients who received R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) as a first-line chemotherapy.
Methods..
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Costs and clinical outcomes of patients with diffuse large B-cell lymphoma in first remission: role of PET/CT surveillance
Koung Jin Suh, Ki Hwan Kim, Ryul Kim, Ja Min Byun, Miso Kim, Jin Hyun Park, Bhumsuk Keam, Tae Min Kim, Jin-Soo Kim, In Sil Choi, Dae Seog Heo
Korean J Intern Med. 2019;34(4):894-901. Published online February 23, 2018
Background/Aims: The role of [18F]-f luorodeoxyglucose positron emission tomography-computed tomography (PET/CT) in patients with diffuse large B-cell lymphoma (DLBCL) in first remission is unclear.
Methods: Medical costs within the first 3 years of treatment completion and clinical outcomes of 118..
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Infectious diseases
Application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndrome
Jeong Rae Yoo, Sun Hyung Kim, Young Ree Kim, Keun Hwa Lee, Won Sup Oh, Sang Taek Heo
Korean J Intern Med. 2019;34(4):902-909. Published online November 10, 2017
Background/Aims: Severe fever with thrombocytopenia syndrome (SFTS) is a viral hemorrhagic fever with a high fatality rate. However, effective treatments for SFTS cases not responded to supportive therapy have not been established. Herein, we introduced the therapeutic plasma exchange (TPE) in SFTS ..
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Rheumatology
Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis
Soo-Kyoung Cho, Dam Kim, Soyoung Won, Jiyoung Lee, Chan-Bum Choi, Jung-Yoon Choe, Seung-Jae Hong, Jae-Bum Jun, Tae-Hwan Kim, Eunmi Koh, Hye-Soon Lee, Jisoo Lee, Dae-Hyun Yoo, Bo Young Yoon, Sang-Cheol Bae, Yoon-Kyoung Sung; Korean Observational Study Network for Arthritis (KORONA) Investigators
Korean J Intern Med. 2019;34(4):910-916. Published online December 15, 2017
Background/Aims: To identify the factors associated with time to diagnosis after symptom onset in patients with early rheumatoid arthritis (RA).
Methods: Early RA patients with ≤ 1 year of disease duration in the KORean Observational study Network for Arthritis (KORONA) database were included in t..
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Efficacy and safety of tocilizumab in Korean patients with active rheumatoid arthritis
Han Joo Baek, Mie Jin Lim, Won Park, Sung Hwan Park, Seung-Cheol Shim, Dae-Hyun Yoo, Hyun Ah Kim, Soo Kon Lee, Yun Jong Lee, Young Eun Park, Hoon-Suk Cha, Yeong-Wook Song
Korean J Intern Med. 2019;34(4):917-931. Published online January 17, 2018
Background/Aims: To investigate the efficacy and safety of tocilizumab (TCZ) humanized anti-interleukin-6 receptor monoclonal antibody, in Korean patients with active rheumatoid arthritis (RA) refractory to conventional disease modifying anti-rheumatic drugs (DMARDs) including methotrexate (MTX)
Me..
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The evaluation of cellular immune function in elderly patients with systemic lupus erythematosus
Kun Men, Yu Chen, Jingwei Zhang, Dianjun Wei
Korean J Intern Med. 2019;34(4):932-937. Published online November 29, 2017
Background/Aims: To evaluate cellular immune function in systemic lupus erythematosus (SLE) patients over 60 years old, the association between antinuclear antibody (ANA) titers and the ratio of CD4+ /CD8+ was analyzed in this study. The distribution of ANAs and extractable nu..
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| Images of interest |
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Direct cholangioscopy with argon plasma coagulation of an intraductal papillary mucinous neoplasm of the bile duct
Boram Cha, Jin-Seok Park, Seok Jeong, Don Haeng Lee, Joon Mee Kim
Korean J Intern Med. 2019;34(4):940-941. Published online May 16, 2018
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Massive ventilator-associated pleural empyema
Philipp Jud, Nicole Fink-Neuboeck, Joerg Lindenmann
Korean J Intern Med. 2019;34(4):942-943. Published online March 8, 2019
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| Corrigendum |
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Update on heart failure management and future directions
Hong-Mi Choi, Myung-Soo Park, Jong-Chan Youn
Korean J Intern Med. 2019;34(4):944-944. Published online July 1, 2019
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