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Gastroenterology / Original Article
Submucosal saline injection and mini-probe endoscopic ultrasound to assess endoscopic resectability of colorectal subepithelial tumors
Jung-Bin Park, Ji Eun Baek, June Hwa Bae, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Dong-Hoon Yang
Korean J Intern Med. 2025;40(4):592-605. Published online July 1, 2025
Background/Aims: This study aimed to evaluate the feasibility and outcomes of mini-probe endoscopic ultrasound (mEUS) followed by submucosal saline injection (SSI-mEUS) for assessing the endoscopic resectability of colorectal subepithelial lesions (SELs).
Methods: From January 2020 to December 2023..
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Gastroenterology / Original Article
Association between acid-suppressive drugs and risk of psoriasis: retrospective study using Korean National Health Insurance Service-National Sample Cohort
Ji Hyun Kim, Joon-hong Min, Young Woo Jo, Jae Woo Kwon, Young Her
Korean J Intern Med. 2025;40(1):57-64. Published online January 1, 2025
Background/Aims: Psoriasis is a common inflammatory skin disorder following non-specific triggers. Involvement of immune system is widely accepted for pathogenesis studies have demonstrated importance of gut microbiota in pathogenesis of inflammatory skin diseases. Proton pump inhibitor (PPI) and hi..
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Allergy / Review
Gut microbiota dysbiosis and its impact on asthma and other lung diseases: potential therapeutic approaches
Young-Chan Kim, Kyoung-Hee Sohn, Hye-Ryun Kang
Korean J Intern Med. 2024;39(5):746-758. Published online August 30, 2024
The emerging field of gut-lung axis research has revealed a complex interplay between the gut microbiota and respiratory health, particularly in asthma. This review comprehensively explored the intricate relationship between these two systems, focusing on their influence on immune responses, inflamm..
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Gastroenterology / Original Article
Clinical course of asymptomatic duodenal subepithelial lesions
Seokin Kang, Kwangbeom Park, Do Hoon Kim, Yuri Kim, Hee Kyong Na, Jeong Hoon Lee, Ji Yong Ahn, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Korean J Intern Med. 2024;39(4):603-611. Published online June 13, 2024
Background/Aims: There is limited knowledge regarding the management of duodenal subepithelial lesions (SELs) owing to a lack of understanding of their natural course. This study aimed to assess the natural course of asymptomatic duodenal SELs and provide management recommendations.
Methods: Patien..
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Gastroenterology / Original Article
Reduced risk of gastrointestinal bleeding associated with eupatilin in aspirin plus acid suppressant users: nationwide population-based study
Hyun Seok Lee, Ji Hyung Nam, Dong Jun Oh, Yeo Rae Moon, Yun Jeong Lim
Korean J Intern Med. 2024;39(2):261-271. Published online December 14, 2023
Background/Aims: Mucoprotective agents, such as eupatilin, are often prescribed to prevent gastrointestinal (GI) bleeding in addition to an acid suppressant despite the absence of a large-scale study. We evaluated the additional effect of eupatilin on the prevention of GI bleeding in both the upper ..
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Gastroenterology / Original Article
Risk factors for anticoagulant-associated gastrointestinal hemorrhage: a systematic review and meta-analysis
Fuxin Ma, Shuyi Wu, Shiqi Li, Zhiwei Zeng, Jinhua Zhang
Korean J Intern Med. 2024;39(1):77-85. Published online December 8, 2023
Background/Aims: There may be many predictors of anticoagulation-related gastrointestinal bleeding (GIB), but until now, systematic reviews and assessments of the certainty of the evidence have not been published. We conducted a systematic review to identify all risk factors for anticoagulant-associ..
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Gastroenterology / Original Article
Comparative study of the efficacy and safety of Abexol (suspension versus tablets) in patients with gastrointestinal symptoms
Alfredo Hierro González, Julio César Fernández Travieso, Yoandy Hernández Casas, Susana Borges González, María de los Angeles Camacho Morales, Elena Ferrer Batallie, Anaisa Roja Carralera, Yenney Reyes Nuñez, Sarahi Mendoza Castaño, Maytee Robaina García, Diana Margarita Rey Kaba
Korean J Intern Med. 2024;39(1):57-67. Published online November 30, 2023
Background/Aims: Abexol is a mixture of primary aliphatic alcohols purified from beeswax (Apis mellifera), that produces anti-inflammatory, antioxidant and gastroprotective effects, as well as it is safe and well tolerated. To investigate and compare the efficacy and safety of Abexol (suspens..
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Pulmonology / Original Article
Alterations in lung and gut microbiota reduce diversity in patients with nontuberculous mycobacterial pulmonary disease
Ji Yeon Choi, Bora Shim, Youngmok Park, Young Ae Kang
Korean J Intern Med. 2023;38(6):879-892. Published online October 23, 2023
Background/Aims: Although the incidence of nontuberculous mycobacteria pulmonary disease (NTM-PD), a chronic infectious disease, is increasing, lung and gut microbiota dysbiosis in NTM patients has rarely been studied and was therefore the focus of this study.
Methods: We analyzed the microbiota di..
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Gastroenterology / Original Article
Association between eupatilin and reduction in small bowel bleeding in aspirin users and aspirin plus acid suppressant users
Hyun Seok Lee, Ji Hyung Nam, Dong Jun Oh, Hyun Jung Ahn, Yun Jeong Lim
Korean J Intern Med. 2023;38(4):484-492. Published online May 19, 2023
Background/Aims: Capsule endoscopy (CE) has shown that low-dose aspirin occasionally causes small bowel (SB) bleeding. We herein evaluated the protective effects of mucoprotective agents (MPAs) on SB bleeding in aspirin users using the nationwide database of claims data from the National Health Insu..
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Gastroenterology / Original Article
Outcomes according to treatment modalities as a bridge to curative surgery for malignant obstruction of the proximal colon: stent versus stoma
Yong Eun Park, Seung Min Hong, Seung Bum Lee, Hong Sub Lee, Dong Hoon Baek, Rari Cha, Jong Yoon Lee, Tae Oh Kim, Jong Hoon Lee; Busan Ulsan Gyeongnam Intestinal Study Group Society (BIGS)
Korean J Intern Med. 2023;38(2):186-194. Published online January 2, 2023
Background/Aims: The optimal treatment for acute malignant obstruction of the proximal colon (MOPC, proximal to the splenic flexure) remains challenging. Emergency resection, the traditional modality for MOPC, has shown significantly high mortality and morbidity rates, according to recent studies. T..
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Gastroenterology / Original Article
Clinical outcomes of acute upper gastrointestinal bleeding according to the risk indicated by Glasgow-Blatchford risk score-computed tomography score in the emergency room
Hyun Ae Lee, Hye-Kyung Jung, Tae Oh Kim, Ju-Ran Byeon, Eui-Sun Jeong, Hyun-Ji Cho, Chung Hyun Tae, Chang Mo Moon, Seong-Eun Kim, Ki-Nam Shim, Sung-Ae Jung
Korean J Intern Med. 2022;37(6):1176-1185. Published online November 1, 2022
Background/Aims: Acute upper gastrointestinal (UGI) bleeding is a significant emergency situation with a mortality rate of 2% to 10%. Therefore, initial risk stratification is important for proper management. We aimed to evaluate the role of contrast-enhanced multidetector computed tomography (MDCT)..
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Gastroenterology / Original Article
The effect of rebamipide on non-steroidal anti-inflammatory drug-induced gastro-enteropathy: a multi-center, randomized pilot study
Dong Jun Oh, Hyuk Yoon, Hyun Soo Kim, Yoon Jin Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, You-Jung Ha, Eun Ha Kang, Yun Jong Lee, Nayoung Kim, Ki-Jeoung Kim, Fei Liu
Korean J Intern Med. 2022;37(6):1153-1166. Published online November 1, 2022
Background/Aims: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly-used medications, and ailments such as arthritis or heart disease, require long-term use of these drugs, which can induce gastroenteropathy with bleeding and ulcers. This study investigated the associations between efficacy..
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Image of interest
Gastric Coccidioidomycosis Presenting As Gastric Outlet Obstruction
Taher Jamali, Kati Choi, Syed Tasleem, Neda Zarrin-Khameh, Robert J. Sealock
Korean J Intern Med. 2022;37(1):241-242. Published online March 17, 2021
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Rheumatology / Original Article
Reliability and validity of the Korean version of the University of California–Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract instrument in patients with systemic sclerosis
Tae Hee Lee, Joon Seong Lee, Suyeon Park, Kyung-Ann Lee, Hyun-Sook Kim
Korean J Intern Med. 2021;36(6):1504-1514. Published online February 10, 2021
Background/Aims: Systemic sclerosis (SSc) is associated with a wide range of gastrointestinal (GI) changes. The University of California–Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract (UCLA SCTC GIT 2.0) instrument is a self-administered GI assessment instrument for patie..
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Gastroenterology / Original Article
Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals
Weitao Shen, Jiayu Sun, Zhiyang Li, Fen Yao, Kaihuang Lin, Xiaoyang Jiao
Korean J Intern Med. 2021;36(3):568-583. Published online November 10, 2020
Background/Aim: It is known that an imbalance in the intestinal f lora plays a crucial role in colorectal cancer (CRC), but the effect of food consumption patterns on the types of intestinal flora remains to be clarified. We aimed to analyze the associations between food intake and intestinal flora ..
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Review
The clinical impact of gut microbiota in chronic kidney disease
So Mi Kim, Il han Song
Korean J Intern Med. 2020;35(6):1305-1316. Published online September 29, 2020
Gut microorganisms play critical roles in both maintaining host homeostasis and the development of diverse diseases. Gut dysbiosis, an alteration of the composition and function of gut microorganisms, is commonly seen in patients with chronic kidney disease (CKD). CKD itself contributes to a disrupt..
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Gastroenterology / Original Article
Predictors for the need for endoscopic therapy in patients with presumed acute upper gastrointestinal bleeding
Su Sun Kim, Kyung Up Kim, Sung Jun Kim, Seung In Seo, Hyoung Su Kim, Myoung Kuk Jang, Hak Yang Kim, Woon Geon Shin
Korean J Intern Med. 2019;34(2):288-295. Published online December 15, 2017
Background/Aims: Selecting patients with an urgent need for endoscopic hemostasis is difficult based only on simple parameters of presumed acute upper gastrointestinal bleeding. This study assessed easily applicable factors to predict cases in need of urgent endoscopic hemostasis due to acute upper ..
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Cardiology / Original Article
Olmesartan is not associated with the risk of enteropathy: a Korean nationwide observational
cohort study
Seng Chan You, Hojun Park, Dukyong Yoon, Sooyoung Park, Boyoung Joung, Rae Woong Park
Korean J Intern Med. 2019;34(1):90-98. Published online November 27, 2017
Background/Aims: Olmesartan, a widely used angiotensin II receptor blocker (ARB), has been linked to sprue-like enteropathy. No cases of olmesartan-associated enteropathy have been reported in Northeast Asia. We investigated the associations between olmesartan and other ARBs and the incidence of ent..
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Hemato-oncology / Original Article
Prevalence of and factors associated with anxiety and depression in Korean patients with newly diagnosed advanced gastrointestinal cancer
Junghwa Chung, Gawon Ju, Jiyoul Yang, Jiwon Jeong, Yusook Jeong, Moon Ki Choi, Jihyun Kwon, Ki Hyeong Lee, Seung Taik Kim, Hye Sook Han
Korean J Intern Med. 2018;33(3):585-594. Published online February 14, 2017
Background/Aims: The purpose of the present study was to assess the prevalence of and factors associated with anxiety and depression in Korean patients with advanced gastrointestinal cancer.
Methods: One hundred and twenty consecutive patients with newly diagnosed, advanced gastrointestinal cancer ..
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Letter to the editor
Synchronous diffuse large B-cell lymphoma of the small intestine and adenocarcinoma of the colon
Ji Hyun Yang, Jain Lee, Shin Bum Kim, Seon Hoo Kim, Guk Jin Lee
Korean J Intern Med. 2018;33(2):438-441. Published online November 10, 2017
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