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Cardiology / Review
Infective endocarditis involving an apparently structurally normal valve: new epidemiological trend?
Jae-Kwan Song
Korean J Intern Med. 2015;30(4):434-442. Published online June 29, 2015
Infective endocarditis (IE) has been increasingly diagnosed in patients without previously detected predisposing heart disease, but its clinical features have yet to be fully determined. A recent single-center study including echocardiographic images and surgical findings investigated the incidence ..
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Gastroenterology / Review
A 2015 roadmap for the management of hepatitis C virus infections in Asia
Seng Gee Lim, Yock Young Dan
Korean J Intern Med. 2015;30(4):423-433. Published online June 29, 2015
The prevalence of hepatitis C virus (HCV) in Asia is 0.5% to 4.7%, with three different genotypes predominating, depending on the geographic region: genotype 1b in East Asia, genotype 3 in South and Southeast Asia, and genotype 6 in Indochina. Official approval for direct-acting antiviral agents (DA..
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Hemato-oncology / Original Article
Role of frontline autologous stem cell transplantation in young, high-risk diffuse large B-cell lymphoma patients
Jae-Ho Yoon, Jong-Wook Kim, Young-Woo Jeon, Sung-Eun Lee, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chang-Ki Min, Jong-Wook Lee, Woo-Sung Min, Chong-Won Park, Seok-Goo Cho
Korean J Intern Med. 2015;30(3):362-371. Published online April 29, 2015
Background/Aims: Several studies have demonstrated the effect of autologous hematopoietic stem cell transplantation (auto-HSCT) as a salvage treatment for patients with relapsed diffuse large B-cell lymphoma (DLBCL). However, the role of auto-HSCT as a frontline treatment has not been fully investig..
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Endocrinology-metabolism / Original Article
Reference interval for thyrotropin in a ultrasonography screened Korean population
Mijin Kim, Tae Yong Kim, Soo Han Kim, Yunkyoung Lee, Su-yeon Park, Hyung-Don Kim, Hyemi Kwon, Yun Mi Choi, Eun Kyung Jang, Min Ji Jeon, Won Gu Kim, Young Kee Shong, Won Bae Kim
Korean J Intern Med. 2015;30(3):335-344. Published online April 29, 2015
Background/Aims: The diagnostic accuracy of thyroid dysfunctions is primarily affected by the validity of the reference interval for serum thyroid-stimulating hormone (TSH). Thus, the present study aimed to establish a reference interval for TSH using a normal Korean population.
Methods: This study..
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Pulmonology / Original Article
Drug-resistance pattern of Mycobacterium tuberculosis strains from patients with pulmonary and extrapulmonary tuberculosis during 2006 to 2013 in a Korean tertiary medical center
Ho Young Lee, Jin Lee, Young Seok Lee, Mi-Yeong Kim, Hyun-Kyung Lee, Young-Min Lee, Jeong Hwan Shin, Yousang Ko
Korean J Intern Med. 2015;30(3):325-334. Published online April 29, 2015
Background/Aims: We evaluated the trend in the rates of drug-resistant tuberculosis (TB) over time, as well as the difference in the drug-resistance pattern between pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) at a private referral center in South Korea.
Methods: All patients..
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Gastroenterology / Original Article
Use of 18F-FDG PET to predict tumor progression and survival in patients with intermediate hepatocellular carcinoma treated by transarterial chemoembolization
Min Jin Kim, Young Seok Kim, Youn Hee Cho, Hee Yoon Jang, Jeong-Yeop Song, Sae Hwan Lee, Soung Won Jeong, Sang Gyune Kim, Jae Young Jang, Hong Su Kim, Boo Sung Kim, Won Hyung Lee, Jung Mi Park, Jae Myung Lee, Min Hee Lee, Deuk Lin Choi
Korean J Intern Med. 2015;30(3):308-315. Published online April 29, 2015
Background/Aims: 18F-Fluorodeoxyglucose positron-emission tomography (18F-FDG PET) has been used to assess the biological behavior of hepatocellular carcinoma (HCC). In this study, we investigated the usefulness of 18F-FDG PET for predicting tumor progression and sur..
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Biomedical Engineering / Review
Hard tissue regeneration using bone substitutes: an update on innovations in materials
Swapan Kumar Sarkar, Byong Taek Lee
Korean J Intern Med. 2015;30(3):279-293. Published online April 29, 2015
Bone is a unique organ composed of mineralized hard tissue, unlike any other body part. The unique manner in which bone can constantly undergo self-remodeling has created interesting clinical approaches to the healing of damaged bone. Healing of large bone defects is achieved using implant materials..
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Gastroenterology / Review
Recent trends in diagnostic techniques for inflammatory bowel disease
Makoto Naganuma, Naoki Hosoe, Takanori Kanai, Haruhiko Ogata
Korean J Intern Med. 2015;30(3):271-278. Published online April 29, 2015
Although ileocolonoscopy is the gold standard for diagnosis of inflammatory bowel disease and is useful for assessing the disease severity in the colon and terminal ileum, several alternative diagnostic techniques have been developed recently. For ulcerative colitis (UC), magnification colonoscopy, ..
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Rheumatology / Original Article
Pulmonary hypertension in systemic lupus erythematosus: an independent predictor of patient survival
Hong Ki Min, Jae Ho Lee, Seung Min Jung, Jennifer Lee, Kwi Young Kang, Seung-Ki Kwok, Ji Hyeon Ju, Kyung-Su Park, Sung-Hwan Park
Korean J Intern Med. 2015;30(2):232-241. Published online February 27, 2015
Background/Aims: We investigated whether transthoracic echocardiography-suspected pulmonary hypertension (PH) affects survival in systemic lupus erythematosus (SLE) patients and examined factors associated with PH occurrence and survival.
Methods: This retrospective single-center study included 154..
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Nephrology / Original Article
Relationship between duration of hospital-acquired acute kidney injury and mortality: a prospective observational study
Jinyoung Yoo, Ji Sung Lee, Jiyeon Lee, Jin Seok Jeon, Hyunjin Noh, Dong Cheol Han, Soon Hyo Kwon
Korean J Intern Med. 2015;30(2):205-211. Published online February 27, 2015
Background/Aims: New definitions of acute kidney injury (AKI) have recently emerged. Some studies have suggested that duration of AKI is an additional predictive parameter for mortality. Here, we evaluated whether AKI duration was predictive of long-term mortality in patients with hospital-acquired ..
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Cardiology / Original Article
Effect of revascularization strategy in patients with acute myocardial infarction and renal insuf-ficiency with multivessel disease
Hyukjin Park, Young Joon Hong, Si Hyun Rhew, Sung Soo Kim, Young Wook Jeong, Hae Chang Jeong, Jae Yeong Cho, Soo Young Jang, Ki Hong Lee, Keun Ho Park, Doo Sun Sim, Nam Sik Yoon, Hyun Ju Yoon, Kye Hun Kim, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park
Korean J Intern Med. 2015;30(2):177-190. Published online February 27, 2015
Background/Aims: The aim of this study was to compare the risk of complications and outcome between infarct-related artery (IRA)-only revascularization and multivessel (MV) revascularization in patients with acute myocardial infarction (MI) with renal insufficiency and MV disease.
Methods: A total ..
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Gastroenterology / Review
Roadmap for elimination of gastric cancer in Korea
David Y. Graham
Korean J Intern Med. 2015;30(2):133-139. Published online February 27, 2015
Most gastric cancers are caused by infection with the common human bacterial pathogen, Helicobacter pylori. It is now accepted that gastric cancer can be prevented and virtually eliminated by H. pylori eradication and this knowledge was responsible for country-wide H. pylori era..
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Infectious diseases / Original Article
Utilization of the respiratory virus multiplex reverse transcription-polymerase chain reaction test for adult patients at a Korean tertiary care center
Mi Young Ahn, Seong-Ho Choi, Jin-Won Chung, Hye Ryoun Kim
Korean J Intern Med. 2015;30(1):96-103. Published online December 30, 2014
Background/Aims: Respiratory viruses (RVs) are considered to be important respiratory pathogens in adult patients, and the multiplex reverse transcription-polymerase chain reaction (RT-PCR) test is used frequently in adult patients with respiratory infections. However, clinical data regarding utiliz..
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Hemato-oncology / Original Article
The efficacy of low-dose transdermal fentanyl in opioid-naïve cancer patients with moderate-to-severe pain
Jung Hun Kang, Sung Yong Oh, Seo-Young Song, Hui-Young Lee, Jung Han Kim, Kyoung Eun Lee, Hye Ran Lee, In Gyu Hwang, Se Hoon Park, Won Seok Kim, Young Suk Park, Keunchil Park
Korean J Intern Med. 2015;30(1):88-95. Published online December 30, 2014
Background/Aims: Little is known about the efficacy of low-dose transdermal fentanyl (TDF) patches in opioid-naïve patients with moderate-to-severe cancer pain.
Methods: This study had an open-label, prospective design, and was conducted between April 2007 and February 2009 in seven tertiary cance..
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Pulmonology / Original Article
Proteomic differences with and without ozone-exposure in a smoking-induced emphysema lung model
Soo-Taek Uh, So-My Koo, An Soo Jang, Sung Woo Park, Jae Sung Choi, Yong-Hoon Kim, Choon Sik Park
Korean J Intern Med. 2015;30(1):62-72. Published online December 30, 2014
Background/Aims: Acute exacerbations in chronic obstructive pulmonary disease may be related to air pollution, of which ozone is an important constituent. In this study, we investigated the protein profiles associated with ozone-induced exacerbations in a smoking-induced emphysema model.
Methods: M..
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Pulmonology / Original Article
Pleural fluid characteristics of pleuropulmonary paragonimiasis masquerading as pleural tuberculosis
Ki-Eun Hwang, Hyo-Yeop Song, Jae-Wan Jung, Su-Jin Oh, Kwon-Ha Yoon, Do-Sim Park, Eun-Taik Jeong, Hak-Ryul Kim
Korean J Intern Med. 2015;30(1):56-61. Published online December 30, 2014
Background/Aims: Pleuropulmonary paragonimiasis produces no specific symptoms or radiologic findings, allowing for the possibility of misdiagnosis. We evaluated the specific clinical and pleural fluid features of pleuropulmonary paragonimiasis masquerading as pleural tuberculosis.
Methods: We retro..
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Cardiology / Original Article
Clinical impact of routine follow-up coronary angiography after second- or third-generation drug-eluting stent insertion in clinically stable patients
Seonghoon Choi, Hee-Sun Mun, Min-Kyung Kang, Jung Rae Cho, Seong Woo Han, Namho Lee Lee
Korean J Intern Med. 2015;30(1):49-55. Published online December 30, 2014
Background/Aims: In the bare-metal stent era, routine follow-up coronary angiography (RFU CAG) was used to ensure stent patency. With the advent of drug-eluting stents (DESs) with better safety and efficacy profiles, RFU CAG has been performed less often. There are few data on the clinical impact of..
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Rheumatology / Review
Methods for the morphological and functional evaluation of microvascular damage in systemic sclerosis
Barbara Ruaro, Vanessa Smith, Alberto Sulli, Saskia Decuman, Carmen Pizzorni, Maurizio Cutolo
Korean J Intern Med. 2015;30(1):1-5. Published online December 30, 2014
Systemic sclerosis is a connective tissue disease characterized by alterations in microvascular structure and function. In these patients, numerous studies have demonstrated a relationship between capillary morphology and peripheral blood perfusion. Nailfold videocapillaroscopy reveals the periphera..
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Letter to the editor
Parvimonas micra chest wall abscess following transthoracic lung needle biopsy
Luis Gorospe, Isabel Bermudez-Coronel-Prats, Carol F. Gomez-Barbosa, Maria E. Olmedo-Garcia, Angel Ruedas-Lopez, Vicente Gomez del Olmo
Korean J Intern Med. 2014;29(6):834-837. Published online October 31, 2014
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Letter to the editor
Graves’ disease presenting with acute renal infarction
Cho-Ok Baek, Kyung Ae Lee, Tae Sun Park, Heung Yong Jin
Korean J Intern Med. 2014;29(6):825-826. Published online October 31, 2014
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