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Gastroenterology / Original Article
Clarithromycin resistance and female gender affect Helicobacter pylori eradication failure in chronic gastritis
Young Woon Chang, Weon Jin Ko, Chi Hyuk Oh, Yoo Min Park, Shin Ju Oh, Jung Rock Moon, Jun-Hyung Cho, Jung-Wook Kim, Jae-Young Jang
Korean J Intern Med. 2019;34(5):1022-1029. Published online June 14, 2018
Background/Aims: The eradication rate of the first-line triple therapy (a proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has gradually decreased in Korea. We evaluated whether clinical parameters, clarithromycin resistance, and CYP2C19 genotype can affect t..
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Review
Cellular immunotherapy in multiple myeloma
Manh-Cuong Vo, Thangaraj Jaya Lakshmi, Sung-Hoon Jung, Duck Cho, Hye-Seong Park, Tan-Huy Chu, Hyun-Ju Lee, Hyeoung-Joon Kim, Sang-Ki Kim, Je-Jung Lee
Korean J Intern Med. 2019;34(5):954-965. Published online February 15, 2019
In multiple myeloma (MM), the impaired function of several types of immune cells favors the tumor’s escape from immune surveillance and, therefore, its growth and survival. Tremendous improvements have been made in the treatment of MM over the past decade but cellular immunotherapy using dendritic..
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Rheumatology / Original Article
The evaluation of cellular immune function in elderly patients with systemic lupus erythematosus
Kun Men, Yu Chen, Jingwei Zhang, Dianjun Wei
Korean J Intern Med. 2019;34(4):932-937. Published online November 29, 2017
Background/Aims: To evaluate cellular immune function in systemic lupus erythematosus (SLE) patients over 60 years old, the association between antinuclear antibody (ANA) titers and the ratio of CD4+ /CD8+ was analyzed in this study. The distribution of ANAs and extractable nu..
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Infectious diseases / Original Article
Application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndrome
Jeong Rae Yoo, Sun Hyung Kim, Young Ree Kim, Keun Hwa Lee, Won Sup Oh, Sang Taek Heo
Korean J Intern Med. 2019;34(4):902-909. Published online November 10, 2017
Background/Aims: Severe fever with thrombocytopenia syndrome (SFTS) is a viral hemorrhagic fever with a high fatality rate. However, effective treatments for SFTS cases not responded to supportive therapy have not been established. Herein, we introduced the therapeutic plasma exchange (TPE) in SFTS ..
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Hemato-oncology / Original Article
Costs and clinical outcomes of patients with diffuse large B-cell lymphoma in first remission: role of PET/CT surveillance
Koung Jin Suh, Ki Hwan Kim, Ryul Kim, Ja Min Byun, Miso Kim, Jin Hyun Park, Bhumsuk Keam, Tae Min Kim, Jin-Soo Kim, In Sil Choi, Dae Seog Heo
Korean J Intern Med. 2019;34(4):894-901. Published online February 23, 2018
Background/Aims: The role of [18F]-f luorodeoxyglucose positron emission tomography-computed tomography (PET/CT) in patients with diffuse large B-cell lymphoma (DLBCL) in first remission is unclear.
Methods: Medical costs within the first 3 years of treatment completion and clinical outcomes of 118..
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Hemato-oncology / Original Article
Clinical significance of rituximab infusion-related reaction in diffuse large B-cell lymphoma patients receiving R-CHOP
Kyoung Min Cho, Bhumsuk Keam, Hyerim Ha, Miso Kim, Jae-Woo Jung, Woo-Jung Song, Tae Min Kim, Yoon Kyung Jeon, Hye-Ryun Kang, Dong-Wan Kim, Chul Woo Kim, Dae Seog Heo
Korean J Intern Med. 2019;34(4):885-893. Published online November 20, 2017
Background/Aims: This study was to evaluate the clinical significance of infusion-related reaction (IRR) of rituximab in diffuse large B-cell lymphoma (DLBCL) patients who received R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) as a first-line chemotherapy.
Methods..
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Pulmonology / Original Article
Birt-Hogg-Dubé syndrome in Korean: clinicoradiologic features and long term follow-up
Joo Hee Lee, Min Joo Jeon, Joon Seon Song, Eun Jin Chae, Jin-Ho Choi, Gu-Hwan Kim, Jin Woo Song
Korean J Intern Med. 2019;34(4):830-840. Published online October 26, 2018
Background/Aims: Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant disorder that is characterized by skin fibrofolliculomas, pulmonary cysts, and renal tumors. The objective of this study was to describe the features of Korean patients with BHD syndrome.
Methods: Clinical data were retro..
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Cardiology / Original Article
Intravascular imaging analysis of a drug-eluting balloon followed by a bare metal stent compared to a drug-eluting stent for treatment of de novo lesions
Wonsuk Choi, In-Ho Chae, Jin Joo Park, Sun-Hwa Kim, Si-Hyuck Kang, Il-Young Oh, Chang-Hwan Yoon, Young-Seok Cho, Tae-Jin Youn, Dong-Ju Choi
Korean J Intern Med. 2019;34(4):819-829. Published online July 4, 2018
Background/Aims: After a study comparing drug-eluting stents (DESs) to sequential treatment with drug-eluting balloons (DEBs) and bare metal stents (BMSs), we retrospectively analysed strut malapposition and neointimal hyperplasia in de novo coronary lesions using optical coherence tomography (OCT) ..
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Gastroenterology / Original Article
Efficacy of long-term tenofovir disoproxil fumarate therapy in chronic hepatitis B patients with partial virologic response in real practice
Jeong Eun Song, Chang Hyeong Lee, Byung Seok Kim
Korean J Intern Med. 2019;34(4):802-810. Published online April 8, 2019
Background/Aims: The optimal management of chronic hepatitis B (CHB) patients with partial virologic response (PVR) to tenofovir disoproxil fumarate (TDF) remains unclear. We aimed to evaluate the long-term efficacy of prolonged TDF therapy in treatment-naïve CHB patients with PVR to TDF therapy in..
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Review
Current status of pulmonary arterial hypertension in Korea
Albert Youngwoo Jang, Wook-Jin Chung
Korean J Intern Med. 2019;34(4):696-707. Published online July 1, 2019
Pulmonary arterial hypertension (PAH) is characterized by remodeling of the distal pulmonary arteries resulting in high pulmonary vascular resistance and, eventually, right ventricular heart failure. Although current advances in PAH therapy have improved outcomes, poor survival remains a reality wor..
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Review
Current status and therapeutic considerations of hypertension in the elderly
Ju-Hee Lee, Kwang-Il Kim, Myeong-Chan Cho
Korean J Intern Med. 2019;34(4):687-695. Published online July 1, 2019
As the prevalence of hypertension in the elderly population is increasing, information regarding the characteristics, optimal blood pressure targets, and special considerations for elderly hypertensive patients is needed to improve clinical outcomes. Various factors should be considered when managin..
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Infectious diseases / Original Article
MicroRNA-16 inhibits cell proliferation and migration by targeting heat shock protein 70 in heat-denatured dermal fibroblasts
[retracted-article]
Chun Zhang, Jinhua Dai, Youfen Fan, Xianghui He, Renxiong Wei
Korean J Intern Med. 2019;34(3):634-642. Published online January 5, 2018
Background/Aims: This study aimed to investigate the precise mechanism and function of miR-16 in heat-denatured primary human dermal fibroblasts.
Methods: Primary human dermal fibroblasts were separated from normal human skin samples. Under heat stress, the levels of miR-16 and heat shock protein 7..
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Hemato-oncology / Original Article
Surrogate decision making of chemotherapy consent: do we really provide informed consent of chemotherapy for patients?
Jung Hye Kwon, Sun Kyung Baek, Bong-Seog Kim, Su-Jin Koh, Hee Kyung Ahn, Joo Han Lim, Chiyeon Lim, Do Yeun Kim
Korean J Intern Med. 2019;34(3):626-633. Published online May 31, 2018
Background/Aims: Despite increased demand for cancer patient’s to make their own decisions based on an adequate understanding of what is involved in chemotherapy, the primary signing agent and the reasons for surrogate signing have not been appropriately evaluated.
Methods: The ethics committee of..
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Hemato-oncology / Original Article
Comparison of the morphologic criteria (RECIST) and metabolic criteria (EORTC and PERCIST) in tumor response assessments: a pooled analysis
Hong Deok Kim, Bum Jun Kim, Hyeong Su Kim, Jung Han Kim
Korean J Intern Med. 2019;34(3):608-617. Published online January 17, 2018
Background/Aims: The Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) or European Organization for Research and Treatment of Cancer (EORTC) criteria are used to assess metabolic tumor responses. However, tumor responses have shown considerable discrepancies between the morpho..
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Nephrology / Original Article
Intradialytic exercise improves physical function and reduces intradialytic hypotension and depression in hemodialysis patients
So Yon Rhee, Jin Kyung Song, Suk Chul Hong, Jae Won Choi, Hee Jung Jeon, Dong Ho Shin, Eun Hee Ji, Eun-Hee Choi, Jiyeon Lee, Aram Kim, Seung Wook Choi, Jieun Oh
Korean J Intern Med. 2019;34(3):588-598. Published online August 25, 2017
Background/Aims: As numbers of maintenance hemodialysis patients are growing, debilitating conditions of muscle wasting and atrophy are becoming some of the greatest concerns in end-stage renal disease patients. Exercise training has various potential benefits in terms of prevention of a sustained d..
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Cardiology / Original Article
Gender difference in the association between brachial-ankle pulse wave velocity and cardiovascular risk scores
Tae-Min Rhee, Hack-Lyoung Kim, Sohee Oh, Woo-Hyun Lim, Jae-Bin Seo, Woo-Young Chung, Sang-Hyun Kim, Myung-A Kim, Joo-Hee Zo
Korean J Intern Med. 2019;34(3):539-548. Published online March 16, 2018
Background/Aims: Although brachial-ankle pulse wave velocity (baPWV) has been validated as a novel method to predict the cardiovascular risk in general population, the relevance of baPWV to the traditional risk scores has not been clearly revealed. This study investigated the relationship between b..
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Gastroenterology / Original Article
Epidemiologic features of ınflammatory bowel disease in Western Blacksea region of Turkey for the last 10 years: retrospective cohort study
Güray Can, Emrah Poşul, Bülent Yılmaz, Hatice Can, Uğur Korkmaz, Fatih Ermiş, Mevlüt Kurt, Ülkü Dağlı
Korean J Intern Med. 2019;34(3):519-529. Published online April 27, 2018
Background/Aims: There are only a few epidemiological study about inflammatory bowel disease in the last 10 years in Turkey, especially in Western Blacksea region. In our study, we aimed to identify the changes in the incidence and the prevalence of inflammatory bowel disease in Western Blacksea reg..
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Gastroenterology / Original Article
Time-dependent reversal of significant intrapulmonary shunt after liver transplantation
Xin Jin, Byung Joo Sun, Jae-Kwan Song, Jae-Hyung Roh, Jeong Yoon Jang, Dae-Hee Kim, Young-Suk Lim, Jong-Min Song, Duk-Hyun Kang, Sung Gyu Lee
Korean J Intern Med. 2019;34(3):510-518. Published online March 5, 2018
Background/Aims: Although the association between intrapulmonary shunt (IPS) and liver cirrhosis is clear, data of repeated contrast echocardiography (CE) before and after liver transplantation (LT) to evaluate factors associated with IPS are limited.
Methods: Hand-agitated saline was used for CE a..
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Rheumatology / Review
Molecular targeted therapies for microscopic polyangiitis and granulomatosis with polyangiitis
Masayoshi Harigai, Michi Tsutsumino, Hideto Takada, Kenji Nagasaka
Korean J Intern Med. 2019;34(3):492-503. Published online January 9, 2019
Clinical trials and observational studies have established cyclophosphamide (CY) or rituximab plus glucocorticoid (GC) as standard remission induction therapies in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). However, because these regimens are associated ..
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Cardiology / Review
Extracellular vesicles in renal physiology and clinical applications for renal disease
Soon Hyo Kwon
Korean J Intern Med. 2019;34(3):470-479. Published online April 30, 2019
Many cells in the nephron release extracellular vesicles (EVs). EVs envelop nucleic acids, proteins, and lipids. The surfaces of EVs express donor cell-specific markers, ligands, and major histocompatibility complex molecules. They are involved in cell-to-cell communication, immune modulation, and t..
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