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Recent advances in airway imaging using micro-computed tomography and computed tomography for chronic obstructive pulmonary disease
Naoya Tanabe, Toyohiro Hirai
Korean J Intern Med. 2021;36(6):1294-1304. Published online October 6, 2021
Chronic obstructive pulmonary disease (COPD) is a complex lung disease characterized by a combination of airway disease and emphysema. Emphysema is classified as centrilobular emphysema (CLE), paraseptal emphysema (PSE), or panlobular emphysema (PLE), and airway disease extends from the respiratory,..
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Hepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic cell transplantation: historical and current considerations in Korea
Jae-Ho Yoon, Chul Won Choi, Jong-Ho Won
Korean J Intern Med. 2021;36(6):1261-1280. Published online September 24, 2021
Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a rare but severe complication of hematopoietic cell transplantation (HCT) showing high mortality. Multiple risk factors for SOS/VOD were identified, but it is often confused with other hepatic complications due to nonspecif..
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Infectious diseases
Evaluation of copper alloys for reducing infection by methicillin resistant Staphylococcus aureus and vancomycin resistant Enterococcus faecium in intensive care unit and in vitro
Sung Im Choi, Mee Soo Chang, Taeeun Kim, Kyung Hwa Chung, Seongman Bae, Sung-Han Kim, Chan Jin Yoon, Young Kyoon Kim, Jun Hee Woo
Korean J Intern Med. 2021;36(5):1204-1210. Published online August 18, 2021
Background/Aims: Multi-drug resistant pathogens are increasing among healthcare-associated infections. It is well known that copper and copper alloys have antimicrobial activity. We evaluated the activity of copper against bacteria in a hospital setting in Korea.
Methods: This study was conducted i..
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Pulmonology
Patterns of medical care utilization according to environmental factors in asthma and chronic obstructive pulmonary disease patients
Eun-Jung Jo, Min-Hyeok Choi, Chang-Hoon Kim, Kyung-Mi Won, Yoo-Keun Kim, Ju-Hee Jeong, Hye Yeon An, Mi-Kyoung Hwang, Hye-Kyung Park
Korean J Intern Med. 2021;36(5):1146-1156. Published online February 10, 2021
Background/Aims: Weather and air pollution are associated with the exacerbation of respiratory diseases. We investigated patterns of medical care use according to meteorological factors and air pollution in patients with asthma or chronic obstructive pulmonary disease (COPD).
Methods: We analyzed t..
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Estimating the burden of nosocomial exposure to tuberculosis in South Korea, a nationwide population based cross-sectional study
Hyung Woo Kim, Jun-Pyo Myong, Ju Sang Kim
Korean J Intern Med. 2021;36(5):1134-1145. Published online December 18, 2020
Background/Aims: The aim of the study was to investigate the current nationwide burden of nosocomial exposure to tuberculosis (TB) using national health insurance claims data.
Methods: All patients who had claims for drug susceptibility testing for TB from 2012 to 2016, which indicated culture-prov..
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Cardiology
Prevalence and characteristics of isolated nocturnal hypertension in the general population
Moo-Yong Rhee, Je Sang Kim, Chee Hae Kim, Ji-Hyun Kim, Jung-Ha Lee, Sun-Woong Kim, Deuk-Young Nah, Namyi Gu, Eun-Joo Cho, Ki-Chul Sung, Kyung-Soon Hong
Korean J Intern Med. 2021;36(5):1126-1133. Published online April 5, 2021
Background/Aims: Ascertaining the prevalence of isolated nocturnal hypertension (INHT) in the general population and identifying the characteristics of patients with INHT may be important to determine patients who should receive 24- hour ambulatory blood pressure (BP) measurements. This study aimed ..
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Gastroenterology
Risk of colorectal cancer in patients with positive results of fecal immunochemical test performed within 5 years since the last colonoscopy
Yoon Suk Jung, Jinhee Lee, Chang Mo Moon
Korean J Intern Med. 2021;36(5):1083-1091. Published online June 18, 2021
Background/Aims: Annual fecal immunochemical tests (FITs) are often repeated within the recommended colonoscopy surveillance intervals. However, it remains unclear whether interval FITs are useful. To answer this question, we assessed the risk of colorectal cancer (CRC) according to the interval fro..
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Risk stratification of patients with gastric lesions indefinite for dysplasia
Young Sin Cho, Il-Kwun Chung, Yunho Jung, Su Jung Han, Jae Kook Yang, Tae Hoon Lee, Sang-Heum Park, Sun-Joo Kim
Korean J Intern Med. 2021;36(5):1074-1082. Published online September 9, 2020
Background/Aims: There are no definite guidelines for the management of gastric lesions diagnosed as indefinite for dysplasia (IND) by endoscopic forceps biopsy (EFB). Therefore, this study aimed to evaluate the clinical outcomes of gastric IND and predictive factors for gastric neoplasm.
Methods: ..
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Second-look endoscopy findings after endoscopic submucosal dissection for colorectal epithelial neoplasms
Soo-kyung Park, Hyeon Jeong Goong, Bong Min Ko, Haewon Kim, Hyo Sun Seok, Moon Sung Lee
Korean J Intern Med. 2021;36(5):1063-1073. Published online June 9, 2021
Background/Aims: Although second-look endoscopy (SLE) is frequently performed after gastric endoscopic submucosal dissection (ESD) to prevent bleeding, no studies have reported SLE findings after colorectal ESD. This study aimed to investigate SLE findings and their role in preventing delayed bleedi..
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Allergy
Effect of omalizumab as add-on therapy to Quality of Life Questionnaire for Korean Asthmatics (KAQLQ) in Korean patients with severe persistent allergic asthma
[corrected-article]
Jae-Woo Jung, Hae-Sim Park, Choon-Sik Park, Sang-Heon Cho, Inseon S. Choi, Hee-Bom Moon, Soon Seog Kwon, Ho Joo Yoon, Jung Won Park, Jong-Myung Lee, Dong-Chull Choi, Byoung Whui Choi
Korean J Intern Med. 2021;36(4):1001-1013. Published online June 1, 2021
Background/Aims: Omalizumab is the first biologic known to be effective in patients with severe allergic asthma.
Methods: This study was conducted as a multicenter, single-group, open trial to evaluate the improvement in the quality of life with the additional administration of omalizumab for 24 w..
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Infectious diseases
Varicella zoster virus (VZV)-specific immunity and subclinical VZV reactivation in patients with autoimmune diseases
Kwang-Hoon Lee, Sungim Choi, Ji-Soo Kwon, Sung-Han Kim, Seong Yeon Park
Korean J Intern Med. 2021;36(4):992-1000. Published online June 15, 2021
Background/Aims: The risk of herpes zoster (HZ) is increased in patients with autoimmune diseases (AID), probably due to immunosuppressive therapy.
Methods: This prospective cross-sectional study investigated varicella zoster virus (VZV)-specific immunity in relation to subclinical VZV reactivation..
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Hemato-oncology
Clinical characteristics and survival of colorectal cancer patients in Korea stratified by age
Sun Kyung Baek, Ji Sung Lee, In Gyu Hwang, Jong Gwang Kim, Tae Won Kim, Seung Kook Sohn, Mi Yeon Kang, Sang-Cheol Lee
Korean J Intern Med. 2021;36(4):985-991. Published online April 6, 2021
Background/Aims: This nationwide study was undertaken to determine differences in clinicopathologic characteristics and survival of patients with colorectal cancer (CRC) according to age using big data from the Korean National Health Insurance Service (NHIS).
Methods: The NHIS data including qualit..
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Cardiology
The effect of beta-blockers in acute heart failure according to heart rate
Hyun-Jin Kim, Sang-Ho Jo, Min-Ho Lee, Won-Woo Seo, Jin-Oh Choi, Kyu-Hyung Ryu
Korean J Intern Med. 2021;36(4):898-905. Published online September 21, 2020
Background/Aims: Beta-blockers (BBs) have been shown to improve clinical outcomes in heart failure (HF) patients. We evaluated the prescribing status of BBs in patients with HF with reduced ejection fraction (HFrEF) at discharge according to the presence or not of bradycardia, and its effect on prog..
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Apparent treatment-resistant hypertension among ambulatory hypertensive patients: a cross-sectional study from 13 general hospitals
Sehun Kim, Jin Joo Park, Mi-Seung Shin, Choong Hwan Kwak, Bong-Ryeol Lee, Sung-Ji Park, Hae-Young Lee, Sang-Hyun Kim, Seok-Min Kang, Byung-Su Yoo, Joong-Wha Chung, Si Wan Choi, Sang-Ho Jo, Jinho Shin, Dong-Ju Choi
Korean J Intern Med. 2021;36(4):888-897. Published online June 7, 2021
Background/Aims: To examine the prevalence and clinical characteristics of apparent treatment-resistant hypertension among ambulatory hypertensive patients.
Methods: We enrolled adult ambulatory hypertensive patients at 13 well-qualified general hospitals in Korea from January to June 2012. Apparen..
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Gastroenterology
Helicobacter pylori-derived outer membrane vesicles stimulate interleukin 8 secretion through nuclear factor kappa B activation
Mun Sun Choi, Eun Young Ze, Jae Yong Park, Tae-Seop Shin, Jae Gyu Kim
Korean J Intern Med. 2021;36(4):854-867. Published online November 27, 2020
Background/Aims: Bacteria-derived outer membrane vesicles (OMVs) are commonly associated with various biological activities and functions. Helicobacter pylori-derived OMVs are thought to contribute to pathogenesis. This study aimed to investigate the effects of H. pylori-derived OMVs.
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Application of deep learning to predict advanced neoplasia using big clinical data in colorectal cancer screening of asymptomatic adults
Hyo-Joon Yang, Chang Woo Cho, Jongha Jang, Sang Soo Kim, Kwang-Sung Ahn, Soo-Kyung Park, Dong Il Park
Korean J Intern Med. 2021;36(4):845-856. Published online October 23, 2020
Background/Aims: We aimed to develop a deep learning model for the prediction of the risk of advanced colorectal neoplasia (ACRN) in asymptomatic adults, based on which colorectal cancer screening could be customized.
Methods: We collected data on 26 clinical and laboratory parameters, including ag..
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Evidence based guidelines for the treatment of Helicobacter pylori infection in Korea 2020
Hye-Kyung Jung, Seung Joo Kang, Yong Chan Lee, Hyo-Joon Yang, Seon-Young Park, Cheol Min Shin, Sung Eun Kim, Hyun Chul Lim, Jie-Hyun Kim, Su Youn Nam, Woon Geon Shin, Jae Myung Park, Il Ju Choi, Jae Gyu Kim, Miyoung Choi; Korean College of Helicobacter and Upper Gastrointesinal Research
Korean J Intern Med. 2021;36(4):807-838. Published online June 8, 2021
Helicobacter pylori infection is one of the most common infectious diseases worldwide. H. pylori is responsible for substantial gastrointestinal morbidity with a high disease burden. Since the revision of the H. pylori Clinical Practice Guidelines in 2013 in Korea, the eradicati..
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How important is dietary management in chronic kidney disease progression? A role for low protein diets
Gang-Jee Ko, Kamyar Kalantar-Zadeh
Korean J Intern Med. 2021;36(4):795-806. Published online June 22, 2021
High dietary protein intake may lead to increased intraglomerular pressure and glomerular hyperfiltration, which in the long-term can lead to de novo or aggravating preexisting chronic kidney disease (CKD). Hence, a low protein diet (LPD, 0.6 to 0.8 g/kg/day) is recommended for the management of CKD..
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Rheumatology
Clinical features of Korean elderly patients with antineutrophil cytoplasmic antibody-associated vasculitis
Byung-Woo Yoo, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Korean J Intern Med. 2021;36(3):731-741. Published online August 20, 2020
Background/Aims: We compared the clinical and laboratory data between elderly and non-elderly patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) at diagnosis; further, we investigated the predictors at diagnosis for all-cause mortality and end-stage renal disease (E..
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Pregnancy outcomes in Korean women with ankylosing spondylitis
Eun Hye Park, Jung Sun Lee, Ye-Jee Kim, Seung Mi Lee, Jong Kwan Jun, Eun Bong Lee, Yong-Gil Kim
Korean J Intern Med. 2021;36(3):721-730. Published online September 26, 2019
Background/Aims: Because ankylosing spondylitis (AS) mainly affects sacroiliac joints, special attention should be given to normal labour and pregnancy outcomes. Here, we investigate pregnancy outcomes in Korean women with AS.
Methods: Based on data from the Korean Health Insurance Review and Asses..
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