| Reviews |
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Gastroenterology
Reversal of liver cirrhosis: current evidence and expectations
Young Kul Jung, Hyung Joon Yim
Korean J Intern Med. 2017;32(2):213-228. Published online February 8, 2017
In the past, liver cirrhosis was considered an irreversible phenomenon. However, many experimental data have provided evidence of the reversibility of liver fibrosis. Moreover, multiple clinical studies have also shown regression of fibrosis and reversal of cirrhosis on repeated biopsy samples. As v..
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Pulmonology
Diagnosis and treatment of cystic lung disease
Sanghoon Park, Eun Joo Lee
Korean J Intern Med. 2017;32(2):229-238. Published online February 28, 2017
Cystic lung disease (CLD) is a group of lung disorders characterized by the presence of multiple cysts, defined as air-filled lucencies or low-attenuating areas, bordered by a thin wall (usually < 2 mm). The recognition of CLDs has increased with the widespread use of computed tomography. This artic..
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Endocrinology-metabolism
Linking resistin, inflammation, and cardiometabolic diseases
Hyeong Kyu Park, Mi Kyung Kwak, Hye Jeong Kim, Rexford S. Ahima
Korean J Intern Med. 2017;32(2):239-247. Published online February 16, 2017
Adipose tissue secretes a variety of bioactive substances that are associated with chronic inflammation, insulin resistance, and an increased risk of type 2 diabetes mellitus. While resistin was first known as an adipocyte-secreted hormone (adipokine) linked to obesity and insulin resistance in rode..
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Hemato-oncology
Targeting the CXCL12/CXCR4 axis in acute myeloid leukemia: from bench to bedside
Byung-Sik Cho, Hee-Je Kim, Marina Konopleva
Korean J Intern Med. 2017;32(2):248-257. Published online February 21, 2017
The interactions between the cancerous cells of acute myeloid leukemia (AML) and the bone marrow (BM) microenvironment have been postulated to be important for resistance to chemotherapy and disease relapse in AML. The chemokine receptor CXC chemokine receptor 4 (CXCR4) and its ligand, CXC motif li..
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| Editorial |
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Serum vascular endothelial growth factor as a marker of asthma exacerbation
Joo-Hee Kim
Korean J Intern Med. 2017;32(2):258-260. Published online February 28, 2017
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| Original Articles |
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Gastroenterology
Ultrasound-guided percutaneous portal transplantation of peripheral blood monocytes in patients with liver cirrhosis
Su Jong Yu, Jung-Hwan Yoon, Won Kim, Jeong Min Lee, Yun Bin Lee, Yuri Cho, Dong Hyeon Lee, Minjong Lee, Jeong-Ju Yoo, Eun Ju Cho, Jeong-Hoon Lee, Yoon Jun Kim, Chung Yong Kim
Korean J Intern Med. 2017;32(2):261-268. Published online April 5, 2016
Background/Aims: Liver transplantation offers the only definite cure for cirrhosis but lacking donors is problem. Stem cell therapy is attractive in this setting. In this study, we aimed to explore the safety and efficacy of ultrasound-guided percutaneous portal transplantation of peripheral blood m..
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Decreased S100B expression in chronic liver diseases
Su Jung Baik, Tae Hun Kim, Kwon Yoo, Il Hwan Moon, Ju Young Choi, Kyu Won Chung, Dong Eun Song
Korean J Intern Med. 2017;32(2):269-276. Published online June 3, 2016
Background/Aims: Hepatic innervation in liver diseases is not fully understood. We here evaluated S100B expression as a marker of hepatic nerves in patients with various chronic liver diseases, topographically and semi-quantitatively.
Methods: Liver specimens were obtained from 70 subjects (three c..
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Cardiology
Features of electrocardiogram in patients with stenosis of the proximal right coronary artery
Moo Seong Koh, Jae Hoon Lee, Jin Woo Jeong, Jun Young Chung
Korean J Intern Med. 2017;32(2):277-285. Published online February 14, 2017
Background/Aims: Prediction of lesions of the proximal right coronary artery (pRCA) through electrocardiogram (ECG) is very important because pRCA occlusion has many complications and a high mortality rate, which has frequently been related with right ventricular infarction. The purpose of this stud..
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Atrial conduction times and left atrial mechanical functions and their relation with diastolic function in prediabetic patients
Naile Eris Gudul, Turgut Karabag, Muhammet Rasit Sayin, Taner Bayraktaroglu, Mustafa Aydin
Korean J Intern Med. 2017;32(2):286-294. Published online December 6, 2016
Background/Aims: The aim of this study was to investigate atrial conduction times and left atrial mechanical functions, the noninvasive predictors of atrial fibrillation, in prediabetic patients with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT).
Methods: Study included 59 pat..
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Pulmonology
Clinical significance of serum vascular endothelial growth factor in young male asthma patients
Hea Yon Lee, Kyung Hoon Min, Sang Min Lee, Ji Eun Lee, Chin Kook Rhee
Korean J Intern Med. 2017;32(2):295-301. Published online March 21, 2016
Background/Aims: Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. However, little is known about the potential use of serum levels of VEGF as a biomarker for asthma. We investigated the differences in VEGF levels among normal controls, stable asthma patients, and t..
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Qualitative and quantitative results of interferon-γ release assays for monitoring the response to anti-tuberculosis treatment
I-Nae Park, Tae Sun Shim
Korean J Intern Med. 2017;32(2):302-308. Published online December 13, 2016
Background/Aims: The usefulness of interferon-γ release assays (IGRAs) in monitoring to responses to anti-tuberculosis (TB) treatment is controversial. We compared the results of two IGRAs before and after anti-TB treatment in same patients with active TB.
Methods: From a retrospective review, we..
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Endocrinology-metabolism
Association between thyroid autoimmunity and Helicobacter pylori infection
Yun Mi Choi, Tae Yong Kim, Eui Young Kim, Eun Kyung Jang, Min Ji Jeon, Won Gu Kim, Young Kee Shong, Won Bae Kim
Korean J Intern Med. 2017;32(2):309-313. Published online January 16, 2017
Background/Aims: There have been controversial reports linking Helicobacter pylori infection to autoimmune thyroid disease (AITD). However, data regarding the relationship are limited for Asian populations, which have an extremely high prevalence of H. pylori infection. We performed th..
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Nephrology
Effects of metformin on hyperglycemia in an experimental model of tacrolimus- and sirolimus-induced diabetic rats
Jian Jin, Sun Woo Lim, Long Jin, Ji Hyun Yu, Hyun Seon Kim, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2017;32(2):314-322. Published online September 30, 2016
Background/Aims: Metformin (MET) is a first-line drug for type 2 diabetes mellitus (DM); its effect on new-onset diabetes after transplantation caused by immunosuppressant therapy is unclear. We compared the effects of MET on DM caused by tacrolimus (TAC) or sirolimus (SRL).
Methods: DM was induced..
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Sleep duration and chronic kidney disease: The Korean Genome and Epidemiology Study (KoGES)-Kangwha study
Hansol Choi, Hyeon Chang Kim, Joo Young Lee, Ju-Mi Lee, Dong Phil Choi, Il Suh
Korean J Intern Med. 2017;32(2):323-334. Published online February 15, 2017
Background/Aims: Sleep duration affects health in various ways. The objective of this study was to investigate the associations of sleep duration with chronic kidney disease (CKD) in a Korean adult population.
Methods: This cross-sectional analysis was conducted for total of 1,360 participants who ..
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Hemato-oncology
Clinicopathologic significance of tumor microenvironment CD11c, and FOXP3 expression in diffuse large B-cell lymphoma patients receiving rituximab, cyclophosphamide, anthracycline, vincristine, and prednisone (R-CHOP) combination chemotherapy
Seul Lee, Dong Hyun Kim, Sung Yong Oh, So Yeon Kim, Myeong Seok Koh, Ji Hyun Lee, Suee Lee, Sung-Hyun Kim, Jong-Young Kwak, Min Gyoung Pak, Mi Ha Ju, Hyo-Jin Kim, Jin Sook Jeong
Korean J Intern Med. 2017;32(2):335-344. Published online March 11, 2016
Background/Aims: CD11c is a dendritic cell marker in humans, which potentially induces a cytotoxic effect on lymphoma cells. Forkhead boxP3 (FOXP3) is a regulator of T lymphocyte in the microenvironment of the lymphoma. The principal objective of this study was to determine whether the tumors’ mic..
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Infectious diseases
Association of biofilm production with colonization among clinical isolates of Acinetobacter baumannii
Seong Yeol Ryu, Won-Ki Baek, Hyun Ah Kim
Korean J Intern Med. 2017;32(2):345-351. Published online September 22, 2016
Background/Aims: The pathogen Acinetobacter baumannii is increasingly causing healthcare-associated infections worldwide, particularly in intensive care units. Biofilm formation, a factor contributing to the virulence of A. baumannii, is associated with long-term persistence in hospita..
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Rheumatology
Association of sleep quality in Behcet disease with disease activity, depression, and quality of life in Korean population
Jimin Lee, Sung-Soo Kim, Hye-Jin Jeong, Chang-Nam Son, Ji-Min Kim, Yong-Won Cho, Sang-Hyon Kim
Korean J Intern Med. 2017;32(2):352-359. Published online February 16, 2017
Background/Aims: Sleep disturbance is prime concern in patients with Behcet disease. The purpose of this study was to find out the effects of sleep quality, in Korean patients suffering from Behcet disease. We further investigated the relationship between depression, quality of life and the clinical..
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| Letters to the editor |
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The internal jugular vein as an alternative venous access for a revision of a fractured implantable cardioverter-defibrillator lead
Jong Yop Pae, Yoon-Nyun Kim, Min Young Do, Hyoung-Seob Park, Seongwook Han, Seung-Ho Hur, Sae-Young Choi
Korean J Intern Med. 2017;32(2):360-362. Published online February 4, 2016
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Ascites reinfusion dialysis of refractory ascites as a bridge to kidney and liver transplantation in a patient on hemodialysis
Kyung Yoon Chang, Hyung Wook Kim, Dong Chan Jin, Young Soo Kim
Korean J Intern Med. 2017;32(2):363-364. Published online January 19, 2016
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Everolimus-induced activation of latent Mycobacterium tuberculosis infection in a patient with metastatic renal cell carcinoma
So-Yeon Jeon, Ho-Young Yhim, Na-Ri Lee, Eun-Kee Song, Jae-Yong Kwak, Chang-Yeol Yim
Korean J Intern Med. 2017;32(2):365-368. Published online February 2, 2016
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Outpatient treatment in women with acute pyelonephritis after visiting emergency department
Hee Kyoung Choi, Jin-Won Chung, Won Sup Oh, Jae-Bum Jun, Yee Gyung Kwak, Seong Yeon Park, Baek-Nam Kim
Korean J Intern Med. 2017;32(2):369-373. Published online August 18, 2016
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Ankylosing spondylitis associated with primary aldosteronism in a middle-aged woman
Young Sun Suh, Hyun-Ok Kim, Yun-Hong Cheon, Wonyong Jo, Jeongmin Hong, Sang-Il Lee
Korean J Intern Med. 2017;32(2):374-377. Published online February 3, 2016
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| Images of interest |
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A huge necrotic liver mass in a 45-year-old woman: delayed hepatic metastasis of a gastrointestinal stromal tumor
In Yong Whang, Kyung-Jin Seo, Hee Yeon Kim, Chang Wook Kim, Hye Sung Won
Korean J Intern Med. 2017;32(2):378-379. Published online September 5, 2016
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Dystrophic calcification after palliative chemotherapy in a patient with renal cell carcinoma
Do Hyoung Lim, Soon Il Lee, Keon Woo Park
Korean J Intern Med. 2017;32(2):380-381. Published online January 3, 2017
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