Original Articles |
Neutrophil Elastase Causes MUC5AC Mucin Synthesis Via EGF Receptor, ERK and NF-kB Pathways in A549 Cells
Jeong-Sup Song, Kyung-Sook Cho, Hyung-Kyu Yoon, Hwa-Sik Moon, Sung-Hak Park
Korean J Intern Med. 2005;20(4):275-283. Published online December 31, 2005
BackgroundNeutrophil elastase (NE) was found to increase the respiratory mucin gene, MUC5AC, although the molecular mechanisms of this process remain unknown. We attempted to determine the signal transduction pathway through which NE induces MUC5AC gene expression in bronchial..
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Airway Hyperresponsiveness to Hypertonic Saline as a Predictive Index of Exercise-Induced Bronchoconstriction
Inseon S. Choi, Se-Woong Chung, Youngil I. Koh, Myoung-Ki Sim, Seo-Na Hong, Jang-Sik Moon
Korean J Intern Med. 2005;20(4):284-289. Published online December 31, 2005
BackgroundChanges in airway mucosal osmolarity are an underlying mechanism of bronchoconstrictive responses to exercise and hypertonic saline (HS). The purpose of this study was to examine whether an osmotic challenge test using HS can predict exercise-induced bronchospasm (EI..
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Clinical and Bronchoscopic Findings in Ugandans with Pulmonary Kaposi's Sarcoma
Deok Jong Yoo, Kwan Ho Lee, Paula Munderi, Kyeong Cheol Shin, Jae Kyo Lee
Korean J Intern Med. 2005;20(4):290-294. Published online December 31, 2005
BackgroundPulmonary Kaposi's sarcoma (PKS) directly affects the life expectancy of those infected and yet the
clinical and radiographic features of Kaposi's sarcoma (KS) with pulmonary involvement are nonspecific, which makes diagnosis difficult. In Uganda, pulmonary tuberculo..
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Hypoxic Regulation of VEGF, HIF-1(alpha) in Coronary Collaterals Development
Ki Chul Sung, Kyung Soo Kim, Sang Lee
Korean J Intern Med. 2005;20(4):295-302. Published online December 31, 2005
BackgroundThe interindividual variability for the development of collaterals in coronary artery disease is dependent on the hypoxic induction level of VEGF. To determine whether the hypoxic induction of VEGF is controlled by the transcription of HIF-1 (alpha), the VEGF and HIF..
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Clinical Study of Adrenal Incidentaloma in Korea
Hee Young Kim, Sin Gon Kim, Kye Won Lee, Ji A Seo, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi
Korean J Intern Med. 2005;20(4):303-309. Published online December 31, 2005
BackgroundThis study was designed to evaluate the clinical, endocrinological and histological characteristics of adrenal incidentalomas. MethodsEighty patients (41, males; 38, females; age range 17-80 years) who were diagnosed with adrenal incid..
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Prevalence and Clinical Characteristics of the Metabolic Syndrome in Middle-Aged Korean Adults
Hyuk Sang Kwon, Yong Moon Park, Hye Jung Lee, Jin Hee Lee, Yoon Hee Choi, Seung Hyun Ko, Jung Min Lee, Sung Rae Kim, So Young Kang, Won Chul Lee, Myung Sook Ahn, Jae Hong Noh, Jin Mo Kang, Dong Suk Kim, Kun Ho Yoon, Bong Yun Cha, Kwang Woo Lee, Sung Koo Kang, Ho Young Son
Korean J Intern Med. 2005;20(4):310-316. Published online December 31, 2005
BackgroundThe aim of this study was to analyze the prevalence and clinical characteristic of the metabolic syndrome of adults, over 40 years old, living in Korea. MethodsThis study was carried out for 2 years, 2003-2004, on total 5,330 individua..
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Relationships Between the Expressions of CDX1 and CDX2 mRNA and Clinicopathologic Features in Colorectal Cancers
Gwang Ha Kim, Dong Hyun Lee, Hyung Wook Kim, Jong Yun Cheong, Soo Boon Seo, Jeong Heo, Dae Hwan Kang, Geun Am Song, Mong Cho, Ung Suk Yang, Do Youn Park, Mi Ae Yoo
Korean J Intern Med. 2005;20(4):317-324. Published online December 31, 2005
BackgroundCDX1 and CDX2 are members of the caudal-type homeobox gene family and control the proliferation and differentiation of intestinal mucosal cells. Their expressions are commonly reduced in colorectal cancer, but reports about the relat..
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Case Reports |
A Case of Septic Shock and Disseminated Intravascular Coagulation Complicated by Acute Myocardial Infarction Following Amniocentesis
Kye Hun Kim, Myung Ho Jeong, Ik Joo Chung, Jeong Gwan Cho, Tae Bok Song, Jong Chun Park, Jung Chaee Kang
Korean J Intern Med. 2005;20(4):325-329. Published online December 31, 2005
Maternal septic shock and disseminated intravascular coagulation (DIC) following amniocentesis is a relatively rare condition, and its incidence is only 0.03~0.19%. Acute myocardial infarction (AMI) associated with DIC is also rare. We report here on a 40-year-old female patient who had septic sh..
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Non-Hodgkin's Lymphoma Manifest as Gingival Hyperplasia in a Renal Transplant Recipient
Jung Hyun Kwon, Joon Chang Song, Sang Hun Lee, So Young Lee, Chul Woo Yang, Yong Soo Kim, Byung Kee Bang
Korean J Intern Med. 2005;20(4):330-334. Published online December 31, 2005
Gingival hyperplasia is a frequent complication in transplant patients who receive cyclosporine or calcium channel blockers. We studied an unusual case involving a renal transplant recipient with post-transplant non-Hodgkin's lymphoma that manifested as gingival hyperplasia. We initially consider..
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Management of a Pregnant Patient with Graves' Disease Complicated by Propylthiouracil induced Agranulocytosis
Yoon-Young Cho, Ho Sang Shon, Hyun Dae Yoon
Korean J Intern Med. 2005;20(4):335-338. Published online December 31, 2005
Relapse and exacerbation of Graves' disease during pregnancy is rare, and thionamide induced agranulocytosis is an uncommon side effect. We report a case of a pregnant woman in her 24th week of gestation that experienced a relapse of Graves' disease that was complicated by propylthiour..
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A Case of Polychondritis in a Patient with Behçet's Disease
Mi-Kyung Kim, Kyung-Su Park, Jun-Ki Min, Chul-Soo Cho, Ho-Youn Kim
Korean J Intern Med. 2005;20(4):339-342. Published online December 31, 2005
Polychondritis is an inflammatory disorder that affects various catilagenous structures, and the clinical features include auricular, nasal and respiratory tract chondritis. It also involves the eyes, audiovestibular apparatus, joints and vascular structures. Polychondritis can be associated wit..
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Infected Pneumatocele Following Anaerobic Pneumonia in Adult
Sang Hyun Kim, Yeon Tae Chung, Kyung Duk Lee, Kyoung Youn Seon, Jong Hyun Lee, Sung Ho Lee, Se Ho Choi
Korean J Intern Med. 2005;20(4):343-345. Published online December 31, 2005
We report a case of an infected pneumatocele in the course of anaerobic pneumonia in an adult. To the best of our knowledge, anaerobic pneumonia complicated by a pneumatocele in an adult has not previously been described. The pneumatocele occurred on the fifth day of hospitalization, and rapidly ..
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Neutrophilic Myositis without Cutaneous Involvement as the First Manifestation of Acute Myeloid Leukemia
Mi-Kyeong Kim, Jeong Woo Park, Se Hoon Park, Soo Mee Bang, Jae Gul Chung, Jeong Yeal Ahn, Han Joo Baek
Korean J Intern Med. 2005;20(4):346-348. Published online December 31, 2005
Muscle involvement in acute febrile neutrophilic dermatosis is uncommon. Herein, we report a case of acute febrile neutrophilic myositis, without cutaneous involvement, as the first manifestation of acute myeloid leukemia. The patient was a 35-year-old male, referred due to painful swelling of th..
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