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Hemato-oncology / Review
Does the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor differ according to the type of EGFR mutation in non-small cell lung cancer?
Yong Won Choi, Jin-Hyuk Choi
Korean J Intern Med. 2017;32(3):422-428. Published online March 30, 2017
An exon 19 deletion and a L858R mutation in exon 21 of the epidermal growth factor receptor (EGFR) are the two most common mutations that predict favorable efficacy of EGFR tyrosine kinase inhibitors (TKIs) in patients with non-small cell lung cancer (NSCLC). Many retrospective and prospective studi..
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Endocrinology-metabolism / Review
Diabetic cardiomyopathy: where we are and where we are going
Wang-Soo Lee, Jaetaek Kim
Korean J Intern Med. 2017;32(3):404-421. Published online April 18, 2017
The global burden of diabetes mellitus and its related complications are currently increasing. Diabetes mellitus affects the heart through various mechanisms including microvascular impairment, metabolic disturbance, subcellular component abnormalities, cardiac autonomic dysfunction, and a maladapti..
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Cardiology / Review
Practical management of peripartum cardiomyopathy
Mi-Jeong Kim, Mi-Seung Shin
Korean J Intern Med. 2017;32(3):393-403. Published online April 14, 2017
Peripartum cardiomyopathy (PPCM) is an idiopathic cardiomyopathy that causes systolic heart failure (HF) in previously healthy young women. Despite latest remarkable achievement, unifying pathophysiologic mechanism is not well established. Considering close temporal relationship to pregnancy, the re..
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Gastroenterology / Review
Approach to cytomegalovirus infections in patients with ulcerative colitis
[corrected-article]
Sung Chul Park, Yoon Mi Jeen, Yoon Tae Jeen
Korean J Intern Med. 2017;32(3):383-392. Published online April 20, 2017
Cytomegalovirus (CMV) reactivation is common in patients with severe ulcerative colitis (UC), and may ref lect exacerbation of mucosal inf lammation and/or administration of immunosuppressants. The question of whether CMV is an active pathogen or ‘an innocent bystander’ in the exacerbation of UC ..
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Image of interest
Dystrophic calcification after palliative chemotherapy in a patient with renal cell carcinoma
Do Hyoung Lim, Soon Il Lee, Keon Woo Park
Korean J Intern Med. 2017;32(2):380-381. Published online January 3, 2017
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Image of interest
A huge necrotic liver mass in a 45-year-old woman: delayed hepatic metastasis of a gastrointestinal stromal tumor
In Yong Whang, Kyung-Jin Seo, Hee Yeon Kim, Chang Wook Kim, Hye Sung Won
Korean J Intern Med. 2017;32(2):378-379. Published online September 5, 2016
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Letter to the editor
Ankylosing spondylitis associated with primary aldosteronism in a middle-aged woman
Young Sun Suh, Hyun-Ok Kim, Yun-Hong Cheon, Wonyong Jo, Jeongmin Hong, Sang-Il Lee
Korean J Intern Med. 2017;32(2):374-377. Published online February 3, 2016
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Letter to the editor
Outpatient treatment in women with acute pyelonephritis after visiting emergency department
Hee Kyoung Choi, Jin-Won Chung, Won Sup Oh, Jae-Bum Jun, Yee Gyung Kwak, Seong Yeon Park, Baek-Nam Kim
Korean J Intern Med. 2017;32(2):369-373. Published online August 18, 2016
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Letter to the editor
Everolimus-induced activation of latent Mycobacterium tuberculosis infection in a patient with metastatic renal cell carcinoma
So-Yeon Jeon, Ho-Young Yhim, Na-Ri Lee, Eun-Kee Song, Jae-Yong Kwak, Chang-Yeol Yim
Korean J Intern Med. 2017;32(2):365-368. Published online February 2, 2016
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Letter to the editor
Ascites reinfusion dialysis of refractory ascites as a bridge to kidney and liver transplantation in a patient on hemodialysis
Kyung Yoon Chang, Hyung Wook Kim, Dong Chan Jin, Young Soo Kim
Korean J Intern Med. 2017;32(2):363-364. Published online January 19, 2016
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Letter to the editor
The internal jugular vein as an alternative venous access for a revision of a fractured implantable cardioverter-defibrillator lead
Jong Yop Pae, Yoon-Nyun Kim, Min Young Do, Hyoung-Seob Park, Seongwook Han, Seung-Ho Hur, Sae-Young Choi
Korean J Intern Med. 2017;32(2):360-362. Published online February 4, 2016
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Rheumatology / Original Article
Association of sleep quality in Behcet disease with disease activity, depression, and quality of life in Korean population
Jimin Lee, Sung-Soo Kim, Hye-Jin Jeong, Chang-Nam Son, Ji-Min Kim, Yong-Won Cho, Sang-Hyon Kim
Korean J Intern Med. 2017;32(2):352-359. Published online February 16, 2017
Background/Aims: Sleep disturbance is prime concern in patients with Behcet disease. The purpose of this study was to find out the effects of sleep quality, in Korean patients suffering from Behcet disease. We further investigated the relationship between depression, quality of life and the clinical..
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Infectious diseases / Original Article
Association of biofilm production with colonization among clinical isolates of Acinetobacter baumannii
Seong Yeol Ryu, Won-Ki Baek, Hyun Ah Kim
Korean J Intern Med. 2017;32(2):345-351. Published online September 22, 2016
Background/Aims: The pathogen Acinetobacter baumannii is increasingly causing healthcare-associated infections worldwide, particularly in intensive care units. Biofilm formation, a factor contributing to the virulence of A. baumannii, is associated with long-term persistence in hospita..
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Hemato-oncology / Original Article
Clinicopathologic significance of tumor microenvironment CD11c, and FOXP3 expression in diffuse large B-cell lymphoma patients receiving rituximab, cyclophosphamide, anthracycline, vincristine, and prednisone (R-CHOP) combination chemotherapy
Seul Lee, Dong Hyun Kim, Sung Yong Oh, So Yeon Kim, Myeong Seok Koh, Ji Hyun Lee, Suee Lee, Sung-Hyun Kim, Jong-Young Kwak, Min Gyoung Pak, Mi Ha Ju, Hyo-Jin Kim, Jin Sook Jeong
Korean J Intern Med. 2017;32(2):335-344. Published online March 11, 2016
Background/Aims: CD11c is a dendritic cell marker in humans, which potentially induces a cytotoxic effect on lymphoma cells. Forkhead boxP3 (FOXP3) is a regulator of T lymphocyte in the microenvironment of the lymphoma. The principal objective of this study was to determine whether the tumors’ mic..
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Nephrology / Original Article
Sleep duration and chronic kidney disease: The Korean Genome and Epidemiology Study (KoGES)-Kangwha study
Hansol Choi, Hyeon Chang Kim, Joo Young Lee, Ju-Mi Lee, Dong Phil Choi, Il Suh
Korean J Intern Med. 2017;32(2):323-334. Published online February 15, 2017
Background/Aims: Sleep duration affects health in various ways. The objective of this study was to investigate the associations of sleep duration with chronic kidney disease (CKD) in a Korean adult population.
Methods: This cross-sectional analysis was conducted for total of 1,360 participants who ..
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Nephrology / Original Article
Effects of metformin on hyperglycemia in an experimental model of tacrolimus- and sirolimus-induced diabetic rats
Jian Jin, Sun Woo Lim, Long Jin, Ji Hyun Yu, Hyun Seon Kim, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2017;32(2):314-322. Published online September 30, 2016
Background/Aims: Metformin (MET) is a first-line drug for type 2 diabetes mellitus (DM); its effect on new-onset diabetes after transplantation caused by immunosuppressant therapy is unclear. We compared the effects of MET on DM caused by tacrolimus (TAC) or sirolimus (SRL).
Methods: DM was induced..
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Endocrinology-metabolism / Original Article
Association between thyroid autoimmunity and Helicobacter pylori infection
Yun Mi Choi, Tae Yong Kim, Eui Young Kim, Eun Kyung Jang, Min Ji Jeon, Won Gu Kim, Young Kee Shong, Won Bae Kim
Korean J Intern Med. 2017;32(2):309-313. Published online January 16, 2017
Background/Aims: There have been controversial reports linking Helicobacter pylori infection to autoimmune thyroid disease (AITD). However, data regarding the relationship are limited for Asian populations, which have an extremely high prevalence of H. pylori infection. We performed th..
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Pulmonology / Original Article
Qualitative and quantitative results of interferon-γ release assays for monitoring the response to anti-tuberculosis treatment
I-Nae Park, Tae Sun Shim
Korean J Intern Med. 2017;32(2):302-308. Published online December 13, 2016
Background/Aims: The usefulness of interferon-γ release assays (IGRAs) in monitoring to responses to anti-tuberculosis (TB) treatment is controversial. We compared the results of two IGRAs before and after anti-TB treatment in same patients with active TB.
Methods: From a retrospective review, we..
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Pulmonology / Original Article
Clinical significance of serum vascular endothelial growth factor in young male asthma patients
Hea Yon Lee, Kyung Hoon Min, Sang Min Lee, Ji Eun Lee, Chin Kook Rhee
Korean J Intern Med. 2017;32(2):295-301. Published online March 21, 2016
Background/Aims: Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. However, little is known about the potential use of serum levels of VEGF as a biomarker for asthma. We investigated the differences in VEGF levels among normal controls, stable asthma patients, and t..
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Cardiology / Original Article
Atrial conduction times and left atrial mechanical functions and their relation with diastolic function in prediabetic patients
Naile Eris Gudul, Turgut Karabag, Muhammet Rasit Sayin, Taner Bayraktaroglu, Mustafa Aydin
Korean J Intern Med. 2017;32(2):286-294. Published online December 6, 2016
Background/Aims: The aim of this study was to investigate atrial conduction times and left atrial mechanical functions, the noninvasive predictors of atrial fibrillation, in prediabetic patients with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT).
Methods: Study included 59 pat..
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