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Korean Society of Nephrology 2022 recommendations on controversial issues in diagnosis and management of hyponatremia
Yeonhee Lee, Kyung Don Yoo, Seon Ha Baek, Yang Gyun Kim, Hyo Jin Kim, Ji Young Ryu, Jin Hyuk Paek, Sang Heon Suh, Se Won Oh, Jeonghwan Lee, Jong Hyun Jhee, Jin-Soon Suh, Eun Mi Yang, Young Ho Park, Yae Lim Kim, Miyoung Choi, Kook-Hwan Oh, Sejoong Kim; on behalf of the Hyponatremia Guideline Development Group
Korean J Intern Med. 2022;37(6):1120-1137. Published online October 17, 2022
The Korean Society for Electrolyte and Blood Pressure Research, in collaboration with the Korean Society of Nephrology, has published a clinical practice guideline (CPG) document for hyponatremia treatment. The document is based on an extensive evidence-based review of the diagnosis, evaluation, and..
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Nephrology
Therapeutic effect of multiple functional minicircle vector encoding anti-CD25/IL-10/CXCR3 in allograft rejection model
Sun Woo Lim, Yoo Jin Shin, Sheng Cui, Eun Jeong Ko, Seok Ho Yoo, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2022;37(5):1031-1049. Published online June 21, 2022
Background/Aims: We previously proposed minicircle vector technology as the potential platform for the development and production of new biologics. In this study, we have designed a novel target molecule for the treatment of allograft rejection and evaluated its feasibility as the therapeutic agent ..
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Pulmonology
Prevalence of chronic rhinosinusitis and its relating factors in patients with bronchiectasis: findings from KMBARC registry
Iseul Yu, Suk Joong Yong, Won-Yeon Lee, Sang-Ha Kim, Hyun Lee, Ju Ock Na, Deog Kyeom Kim, Yeon-Mok Oh, Ji-Ho Lee; on behalf of the KMBARC
Korean J Intern Med. 2022;37(5):1002-1010. Published online August 18, 2022
Background/Aims: Patients with bronchiectasis often present with respiratory symptoms caused by chronic rhinosinusitis (CRS). However, studies on the prevalence of CRS and its relationship with bronchiectasis are limited.
Methods: The baseline characteristics of patients with bronchiectasis recruit..
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Clinical characteristics of patients with COVID-19 vaccine-related pneumonitis: a case series and literature review
Ji Young Park, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Hwan Il Kim, Seung Hun Jang, Ki-Suck Jung, Yong Kyun Kim, Hyun Ah Kim, In Jae Lee
Korean J Intern Med. 2022;37(5):989-1001. Published online August 22, 2022
Background/Aims: Pulmonary toxicities of coronavirus disease 2019 (COVID-19) vaccination are exceedingly rare. However, there are a few reported cases after mRNA vaccination, especially from Asian countries. The purpose of this study was to report the clinical characteristics of patients with COVID-..
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Granulocyte colony-stimulating factor in bronchoalveolar lavage fluid is a potential biomarker for prognostic prediction of idiopathic pulmonary fibrosis
Jong-Uk Lee, Jae Sung Choi, Min Kyung Kim, Sun A Min, Jong-Sook Park, Choon-Sik Park
Korean J Intern Med. 2022;37(5):979-988. Published online June 22, 2022
Background/Aims: Neutrophilia is frequently observed in bronchoalveolar lavage fluid (BALF) of idiopathic pulmonary fibrosis (IPF) patients. Granulocyte colony-stimulating factor (G-CSF) is a potent neutrophil-activating glycoprotein. However, the clinical implications of G-CSF remain poorly underst..
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Gastroenterology
Factors associated with the risk of colorectal neoplasia in young adults under age 40
Ilsoo Kim, Han Hee Lee, Young Jae Ko, Ho Eun Chang, Dae Young Cheung, Bo-In Lee, Young-Seok Cho, Jin Il Kim, Myung-Gyu Choi
Korean J Intern Med. 2022;37(5):969-978. Published online July 25, 2022
Background/Aims: Recent epidemiologic studies have shown a continued increase in colorectal cancer incidence among younger adults. Little is known about the factors that contribute to the development of young-onset colorectal neoplasia (CRN).
Methods: A cross-sectional analysis was performed for ind..
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2022 Consensus statement on the management of familial hypercholesterolemia in Korea
Chan Joo Lee, Minjae Yoon, Hyun-Jae Kang, Byung Jin Kim, Sung Hee Choi, In-Kyung Jeong, Sang-Hak Lee; on behalf of Task Force Team for Familial Hypercholesterolemia; Korean Society of Lipid and Atherosclerosis
Korean J Intern Med. 2022;37(5):931-944. Published online July 27, 2022
Familial hypercholesterolemia (FH) is the most common monogenic disorder. Due to the marked elevation of cardiovascular risk, the early detection, diagnosis, and proper management of this disorder are critical. Herein, the 2022 Korean guidance on this disease is presented. Clinical features include ..
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Management of inflammatory bowel disease beyond tumor necrosis factor inhibitors: novel biologics and small-molecule drugs
Soo-Young Na, You Sun Kim
Korean J Intern Med. 2022;37(5):906-919. Published online August 10, 2022
The incidence and prevalence of inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, have increased in Asia and developing countries. In the past two decades, anti-tumor necrosis factor (TNF) agents have revolutionized the treatment of IBD, in part by decreasing the..
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Updates on conventional therapies for inflammatory bowel diseases: 5-aminosalicylates, corticosteroids, immunomodulators, and anti-TNF-α
Jihye Park, Jae Hee Cheon
Korean J Intern Med. 2022;37(5):895-905. Published online July 27, 2022
The incidence and prevalence of inflammatory bowel diseases (IBDs) are rapidly increasing worldwide. IBDs are considered an emerging problem not only in Western countries but also in developing counties. The relapses and complications of active IBD mandate various medications. Nevertheless, hospital..
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Endocrinology-metabolism
Benefits of lumican on human bone health: clinical evidence using bone marrow aspirates
Yun Sun Lee, So Jeong Park, Jin Young Lee, Eunah Choi, Beom-Jun Kim
Korean J Intern Med. 2022;37(4):821-829. Published online April 26, 2022
Background/Aims: Lumican, a small leucine-rich proteoglycan, has shown osteoprotective effects by synchronously stimulating bone formation and suppressing bone resorption. To clarify the role of lumican in human bone metabolism, the association between lumican concentrations and osteoporosis-related..
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Pulmonology
Prognostic outcome of treatment modalities for epidermal growth factor receptor-mutated advanced lung cancer
Seung Hun Jang, Dong Yoon Lee, Jihyeon Jeong, Won-Il Choi
Korean J Intern Med. 2022;37(4):811-820. Published online June 3, 2022
Background/Aims: The treatment of epidermal growth factor receptor (EGFR)-mutated lung cancer cases has shown remarkable development in the past two decades. However, there have been limited studies comparing the prognostic effects of EGFR-tyrosine kinase inhibitor (TKI) and other treatment modaliti..
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Cardiology
Treatment delay and outcomes of ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention during the COVID-19 era in South Korea
Seok Oh, Myung Ho Jeong, Kyung Hoon Cho, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn
Korean J Intern Med. 2022;37(4):786-799. Published online June 28, 2022
Background/Aims: Little is known about the clinical characteristics and treatment outcomes of ST-segment elevation myocardial infarction (STEMI) in Korea during the coronavirus disease 2019 (COVID-19) era. We aimed to evaluate the clinical characteristics and treatment outcomes of patients with STEM..
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Predictors of recurrent acute myocardial infarction despite successful percutaneous coronary intervention
Sang Hun Lee, Myung Ho Jeong, Joon Ho Ahn, Dae Young Hyun, Kyung Hoon Cho, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Jin Yong Hwang, Weon Kim, Jong Seon Park, Chang-Hwan Yoon, Seung Ho Hur, Sang Rok Lee, Kwang Soo Cha; on behalf of the KAMIR (Korea Acute Myocardial Infarction Registry)-NIH Investigators
Korean J Intern Med. 2022;37(4):777-785. Published online June 28, 2022
Background/Aims: Recurrent acute myocardial infarction (AMI) is an adverse cardiac event in patients with a first AMI. The predictors of recurrent AMI after the first AMI in patients who underwent successful percutaneous coronary intervention (PCI) have not been elucidated.
Methods: We analyzed th..
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Gastroenterology
Clinical outcomes of metachronous recurrence of gastric epithelial neoplasia based on Helicobacter pylori infection status and microsatellite stability
Yeon-Ji Kim, Jaeyoung Kim, Woo Chul Chung
Korean J Intern Med. 2022;37(4):768-776. Published online May 4, 2022
Background/Aims: Helicobacter pylori eradication may prevent the recurrence of gastric epithelial neoplasia after endoscopic treatment. However, H. pylori eradication therapy is unlikely to prevent gastric cancer. This study determined the longterm results and clinical outcomes of pati..
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Improved anti-fibrotic effects by combined treatments of simvastatin and NS-398 in experimental liver fibrosis models
Seong Hee Kang, Hyung Joon Yim, Ji-won Hwang, Mi-jung Kim, Young-Sun Lee, Young Kul Jung, Hyungshin Yim, Baek-Hui Kim, Hae-Chul Park, Yeon Seok Seo, Ji Hoon Kim, Jong Eun Yeon, Soon Ho Um, Kwan Soo Byun
Korean J Intern Med. 2022;37(4):745-756. Published online June 8, 2022
Background/Aims: Efficient anti-fibrotic therapies are required for the treatment of liver cirrhosis. Hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) and cyclooxygenase-2 (COX-2) inhibitors have been reported to have anti-fibrotic effects. Here, we investigated whether combined treat..
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Executive summary of the Korean Society of Nephrology 2021 clinical practice guideline for optimal hemodialysis treatment
Ji Yong Jung, Kyung Don Yoo, Eunjeong Kang, Hee Gyung Kang, Su Hyun Kim, Hyoungnae Kim, Hyo Jin Kim, Tae-Jin Park, Sang Heon Suh, Jong Cheol Jeong, Ji-Young Choi, Young-Hwan Hwang, Miyoung Choi, Yae Lim Kim, Kook-Hwan Oh; the Clinical Practice Guideline Work Group
Korean J Intern Med. 2022;37(4):701-718. Published online June 3, 2022
The Korean Society of Nephrology (KSN) has published a clinical practice guideline (CPG) document for maintenance hemodialysis (HD). The document, 2021 Clinical Practice Guideline on Optimal HD Treatment, is based on an extensive evidence-oriented review of the benefits of preparation, initiation, a..
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Pulmonology
Acute exacerbation of COPD increases the risk of hip fractures: a nested case-control study from the Korea National Health Insurance Service
Kang-Mo Gu, Sang-Won Yoon, Sun-Young Jung, Moon Seong Baek, Won Young Kim, Jae-Woo Jung, Jae-Chol Choi, Jong-Wook Shin, Jae-Yeol Kim, Byoung-Whui Choi, In-Won Park
Korean J Intern Med. 2022;37(3):631-638. Published online February 8, 2022
Background/Aims: Hip fracture and acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) could increase mortality in patients with COPD. There are no data on the relationship between AE-COPD and hip fracture, which may significantly affect the prognosis of patients with COPD. Therefor..
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Cardiology
Long-term outcomes in ST-elevation myocardial infarction patients treated according to hospital visit time
Seok Oh, Dae Young Hyun, Kyung Hoon Cho, Ju Han Kim, Myung Ho Jeong
Korean J Intern Med. 2022;37(3):605-617. Published online November 16, 2021
Background/Aims: Rapid percutaneous coronary intervention (PCI) is the cornerstone of treatment for ST-elevation myocardial infarction (STEMI). However, there have been conflicting results regarding the differences in clinical outcomes between on-hours and off-hours presentation in STEMI patients. W..
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Off-hour presentation and outcomes for percutaneous coronary intervention in acute myocardial infarction with Killip III–IV
Seok Oh, Ju Han Kim, Kyung Hoon Cho, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong
Korean J Intern Med. 2022;37(3):591-604. Published online April 28, 2022
Background/Aims: Acute myocardial infarction (AMI) is conventionally recognized as an urgent medical condition requiring timely and effective reperfusion therapy. However, the results of studies on the clinical outcomes in AMI according to hospital visit timings are inconclusive. To explore the differ..
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Gastroenterology
Long-term effect of the eradication of Helicobacter pylori on the hemoglobin A1c in type 2 diabetes or prediabetes patients
Won Seok Kim, Yonghoon Choi, Nayoung Kim, Seon Hee Lim, Gitark Noh, Ki Wook Kim, Jaehyung Park, Hyeongho Jo, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee
Korean J Intern Med. 2022;37(3):579-590. Published online January 7, 2022
Background/Aims: The long-term effect of Helicobacter pylori eradication on the metabolic syndrome or diabetes are unclear. The aim of this study was to evaluate the effect of H. pylori eradication on glycemic control in type 2 diabetes mellitus (T2DM) or prediabetes mellitus (preDM).
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