| Reviews |
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Cardiology
Supplementary nutrients for prevention of vascular calcification in patients with chronic kidney disease
Su Mi Lee, Won Suk An
Korean J Intern Med. 2019;34(3):459-469. Published online April 30, 2019
Vascular calcification (VC) and malnutrition associated with cardiovascular disease are common in patients with chronic kidney disease (CKD) treated with dialysis. VC, which reflects vascular aging, and malnutrition are also encountered in the non-CKD elderly population. This similarity of clinical ..
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Extracellular vesicles in renal physiology and clinical applications for renal disease
Soon Hyo Kwon
Korean J Intern Med. 2019;34(3):470-479. Published online April 30, 2019
Many cells in the nephron release extracellular vesicles (EVs). EVs envelop nucleic acids, proteins, and lipids. The surfaces of EVs express donor cell-specific markers, ligands, and major histocompatibility complex molecules. They are involved in cell-to-cell communication, immune modulation, and t..
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Adiponectin for the treatment of diabetic nephropathy
Jun Young Lee, Jae Won Yang, Byoung Geun Han, Seung Ok Choi, Jae Seok Kim
Korean J Intern Med. 2019;34(3):480-491. Published online April 30, 2019
The metabolic burden caused by hyperglycemia can result in direct and immediate metabolic injuries, such as oxidative stress and tissue inflammation, in the kidney. Furthermore, chronic hyperglycemia can lead to substantial structural changes such as formation of advanced glycation end-products, glo..
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Rheumatology
Molecular targeted therapies for microscopic polyangiitis and granulomatosis with polyangiitis
Masayoshi Harigai, Michi Tsutsumino, Hideto Takada, Kenji Nagasaka
Korean J Intern Med. 2019;34(3):492-503. Published online January 9, 2019
Clinical trials and observational studies have established cyclophosphamide (CY) or rituximab plus glucocorticoid (GC) as standard remission induction therapies in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). However, because these regimens are associated ..
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| Editorials |
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Arterial stiffness and cardiovascular risk
Jae-Geun Lee, Seung-Jae Joo
Korean J Intern Med. 2019;34(3):504-506. Published online April 30, 2019
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Is sarcopenia a real risk factor for mortality in patients undergoing hemodialysis?
Eun Hui Bae
Korean J Intern Med. 2019;34(3):507-509. Published online April 30, 2019
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| Original Articles |
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Gastroenterology
Time-dependent reversal of significant intrapulmonary shunt after liver transplantation
Xin Jin, Byung Joo Sun, Jae-Kwan Song, Jae-Hyung Roh, Jeong Yoon Jang, Dae-Hee Kim, Young-Suk Lim, Jong-Min Song, Duk-Hyun Kang, Sung Gyu Lee
Korean J Intern Med. 2019;34(3):510-518. Published online March 5, 2018
Background/Aims: Although the association between intrapulmonary shunt (IPS) and liver cirrhosis is clear, data of repeated contrast echocardiography (CE) before and after liver transplantation (LT) to evaluate factors associated with IPS are limited.
Methods: Hand-agitated saline was used for CE a..
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Epidemiologic features of ınflammatory bowel disease in Western Blacksea region of Turkey for the last 10 years: retrospective cohort study
Güray Can, Emrah Poşul, Bülent Yılmaz, Hatice Can, Uğur Korkmaz, Fatih Ermiş, Mevlüt Kurt, Ülkü Dağlı
Korean J Intern Med. 2019;34(3):519-529. Published online April 27, 2018
Background/Aims: There are only a few epidemiological study about inflammatory bowel disease in the last 10 years in Turkey, especially in Western Blacksea region. In our study, we aimed to identify the changes in the incidence and the prevalence of inflammatory bowel disease in Western Blacksea reg..
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Performance of disposable endoscopic forceps according to the manufacturing techniques
Chang-Il Kwon, Gwangil Kim, Jong Pil Moon, Ho Yun, Weon Jin Ko, Joo Young Cho, Sung Pyo Hong
Korean J Intern Med. 2019;34(3):530-538. Published online March 5, 2018
Background/Aims: Recently, to lower the production costs and risk of infection, new disposable biopsy forceps made using simple manufacturing techniques have been introduced. However, the effects of the manufacturing techniques are unclear. The aim of this study was to evaluate which types of biopsy..
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Cardiology
Gender difference in the association between brachial-ankle pulse wave velocity and cardiovascular risk scores
Tae-Min Rhee, Hack-Lyoung Kim, Sohee Oh, Woo-Hyun Lim, Jae-Bin Seo, Woo-Young Chung, Sang-Hyun Kim, Myung-A Kim, Joo-Hee Zo
Korean J Intern Med. 2019;34(3):539-548. Published online March 16, 2018
Background/Aims: Although brachial-ankle pulse wave velocity (baPWV) has been validated as a novel method to predict the cardiovascular risk in general population, the relevance of baPWV to the traditional risk scores has not been clearly revealed. This study investigated the relationship between b..
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Pre-discharge anemia as a predictor of adverse clinical outcomes in patients with acute decompensated heart failure
Min Chul Kim, Kye Hun Kim, Jae Yeong Cho, Ki Hong Lee, Doo Sun Sim, Hyun Ju Yoon, Nam Sik Yoon, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park
Korean J Intern Med. 2019;34(3):549-558. Published online March 23, 2018
Background/Aims: The impact of the timing of anemia during hospitalization on future clinical outcomes after surviving discharge from an index heart failure (HF) has been poorly studied in patients with acute decompensated heart failure (ADHF).
Methods: A total of 384 surviving patients with acute ..
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Pulmonology
Efficacy and predictors of response to inhaled corticosteroid treatment for chronic cough
Ji Young Hong, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Ki-Suck Jung, Seung Hun Jang
Korean J Intern Med. 2019;34(3):559-568. Published online December 13, 2018
Background/Aims: Inhaled corticosteroids (ICS) are a treatment of choice for eosinophilic airway diseases, but their efficacy for other causes of chronic cough is controversial.
Methods: We conducted a prospective observational study to determine the ICS efficacy and clinical predictors of response t..
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Left ventricular dysfunction in relation with systemic inflammation in chronic obstructive pulmonary disease patients
Sule Tas Gulen, Ufuk Eryilmaz, Mustafa Yilmaz, Fisun Karadag
Korean J Intern Med. 2019;34(3):569-578. Published online October 29, 2018
Background/Aims: Most important cause of mortality in chronic obstructive pulmonary disease (COPD) patients is known to be cardiovascular disease (CVD). The objective of the present study was to evaluate the echocardiographic parameters in COPD patients with or without pre-diagnosed CVD and to inves..
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Endocrinology-metabolism
Aromatase inhibitor use is a risk factor of carotid plaque presence in endocrine-responsive breast cancer patients
Da Hea Seo, Yongin Cho, Sujin Lee, Seho Park, Seung-Il Kim, Byeong Woo Park, Yumie Rhee
Korean J Intern Med. 2019;34(3):579-587. Published online August 25, 2017
Background/Aims: The aromatase inhibitors (AIs) are well known anti-hormonal therapy in endocrine-responsive breast cancer patients. It can lead to dyslipidemia and be the risk factor of cardiovascular disease due to low estrogen level. However, some recent studies comparing AIs with placebo have sh..
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Nephrology
Intradialytic exercise improves physical function and reduces intradialytic hypotension and depression in hemodialysis patients
So Yon Rhee, Jin Kyung Song, Suk Chul Hong, Jae Won Choi, Hee Jung Jeon, Dong Ho Shin, Eun Hee Ji, Eun-Hee Choi, Jiyeon Lee, Aram Kim, Seung Wook Choi, Jieun Oh
Korean J Intern Med. 2019;34(3):588-598. Published online August 25, 2017
Background/Aims: As numbers of maintenance hemodialysis patients are growing, debilitating conditions of muscle wasting and atrophy are becoming some of the greatest concerns in end-stage renal disease patients. Exercise training has various potential benefits in terms of prevention of a sustained d..
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Impact of sarcopenia on long-term mortality and cardiovascular events in patients undergoing hemodialysis
Jwa-Kyung Kim, Sung Gyun Kim, Ji-Eun Oh, Young-Ki Lee, Jung-Woo Noh, Hyung Jik Kim, Young Rim Song
Korean J Intern Med. 2019;34(3):599-607. Published online November 23, 2017
Background/Aims: A high body mass index (BMI) is known to correlate with better survival in patients on hemodialysis (HD). However, the impacts of body composition and sarcopenia on survival have not been well studied in this population.
Methods: One hundred and forty-two prevalent HD patients were..
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Hemato-oncology
Comparison of the morphologic criteria (RECIST) and metabolic criteria (EORTC and PERCIST) in tumor response assessments: a pooled analysis
Hong Deok Kim, Bum Jun Kim, Hyeong Su Kim, Jung Han Kim
Korean J Intern Med. 2019;34(3):608-617. Published online January 17, 2018
Background/Aims: The Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) or European Organization for Research and Treatment of Cancer (EORTC) criteria are used to assess metabolic tumor responses. However, tumor responses have shown considerable discrepancies between the morpho..
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β-Catenin expression is associated with cell invasiveness in pancreatic cancer
Jin Niang Nan, Ok Ran Kim, Myung Ah Lee
Korean J Intern Med. 2019;34(3):618-625. Published online October 26, 2018
Background/Aims: This study was tried to determine the role of β-catenin in invasion in pancreatic cancer.
Methods: We analyzed cancer invasiveness according to β-catenin expression in pancreatic cancer cell line. We also investigated the change in cancer invasiveness when β-catenin expression was ch..
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Surrogate decision making of chemotherapy consent: do we really provide informed consent of chemotherapy for patients?
Jung Hye Kwon, Sun Kyung Baek, Bong-Seog Kim, Su-Jin Koh, Hee Kyung Ahn, Joo Han Lim, Chiyeon Lim, Do Yeun Kim
Korean J Intern Med. 2019;34(3):626-633. Published online May 31, 2018
Background/Aims: Despite increased demand for cancer patient’s to make their own decisions based on an adequate understanding of what is involved in chemotherapy, the primary signing agent and the reasons for surrogate signing have not been appropriately evaluated.
Methods: The ethics committee of..
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Infectious diseases
MicroRNA-16 inhibits cell proliferation and migration by targeting heat shock protein 70 in heat-denatured dermal fibroblasts
[retracted-article]
Chun Zhang, Jinhua Dai, Youfen Fan, Xianghui He, Renxiong Wei
Korean J Intern Med. 2019;34(3):634-642. Published online January 5, 2018
Background/Aims: This study aimed to investigate the precise mechanism and function of miR-16 in heat-denatured primary human dermal fibroblasts.
Methods: Primary human dermal fibroblasts were separated from normal human skin samples. Under heat stress, the levels of miR-16 and heat shock protein 7..
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Allergy
Prevalence of anaphylaxis and prescription rates of epinephrine auto-injectors in urban and rural areas of Korea
Hyunseok Cho, Jae-Woo Kwon
Korean J Intern Med. 2019;34(3):643-650. Published online October 26, 2018
Background/Aims: Despite the clinical importance anaphylaxis and the recent increase in its occurrence, studies regarding the epidemiology of anaphylaxis, risk factors for anaphylaxis, and epinephrine auto-injector (EAI) prescription status for patients with anaphylaxis remain poorly described. Thus..
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Rheumatology
Magnetic resonance imaging-assessed synovial and bone changes in hand and wrist joints of rheumatoid arthritis patients
Kyung-Ann Lee, Sang-Ho Min, Tae-Hyung Kim, Sang-Heon Lee, Hae-Rim Kim
Korean J Intern Med. 2019;34(3):651-659. Published online November 24, 2017
Background/Aims: Magnetic resonance imaging (MRI) is a sensitive and useful method for the detection of synovitis and joint destruction in rheumatoid arthritis (RA) patients. However, the patterns of MRI-detected bone erosion, bone marrow edema (BME), synovitis, and tenosynovitis have received insuf..
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Korean rheumatology workforce from 1992 to 2015: current status and future demand
Chan Uk Lee, Ji Na Kim, Ji-Won Kim, Sung-Hoon Park, Hwajeong Lee, Seong-Kyu Kim, Jung-Yoon Choe
Korean J Intern Med. 2019;34(3):660-668. Published online December 15, 2017
Background/Aims: Rheumatology in Korea has rapidly advanced in the 24 years since the subspecialty board certification program was established in 1992. The objective of this investigation was to analyze the distribution of rheumatology practices in Korea in order to better understand the rheumatolog..
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Risk of malignancy in patients with rheumatoid arthritis after anti-tumor necrosis factor therapy: results from Korean National Health Insurance claims data
Seung Min Jung, Seung-Ki Kwok, Ji Hyeon Ju, Yong-Beom Park, Sung-Hwan Park
Korean J Intern Med. 2019;34(3):669-677. Published online November 29, 2017
Background/Aims: Inhibition of tumor necrosis factor (TNF) is an effective treatment for rheumatoid arthritis (RA), but safety concerns about malignancy remain. The aim of this study was to evaluate cancer risk in RA patients treated with TNF inhibitors (TNFi), based on Korean Nationwide Health Insu..
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| Images of interest |
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Giant intra-abdominal cystic lymphangioma
Fatih Altintoprak, Mustafa Yener Uzunoglu, Kayhan Ozdemir, Enis Dikicier, Zeynep Kahyaoglu
Korean J Intern Med. 2019;34(3):678-679. Published online January 7, 2019
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Rapid changes in capillary morphology and architecture in a patient with dermatomyositis
Sung-Jo Park, In-Ho Choi, Hyun-Sook Kim
Korean J Intern Med. 2019;34(3):680-682. Published online January 5, 2018
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Fever of unknown origin caused by intrathyroidal thymic carcinoma
Seung Min Chung, Kyung-Ju Kim, Jun Sung Moon, Young Hoon Hong, Su Hwan Kang
Korean J Intern Med. 2019;34(3):683-684. Published online August 13, 2018
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| Corrigenda |
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Effect of vitamin D deficiency in Korean patients with acute respiratory distress syndrome
Sojung Park, Min Gee Lee, Sang-Bum Hong, Chae-Man Lim, Younsuck Koh, Jin Won Huh
Korean J Intern Med. 2019;34(3):685-685. Published online April 30, 2019
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