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Pulmonology
Timing and predictors of death during treatment in patients with multidrug/rifampin-resistant tuberculosis in South Korea
Eunjeong Son, Hongjo Choi, Jeongha Mok, Young Ae Kang, Dawoon Jeong, Doosoo Jeon
Korean J Intern Med. 2024;39(4):640-649. Published online June 24, 2024
Background/Aims: This study aimed to investigate the timing and predictors of death during treatment among patients with multidrug/rifampin-resistant tuberculosis (MDR/RR-TB) in South Korea.
Methods: This was a retrospective cohort study that included MDR/RR-TB cases notified between 2011 and 2017 ..
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Risk factors for progressing to critical illness in patients with hospital-acquired COVID-19
Kyung-Eui Lee, Jinwoo Lee, Sang-Min Lee, Hong Yeul Lee
Korean J Intern Med. 2024;39(3):477-487. Published online April 18, 2024
Background/Aims: Risk factors for progression to critical illness in hospital-acquired coronavirus disease 2019 (COVID-19) remain unknown. Here, we assessed the incidence and risk factors for progression to critical illness and determined their effects on clinical outcomes in patients with hospital-..
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Cardiology
Association of epicardial adipose tissue with metabolic risk factors on cardiovascular outcomes: serial coronary computed tomography angiography study
Sungjoon Park, Dong Eun Kim, Su Min Kim, JungMin Choi, Sang Joon Park, Hae-Young Lee, Eun Ju Chun
Korean J Intern Med. 2024;39(2):283-294. Published online February 14, 2024
Background/Aims: Epicardial adipose tissue (EAT) shares pathophysiological properties with other visceral fats and potentially triggers local inflammation. However, the association of EAT with cardiovascular disease (CVD) is still debatable. The study aimed to observe the changes and associations in..
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Rheumatology
Clinical characteristics and prognostic factors of non-tuberculous mycobacterial disease in patients with rheumatoid arthritis
Hyemin Kim, Soyoung Lee, Ji-Won Kim, Ju-Yang Jung, Chang-Hee Suh, Hyoun-Ah Kim
Korean J Intern Med. 2024;39(1):172-183. Published online November 30, 2023
Background/Aims: This study aimed to identify the clinical characteristics of patients with concurrent rheumatoid arthritis (RA) and suspected non-tuberculous mycobacterial (NTM) infections as well as determine their prognostic factors.
Methods: We retrospectively reviewed the medical records of 91..
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Gastroenterology
Risk factors for anticoagulant-associated gastrointestinal hemorrhage: a systematic review and meta-analysis
Fuxin Ma, Shuyi Wu, Shiqi Li, Zhiwei Zeng, Jinhua Zhang
Korean J Intern Med. 2024;39(1):77-85. Published online December 8, 2023
Background/Aims: There may be many predictors of anticoagulation-related gastrointestinal bleeding (GIB), but until now, systematic reviews and assessments of the certainty of the evidence have not been published. We conducted a systematic review to identify all risk factors for anticoagulant-associ..
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Infectious diseases
Clinical significance of antinuclear antibody positivity in patients with severe coronavirus disease 2019
Soo Hyun Park, Jin Woong Suh, Kyung-Sook Yang, Jeong Yeon Kim, Sun Bean Kim, Jang Wook Sohn, Young Kyung Yoon
Korean J Intern Med. 2023;38(3):417-426. Published online April 6, 2023
Background/Aims: This study aimed to investigate the clinical characteristics and outcomes of fluorescent antinuclear antibody (FANA)-positive patients admitted for coronavirus disease 2019 (COVID‐19) and identify FANA as a prognostic factor of mortality.
Methods: This retrospective study was con..
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Rheumatology
Prevalence, incidence, and risk factors of malignancy in patients with rheumatoid arthritis: a nationwide cohort study from Korea
Kyung Min Ko, Su-Jin Moon
Korean J Intern Med. 2023;38(1):113-124. Published online August 20, 2021
Background/Aims: This study aims to evaluate the incidence of malignancy in patients with rheumatoid arthritis (RA) and to investigate risk factors for such in a nationwide, population-based cohort.
Methods: In a large, prospective, observational cohort study, 5,077 patients with RA were enrolled f..
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Gastroenterology
Clinical outcomes of acute upper gastrointestinal bleeding according to the risk indicated by Glasgow-Blatchford risk score-computed tomography score in the emergency room
Hyun Ae Lee, Hye-Kyung Jung, Tae Oh Kim, Ju-Ran Byeon, Eui-Sun Jeong, Hyun-Ji Cho, Chung Hyun Tae, Chang Mo Moon, Seong-Eun Kim, Ki-Nam Shim, Sung-Ae Jung
Korean J Intern Med. 2022;37(6):1176-1185. Published online November 1, 2022
Background/Aims: Acute upper gastrointestinal (UGI) bleeding is a significant emergency situation with a mortality rate of 2% to 10%. Therefore, initial risk stratification is important for proper management. We aimed to evaluate the role of contrast-enhanced multidetector computed tomography (MDCT)..
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Factors associated with the risk of colorectal neoplasia in young adults under age 40
Ilsoo Kim, Han Hee Lee, Young Jae Ko, Ho Eun Chang, Dae Young Cheung, Bo-In Lee, Young-Seok Cho, Jin Il Kim, Myung-Gyu Choi
Korean J Intern Med. 2022;37(5):969-978. Published online July 25, 2022
Background/Aims: Recent epidemiologic studies have shown a continued increase in colorectal cancer incidence among younger adults. Little is known about the factors that contribute to the development of young-onset colorectal neoplasia (CRN).
Methods: A cross-sectional analysis was performed for ind..
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2022 Consensus statement on the management of familial hypercholesterolemia in Korea
Chan Joo Lee, Minjae Yoon, Hyun-Jae Kang, Byung Jin Kim, Sung Hee Choi, In-Kyung Jeong, Sang-Hak Lee; on behalf of Task Force Team for Familial Hypercholesterolemia; Korean Society of Lipid and Atherosclerosis
Korean J Intern Med. 2022;37(5):931-944. Published online July 27, 2022
Familial hypercholesterolemia (FH) is the most common monogenic disorder. Due to the marked elevation of cardiovascular risk, the early detection, diagnosis, and proper management of this disorder are critical. Herein, the 2022 Korean guidance on this disease is presented. Clinical features include ..
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Infectious diseases
Risk factors and clinical impact of COVID-19-associated pulmonary aspergillosis: Multicenter retrospective cohort study
Raeseok Lee, Sung-Yeon Cho, Dong-Gun Lee, Hyojin Ahn, Hyeah Choi, Su-Mi Choi, Jae-Ki Choi, Jung-Hyun Choi, Shin Young Kim, Youn Jeong Kim, Hyo-Jin Lee
Korean J Intern Med. 2022;37(4):851-863. Published online May 26, 2022
Background/Aims: The risk factors and clinical impacts of coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) remain controversial, and no data have been reported in Korea. This study aimed to investigate the epidemiology and importance of CAPA diagnostic efforts and to ide..
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Cardiology
Predictors of recurrent acute myocardial infarction despite successful percutaneous coronary intervention
Sang Hun Lee, Myung Ho Jeong, Joon Ho Ahn, Dae Young Hyun, Kyung Hoon Cho, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Jin Yong Hwang, Weon Kim, Jong Seon Park, Chang-Hwan Yoon, Seung Ho Hur, Sang Rok Lee, Kwang Soo Cha; on behalf of the KAMIR (Korea Acute Myocardial Infarction Registry)-NIH Investigators
Korean J Intern Med. 2022;37(4):777-785. Published online June 28, 2022
Background/Aims: Recurrent acute myocardial infarction (AMI) is an adverse cardiac event in patients with a first AMI. The predictors of recurrent AMI after the first AMI in patients who underwent successful percutaneous coronary intervention (PCI) have not been elucidated.
Methods: We analyzed th..
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Nephrology
The presence of simple renal cysts is associated with an increased risk of albuminuria in young adults
Hyo Jin Boo, Jung Eun Lee, Son Mi Chung, Hye Ryoun Jang, Wooseong Huh, Dae Joong Kim, Yoon-Goo Kim
Korean J Intern Med. 2022;37(2):425-433. Published online December 7, 2021
Background/Aims: The prevalence of simple renal cysts increases with age; however, they are occasionally found in adults aged < 40 years. This cross-sectional study evaluated the clinical significance of simple cysts in young adults, focusing on their associations with hematuria and albuminuria.
Me..
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Hemato-oncology
Influence of creatinine levels on survival in patients with veno-occlusive disease treated with defibrotide
Seom Gim Kong, Je-Hwan Lee, Young Tak Lim, Ji Hyun Lee, Hyeon-Seok Eom, Hyewon Lee, Do Young Kim, Sung-Nam Lim, Sung-Soo Yoon, Sung-Yong Kim, Ho Sup Lee
Korean J Intern Med. 2022;37(1):179-189. Published online December 14, 2021
Background/Aims: Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is one of the most fatal complications of hematopoietic cell transplantation (HCT), and defibrotide is the only curative drug. We conducted this study to confirm the survival rate of VOD/SOS patients diagnosed in Korea..
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Pulmonology
Clinical efficacy of adjuvant chemotherapy in stage IB (< 4 cm) non-small cell lung cancer patients with high-risk factors
Juwhan Choi, Jee Youn Oh, Young Seok Lee, Kyung Hoon Min, Jae Jeong Shim, Sue In Choi, Dong Won Park, Chan Kwon Park, Eun Joo Kang, Hwan Seok Yong, Bong Kyung Shin, Hyun Koo Kim, Sung Yong Lee
Korean J Intern Med. 2022;37(1):127-136. Published online July 29, 2021
Background/Aims: Adjuvant chemotherapy is the standard of care for resected stage II-IIIA non-small cell lung cancer (NCSLC). The efficacy of adjuvant chemotherapy in stage IB (< 4 cm) NSCLC with high-risk factors is controversial.
Methods: This retrospective multicenter study included 285 stage IB..
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Characteristics and risk factors associated with missed diagnosis in patients with smear-negative pulmonary tuberculosis
Se Hyun Kwak, Ji Soo Choi, Eun Hye Lee, Su Hwan Lee, Ah Young Leem, Sang Hoon Lee, Song Yee Kim, Kyung Soo Chung, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Joon Chang, Young Ae Kang
Korean J Intern Med. 2021;36(Suppl 1):S151-S159. Published online August 20, 2020
Background/Aims: Delayed diagnosis and treatment of smear-negative pulmonary tuberculosis (TB) are major concerns for TB control. We evaluated characteristics of patients with smear-negative pulmonary TB who received a delayed diagnosis and identified risk factors that may have contributed to this d..
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Gastroenterology
Risk stratification of patients with gastric lesions indefinite for dysplasia
Young Sin Cho, Il-Kwun Chung, Yunho Jung, Su Jung Han, Jae Kook Yang, Tae Hoon Lee, Sang-Heum Park, Sun-Joo Kim
Korean J Intern Med. 2021;36(5):1074-1082. Published online September 9, 2020
Background/Aims: There are no definite guidelines for the management of gastric lesions diagnosed as indefinite for dysplasia (IND) by endoscopic forceps biopsy (EFB). Therefore, this study aimed to evaluate the clinical outcomes of gastric IND and predictive factors for gastric neoplasm.
Methods: ..
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Application of deep learning to predict advanced neoplasia using big clinical data in colorectal cancer screening of asymptomatic adults
Hyo-Joon Yang, Chang Woo Cho, Jongha Jang, Sang Soo Kim, Kwang-Sung Ahn, Soo-Kyung Park, Dong Il Park
Korean J Intern Med. 2021;36(4):845-856. Published online October 23, 2020
Background/Aims: We aimed to develop a deep learning model for the prediction of the risk of advanced colorectal neoplasia (ACRN) in asymptomatic adults, based on which colorectal cancer screening could be customized.
Methods: We collected data on 26 clinical and laboratory parameters, including ag..
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Cardiology
Impact of carotid atherosclerosis in CHA2DS2-VASc-based risk score on predicting ischemic stroke in patients with atrial fibrillation
Dong-Hyuk Cho, Jong-Il Choi, Jimi Choi, Yun Gi Kim, Suk-Kyu Oh, Hyungdon Kook, Kwang No Lee, Jaemin Shim, Seong-Mi Park, Wan Joo Shim, Young-Hoon Kim
Korean J Intern Med. 2021;36(2):342-351. Published online February 27, 2020
Background/Aims: Vascular disease is an established risk factor for stroke in patients with atrial fibrillation (AF), which is included in CHA2DS2-VASc score. However, the role of carotid atherosclerosis remains to be determined.
Methods: Three hundred-ten patients with AF who..
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Gastroenterology
Environmental risk factors and comorbidities of primary biliary cholangitis in Korea: a case-control study
Kyung-Ah Kim, Young Seok Kim, Sang Hoon Park, Woo Jin Chung, Dae Hee Choi, Eun Sun Jang, Sook-Hyang Jeong
Korean J Intern Med. 2021;36(2):313-321. Published online March 26, 2020
Background/Aims: The risk factors for the development of primary biliary cholangitis (PBC) is unclear. This study aimed to investigate the risk factors associated with PBC in Korea through a questionnaire survey.
Methods: Consecutively enrolled 103 PBC patients from six referral hospitals and 100 a..
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