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Gastroenterology
Prevalence and predictors of multidrug-resistant bacteremia in liver cirrhosis
Aryoung Kim, Byeong Geun Song, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Myung Ji Goh
Korean J Intern Med. 2024;39(3):448-457. Published online April 30, 2024
Background/Aims: Improved knowledge of local epidemiology and predicting risk factors of multidrug-resistant (MDR) bacteria are required to optimize the management of infections. This study examined local epidemiology and antibiotic resistance patterns of liver cirrhosis (LC) patients and evaluated ..
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Hemato-oncology
Predictive role of absolute lymphocyte count in daratumumab-treated patients with relapsed/ refractory multiple myeloma
[corrected-article]
Hee Jeong Cho, Jae-Cheol Jo, Yoo Jin Lee, Myung Won Lee, Do Young Kim, Ho Jin Shin, Sung Nam Im, Ji Hyun Lee, Sung Hwa Bae, Young Rok Do, Won Sik Lee, Min Kyung Kim, Jina Jung, Jung Min Lee, Ju-Hyung Kim, Dong Won Baek, Sang-Kyun Sohn, Joon Ho Moon
Korean J Intern Med. 2023;38(2):238-247. Published online January 26, 2023
Background/Aims: Daratumumab has shown an encouraging antitumor effect in patients with multiple myeloma (MM), and was known to alter the immune properties by off-targeting immunosuppressive cells. Here, we aimed to evaluate the change in absolute lymphocyte count (ALC) as a surrogate marker for pre..
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Endocrinology-metabolism
Clinical features and signaling effects of RET D631Y variant multiple endocrine neoplasia type 2 (MEN2)
Ji-young Lee, Su Yeon Kim, Kwan Hoon Jo, Eun Yeong Mo, Eun Sook Kim, Hye Soo Kim, Je Ho Han, Sung-dae Moon
Korean J Intern Med. 2022;37(2):398-410. Published online December 15, 2021
Background/Aims: Germline mutations of the rearranged during transfection (RET) gene cause multiple endocrine neoplasia type 2 (MEN2). About 85% of RET mutations in MEN2 occur in codon Cys634. The RET D631Y mutation has recently been discovered, and we have studied its molecular expres..
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Urgent need for novel antibiotics in Republic of Korea to combat multidrug-resistant bacteria
Hyo-Jin Lee, Dong-Gun Lee
Korean J Intern Med. 2022;37(2):271-280. Published online February 28, 2022
Multidrug resistance in bacteria is an important issue and is increasing in frequency worldwide because of the limitations of therapeutic agents. From 2010 to 2019, 14 new systemic antibiotics received regulatory approval in the United States. However, few new antibiotics have been introduced in Rep..
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Hemato-oncology
The effect of the response to the coronavirus disease pandemic on treatment outcomes in patients with lymphoma and multiple myeloma
Ka-Won Kang, Byung-Hyun Lee, Min Ji Jeon, Eun Sang Yu, Dae Sik Kim, Se Ryeon Lee, Hwa Jung Sung, Chul Won Choi, Yong Park, Byung Soo Kim
Korean J Intern Med. 2021;36(6):1459-1470. Published online October 21, 2021
Background/Aims: Relatively little data are available on how the response to the coronavirus disease 2019 (COVID-19) pandemic has affected treatment outcomes in patients receiving chemotherapy for lymphoma or multiple myeloma. We aimed to determine the effect of COVID-19 countermeasures on treatment..
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Gastroenterology
Clinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell carcinomas
Zhiqin Chen, Sihan Li, Zheng He, Guang Li
Korean J Intern Med. 2021;36(6):1356-1364. Published online April 29, 2020
Background/Aims: We aimed to study the clinical characteristics, treatment modality, and the prognosis of synchronous multiple primary esophageal squamous cell carcinomas (SMPESCC).
Methods: A total of 117 SMPESCC cases were evaluated retrospectively from 2010 to 2015.
Results: The most common loc..
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Outcomes and clinical relevance of stool multiplex bacterial polymerase chain reaction in patients with acute diarrhea: single center experience
Won Gun Kwack, Yun Jeong Lim, Ki Hwan Kwon, Jae Woo Chung, Jin Young Oh
Korean J Intern Med. 2020;35(2):300-309. Published online January 29, 2019
Background/Aims: Diagnostic stool multiplex polymerase chain reaction (PCR) testing has attracted considerable interest, because of its high sensitivity, short turnaround time, and ability to detect multiple organisms simultaneously. This study investigates the clinical usefulness of a stool multipl..
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Hemato-oncology
Modified dose of melphalan-prednisone in multiple myeloma patients receiving bortezomib plus melphalan-prednisone treatment
Se Ryeon Lee, Hojoon Choi, Byung Hyun Lee, Ka-Won Kang, Eun Sang Yu, Dae Sik Kim, Yong Park, Chul Won Choi, Byung Soo Kim, Hwa Jung Sung
Korean J Intern Med. 2019;34(6):1333-1346. Published online October 26, 2018
Background/Aims: Bortezomib plus melphalan-prednisone (VMP) is a standard treatment for multiple myeloma, particularly for patients who are ineligible for high-dose therapy. However, early discontinuation or treatment modification is often needed owing to adverse events. The aim of this study was to..
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Cellular immunotherapy in multiple myeloma
Manh-Cuong Vo, Thangaraj Jaya Lakshmi, Sung-Hoon Jung, Duck Cho, Hye-Seong Park, Tan-Huy Chu, Hyun-Ju Lee, Hyeoung-Joon Kim, Sang-Ki Kim, Je-Jung Lee
Korean J Intern Med. 2019;34(5):954-965. Published online February 15, 2019
In multiple myeloma (MM), the impaired function of several types of immune cells favors the tumor’s escape from immune surveillance and, therefore, its growth and survival. Tremendous improvements have been made in the treatment of MM over the past decade but cellular immunotherapy using dendritic..
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Hemato-oncology
Clinicopathological characteristics of extremely young Korean multiple myeloma patients: therapeutic implications
Junghoon Shin, Youngil Koh, Jeonghwan Youk, Miso Kim, Byung Soo Kim, Chul Won Choi, Hwa Jung Sung, Yong Park, Sung-Soo Yoon, Inho Kim
Korean J Intern Med. 2017;32(4):722-730. Published online June 26, 2017
Background/Aims: Although multiple myeloma (MM) is typically a disease of the elderly, a certain subset of extremely young patients exists. It is necessary to establish clinicopathological characteristics for this population.
Methods: We reviewed the medical records of MM patients whose age was 40 ..
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Myeloma prognostic index at diagnosis might be a prognostic marker in patients newly diagnosed with multiple myeloma
Dae Sik Kim, Eun Sang Yu, Ka-Won Kang, Se Ryeon Lee, Yong Park, Hwa Jung Sung, Chul Won Choi, Byung Soo Kim
Korean J Intern Med. 2017;32(4):711-721. Published online November 4, 2016
Background/Aims: The aims of this study were to identify the value of inflammatory markers as pretreatment prognostic factors for patients with multiple myeloma (MM) and to estimate the value of a prognostic index including these markers at diagnosis.
Methods: A total of 273 newly diagnosed MM pati..
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Left ventricular thrombi after simultaneous thrombotic occlusions of multiple coronary arteries presenting acute myocardial infarction: need anticoagulant?
Hyun Joong Kim, Kyung Jin Choe, Woo-Dae Bang, Sang Jin Ha, Sang-Yong Yoo, Sangsig Cheong
Korean J Intern Med. 2017;32(3):552-554. Published online December 20, 2016
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Cardiology
Association between left ventricular function and paraprotein type in patients with multiple
myeloma
Jeong-Eun Yi, Sung-Eun Lee, Hae-Ok Jung, Chang-Ki Min, Ho-Joong Youn
Korean J Intern Med. 2017;32(3):459-468. Published online April 6, 2016
Background/Aims: Multiple myeloma (MM)–associated cardiac damage, particularly according to the type of monoclonal (M) protein has not been elucidated. We sought to investigate relationship between elevated serum M protein levels and echocardiographic indices of cardiac structure and function in pa..
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Infectious diseases
Risk factors and molecular epidemiology of community-onset, multidrug resistance extended-spectrum β-lactamase-producing Escherichia coli infections
So Yeon Park, Cheol-In Kang, Yu Mi Wi, Doo Ryeon Chung, Kyong Ran Peck, Nam-Yong Lee, Jae-Hoon Song
Korean J Intern Med. 2017;32(1):146-157. Published online April 20, 2016
Background/Aims: Although multidrug resistance (MDR) among extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) poses significant therapeutic challenges, little is known regarding the risk factors and epidemiology of community-onset MDR‑ESBL‑EC infections. We performed this study t..
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A confusing case of multiple sclerosis and central nervous system graft versus host disease
Byung-Nam Yoon, Choong Kun Ha, Kwang-Woo Lee, Sung-Hye Park, Jung-Joon Sung
Korean J Intern Med. 2016;31(5):995-998. Published online February 3, 2016
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Hemato-oncology
Recent advances in multiple myeloma: a Korean perspective
Junshik Hong, Jae Hoon Lee
Korean J Intern Med. 2016;31(5):820-834. Published online September 1, 2016
Epidemiologically, multiple myeloma (MM) is a malignant disorder of plasma cells with a higher incidence among Western populations than among Asians. However, there is growing evidence of a recent increase in the age-standardized incidence rate (ASR) of MM in Asian countries, particularly Korea. App..
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Optimal maintenance and consolidation therapy for multiple myeloma in actual clinical practice
Ho Sup Lee, Chang-Ki Min
Korean J Intern Med. 2016;31(5):809-819. Published online September 1, 2016
Multiple myeloma is an incurable malignant plasma cell-originating cancer. Although its treatment outcomes have improved with the use of glucocorticoids, alkylating drugs, and novel agents, including proteasome inhibitors (bortezomib and carfilzomib) and immunomodulatory drugs (thalidomide, lenalido..
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Gastroenterology
Synchronous second primary cancers in patients with squamous esophageal cancer: clinical features and survival outcome
Jin Seo Lee, Ji Yong Ahn, Kee Don Choi, Ho June Song, Yong Hee Kim, Gin Hyug Lee, Hwoon-Yong Jung, Jin-Sook Ryu, Sung-Bae Kim, Jong Hoon Kim, Seung-Il Park, Kyung-Ja Cho, Jin-Ho Kim
Korean J Intern Med. 2016;31(2):253-259. Published online February 11, 2016
Background/Aims: Unexpected diagnosis of synchronous second primary cancers (SPC) complicates physicians’ decision-making because clinical details of squamous esophageal cancer (EC) patients with SPC have been limited. We evaluated clinical features and treatment outcomes of patients with synchron..
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Pulmonology
Clinical manifestations of pneumonia according to the causative organism in patients in the intensive care unit
Jung-Kyu Lee, Jinwoo Lee, Young Sik Park, Chang Hoon Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Sang-Min Lee
Korean J Intern Med. 2015;30(6):829-836. Published online October 30, 2015
Background/Aims: Whether the causative organism influences the clinical course of pneumonia in the intensive care unit (ICU) is controversial. We assessed the clinical manifestations and prognosis of pneumonia according to the causative pathogens in patients in a medical ICU.
Methods: A retrospecti..
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Hemato-oncology
The prognostic impact of inflammatory factors in patients with multiple myeloma treated with thalidomide in Korea
Cheolsu Kim, Ho Sup Lee, Chang-Ki Min, Je Jung Lee, Kihyun Kim, Dok Hyun Yoon, Hyeon Seok Eom, Hyewon Lee, Won Sik Lee, Ho-Jin Shin, Ji Hyun Lee, Yong Park, Jae-Cheol Jo, Young Rok Do, Yeung-Chul Mun
Korean J Intern Med. 2015;30(5):675-683. Published online August 27, 2015
Background/Aims: The purpose of this study was to determine the correlations between inflammatory factors—including absolute lymphocyte count, lactate dehydrogenase, β2-microglobulin, albumin, C-reactive protein, and ferritin—and the prognosis for survival in patients with multiple myeloma (MM) ..
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