KJIM :: Korean Journal of Internal Medicine

Targeting integrins in drug‐resistant acute myeloid leukaemia

Heather A. Ogana, Samantha Hurwitz, Nathan Wei, Eliana Lee, Kayla Morris, Karina Parikh, Yong‐Mi Kim

British Journal of Pharmacology.2024; 181(2): 295. CrossRef

Advantages of nanomedicine over the conventional treatment in Acute myeloid leukemia

Gopalarethinam Janani, Agnishwar Girigoswami, Koyeli Girigoswami

Journal of Biomaterials Science, Polymer Edition.2024; 35(3): 415. CrossRef

Multifunctional aptamer grafted targeted nano‐drugs execute molecular cross‐talks with cancer cells

Sounik Manna, Rumi Mahata, Surya K. Dey, Angsuman Das Chaudhuri, Sujata M. Choudhury

Exploring the intricate cross-talk between clonal expansion and the bone marrow niche

Steven Ngo, Despoina Papazoglou, Hector Huerga Encabo, Dominique Bonnet

Prognostic impact of ARHGAP43(SH3BP1) in acute myeloid leukemia

Journal of the Formosan Medical Association.2024; 123(9): 992. CrossRef

Investigational CXCR4 inhibitors in early phase development for the treatment of hematological malignancies

Enrica Antonia Martino, Antonella Bruzzese, Caterina Labanca, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Gaia Stanzione, Annamaria Zimbo, Stefano Pozzi, Antonino Neri, Fortunato Morabito, Ernesto Vigna, Massimo Gentile

Expert Opinion on Investigational Drugs.2024; 33(9): 915. CrossRef

Mechanisms of myeloid leukemogenesis: Current perspectives and therapeutic objectives

Microenvironmental CXCL12 deletion enhances Flt3-ITD acute myeloid leukemia stem cell response to therapy by reducing p38 MAPK signaling

Nicholas R. Anderson, Vipul Sheth, Hui Li, Mason W. Harris, Shaowei Qiu, David K. Crossman, Harish Kumar, Puneet Agarwal, Takashi Nagasawa, Andrew J. Paterson, Robert S. Welner, Ravi Bhatia

Resveratrol and Its Role in the Management of B-Cell Malignancies—A Recent Update

Dhruv Sanjay Gupta, Vaishnavi Gadi, Ginpreet Kaur, Meena Chintamaneni, Hardeep Singh Tuli, Seema Ramniwas, Gautam Sethi

T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo

Yáiza Núñez, Annabel Garcia-León, Aïda Falgàs, Naroa Serna, Laura Sánchez-García, Ana Garrido, Jorge Sierra, Alberto Gallardo, Ugutz Unzueta, Esther Vázquez, Antonio Villaverde, Ramon Mangues, Isolda Casanova

Role of chemokines in T-cell acute lymphoblastic Leukemia: From pathogenesis to therapeutic options

YiFan Zhao, RuiTing Guo, XinPing Cao, Yi Zhang, Rui Sun, WenYi Lu, MingFeng Zhao

International Immunopharmacology.2023; 121: 110396. CrossRef

A comprehensive analysis of cell‐autonomous and non‐cell‐autonomous regulation of myeloid leukemic cells: The prospect of developing novel niche‐targeting therapies

Shalmali Pendse, Sayali Chavan, Vaijayanti Kale, Anuradha Vaidya

Cell Biology International.2023; 47(10): 1667. CrossRef

The role of bone marrow microenvironment (BMM) cells in acute myeloid leukemia (AML) progression: immune checkpoints, metabolic checkpoints, and signaling pathways

Maryam Bakhtiyari, Mahsa Liaghat, Fatemeh Aziziyan, Hooriyeh Shapourian, Sheida Yahyazadeh, Maedeh Alipour, Shaghayegh Shahveh, Fahimeh Maleki-Sheikhabadi, Hossein Halimi, Razieh Forghaniesfidvajani, Hamidreza Zalpoor, Mohsen Nabi-Afjadi, Majid Pornour

Cell Communication and Signaling.2023;[Epub] CrossRef

Microenvironment and drug resistance in acute myeloid leukemia: Do we know enough?

International Journal of Cancer.2022; 150(9): 1401. CrossRef

The contributory roles of the CXCL12/CXCR4/CXCR7 axis in normal and malignant hematopoiesis: A possible therapeutic target in hematologic malignancies

European Journal of Pharmacology.2022; 920: 174831. CrossRef

Circulating miR-126-3p and miR-423-5p Expression in de novo Adult Acute Myeloid Leukemia: Correlations with Response to Induction Therapy and the 2-Year Overall Survival

Faez Almohsen, Haithem A Al-Rubaie, Manal A Habib, Sherif A Nasr, Rajendra Perni, Lubab Al-Quraishi

Journal of Blood Medicine.2022; Volume 13: 83. CrossRef

Bone Marrow Aging and the Leukaemia-Induced Senescence of Mesenchymal Stem/Stromal Cells: Exploring Similarities

Journal of Personalized Medicine.2022; 12(5): 716. CrossRef

Leukemic stem cells as a target for eliminating acute myeloid leukemia: Gaps in translational research

Sophia K. Khaldoyanidi, Antreas Hindoyan, Anthony Stein, Marion Subklewe

Critical Reviews in Oncology/Hematology.2022; 175: 103710. CrossRef

One-Chip Isolation of Drug-Resistant Acute Myeloid Leukemia Cells with CXCR4-Targeted Magnetic Fluorescent Nanoprobes

Fan Wang, Yuqi Jiang, Luhai Wang, Yi Chen, Yu Zhang, Ming Ma

Role of chemokine systems in cancer and inflammatory diseases

A Systems Biology- and Machine Learning-Based Study to Unravel Potential Therapeutic Mechanisms of Midostaurin as a Multitarget Therapy on FLT3-Mutated AML

Marina Díaz-Beyá, María García-Fortes, Raquel Valls, Laura Artigas, Mª Teresa Gómez-Casares, Pau Montesinos, Fermín Sánchez-Guijo, Mireia Coma, Meritxell Vendranes, Joaquín Martínez-López

Michela Luciano, Peter W. Krenn, Jutta Horejs-Hoeck

At the Bedside: Profiling and treating patients with CXCR4-expressing cancers

Miguel Martin, Ingrid A Mayer, Annemiek M E Walenkamp, Constantin Lapa, Michael Andreeff, Alexandra Bobirca

Journal of Leukocyte Biology.2021; 109(5): 953. CrossRef

Targeted dendrimers for antagonizing the migration and viability of NALM-6 lymphoblastic leukemia cells

The CXCL12 Crossroads in Cancer Stem Cells and Their Niche

Juan Carlos López-Gil, Laura Martin-Hijano, Patrick C. Hermann, Bruno Sainz

Application of Single-Cell Approaches to Study Myeloproliferative Neoplasm Biology

Hematology/Oncology Clinics of North America.2021; 35(2): 279. CrossRef

The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy

Laura Mosteo, Joanna Storer, Kiran Batta, Emma J. Searle, Delfim Duarte, Daniel H. Wiseman

Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef

Antineoplastic effect of a diphtheria toxin-based nanoparticle targeting acute myeloid leukemia cells overexpressing CXCR4

Victor Pallarès, Yáiza Núñez, Laura Sánchez-García, Aïda Falgàs, Naroa Serna, Ugutz Unzueta, Alberto Gallardo, Lorena Alba-Castellón, Patricia Álamo, Jorge Sierra, Antonio Villaverde, Esther Vázquez, Isolda Casanova, Ramon Mangues

Journal of Controlled Release.2021; 335: 117. CrossRef

Importance of Altered Gene Expression of Metalloproteinases 2, 9, and 16 in Acute Myeloid Leukemia: Preliminary Study

Jacek Pietrzak, Marek Mirowski, Rafał Świechowski, Damian Wodziński, Agnieszka Wosiak, Katarzyna Michalska, Ewa Balcerczak, Liren Qian

Hematopoietic versus leukemic stem cell quiescence: Challenges and therapeutic opportunities

Eimear O'Reilly, Hojjat Alizadeh Zeinabad, Eva Szegezdi

Relevance of plasma bone marrow Activin-A and CXCL-12 concentration levels as a biomarker in acute myeloid leukemia

Salah Aref, Lamiaa Ebrahim, Shaimaa El-Ashwah, Mohamed El Agdar, Mohamed Ayed

Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression

L. C. Stetson, Dheepa Balasubramanian, Susan Pereira Ribeiro, Tammy Stefan, Kalpana Gupta, Xuan Xu, Slim Fourati, Anne Roe, Zachary Jackson, Robert Schauner, Ashish Sharma, Banumathi Tamilselvan, Samuel Li, Marcos de Lima, Tae Hyun Hwang, Robert Balderas,

In Silico Methods for the Identification of Diagnostic and Favorable Prognostic Markers in Acute Myeloid Leukemia

Hande Yılmaz, Halil Ibrahim Toy, Stephan Marquardt, Gökhan Karakülah, Can Küçük, Panagiota I. Kontou, Stella Logotheti, Athanasia Pavlopoulou

International Journal of Molecular Sciences.2021; 22(17): 9601. CrossRef

A Role for the Bone Marrow Microenvironment in Drug Resistance of Acute Myeloid Leukemia

Seyed Mohammadreza Bolandi, Mahdi Pakjoo, Peyman Beigi, Mohammad Kiani, Ali Allahgholipour, Negar Goudarzi, Jamshid S. Khorashad, Anna M. Eiring

Blocking migration of regulatory T cells to leukemic hematopoietic microenvironment delays disease progression in mouse leukemia model

Rong Wang, Wenli Feng, Hao Wang, Lina Wang, Xiao Yang, Feifei Yang, Yingchi Zhang, Xiaoli Liu, Dongyue Zhang, Qian Ren, Xiaoming Feng, Guoguang Zheng

Overexpressed microRNA‐103a‐3p inhibits acute lower‐extremity deep venous thrombosis via inhibition of CXCL12

CXCL12/CXCR4 signal transduction in diseases and its molecular approaches in targeted-therapy

Bone marrow niches in haematological malignancies

Simón Méndez-Ferrer, Dominique Bonnet, David P. Steensma, Robert P. Hasserjian, Irene M. Ghobrial, John G. Gribben, Michael Andreeff , Daniela S. Krause

DNA methylation disruption reshapes the hematopoietic differentiation landscape

Franco Izzo, Stanley C. Lee, Asaf Poran, Ronan Chaligne, Federico Gaiti, Baptiste Gross, Rekha R. Murali, Sunil D. Deochand, Chelston Ang, Philippa Wyndham Jones, Anna S. Nam, Kyu-Tae Kim, Steven Kothen-Hill, Rafael C. Schulman, Michelle Ki, Priscillia Lh

Dissecting the role of the CXCL12/CXCR4 axis in acute myeloid leukaemia

Eleni E Ladikou, Timothy Chevassut, Chris J Pepper, Andrea GS Pepper

British Journal of Haematology.2020; 189(5): 815. CrossRef

An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination

Victor Pallarès, Ugutz Unzueta, Aïda Falgàs, Laura Sánchez-García, Naroa Serna, Alberto Gallardo, Gordon A. Morris, Lorena Alba-Castellón, Patricia Álamo, Jorge Sierra, Antonio Villaverde, Esther Vázquez, Isolda Casanova, Ramon Mangues

Journal of Hematology & Oncology.2020;[Epub] CrossRef

Aptamers, the Nucleic Acid Antibodies, in Cancer Therapy

International Journal of Molecular Sciences.2020; 21(8): 2793. CrossRef

Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?

Julia Zinngrebe, Klaus-Michael Debatin, Pamela Fischer-Posovszky

Has Drug Repurposing Fulfilled Its Promise in Acute Myeloid Leukaemia?

Journal of Clinical Medicine.2020; 9(6): 1892. CrossRef

The CXCR4 Antagonist, AMD3100, Reverses Mesenchymal Stem Cell-Mediated Drug Resistance in Relapsed/Refractory Acute Lymphoblastic Leukemia

Shan Wang, Xiaojiao Wang, Sha Liu, Shengnan Zhang, Xudong Wei, Yongping Song, Qingsong Yin

OncoTargets and Therapy.2020; Volume 13: 6583. CrossRef

Extracellular Adenine Nucleotides and Adenosine Modulate the Growth and Survival of THP-1 Leukemia Cells

Kamila Puchałowicz, Maciej Tarnowski, Marta Tkacz, Dariusz Chlubek, Patrycja Kłos, Violetta Dziedziejko

International Journal of Molecular Sciences.2020; 21(12): 4425. CrossRef

Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia

Daniel Cancilla, Michael P. Rettig, John F. DiPersio

Plerixafor in combination with chemotherapy and/or hematopoietic cell transplantation to treat acute leukemia: A systematic review and metanalysis of preclinical and clinical studies

Harinad Maganti, Alissa Visram, Risa Shorr, Jill Fulcher, Mitchell Sabloff, David S. Allan

Chemokine receptor CXCR4: An important player affecting the molecular-targeted drugs commonly used in hematological malignancies

Expert Review of Hematology.2020; 13(12): 1387. CrossRef

The Role of Bone Stem Cell Niches in Bone Metastasis

Risk Stratification in Acute Myeloid Leukemia Using CXCR Gene Signatures: A Bioinformatics Analysis

Cong Lu, Jiang Zhu, Xiangjun Chen, Yanjie Hu, Wei Xie, Junxia Yao, Shiang Huang

3D models of the bone marrow in health and disease: yesterday, today, and tomorrow

Annamarija Raic, Toufik Naolou, Anna Mohra, Chandralekha Chatterjee, Cornelia Lee-Thedieck

Alteration of cellular and immune‐related properties of bone marrow mesenchymal stem cells and macrophages by K562 chronic myeloid leukemia cell derived exosomes

Nazli Jafarzadeh, Zohreh Safari, Majid Pornour, Naser Amirizadeh, Mehdi Forouzandeh Moghadam, Majid Sadeghizadeh

Journal of Cellular Physiology.2019; 234(4): 3697. CrossRef

Defining the in vivo characteristics of acute myeloid leukemia cells behavior by intravital imaging

Delfim Duarte, Saoirse Amarteifio, Heather Ang, Isabella Y Kong, Nicola Ruivo, Gunnar Pruessner, Edwin D Hawkins, Cristina Lo Celso

Immunology & Cell Biology.2019; 97(2): 229. CrossRef

Adhesion Deregulation in Acute Myeloid Leukaemia

Alicja M. Gruszka, Debora Valli, Cecilia Restelli, Myriam Alcalay

High Constitutive Cytokine Release by Primary Human Acute Myeloid Leukemia Cells Is Associated with a Specific Intercellular Communication Phenotype

Håkon Reikvam, Elise Aasebø, Annette K. Brenner, Sushma Bartaula-Brevik, Ida Sofie Grønningsæter, Rakel Brendsdal Forthun, Randi Hovland, Øystein Bruserud

Journal of Clinical Medicine.2019; 8(7): 970. CrossRef

The FLT3-ITD mutation and the expression of its downstream signaling intermediates STAT5 and Pim-1 are positively correlated with CXCR4 expression in patients with acute myeloid leukemia

Tingyong Cao, Nenggang Jiang, Hongyan Liao, Xiao Shuai, Jun Su, Qin Zheng

Germline mutations in the bone marrow microenvironment and dysregulated hematopoiesis

Interactions Between Disseminated Tumor Cells and Bone Marrow Stromal Cells Regulate Tumor Dormancy

D. Brooke Widner, Sun H. Park, Matthew R. Eber, Yusuke Shiozawa

Current Osteoporosis Reports.2018; 16(5): 596. CrossRef

Cancer Cells Exploit Notch Signaling to Redefine a Supportive Cytokine Milieu

Michela Colombo, Leonardo Mirandola, Maurizio Chiriva-Internati, Andrea Basile, Massimo Locati, Elena Lesma, Raffaella Chiaramonte, Natalia Platonova

Pathological roles of the homeostatic chemokine CXCL12

Cytokine & Growth Factor Reviews.2018; 44: 51. CrossRef

Detection of high serum concentration of CXC chemokine ligand-12 in acute intracerebral hemorrhage

Jia Shen, Bin Chen, Guan-Rong Zheng, Shen-Zhong Qiu, Huai-Ming Yin, Wei Mao, Hong-Xiang Wang, Jian-Bo Gao

The role of hypoxia on the acquisition of epithelial-mesenchymal transition and cancer stemness: a possible link to epigenetic regulation

Chang Dong Yeo, Nahyeon Kang, Su Yeon Choi, Bit Na Kim, Chan Kwon Park, Jin Woo Kim, Young Kyoon Kim, Seung Joon Kim

The Korean Journal of Internal Medicine.2017; 32(4): 589. CrossRef