| Brief Communications |
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Review
Current laboratory diagnosis of coronavirus disease 2019
Jihyang Lim, Jehoon Lee
Korean J Intern Med. 2020;35(4):741-748. Published online July 1, 2020
Coronavirus disease 2019 (COVID-19) emerged in December 2019 in Wuhan, China; it has since caused a pandemic, with more than 10,000 confirmed cases (> 800,000 tests) in Korea as of May 2020. Real-time reverse transcription polymerase chain reaction (RT-PCR) is currently the most commonly used method..
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Guideline
Consensus statement on coronary intervention during the coronavirus disease 19 pandemic: from the Korean Society of Interventional Cardiology
Kwan Yong Lee, Bong-Ki Lee, Won-Jang Kim, Se Hun Kang, Taek Kyu Park, Song-Yi Kim, Jung-Won Suh, Chang-Hwan Yoon, Dong Heon Yang, Sung Kee Ryu, Sang-Hyun Kim, Sung Yun Lee, In-Ho Chae; The Korean Society of Interventional Cardiology COVID-19 Task Force Team
Korean J Intern Med. 2020;35(4):749-757. Published online July 1, 2020
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the novel virus severe acute respiratory syndrome coronavirus 2. The first case developed in December, 2019 in Wuhan, China; several months later, COVID-19 has become pandemic, and there is no end in sight. This disaster is..
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Original Article
A cluster of tertiary transmissions of 2019 novel coronavirus (SARS-CoV-2) in the community from infectors with common cold symptoms
Nam Joong Kim, Pyoeng Gyun Choe, Sang-Joon Park, Jaegyun Lim, Wang Jun Lee, Chang Kyung Kang, Wan Beom Park, Moon-Woo Seong, Myoung-don Oh
Korean J Intern Med. 2020;35(4):758-764. Published online June 11, 2020
Background/Aims: As the global impact of the novel coronavirus disease 2019 (COVID-19) has been severe, many countries have intensified containment activities to eliminate virus transmission, through early detection and isolation strategies. To establish a proper quarantine strategy, it is essential..
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Selecting coronavirus disease 2019 patients with negligible risk of progression: early experience from non-hospital isolation facility in Korea
Pyoeng Gyun Choe, Eun Kyo Kang, Sun Young Lee, Boram Oh, Dahae Im, Hyo Yeon Lee, Hyemin Jung, Chang Kyung Kang, Min Sun Kim, Wan Beom Park, Eun Hwa Choi, BeLong Cho, Myoung-don Oh, Nam Joong Kim
Korean J Intern Med. 2020;35(4):765-770. Published online May 29, 2020
Background/Aims: As the novel coronavirus (coronavirus disease 2019 [COVID-19]) outbreak progresses rapidly, staying home is recommended for suspected patients; however, the safety of this recommendation is uncertain. In Korea, non-hospital facilities called “living and treatment centers (LTCs)” ..
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Lung ultrasound for early diagnosis and severity assessment of pneumonia in patients with coronavirus disease 2019
[corrected-article]
Young-Jae Cho, Kyoung-Ho Song, Yunghee Lee, Joo Heung Yoon, Ji Young Park, Jongtak Jung, Sung Yoon Lim, Hyunju Lee, Ho Il Yoon, Kyoung Un Park, Hong Bin Kim, Eu Suk Kim
Korean J Intern Med. 2020;35(4):771-781. Published online July 1, 2020
Background/Aims: Current evidence supports lung ultrasound as a point-ofcare alternative diagnostic tool for various respiratory diseases. We sought to determine the utility of lung ultrasound for early detection of pneumonia and for assessment of respiratory failure among patients with coronavirus ..
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In vitro activity of lopinavir/ritonavir and hydroxychloroquine against severe acute respiratory syndrome coronavirus 2 at concentrations achievable by usual doses
Chang Kyung Kang, Moon-Woo Seong, Su-Jin Choi, Taek Soo Kim, Pyoeng Gyun Choe, Sang Hoon Song, Nam-Joong Kim, Wan Beom Park, Myoung-don Oh
Korean J Intern Med. 2020;35(4):782-787. Published online May 29, 2020
Background/Aims: As the coronavirus disease-2019 global pandemic progresses, screening of antiviral agents effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is urgently needed. In addition, considering the viral load kinetics of SARS-CoV-2, which peaks early in the illne..
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Rapid Communication
Four cases of coronavirus disease 2019 in the early stage of pandemic of South Korea: a single public hospital experience
Mi Young Ahn, Dong Hyun Oh, Suhyun Kim, Jae-Phil Choi, Ji Hyeon Lee, Young Kyung Lee, Ki Ho Hong
Korean J Intern Med. 2020;35(4):788-792. Published online July 1, 2020
In view of this pandemic, as of February 2020, South Korea has the second highest number of confirmed cases in the world. Herein, we report four confirmed coronavirus disease 2019 (COVID-19) cases in the early stage of the pandemic in South Korea and describe the identification, diagnosis, clinical ..
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Persistent severe acute respiratory syndrome coronavirus 2 detection after resolution of coronavirus disease 2019-associated symptoms/signs
Se Yoon Park, Soon Gyu Yun, Jeong Won Shin, Bo Young Lee, Hyo-Ju Son, Seungjae Lee, Eunjung Lee, Tae Hyong Kim
Korean J Intern Med. 2020;35(4):793-796. Published online June 19, 2020
There are limited data on the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory specimens after resolution of coronavirus disease 2019 (COVID-19)-associated symptoms/signs. We determined duration of SARS-CoV-2 virus shedding in symptomatic patients after rem..
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| Reviews |
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Alcohol use disorder and liver transplant: new perspectives and critical issues
Stefano Gitto, Silvia Aspite, Lucia Golfieri, Fabio Caputo, Francesco Vizzutti, Silvana Grandi, Valentino Patussi, Fabio Marra
Korean J Intern Med. 2020;35(4):797-810. Published online April 3, 2020
Alcoholic liver disease is a consolidated indication for liver transplantation, but many unsolved issues can be highlighted. Patients with alcohol use disorder develop peculiar comorbidities that can become contraindications for transplantation. Moreover, a number of social and psychological pattern..
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Recent progress in the management of chronic cough
Woo-Jung Song, Jin An, Lorcan McGarvey
Korean J Intern Med. 2020;35(4):811-822. Published online May 20, 2020
Chronic cough is a common clinical condition with significant impact on quality of life and for which effective therapy remains an unmet clinical need. Over the past decade, there has been a major shift in how we approach this problem, driven by better appreciation of the clinical manifestation of ch..
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Distinct functions of eosinophils in severe asthma with type 2 phenotype: clinical implications
Youngwoo Choi, Soyoon Sim, Hae-Sim Park
Korean J Intern Med. 2020;35(4):823-833. Published online May 29, 2020
Asthma is commonly recognized as a heterogeneous condition with a complex pathophysiology. With advances in the development of multiple medications for patients with asthma, most asthma symptoms are well managed. Nevertheless, 5% to 10% of adult asthmatic patients (called severe asthma) are in uncon..
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Systemic treatment for advanced urothelial cancer: an update on recent clinical trials and current treatment options
Inkeun Park, Jae Lyun Lee
Korean J Intern Med. 2020;35(4):834-853. Published online July 1, 2020
After cisplatin-based chemotherapy became the standard treatment for metastatic urothelial cancer (mUC), very little progress has been made in the treatment landscape of this condition until recently. With increased knowledge about the molecular biology of mUC and advances in the field of cancer imm..
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| Editorials |
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Use of small bowel capsule endoscopy in clinical practice: how has it performed?
Seong Ran Jeon
Korean J Intern Med. 2020;35(4):854-856. Published online July 1, 2020
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Blood molecular biomarkers of the inflammatory phenotypes of asthma
Sae-Hoon Kim
Korean J Intern Med. 2020;35(4):857-860. Published online July 1, 2020
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| Original Articles |
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Gastroenterology
The quick sepsis-related organ failure score has limited value for predicting adverse outcomes in sepsis patients with liver cirrhosis
Jeongsuk Son, Sunhui Choi, Jin Won Huh, Chae-Man Lim, Younsuck Koh, Kang Mo Kim, Ju Hyun Shim, Young-Suk Lim, Sang-Bum Hong
Korean J Intern Med. 2020;35(4):861-872. Published online October 28, 2019
Background/Aims: The quick Sepsis-related Organ Failure Assessment (qSOFA) is a newly developed risk stratification tool, which has been presented along with a new sepsis definition, to classify infected patients outside of the intensive care unit (ICU). We evaluated the clinical usefulness of qSOFA..
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A prospective randomized clinical study evaluating the efficacy and compliance of oral sulfate solution and 2-L ascorbic acid plus polyethylene glycol
Ki Hwan Kwon, Ji Ae Lee, Yun Jeong Lim, Beom Jae Lee, Moon Kyung Joo, Yu Ra Sim, Wonjae Choi, Taehyun Kim, Ji Yoon Kim, Ei Rie Cho, Yoon Tae Jeen, Jong-Jae Park
Korean J Intern Med. 2020;35(4):873-880. Published online January 30, 2019
Background/Aims: Oral sulfate solution (OSS) is an emerging cleansing agent for bowel preparation. However, data comparing OSS to other conventional bowel preparations in Asian patients are limited. Therefore, the objective of this study was to compare the efficacy and tolerability of OSS to ascorbi..
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Adenoma miss rate of polypectomy-referring hospitals is high in Korea
Ju Hyun Seo, Bo-In Lee, Kyungjin Lee, Jae Myung Park, Jin Soo Kim, Young-Seok Cho, Kang-Moon Lee, Sang Woo Kim, Hwang Choi, Myung-Gyu Choi
Korean J Intern Med. 2020;35(4):881-888. Published online October 17, 2019
Background/Aims: We evaluated the miss rates of polyps, adenomas, and advanced neoplasia of polypectomy-referring hospitals and risk factors for missed adenomas.
Methods: We compared medical records and electronic images of initial colonoscopies from polypectomy-referring hospitals with those of corr..
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Changes in performance of small bowel capsule endoscopy based on nationwide data from a Korean Capsule Endoscopy Registry
Su Hwan Kim, Yun Jeong Lim, Junseok Park, Ki-Nam Shim, Dong-Hoon Yang, Jaeyoung Chun, Jin Su Kim, Hyun Seok Lee, Hoon Jai Chun; Research Group for Capsule Endoscopy/Small Bowel Endoscopy
Korean J Intern Med. 2020;35(4):889-896. Published online December 30, 2019
Background/Aims: Capsule endoscopy (CE) is widely used for the diagnosis of small bowel diseases. The clinical performance and complications of small bowel CE, including completion rate, capsule retention rate, and indications, have been previously described in Korea. This study aimed at estimating ..
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Cardiology
Clinical significance of postoperative atrial arrhythmias in patients who underwent lung transplantation
Byung Gyu Kim, Jae-Sun Uhm, Pil-Sung Yang, Hee Tae Yu, Tae-Hoon Kim, Boyoung Joung, Hui-Nam Pak, Song Yee Kim, Moo Suk Park, Jin Gu Lee, Hyo Chae Paik, Moon-Hyoung Lee
Korean J Intern Med. 2020;35(4):897-905. Published online November 25, 2019
Background/Aims: Atrial arrhythmia (AA) occasionally occurs after lung transplantation (LT); however, risk factors for AA and their impact on clinical outcomes are inconsistent. We aimed to investigate the incidence, predisposing factors, and clinical outcomes of AA after LT.
Methods: We retrospect..
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The effect of alcohol dose on the development of hypertension in Asian and Western men: systematic review and meta-analysis
Mi-Hyang Jung, Ein-Soon Shin, Sang-Hyun Ihm, Jin-Gyu Jung, Hae-Young Lee, Cheol-Ho Kim
Korean J Intern Med. 2020;35(4):906-916. Published online December 6, 2019
Background/Aims: There are inconsistencies in the effects of low to moderate dose alcohol consumption on the development of hypertension in adult men. We hypothesized that a region-specific effect might participate in this heterogeneity.
Methods: We conducted a systematic review and meta-analysis t..
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Hydrochlorothiazide use and the risk of skin cancer in patients with hypertensive disorder: a nationwide retrospective cohort study from Korea
Eunjung Park, Young Lee, Mihn-Sook Jue
Korean J Intern Med. 2020;35(4):917-928. Published online December 18, 2019
Background/Aims: Recent studies have shown a cumulative dose-dependent association between the use of hydrochlorothiazide (HCTZ) and skin cancer, including melanoma and non-melanoma skin cancer (NMSC) in Western Europe. However, whether this pattern is present in East Asia countries is unknown. The ..
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Pulmonology
The effect of susceptibility variants, identified in never-smoking female lung cancer cases, on male smokers
Seung Soo Yoo, Hyo-Gyoung Kang, Jin Eun Choi, Mi Jeong Hong, Sook Kyung Do, Jang Hyuck Lee, Won Kee Lee, Shin Yup Lee, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, Eung Bae Lee, Jae Yong Park
Korean J Intern Med. 2020;35(4):929-935. Published online December 30, 2019
Background/Aims: Genome wide and candidate gene association studies have identified polymorphisms associated with the risk of lung cancer in never-smokers. This study was conducted to evaluate the association between 11 polymorphisms identified in female never smokers and the lung cancer risk in mal..
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Endocrinology-metabolism
Predictive costs in medical care for Koreans with metabolic syndrome from 2009 to 2013 based on the National Health Insurance claims dataset
Jeong Seon Yoo, Eun Yeong Choe, Yoo Mee Kim, Se Hwa Kim, Young Jun Won
Korean J Intern Med. 2020;35(4):936-945. Published online August 19, 2019
Background/Aims: Although metabolic syndrome has been associated with increasing medical costs worldwide, there have been no studies using a nationwide and longitudinal South Korean dataset. We investigated trends in subsidized medical costs among Korean adults with metabolic syndrome.
Methods: Thi..
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Hemato-oncology
Asian variant of intravascular large B-cell lymphoma: a comparison of clinical features based on involvement of the central nervous system
Sang Eun Yoon, Won Seog Kim, Seok Jin Kim
Korean J Intern Med. 2020;35(4):946-956. Published online November 25, 2019
Background/Aims: There are limited data about the influence of the central nervous system (CNS) involvement on the prognosis for patients with the Asian variant of intravascular large B-cell lymphoma (IVLBCL).
Methods: We analyzed 46 patients who were diagnosed with IVLBCL between 2001 and 2018. Al..
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Is immunological recovery clinically relevant at 100 days after allogeneic transplantation?
Jin Park, Sung Hee Lim, Se Hyung Kim, Jina Yun, Chan Kyu Kim, Sang Cheol Lee, Jong Ho Won, Dae Sik Hong, Seong Kyu Park
Korean J Intern Med. 2020;35(4):957-969. Published online April 21, 2020
Background/Aims: Immune reconstitution following allogeneic hematopoietic stem cell transplantation (HSCT) is affected by multiple variables during the transplantation.
Methods: We assessed the clinical factors contributing to immune function reconstitution at 100 days post-allogeneic HSCT in 114 p..
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Immature platelet fraction based diagnostic predictive scoring model for immune thrombocytopenia
Min Ji Jeon, Eun Sang Yu, Ka-Won Kang, Byung-Hyun Lee, Yong Park, Se Ryeon Lee, Hwa Jung Sung, Soo Yong Yoon, Chul Won Choi, Byung Soo Kim, Dae Sik Kim
Korean J Intern Med. 2020;35(4):970-978. Published online April 10, 2020
Background/Aims: The diagnosis of immune thrombocytopenia (ITP) is based on clinical manifestations and there is no gold standard. Thus, even hematologic malignancy is sometimes misdiagnosed as ITP and adequate treatment is delayed. Therefore, novel diagnostic parameters are needed to distinguish IT..
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Infectious diseases
Cancer patients with neutropenic septic shock: etiology and antimicrobial resistance
Sung Min Jung, Youn Jung Kim, Seung Mok Ryoo, Chang Hwan Sohn, Dong Woo Seo, Kyoung Soo Lim, Won Young Kim
Korean J Intern Med. 2020;35(4):979-987. Published online October 28, 2019
Background/Aims: Among patients with febrile neutropenia that developed after chemotherapy, high-risk patients, such as those having clinical instability or Multinational Association of Supportive Care in Cancer score of < 21, require hospitalization for intravenous empiric antibiotic therapy. Mono..
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Allergy
Serum potential biomarkers according to sputum inflammatory cell profiles in adult asthmatics
Gyu-Young Hur, Young-Min Ye, Eunmi Yang, Hae-Sim Park
Korean J Intern Med. 2020;35(4):988-997. Published online November 15, 2019
Background/Aims: Asthma is not a single disease but, rather, a heterogeneous inf lammatory disorder with various pathogenic mechanisms. We analyzed the associations between the cellular profile of sputum and the serum levels of inflammatory mediators/cytokines in a cohort of adult asthmatics.
Metho..
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Rheumatology
Renal safety and urate-lowering efficacy of febuxostat in gout patients with stage 4–5 chronic kidney disease not yet on dialysis
Sang-Hyon Kim, So-Yeon Lee, Ji-Min Kim, Chang-Nam Son
Korean J Intern Med. 2020;35(4):998-1003. Published online April 8, 2019
Background/Aims: The safety and efficacy of febuxostat in patients with stage 4–5 chronic kidney disease (CKD) are still unclear owing to a lack of studies in these patients. Therefore, we aimed to evaluate the effect of febuxostat on renal function, general safety, and efficacy in gout patients wi..
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Geriatrics
What are the illnesses associated with frailty in community-dwelling older adults: the Korean Frailty and Aging Cohort Study
Sunyoung Kim, Hee-Won Jung, Chang Won Won
Korean J Intern Med. 2020;35(4):1004-1013. Published online April 9, 2020
Background/Aims: Frailty is mainly due to an age-related decrease in the physiological reserves needed to maintain biological homeostasis, but it can also occur as a result of chronic diseases. The purpose of this study was to identify illnesses associated with frailty in Korean community-dwelling o..
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| Correspondences |
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| Images of interest |
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Plasmablastic lymphoma presenting with ileocecal intussusception in an immunocompetent patient
Ok Ran Shin, Jiyeon Hyeon, Sang-Bum Kang, Jong Ok Kim
Korean J Intern Med. 2020;35(4):1018-1019. Published online February 28, 2019
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Acute ST-elevation myocardial infarction due to prosthetic valve endocarditis after transcatheter aortic valve implantation
Jun Hwan Cho, Jung-Kyu Han, Han-Mo Yang, Bon-Kwon Koo, Hyo-Soo Kim
Korean J Intern Med. 2020;35(4):1020-1021. Published online March 8, 2019
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Right heart failure due to arteriovenous fistula after lumbar spine surgery
Seong Soon Kwon, Byoung-Won Park, Min-Ho Lee, Dong Erk Goo, Bo Da Nam
Korean J Intern Med. 2020;35(4):1022-1023. Published online April 9, 2019
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| Corrigendum |
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Heart failure with preserved ejection fraction: insights from recent clinical researches
Mi-Na Kim, Seong-Mi Park
Korean J Intern Med. 2020;35(4):1026-1026. Published online July 1, 2020
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