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Endocrinology-metabolism / Original Article
Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea
Suk Kyeong Kim, Ju-Young Jang, Dong-Lim Kim, Young A Rhyu, Suh Eun Lee, Seung-Hyun Ko, Kyungdo Han, Kee-Ho Song; On behalf of the Task Force Team for Diabetes Fact Sheet of the Korean Diabetes Association
Korean J Intern Med. 2020;35(3):641-651. Published online September 3, 2018
Background/Aims: We aimed to evaluate site-specific cancer risk in diabetic patients and to investigate causal and temporal relationships by analyzing organ-specific cancer risk according to the duration of diabetes.
Methods: Using a database provided by the Korean National Health Insurance Service..
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Cardiology / Original Article
Prevention of medical malpractice and disputes through analysis of lawsuits related to coronary angiography and intervention
Cheol Won Hyeon, Won Lee, So Yoon Kim, Ji Yong Park, Su Hwan Shin
Korean J Intern Med. 2020;35(3):605-618. Published online June 14, 2019
Background/Aims: Possible fatal complications arising from coronary angiography (CAG), percutaneous coronary intervention (PCI), and coronary artery disease itself, are likely to cause medical disputes. Presenting the current status and reasons for judgments given in lawsuits related to CAG/PCI, thi..
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Cardiology / Original Article
Gender differences in the presentation of chest pain in obstructive coronary artery disease: results from the Korean Women’s Chest Pain Registry
Dong-Hyuk Cho, Jimi Choi, Mi-Na Kim, Hack-Lyoung Kim, Yong Hyun Kim, Jin Oh Na, Jin-Ok Jeong, Hyun Ju Yoon, Mi-Seung Shin, Myung-A Kim, Kyung-Soon Hong, Gil Ja Shin, Seong-Mi Park, Wan Joo Shim
Korean J Intern Med. 2020;35(3):582-592. Published online March 19, 2019
Background/Aims: Chest pain in patients with obstructive coronary artery disease (OCAD) is affected by several social factors. The gender-based differences in chest pain among Koreans have yet to be investigated.
Methods: The study consecutively enrolled 1,549 patients (male/female, 514/1,035; 61 ..
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Gastroenterology / Original Article
Effects of probiotics or broccoli supplementation on Helicobacter pylori eradication with standard clarithromycin-based triple therapy
Young Woon Chang, Yoo Min Park, Chi Hyuk Oh, Shin Ju Oh, Jun-Hyung Cho, Jung-Wook Kim, Jae-Young Jang
Korean J Intern Med. 2020;35(3):574-581. Published online December 12, 2019
Background/Aims: The eradication failure rate of standard triple therapy (proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has increased owing to antibiotic resistance in Korea. We assessed whether Saccharomyces boulardii probiotic or broccoli s..
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Gastroenterology / Original Article
Prognostic impact of hepatitis B or C on intrahepatic cholangiocarcinoma
Jung Woong Seo, Byung Soo Kwan, Young Koog Cheon, Tae Yoon Lee, Chan Sup Shim, So Young Kwon, Won Hyeok Choe, Byung Chul Yoo, Jeong Min Yoon, Jung Hoon Lee
Korean J Intern Med. 2020;35(3):566-573. Published online January 10, 2020
Background/Aims: Intrahepatic cholangiocarcinoma (ICC) is the second-most common primary liver malignancy, arising from the peripheral intrahepatic bile duct epithelium. Hepatitis B virus (HBV) or hepatitis C virus (HCV) may be involved in the development of ICC. We explored the prognostic value of ..
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Review
Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs
Tae Young Park, Hyoung-Chul Oh, Evan L. Fogel, Glen A. Lehman
Korean J Intern Med. 2020;35(3):535-543. Published online April 29, 2020
Acute pancreatitis is the most common and feared adverse event associated with performance of endoscopic retrograde cholangiopancreatography (ERCP). Unremitting effort has been made for over 40 years to minimize the frequency and severity of this complication. Recently, the use of rectal non-steroid..
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Review
Heart failure with preserved ejection fraction: insights from recent clinical researches
[corrected-article]
Mi-Na Kim, Seong-Mi Park
Korean J Intern Med. 2020;35(3):514-534. Published online April 29, 2020
Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for nearly half of the cases of HF and its incidence might be increasing with the aging society. Patients with HFpEF present with significant symptoms, including exercise intolerance, impaired quality of life, and have a poor progn..
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Review
Current status of heart failure: global and Korea
Jin Joo Park, Dong-Ju Choi
Korean J Intern Med. 2020;35(3):487-497. Published online April 29, 2020
Heart failure (HF) is a condition in which the heart is unable to pump enough blood to meet the body’s needs for blood and oxygen. Thus, HF is a grave disease with high morbidity and mortality. Because the prevalence of and exposure to the risk factors for HF increase with age, the prevalence of H..
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Infectious diseases / Original Article
Diagnostic usefulness of the cytomegalovirus (CMV)-specific T cell-based assay for predicting CMV infection after kidney transplant
Taeeun Kim, Hyun-Jeong Lee, Sun-Mi Kim, Joo Hee Jung, Sung Shin, Young-Hoon Kim, Heungsup Sung, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim, Duck Jong Han
Korean J Intern Med. 2020;35(2):438-448. Published online June 7, 2018
Background/Aims: We evaluated the usefulness in kidney transplant (KT) candidates of cytomegalovirus (CMV)-specific enzyme-linked immunospot (ELISPOT) assays for predicting the development of post-transplant CMV infections.
Methods: All adult recipients admitted for living-donor KT between March 20..
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Hemato-oncology / Original Article
Clinical impact of anti-thymocyte globulin on survival and graft-versus-host disease in patients undergoing human leukocyte antigen mismatched allogeneic stem cell transplantation
Taeyun Kim, Yunsuk Choi, Je-Hwan Lee, Silvia Park, Jae-Sook Ahn, Joon-Ho Moon, Ho-Jin Shin, Won Sik Lee, Dajung Kim, Ho Sup Lee
Korean J Intern Med. 2020;35(2):429-437. Published online January 10, 2019
Background/Aims: Rabbit anti-thymocyte globulin (ATG) is usually incorporated in hematopoietic stem cell transplantation (HSCT) to reduce the incidence of graft-versus-host disease (GVHD). This study aimed to find optimal ATG doses in patients undergoing human leukocyte antigen (HLA)-mismatched allo..
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Hemato-oncology / Original Article
Metabolic comorbidities and medical institution utilization among breast cancer survivors: a national population-based study
Jaesung Heo, Mison Chun, Young-Taek Oh, O Kyu Noh, Logyoung Kim
Korean J Intern Med. 2020;35(2):421-428. Published online September 5, 2019
Background/Aims: We investigated metabolic comorbidity status and patterns of medical institution utilization among breast cancer survivors using medical claims data from the Health Insurance Review and Assessment Service (HIRA).
Methods: Using claims data obtained from the HIRA, we selected breast..
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Cardiology / Original Article
Clinical profiles of patients with surgically resected pheochromocytoma and paraganglioma
Sun Hwa Lee, Jae-Hyeong Park, Ja-Yeon Lee, Sang-Rok Lee, Kyoung-Suk Rhee, Jei-Keon Chae, Won-Ho Kim, Ji-Young Sul, Jin Kyung Oh, Hee-Jin Kwon, Jae-Hwan Lee, In-Whan Seong
Korean J Intern Med. 2020;35(2):351-359. Published online February 28, 2019
Background/Aims: Pheochromocytoma and paraganglioma (PPGL) are catecholamine-producing tumors that can cause blood pressure (BP) elevation and cardiovascular complications. Clinical presentation of these tumors may be changed through widespread use of imaging studies, which enables detection of PPG..
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Gastroenterology / Original Article
Immunological measurement of aspartate/alanine aminotransferase in predicting liver fibrosis and inflammation
Hyun Jeong Kim, Sang Yeol Kim, Suk Pyo Shin, Young Joo Yang, Chang Seok Bang, Gwang Ho Baik, Dong Joon Kim, Young Lim Ham, Eui Yul Choi, Ki Tae Suk
Korean J Intern Med. 2020;35(2):320-330. Published online January 23, 2019
Background/Aims: Enzymatic analysis of aspartate/alanine aminotransferase (AST/ALT) does not exactly represent the progression of liver fibrosis or inflammation. Immunoassay for AST (cytoplasmic [c] AST/mitochondrial [m] AST) and ALT (ALT1/ALT2) has been suggested as one alternatives for enzymatic a..
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Gastroenterology / Original Article
Outcomes and clinical relevance of stool multiplex bacterial polymerase chain reaction in patients with acute diarrhea: single center experience
Won Gun Kwack, Yun Jeong Lim, Ki Hwan Kwon, Jae Woo Chung, Jin Young Oh
Korean J Intern Med. 2020;35(2):300-309. Published online January 29, 2019
Background/Aims: Diagnostic stool multiplex polymerase chain reaction (PCR) testing has attracted considerable interest, because of its high sensitivity, short turnaround time, and ability to detect multiple organisms simultaneously. This study investigates the clinical usefulness of a stool multipl..
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Nephrology / Review
Continuous renal replacement therapy in elderly with acute kidney injury
[corrected-article]
Kristianne Rachel P. Medina-Liabres, Sejoong Kim
Korean J Intern Med. 2020;35(2):284-294. Published online February 28, 2020
The objective of this article is to raise awareness among physicians of the increasing incidence of acute kidney injury in the elderly population and the utility of continuous renal replacement therapy (CRRT) in its management. While CRRT is frequently applied in younger patients, its use in elderly..
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Pulmonology / Review
Role of phosphodiesterase-4 inhibitors in chronic obstructive pulmonary disease
Chin Kook Rhee, Deog Kyeom Kim
Korean J Intern Med. 2020;35(2):276-283. Published online February 28, 2020
Phosphodiesterase-4 inhibitors (PDE4Is) are potent anti-inf lammatory agents and roflumilast has been used to prevent acute exacerbation of chronic obstructive pulmonary disease (COPD). Roflumilast decreases neutrophil migration, restores cystic fibrosis transmembrane conductance regulator activity,..
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Rheumatology / Original Article
Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity
Kichul Shin, Sung Soo Kim, Sang-Heon Lee, Seung-Jae Hong, Sung Jae Choi, Jung-Yoon Choe, Seung-Geun Lee, Hoon-Suk Cha, Eun Young Lee, Sung-Hwan Park, Jin-Wuk Hur, Sung Soo Na, Chang-Hee Suh, Min Wook So, Seung Won Choi, Dong-Hyuk Sheen, Won Park, Shin-Seok Lee, Wan Hee Ryu, Jin Seok Kim, Jung Soo Song, Hye Soon Lee, Seong Ho Kim, Dae-Hyun Yoo
Korean J Intern Med. 2020;35(1):231-239. Published online January 28, 2019
Background/Aims: The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive rheumatoid arthritis (RA) in daily clinical practice. Methods: This was ..
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Hemato-oncology / Original Article
Real world data on follicular lymphoma patients treated by rituximab-containing immunochemotherapy and rituximab maintenance
Hee Kyung Kim, Wonseok Kang, Dong Hyun Sinn, Joon Hyeok Lee, Won Seog Kim, Seok Jin Kim
Korean J Intern Med. 2020;35(1):194-204. Published online April 4, 2019
Background/Aims: Real-world data about the treatment outcomes of patients receiving rituximab-containing immunochemotherapy followed by rituximab maintenance are required to understand better the treatment for follicular lymphoma (FL).
Methods: A cross-sectional study analyzed FL patients who were ..
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Nephrology / Original Article
Low parathyroid hormone level predicts infection-related mortality in incident dialysis patients: a prospective cohort study
Yu Ah Hong, Jeong Ho Kim, Yong Kyun Kim, Yoon Kyung Chang, Cheol Whee Park, Suk Young Kim, Yon Su Kim, Shin-Wook Kang, Nam-Ho Kim, Yong-Lim Kim, Chul Woo Yang
Korean J Intern Med. 2020;35(1):160-170. Published online October 28, 2019
Background/Aims: Parathyroid hormone (PTH) is an important factor influencing immunologic dysfunction, but the effect of PTH level on infection-related outcomes remains unclear in incident dialysis.
Methods: We evaluated a multicenter prospective cohort study of 1,771 incident dialysis patients (1,..
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Pulmonology / Original Article
Analysis of high predicted pulmonary function: possibility of overestimation in small elderly examinees
Youjin Chang, Ho Cheol Kim, Kyung-Wook Jo, Jae Seung Lee, Yeon-Mok Oh, Sang Do Lee, Sei Won Lee
Korean J Intern Med. 2020;35(1):142-149. Published online October 17, 2019
Background/Aims: Few studies have attempted to interpret unusually high predicted pulmonary function test results. This study aimed to investigate the demographic features of patients with an unusually high predicted pulmonary function.
Methods: The demographic data of subjects who underwent pulmon..
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