| Reviews |
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Gastroenterology
Is screening and surveillance for early detection of gastric cancer needed in Korean Americans?
Gwang Ha Kim, Sung Jo Bang, Alexander R. Ende, Joo Ha Hwang
Korean J Intern Med. 2015;30(6):747-758. Published online October 30, 2015
The incidence rate of gastric cancer in Korean Americans is over five times higher than that in non-Hispanic whites, and is similar to the incidence of colorectal cancer in the overall United States population. In Korea, the National Cancer Screening Program recommends endoscopy or upper gastrointes..
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Nephrology
Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation
Sun Woo Lim, Ji Zhe Jin, Long Jin, Jian Jin, Can Li
Korean J Intern Med. 2015;30(6):759-770. Published online October 30, 2015
Despite strict pre- and post-transplantation screening, the incidence of new-onset diabetes after transplantation (NODAT) remains as high as 60%. This complication affects the risk of cardiovascular events and patient and graft survival rates. Thus, reducing the impact of NODAT could improve overall..
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Hemato-oncology
Guidelines for the management of myeloproliferative neoplasms
Chul Won Choi, Soo-Mee Bang, Seongsoo Jang, Chul Won Jung, Hee-Jin Kim, Ho Young Kim, Soo-Jeong Kim, Yeo-Kyeoung Kim, Jinny Park, Jong-Ho Won
Korean J Intern Med. 2015;30(6):771-788. Published online October 30, 2015
Polycythemia vera, essential thrombocythemia, and primary myelofibrosis are collectively known as ‘Philadelphia-negative classical myeloproliferative neoplasms (MPNs).’ The discovery of new genetic aberrations such as Janus kinase 2 (JAK2) have enhanced our understanding of the pathophysio..
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| Editorial |
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Time to learn from the past and prepare for the future in Helicobacter pylori eradication
Chang Seok Bang, Gwang Ho Baik
Korean J Intern Med. 2015;30(6):789-791. Published online October 30, 2015
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| Original Articles |
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Gastroenterology
Incidence of and risk factors for thyroid dysfunction during peginterferon α and ribavirin treatment in patients with chronic hepatitis C
Yong Hwang, Won Kim, So Young Kwon, Hyung Min Yu, Jeong Han Kim, Won Hyeok Choe
Korean J Intern Med. 2015;30(6):792-800. Published online October 30, 2015
Background/Aims: Thyroid dysfunction (TD) is more likely to occur in patients with chronic hepatitis C (CHC) and is particularly associated with interferon (IFN) treatment. The purpose of this study was to investigate the incidence, outcomes, and risk factors for TD during pegylated interferon (PEG-..
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Trends in Helicobacter pylori eradication rates by first-line triple therapy and related factors in eradication therapy
Sung Eun Kim, Moo In Park, Seun Ja Park, Won Moon, Youn Jung Choi, Ji Hyun Cheon, Hye Jung Kwon, Ki Hwan Ku, Chang Hun Yoo, Jae Hyun Kim, Gyu Won Lee, Sung Eun Song
Korean J Intern Med. 2015;30(6):801-807. Published online October 30, 2015
Background/Aims: Trends in successful eradication of Helicobacter pylori using first-line triple therapy, consisting of a proton pump inhibitor, amoxicillin, and clarithromycin, have been understudied. We evaluated H. pylori eradication rates at a single center over the last 10 years a..
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Cardiology
Interatrial septal thickness as a marker of structural and functional remodeling of the left atrium in patients with atrial fibrillation
Hong Euy Lim, Jin Oh Na, Sung Il Im, Cheol Ung Choi, Seong Hwan Kim, Jin Won Kim, Eung Ju Kim, Seong Woo Han, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Chun Hwang
Korean J Intern Med. 2015;30(6):808-820. Published online October 30, 2015
Background/Aims: There have been reports that interatrial septal (IAS) thickness is increased in patients with atrial fibrillation (AF). This study was performed to investigate whether IAS thickness determined by transthoracic echocardiography (TTE) represents the amount of left atrium (LA) structur..
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Temporal trends and in-hospital outcomes of primary percutaneous coronary intervention in nonagenarians with ST-segment elevation myocardial infarction
Joon Young Kim, Myung Ho Jeong, Yong Woo Choi, Yong Keun Ahn, Shung Chull Chae, Seung Ho Hur, Taek Jong Hong, Young Jo Kim, In Whan Seong, In Ho Chae, Myeong Chan Cho, Jung Han Yoon, Ki Bae Seung, Other Korea Acute Myocardial Infarction Registry Investigators
Korean J Intern Med. 2015;30(6):821-828. Published online October 30, 2015
Background/Aims: Data regarding the outcomes of primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) in nonagenarians are very limited. The aim of the present study was to evaluate the temporal trends and in-hospital outcomes of primary PCI in nonag..
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Pulmonology
Clinical manifestations of pneumonia according to the causative organism in patients in the intensive care unit
Jung-Kyu Lee, Jinwoo Lee, Young Sik Park, Chang Hoon Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Sang-Min Lee
Korean J Intern Med. 2015;30(6):829-836. Published online October 30, 2015
Background/Aims: Whether the causative organism influences the clinical course of pneumonia in the intensive care unit (ICU) is controversial. We assessed the clinical manifestations and prognosis of pneumonia according to the causative pathogens in patients in a medical ICU.
Methods: A retrospecti..
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Survival benefits of warfarin in Korean patients with idiopathic pulmonary arterial hypertension
Byung Ju Kang, Yeon-Mok Oh, Sang-Do Lee, Jae Seung Lee
Korean J Intern Med. 2015;30(6):837-845. Published online October 30, 2015
Background/Aims: Idiopathic pulmonary arterial hypertension (IPAH) is an incurable disease with high mortality. Although most studies recommend anticoagulation treatment for IPAH, the benefits are uncertain, particularly in Korea, where it has not been studied. The purpose of this study was to evalu..
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Endocrinology-metabolism
Obstructive sleep apnea with excessive daytime sleepiness is associated with non-alcoholic fatty liver disease regardless of visceral fat
Ji Hee Yu, Jae Hee Ahn, Hye Jin Yoo, Ji A Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Chol Shin, Nan Hee Kim
Korean J Intern Med. 2015;30(6):846-855. Published online October 30, 2015
Background/Aims: Obstructive sleep apnea (OSA) is associated with an increased risk of obesity and non-alcoholic fatty liver disease (NAFLD), but it remains unclear whether the risk of NAFLD is independently related to OSA regardless of visceral obesity. Thus, the aim of the present study was to exa..
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Nephrology
Predicting postoperative total calcium requirements after parathyroidectomy in secondary hyperparathyroidism
Byung Heon Kang, Soon Young Hwang, Jeong Yeop Kim, Yu Ah Hong, Mi Yeon Jung, Eun Ah Lee, Ji Eun Lee, Jae Bok Lee, Gang Jee Ko, Heui Jung Pyo, Young Joo Kwon
Korean J Intern Med. 2015;30(6):856-864. Published online October 30, 2015
Background/Aims: To prevent hypocalcemia after parathyroidectomy (PTX), parenteral calcium is required in addition to oral calcitriol and calcium. After switching to oral calcium, patients can be discharged from the hospital. The aim of this study was to analyze the clinical characteristics and outc..
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Risk factors in the progression of BK virus-associated nephropathy in renal transplant recipients
Hae Min Lee, In-Ae Jang, Dongjae Lee, Eun Jin Kang, Bum Soon Choi, Cheol Whee Park, Yeong Jin Choi, Chul Woo Yang, Yong-Soo Kim, Byung Ha Chung
Korean J Intern Med. 2015;30(6):865-872. Published online October 30, 2015
Background/Aims: BK virus-associated nephropathy (BKVAN) is an important cause of allograft dysfunction in kidney transplant recipients. It has an unfavorable clinical course, and no definite treatment guidelines have yet been established. Here, we report our center’s experience with biopsy-proven ..
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The effects of nonyl phenoxypolyethoxyl ethanol on cell damage pathway gene expression in SK-NSH cells
Samel Park, Il-woong Hwang, Jin-sheon Kim, Hyo-chul Kang, Su-Yeon Park, Hyo-wook Gil, Ho-yeon Song, Sae-yong Hong
Korean J Intern Med. 2015;30(6):873-883. Published online October 30, 2015
Background/Aims: Most pesticide formulations contain both chief and additive ingredients. But, the additives may not have been tested as thoroughly as the chief ingredients. The surfactant, nonyl phenoxypolyethoxylethanol (NP40), is an additive frequently present in pesticide formulations. We invest..
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Hemato-oncology
Analysis of factors affecting hemorrhagic diathesis and overall survival in patients with acute promyelocytic leukemia
Ho Jin Lee, Dong Hyun Kim, Seul Lee, Myeong Seok Koh, So Yeon Kim, Ji Hyun Lee, Suee Lee, Sung Yong Oh, Jin Yeong Han, Hyo-Jin Kim, Sung-Hyun Kim
Korean J Intern Med. 2015;30(6):884-890. Published online October 30, 2015
Background/Aims: This study investigated whether patients with acute promyelocytic leukemia (APL) truly fulfill the diagnostic criteria of overt disseminated intravascular coagulation (DIC), as proposed by the International Society on Thrombosis and Haemostasis (ISTH) and the Korean Society on Throm..
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Clinical efficacy of erlotinib, a salvage treatment for non-small cell lung cancer patients following gefitinib failure
Kyoung Min Cho, Bhumsuk Keam, Tae Min Kim, Se-Hoon Lee, Dong-Wan Kim, Dae Seog Heo
Korean J Intern Med. 2015;30(6):891-898. Published online October 30, 2015
Background/Aims: The purpose of this study was to identify predictive factors for erlotinib treatment in non-small cell lung cancer (NSCLC) patients following gefitinib failure.
Methods: Forty-five patients with NSCLC who were treated with erlotinib following gefitinib failure at Seoul National Uni..
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Infectious diseases
Serum galactomannan levels in the diagnosis of invasive aspergillosis
Yildiz Okuturlar, Fahir Ozkalemkas, Beyza Ener, Sibel Ocak Serin, Esra Kazak, Tulay Ozcelik, Vildan Ozkocaman, Hasan Atilla Ozkan, Halis Akalin, Meral Gunaldi, Ridvan Ali
Korean J Intern Med. 2015;30(6):899-905. Published online October 30, 2015
Background/Aims: In this study, the sensitivity-specificity of galactomannan-enzyme immunoassay (GM-EIA) with a cut-off value of 0.5 for a single, two, or three consecutive positivity in the diagnosis of invasive pulmonary aspergillosis (IPA) in neutropenic patients with hematological malignancy was inves..
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Rheumatology
Factors related to outcomes in lupus-related protein-losing enteropathy
Doo-Ho Lim, Yong-Gil Kim, Seung-Hyeon Bae, Soomin Ahn, Seokchan Hong, Chang-Keun Lee, Bin Yoo
Korean J Intern Med. 2015;30(6):906-912. Published online October 30, 2015
Background/Aims: Protein-losing enteropathy (PLE), characterized by severe hypoalbuminemia and peripheral edema, is a rare manifestation of systemic lupus erythematosus. This present study aimed to identify the distinctive features of lupus-related PLE and evaluate the factors related to the treatme..
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Genetic analysis of ABCG2 and SLC2A9 gene polymorphisms in gouty arthritis in a Korean population
Yun Sung Kim, Yunsuek Kim, Geon Park, Seong-Kyu Kim, Jung-Yoon Choe, Byung Lae Park, Hyun Sook Kim
Korean J Intern Med. 2015;30(6):913-920. Published online October 30, 2015
Background/Aims: Gout is a common inf lammatory arthritis triggered by the crystallization of uric acid in the joints. Serum uric acid levels are highly heritable, suggesting a strong genetic component. Independent studies to confirm the genetic associations with gout in various ethnic populations a..
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| Letters to the editor |
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Acute myocardial infarction caused by a floating thrombus in the proximal ascending aorta
Woong Jeon, Seung-Jin Lee, Sang-Ho Park, Se-Whan Lee, Won-Yong Shin, Dong-Kyu Jin
Korean J Intern Med. 2015;30(6):921-924. Published online October 30, 2015
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Fabry disease previously diagnosed as Henoch-Schonlein purpura
Ji Hyeong Kim, Dong Hoon Han, Moo Yong Park, Soo Jeong Choi, Jin Kuk Kim, Seung Duk Hwang, So Young Jin
Korean J Intern Med. 2015;30(6):925-927. Published online October 30, 2015
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Bone metastasis in pulmonary sclerosing hemangioma
Min Kyoung Kim, Se-Jin Jang, Yong Hee Kim, Sang-We Kim
Korean J Intern Med. 2015;30(6):928-930. Published online October 30, 2015
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Long-term survival after concurrent chemoradiation therapy for esophageal cancer with tracheal
invasion
Joon Hyun Cho, Tae Nyeun Kim
Korean J Intern Med. 2015;30(6):931-933. Published online October 30, 2015
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Takayasu arteritis and antiphospholipid antibody syndrome in an elderly woman
Hee-Jeong Lee, Jae Pil Hwang, Hyun-Sook Kim
Korean J Intern Med. 2015;30(6):934-937. Published online October 30, 2015
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| Images of interest |
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Nutmeg liver cardiac cirrhosis caused by constrictive pericarditis
Kyoung Hwang Shin, Hyun Don Joo, Il Han Song
Korean J Intern Med. 2015;30(6):938-939. Published online October 30, 2015
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Extreme septal hypertrophy in an adolescent with congenital familial hypertrophic cardiomyopathy
Byoung-Won Park, Min-Ho Lee, Duk Won Bang, Min-Su Hyon
Korean J Intern Med. 2015;30(6):940-941. Published online October 30, 2015
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